Cited by 2,033Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 21 of the 24 references it cites were found in a registry or an index.

Close relation of endothelial function in the human coronary and peripheral circulations

Open access

Anderson, Todd J., Uehata, Akimi, Gerhard, Marie D., Meredith, Ian T., Knab, Sarah, Delagrange, Danielle, Lieberman, Eric H., Ganz, Peter, Creager, Mark A., Yeung, Alan C., Selwyn, Andrew P.·1995·Journal of the American College of Cardiology

DOI 10.1016/0735-1097(95)00327-4

Open this paper in CoChat — free account

Abstract

Objectives The relation between endothelium-dependent vasodilator function in the brachial and coronary arteries was determined in the same subjects.Background Coronary artery endothelial dysfunction precedes the development of overt atherosclerosis and is important in its pathogenesis. A noninvasive assessment of endothelial function in a peripheral conduit vessel, the brachial artery, was recently described, but the relation between brachial artery function and coronary artery vasodilator function has not been explored.Methods In 50 patients referred to the catheterization laboratory for the evaluation of coronary artery disease (mean age +/- SD 56 +/- 10 years), the coronary vasomotor response to serial intracoronary infusions of the endothelium-dependent agonist acetylcholine (10(-8) to 10(-6) mol/liter), was studied. Endothelium-dependent vasodilation was also assessed in the brachial artery by measuring the change in brachial artery diameter in response to reactive hyperemia.Results Patients with coronary artery endothelial dysfunction manifested as vasoconstriction in response to acetylcholine had significantly impaired flow-mediated vasodilation in the brachial artery compared with that of patients with normal coronary endothelial function (4.8 +/- 5.5% vs. 10.8 +/- 7.6%, p < 0.01). Patients with coronary artery disease also had an attenuated brachial artery vasodilator response compared with that of patients with angiographically smooth coronary arteries (4.5 +/- 4.6% vs. 9.7 +/- 8.1%, p < 0.02). By multivariate analysis, the strongest predictors of reduced brachial dilator responses to flow were baseline brachial artery diameter (p < 0.001), coronary endothelial dysfunction (p = 0.003), the presence of coronary artery disease (p = 0.007) and cigarette smoking (p = 0.016). The brachial artery vasodilator response to sublingual nitroglycerin was independent of coronary endothelial responses or the presence of coronary artery disease. The positive predictive value of abnormal brachial dilation ( < 3%) in predicting coronary endothelial dysfunction is 95%.Conclusions This study demonstrated a close relation between coronary artery endothelium-dependent vasomotor responses to acetylcholine and flow-mediated vasodilation in the brachial artery. This noninvasive method may become a useful surrogate in assessing the predisposition to atherosclerosis in patients with cardiac risk factors.

Integrity signals

Registry

Crossref · 10.1016/0735-1097(95)00327-4

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
Paradoxical Vasoconstriction Induced by Acetylcholine in Atherosclerotic Coronary Arteries
Ludmer, P. L., Selwyn, A. P., Shook, T., Wayne, R. R., Mudge, G. H., Alexander, R. W., & Ganz, P. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610233151702 · Cited by 2,422
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
Panza, J. A., Quyyumi, A. A., Brush, J. E., & Epstein, S. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230105 · Cited by 2,366
Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
Vallance, P., Collier, J., & Moncada, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91013-1 · Cited by 1,590
Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults.
Celermajer, D. S., Sørensen, K. E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J. T. C., & Deanfield, J. E. (1993) · Circulation · doi:10.1161/01.cir.88.5.2149 · Cited by 1,532
Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.
Vita, J. A., Treasure, C. B., Nabel, E. G., McLenachan, J. M., Fish, R. D., Yeung, A. C., Vekshtein, V. I., Selwyn, A. P., & Ganz, P. (1990) · Circulation · doi:10.1161/01.cir.81.2.491 · Cited by 1,172
Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.
Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., & Dzau, V. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114688 · Cited by 1,017
Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.
Zeiher, A. M., Drexler, H., Wollschläger, H., & Just, H. (1991) · Circulation · doi:10.1161/01.cir.83.2.391 · Cited by 994
Crucial role of endothelium in the vasodilator response to increased flow in vivo.
Pohl, U., Holtz, J., Busse, R., & Bassenge, E. (1986) · Hypertension · doi:10.1161/01.hyp.8.1.37 · Cited by 984

Show all 24 references

Research works printed but not linked: 6

Meredith, 1993, Role of impaired endotheliumdependent vasodilation in ischemic manifestations of coronary artery disease, Circulation, 87, V
Lefroy, 1993, Effects of nitric oxide in the human coronary circulation, Circulation, 88, I
Dyce, 1993, The relationship between endothelial vasodilator function and LDL particle size, density and number in human coronary atherosclerosis, Circulation, 88, 1
Lieberman, 1993, Flow-mediated vasodilation is impaired in the brachial artery of patients with coronary artery disease or with diabetes mellitus, Clin Res, 41, 217A
Uehata, 1992, Non-invasive assessment of flow-mediated vasodilation in brachial arteries: diminished response in young males compared to females, Circulation, 86, I
Lieberman, 1994, Nitric oxide mediates the vasodilator response to flow in humans, Circulation, 90, I

