Cited by 58Pregnancy and preeclampsia studiesNeonatal and fetal brain pathologyNeurological Complications and Syndromes

Ischemic placental disease and risks of perinatal mortality and morbidity and neurodevelopmental outcomes

Ananth, Cande V., Friedman, Alexander M.·2014·Seminars in Perinatology

Abstract

Preeclampsia, intrauterine growth restriction, and placental abruption are serious obstetrical complications that constitute the syndrome of ischemic placental disease and account for a disproportionate degree of perinatal morbidity and mortality. We review the risks of stillbirth and neonatal and infant mortality in relation to ischemic placental disease, focusing on population-based studies. We also review the risks of neonatal morbidity and neurodevelopmental outcomes in relation to ischemic placental disease. A synthesis of the findings of the relevant studies relating ischemic placental disease to adverse perinatal outcomes underscores two important observations. First, despite the low prevalence of each of the three obstetrical complications, all are associated with increased risks of adverse perinatal and infant outcomes, as well as neurodevelopmental deficits. Second, the burden of increased perinatal risks appears strongest during the preterm period. Efforts to reduce the risks of ischemic placental disease remain critically important and developing effective clinical interventions will be a target worthy for consideration.

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Crossref · 10.1053/j.semperi.2014.03.007

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Authors
Ananth, C. V., & Friedman, A. M.
Affiliations
  • Columbia University Irving Medical Center (US)
  • Columbia University (US)
Corresponding author
Ananth, Cande V.
Venue
Seminars in Perinatology
Publisher
Elsevier BV
Published
2014-04
Volume
38
Issue
3
Pages
151-158
ISSN
0146-0005 (ISSN-L)
OpenAlex
W2132868198
Cited by
58
References
89
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 2 · 2014: 2
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Locations
  • Seminars in Perinatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Keywords
ischemic placental disease, preeclampsia, fetal growth restriction, placental abruption, perinatal mortality, stillbirth, neonatal morbidity, neurodevelopmental outcomes, preterm birth, pregnancy complications
MeSH terms
Abruptio Placentae, Child Development, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Premature, Ischemia, Placenta, Placenta Diseases, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Risk Factors, Prevalence, Neurodegenerative Diseases, Stillbirth, Perinatal Mortality

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