Age dependency of the regional cerebral blood volume (rCBV) measured with dynamic susceptibility contrast MR imaging (DSC)
Abstract
The changes of the regional cerebral blood volume (rCBV) with age were studied using dynamic susceptibility contrast MRI (DSC). We examined an unselected, random sample of 71 consecutive patients referred for work-up of suspected intracranial tumors (35 normal examinations, 36 tumors) with a standard 1.5 T clinical MR system. Determination of the rCBV was performed with a T2*-weighted simultaneous dual (SD) FLASH sequence (TR/TE1/TE2/alpha = 32/25/16/10 degrees, 55 images) after bolus injection of Gd-DTPA. Absolute quantification of the rCBV was achieved by normalizing the measured tissue concentration-time curves with the integrated arterial input function (AIF), which was simultaneously measured in the brain feeding arteries. The rCBV (mean +/- SD) was 8.4 +/- 2.9 ml/100 g and 4.2 +/- 1.7 ml/100 g in gray and white matter, respectively, with a decline of about 3% and 6% per decade for white and gray matter, respectively. We conclude that DSC using a SD FLASH sequence allows the simultaneous measurement of the AIF and the tissue concentration-time curve and thus an absolute quantification of the rCBV, which is the basis for interperson comparisons and follow-up studies.
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Cerebral blood volume directly indexes blood volume.
“CBV is a direct measure of blood volume (Wenz et al., 1996; Lu et al., 2005; Barbier et al., 2001)”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Wenz et al., 1996
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- Authors
- Wenz, F., Rempp, K., Brix, G., Knopp, M. V., Gückel, F., Heß, T., & van Kaick, G.
- Affiliations
- German Cancer Research Center (DE)
- Corresponding author
- Wenz, Frederik
- Venue
- Magnetic Resonance Imaging
- Publisher
- Elsevier BV
- Published
- 1996-01
- Volume
- 14
- Issue
- 2
- Pages
- 157-162
- ISSN
- 0730-725X (ISSN-L)
- OpenAlex
- W2074187663
- Cited by
- 57
- References
- 18
- Citations by year
- 2024: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- regional cerebral blood volume, age-related changes, dynamic susceptibility contrast MRI, arterial input function, gray and white matter, intracranial tumors, Gd-DTPA, absolute quantification, cerebral perfusion
- MeSH terms
- Adult, Aging, Brain Neoplasms, Cerebrovascular Circulation, Contrast Media, Pentetic Acid, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Organometallic Compounds, Gadolinium DTPA
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