Studies on medicinal plants of sri lanka. part 14: Toxicity of some traditional medicinal herbs
Abstract
Seventy five medicinal plants of the traditional Ayurvedic pharmacopoeia of Sri Lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while Terminalia chebula and Withania somnifera (L.) dunal produced marked renal lesions.
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Different preparations and extracts of W. somnifera root did not cause any toxicity even on chronic treatment.
“Different preparations and extracts of W. somnifera root did not cause any toxicity even on chronic treatment [170].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [170]
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- Authors
- Arseculeratne, S. N., Gunatilaka, A. A. L., & Panabokke, R. G.
- Affiliations
- University of Peradeniya (LK)
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 1985-07
- Volume
- 13
- Issue
- 3
- Pages
- 323-335
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2081555466
- Cited by
- 131
- References
- 8
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 14 · 2019: 1 · 2018: 3 · 2017: 7 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Resources, Energy and Science Authority of Sri Lanka
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Plant-based Medicinal Research
- Keywords
- medicinal plants, toxicity, pyrrolizidine alkaloids, alkaloids, Aegle marmelos, Hemidesmus indicus, Terminalia chebula, Withania somnifera, hepatotoxicity, nephrotoxicity
- MeSH terms
- Alkaloids, Animals, Kidney, Liver, Medicine, Ayurvedic, Plants, Medicinal, Pyrrolizidine Alkaloids, Rats, Inbred Strains, Sri Lanka, Rats
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