Ischemic placental disease and risks of perinatal mortality and morbidity and neurodevelopmental outcomes
Abstract
Preeclampsia, intrauterine growth restriction, and placental abruption are serious obstetrical complications that constitute the syndrome of ischemic placental disease and account for a disproportionate degree of perinatal morbidity and mortality. We review the risks of stillbirth and neonatal and infant mortality in relation to ischemic placental disease, focusing on population-based studies. We also review the risks of neonatal morbidity and neurodevelopmental outcomes in relation to ischemic placental disease. A synthesis of the findings of the relevant studies relating ischemic placental disease to adverse perinatal outcomes underscores two important observations. First, despite the low prevalence of each of the three obstetrical complications, all are associated with increased risks of adverse perinatal and infant outcomes, as well as neurodevelopmental deficits. Second, the burden of increased perinatal risks appears strongest during the preterm period. Efforts to reduce the risks of ischemic placental disease remain critically important and developing effective clinical interventions will be a target worthy for consideration.
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Abruption is associated with a 2- to 4-fold increased risk of developmental disorders in infants born of abruption pregnancies.
“Abruption is associated with 6 to 10-fold increased risk of cerebral palsy and 2 to 4-fold increased risk of developmental disorders in infants born of abruption pregnancies (62, 118–121).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [120]
Abruption is associated with a 6- to 10-fold increased risk of cerebral palsy in infants born of abruption pregnancies.
“Abruption is associated with 6 to 10-fold increased risk of cerebral palsy and 2 to 4-fold increased risk of developmental disorders in infants born of abruption pregnancies (62, 118–121).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [120]
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- Authors
- Ananth, C. V., & Friedman, A. M.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Ananth, Cande V.
- Venue
- Seminars in Perinatology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 38
- Issue
- 3
- Pages
- 151-158
- ISSN
- 0146-0005 (ISSN-L)
- OpenAlex
- W2132868198
- Cited by
- 58
- References
- 89
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 2 · 2014: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Perinatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
- Keywords
- ischemic placental disease, preeclampsia, fetal growth restriction, placental abruption, perinatal mortality, stillbirth, neonatal morbidity, neurodevelopmental outcomes, preterm birth, pregnancy complications
- MeSH terms
- Abruptio Placentae, Child Development, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Premature, Ischemia, Placenta, Placenta Diseases, Pre-Eclampsia, Pregnancy, Pregnancy Outcome, Risk Factors, Prevalence, Neurodegenerative Diseases, Stillbirth, Perinatal Mortality
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