Cited by 332Liver Disease Diagnosis and TreatmentAdvanced MRI Techniques and ApplicationsNMR spectroscopy and applications

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Quantification of liver fat using magnetic resonance spectroscopy

Thomsen, Carsten, Becker, Ulrik, Winkler, Kjeld, Christoffersen, Per, Jensen, Mikael, Henriksen, Ole·1994·Magnetic Resonance Imaging

DOI 10.1016/0730-725x(94)92543-7

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Abstract

Localized proton MR spectroscopy using stimulated echoes was used to quantify the liver fat concentration in patients with various degrees of fatty liver due to alcohol abuse. Ten patients underwent a liver biopsy followed by chemical triglyceride estimation of the fatty content. A statistically significant correlation was found between the fat concentration measured in the liver biopsies, and the concentration calculated from the spectroscopic experiments (r = 0.9, p < .001). Quantitative assessment of liver fat concentrations using localized spectroscopy is superior to methods based on differences in relaxation times, and can be used to estimate the fat concentration over the full range of fat content in contrast to the spectroscopic imaging methods. Localized spectroscopy may replace liver biopsy in the diagnosis of diffuse fatty infiltrations, and can be used for follow-up, due to its noninvasive nature.

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Authors: Thomsen, C., Becker, U., Winkler, K., Christoffersen, P., Jensen, M., & Henriksen, O.
Affiliations: University of Copenhagen (DK)
Corresponding author: Thomsen, Carsten
ORCID: Becker, Ulrik
Jensen, Mikael
Venue: Magnetic Resonance Imaging
Publisher: Elsevier BV
Published: 1994-01
Volume: 12
Issue: 3
Pages: 487-495
ISSN: 0730-725X (ISSN-L)
DOI: 10.1016/0730-725x(94)92543-7
OpenAlex: W2093071246
Cited by: 332
References: 37
Citations by year: 2025: 4 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 17 · 2016: 7 · 2015: 15 · 2014: 15 · 2013: 18 · 2012: 17
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Magnetic Resonance Imaging (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Physical Sciences › Chemistry › Spectroscopy › NMR spectroscopy and applications
Keywords: liver fat quantification, 1H NMR, stimulated echo, alcoholic fatty liver, liver biopsy, triglyceride content, non-invasive diagnosis
MeSH terms: Adult, Aged, Biopsy, Fatty Liver, Alcoholic, Female, Humans, Lipids, Liver, Male, Middle Aged, Magnetic Resonance Spectroscopy

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Quantification of liver fat using magnetic resonance spectroscopy

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