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Cited by 332Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and ApplicationsNMR spectroscopy and applications

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Quantification of liver fat using magnetic resonance spectroscopy

Thomsen, Carsten, Becker, Ulrik, Winkler, Kjeld, Christoffersen, Per, Jensen, Mikael, Henriksen, Ole·1994·Magnetic Resonance Imaging
DOI 10.1016/0730-725x(94)92543-7
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Abstract

Localized proton MR spectroscopy using stimulated echoes was used to quantify the liver fat concentration in patients with various degrees of fatty liver due to alcohol abuse. Ten patients underwent a liver biopsy followed by chemical triglyceride estimation of the fatty content. A statistically significant correlation was found between the fat concentration measured in the liver biopsies, and the concentration calculated from the spectroscopic experiments (r = 0.9, p < .001). Quantitative assessment of liver fat concentrations using localized spectroscopy is superior to methods based on differences in relaxation times, and can be used to estimate the fat concentration over the full range of fat content in contrast to the spectroscopic imaging methods. Localized spectroscopy may replace liver biopsy in the diagnosis of diffuse fatty infiltrations, and can be used for follow-up, due to its noninvasive nature.

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Crossref · 10.1016/0730-725x(94)92543-7

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37 of 37 references verified0 citation errors · 0 not checkable

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Citations

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Show all 37 references

Research works printed but not linked: 3

  1. Von Rödl, 1985, Die Kernspintomographie zur Untersuchung der Leber und ihrer Erkrankungen, Z. Gastroenterol., 23, 31
  2. Fantazzini, 1987, 1H-NMR in vitro sensitivity to lipid accumulation, Eurospin, 10, 77
  3. Henriksen, 1987, Rekommandation af regime ved perkutan leverbiopsi, Ugeskr. Laeger, 47, 3177

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Metadata

Authors
Thomsen, C., Becker, U., Winkler, K., Christoffersen, P., Jensen, M., & Henriksen, O.
Affiliations
University of Copenhagen (DK)
Corresponding author
Thomsen, Carsten
ORCID
Venue
Magnetic Resonance Imaging
Publisher
Elsevier BV
Published
1994-01
Volume
12
Issue
3
Pages
487-495
ISSN
0730-725X (ISSN-L)
DOI
10.1016/0730-725x(94)92543-7
OpenAlex
W2093071246
Cited by
332
References
37
Citations by year
2025: 4 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 17 · 2016: 7 · 2015: 15 · 2014: 15 · 2013: 18 · 2012: 17
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Chemistry › Spectroscopy › NMR spectroscopy and applications
Keywords
liver fat quantification, 1H NMR, stimulated echo, alcoholic fatty liver, liver biopsy, triglyceride content, non-invasive diagnosis
MeSH terms
Adult, Aged, Biopsy, Fatty Liver, Alcoholic, Female, Humans, Lipids, Liver, Male, Middle Aged, Magnetic Resonance Spectroscopy

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