Sorted by citations

Items 901–1,000 of 1,001

Shear stress abnormalities contribute to endothelial dysfunction in hypertension but not in type II diabetes
Khder, Y., Briançon, S., Petermann, R., Quilliot, D., Stoltz, J., Drouin, P., & Zannad, F. M. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816110-00008 · Cited by 31
Folate Improves Endothelial Function in Patients with Coronary Heart Disease
Doshi, S. N., McDowell, I., Moat, S. J., LEWIS, M. J., & Goodfellow, J. (2003) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2003.231 · Cited by 31
Acute and mid-term combined hormone replacement therapy improves endothelial function in post-menopausal women with angina and angiographically normal coronary arteries
Sitges, M. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2631 · Cited by 31
“coronary arteries has been reported in women with coronary artery disease([23]).”
Background
Endothelial Dysfunction: Implications for Therapy of Cardiovascular Diseases
Bell, D., Johns, T. E., & Lopez, L. M. (1998) · Annals of Pharmacotherapy · doi:10.1345/aph.17084 · Cited by 31
Peripheral hemorheological and vascular correlates of coronary blood flow
Damaske, A., Muxel, S., Fasola, F., Radmacher, M. C., Schaefer, S., Jabs, A., Orphal, D., Wild, P. S., Parker, J. D., Fineschi, M., et al. (2011) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2011-1476 · Cited by 30
“This vasodilatative response A relationship between SCF for major epicardial coronary arteries and FMD has been demonstrated, that endothelial dysfunction appears to be a generalized process affecting both coronary and peripheral vasculature [2, 49].”
Advances in Management of the Female Athlete Triad and Eating Disorders
Zach, K. N., Machin, A. L. S., & Hoch, A. Z. (2011) · Clinics in Sports Medicine · doi:10.1016/j.csm.2011.03.005 · Cited by 30
Excessive visit-to-visit glycemic variability independently deteriorates the progression of endothelial and renal dysfunction in patients with type 2 diabetes mellitus
Wei, F., Sun, X., Zhao, Y., Zhang, H., Diao, Y., & Liu, Z. (2016) · BMC Nephrology · doi:10.1186/s12882-016-0300-0 · Cited by 31
“As endothelial dysfunction is a systemic disorder [40], it is deemed that endothelial dysfunction plays a crucial role in the pathogenesis of diabetic nephropathy [41].”
Background
Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health
Minhas, A., Goerlich, E., Corretti, M. C., Arbab‐Zadeh, A., Kelle, S., Leucker, T. M., Lerman, A., & Hays, A. G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.778762 · Cited by 30
“Studies comparing to coronary systemic endothelial function have shown that the correlation between the two may be modest (38, 84).”
Background
Endothelial function in migraine: a cross-sectional study
Vanmolkot, F. H. M., & Hoon, J. N. J. M. D. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-119 · Cited by 30
“Nevertheless, consistent findings between the peripheral and coronary circulation support the notion that the forearm model is a reasonable surrogate [39].”
Background
Changes in blood dendritic cell counts in relation to type of coronary artery disease and brachial endothelial cell function
Vré, E. A. V., Brussel, I. V., de Beeck, K. O., Hoymans, V. Y., Vrints, C. J., Bult, H., & Bosmans, J. M. (2010) · Coronary Artery Disease · doi:10.1097/mca.0b013e3283368c0e · Cited by 30
Effects of red wine on endothelial function: Postprandial studies vs clinical trials
Karatzi, K., Karatzis, E. N., Papamichael, C. M., Lekakis, J., & Zampelas, A. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.04.006 · Cited by 30
Coronary microvascular function in patients with Cushing’s syndrome
Fallo, F., Famoso, G., Capizzi, D., Sonino, N., Dassie, F., Maffei, P., Martini, C., Paoletta, A., Iliceto, S., & Tona, F. (2012) · Endocrine · doi:10.1007/s12020-012-9764-2 · Cited by 30
“have documented in Cushing’s syndrome an endothelial dysfunction in the peripheral circulation [4, 5, 36], which closely reflects that of coronary artery [37].”
Background
The female athlete triad and cardiovascular dysfunction.
Hoch, A., Lal, S., Jurva, J., & Gutterman, D. (2007) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2007.05.001 · Cited by 30
Dissociation between progression of coronary artery calcification and endothelial function in hemodialysis patients: a prospective pilot study
