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A comparative pharmacological investigation of Ashwagandha and Ginseng
Abstract
The aqueous suspensions of roots of an Indian drug Ashwagandha and the Korean drug Ginseng were tested comparatively for 2 pharmacological activities, namely the anti-stress activity by the 'mice swimming endurance test' and anabolic activity by noting gain in body weights and levator ani muscle in rats. A significant increase in mice swimming time was shown by Ginseng (P < 0.001) and Ashwagandha (P < 0.01) as compared to the control group. Significant increase in body weights in the Ashwagandha treated group (P < 0.05) was better than Ginseng (P < 0.5). Gain in wet weights of the levator ani muscle were also significant in Ginseng (P < 0.001) and Ashwagandha (P < 0.01) treated groups, however, the weight gain of dried levator ani muscles showed comparable results for both these drugs (P < 0.01).
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“Equimolar combination of sitoindosides VII and VIII and withaferin-A (SG-2) when administered once intraperitoneal, the LD50 was 1564 ± 92 mg/kg [172].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [172]
In the citing paper
“Whereas intraperitoneal administration of aqueous-methanol root extract caused 50% lethality in mice at a dose of 1076 ± 78 mg/kg [172].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [172]
In the citing paper
“Withanolide D reportedly decreases anti-apoptotic genes (TERT, Bcl-2, Puma) in the Leukemic Murine mouse model [114].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [114]
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Metadata
- Authors
- Grandhi, A., Mujumdar, A. M., & Patwardhan, B.
- Affiliations
- Savitribai Phule Pune University (IN)
- Corresponding author
- Patwardhan, Bhushan
- ORCID
- Patwardhan, Bhushan
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 44
- Issue
- 3
- Pages
- 131-135
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2088319882
- Cited by
- 142
- References
- 8
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 7
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Bioactive Compounds
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginseng Biological Effects and Applications
- Keywords
- Withania somnifera, ginseng, Panax ginseng, anti-stress activity, swimming endurance, anabolic activity, weight gain, levator ani muscle, aqueous root extract, comparative pharmacology
- MeSH terms
- Administration, Oral, Animals, Body Weight, Chromatography, Thin Layer, Physical Exertion, Panax, Male, Muscles, Plant Extracts, Plants, Medicinal, Stress, Physiological, Swimming, Withania, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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