The DOI matches its Crossref record; 4 of the 8 references it cites were found in a registry or an index.
A comparative pharmacological investigation of Ashwagandha and Ginseng
Abstract
The aqueous suspensions of roots of an Indian drug Ashwagandha and the Korean drug Ginseng were tested comparatively for 2 pharmacological activities, namely the anti-stress activity by the 'mice swimming endurance test' and anabolic activity by noting gain in body weights and levator ani muscle in rats. A significant increase in mice swimming time was shown by Ginseng (P < 0.001) and Ashwagandha (P < 0.01) as compared to the control group. Significant increase in body weights in the Ashwagandha treated group (P < 0.05) was better than Ginseng (P < 0.5). Gain in wet weights of the levator ani muscle were also significant in Ginseng (P < 0.001) and Ashwagandha (P < 0.01) treated groups, however, the weight gain of dried levator ani muscles showed comparable results for both these drugs (P < 0.01).
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“Equimolar combination of sitoindosides VII and VIII and withaferin-A (SG-2) when administered once intraperitoneal, the LD50 was 1564 ± 92 mg/kg [172].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [172]
In the citing paper
“Whereas intraperitoneal administration of aqueous-methanol root extract caused 50% lethality in mice at a dose of 1076 ± 78 mg/kg [172].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [172]
In the citing paper
“Withanolide D reportedly decreases anti-apoptotic genes (TERT, Bcl-2, Puma) in the Leukemic Murine mouse model [114].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [114]
Citations
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Singh, N., Nath, R., & Gupta, M. (1988) · Indian Journal of Pharmacology · Cited by 9
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Cited by
Sorted by citations
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
Mishra, L. C., Singh, B. B., & Dagenais, S. (2000) · PubMed · Cited by 776
Withania somnifera: an Indian ginseng
Kulkarni, S. K., & Dhir, A. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.011 · Cited by 416
Studies on the immunomodulatory effects of Ashwagandha
Ziauddin, M., Phansalkar, N., Patki, P. S., Diwanay, S. S., & Patwardhan, B. (1996) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(95)01318-0 · Cited by 382
Self-citationPharmacologic overview of Withania somnifera, the Indian Ginseng
Dar, N. J., Hamid, A., & Ahmad, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2012-1 · Cited by 391
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306
Metadata
- Authors
- Grandhi, A., Mujumdar, A. M., & Patwardhan, B.
- Affiliations
- Savitribai Phule Pune University (IN)
- Corresponding author
- Patwardhan, Bhushan
- ORCID
- Patwardhan, Bhushan
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 44
- Issue
- 3
- Pages
- 131-135
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2088319882
- Cited by
- 142
- References
- 8
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 7
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginseng Biological Effects and Applications
- Keywords
- Withania somnifera, ginseng, Panax ginseng, anti-stress activity, swimming endurance, anabolic activity, weight gain, levator ani muscle, aqueous root extract, comparative pharmacology
- MeSH terms
- Administration, Oral, Animals, Body Weight, Chromatography, Thin Layer, Physical Exertion, Panax, Male, Muscles, Plant Extracts, Plants, Medicinal, Stress, Physiological, Swimming, Withania, Mice, Rats
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