Kalil, R. S., Flanigan, M. J., Stanford, W. P., & Haynes, W. G. (2011) · Clinical Nephrology · doi:10.5414/cn106830 · Cited by 30
“The endothelium is a major target of multiple inflammatory pathways causing atherosclerotic plaque formation [32, 33].”
Background
Combined use of endothelial function assessed by brachial ultrasound and high‐sensitive C‐reactive protein in predicting cardiovascular events
Huang, P., Chen, J., Lu, T., Ding, P. Y., & Lin, S. (2007) · Clinical Cardiology · doi:10.1002/clc.20058 · Cited by 31
Vascular health and cognitive function in older adults with cardiovascular disease
Forman, D. E., Cohen, R. A., Hoth, K. F., Haley, A. P., Poppas, A., Moser, D. J., Gunstad, J., Paul, R. H., Jefferson, A. L., Tate, D. F., et al. (2008) · Artery Research · doi:10.1016/j.artres.2008.01.001 · Cited by 30
Ascorbic acid improves brachial artery vasodilation during progressive handgrip exercise in the elderly through a nitric oxide-mediated mechanism
Trinity, J. D., Wray, D. W., Witman, M. A., Layec, G., Barrett‐O’Keefe, Z., Ives, S. J., Conklin, J. D., Reese, V. R., Zhao, J., & Richardson, R. S. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00817.2015 · Cited by 30
Cardiovascular complications in acromegaly.
Vitale, G., Pivonello, R., Lombardi, G., & Colao, A. A. L. (2004) · PubMed · Cited by 30
Prognostic value of flow-mediated dilatation following myocardial infarction
Guazzi, M., Rèina, G., Gripari, P., Tumminello, G., Vicenzi, M., & Arena, R. A. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.10.036 · Cited by 30
Vitamin C therapy ameliorates vascular endothelial dysfunction in treated patients with homocystinuria
Pullin, C. H., Bonham, J. R., McDowell, I., Lee, P., Powers, H. J., Wilson, J. F., LEWIS, M. J., & Moat, S. J. (2002) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1015672625913 · Cited by 29
“Endothelial damage, of which reduced NO bioavailability is one consequence (Anderson et al 1995), has a central role in the pathogenesis of vascular disease.”
Background
Raloxifene and endothelial function in healthy postmenopausal women
Sarrel, P. M., Nawaz, H., Chan, W., Fuchs, M., & Katz, D. L. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.28 · Cited by 30
Determinants of Endothelium-Dependent Femoral Artery Vasodilation in Youth
Treiber, F. A., Papavassiliou, D. P., Gutin, B., Malpass, D., Wang, Y., Islam, S., Davis, H., & Strong, W. B. (1997) · Psychosomatic Medicine · doi:10.1097/00006842-199707000-00007 · Cited by 30
Assessment of macrovascular and microvascular function in aging males
Babcock, M. C., DuBose, L. E., Witten, T. L., Brubaker, A., Stauffer, B. L., Hildreth, K. L., & Moreau, K. L. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00616.2020 · Cited by 29
Short‐term exercise‐induced protection of cardiovascular function and health: why and how fast does the heart benefit from exercise?
Thijssen, D. H. J., Uthman, L., Somani, Y. B., & van Royen, N. (2021) · The Journal of Physiology · doi:10.1113/jp282000 · Cited by 32
“This method induces impairments in brachial artery function as measured by flow-mediated dilatation (FMD) (Kharbanda et al. 2001), a measure with strong correlation to coronary artery responses (Anderson et al. 1995; Broxterman et al. 2019).”
BackgroundMethod
Endothelium-dependent and -independent vasodilation of the superficial femoral artery in spinal cord-injured subjects
Thijssen, D. H. J., Kooijman, M., de Groot, P. C. E., Bleeker, M. W. P., Smits, P., GREEN, D. J., & Hopman, M. T. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01039.2007 · Cited by 29
“A significant correlation is, however, present between brachial and coronary NO-mediated dilation (1).”
Background
“Passive exercise” using whole body periodic acceleration: Effects on coronary microcirculation
Fukuda, S., Shimada, K., Kawasaki, T., Kono, Y., Jissho, S., Taguchi, H., Maeda, K., Yoshiyama, M., Fujita, M., & Yoshikawa, J. (2010) · American Heart Journal · doi:10.1016/j.ahj.2009.12.034 · Cited by 29
Safety Evaluation of Routine Intracoronary Acetylcholine Infusion in Patients Undergoing a First Diagnostic Coronary Angiogram
Tio, R. A., Monnink, S. H. J., Amoroso, G., Jessurun, G., Veeger, N. J. G. M., Volkers, C., Hautvast, R. W. M., Tan, E. S., van Gilst, W. H., & Boven, A. J. V. (2002) · Journal of Investigative Medicine · doi:10.2310/6650.2002.31305 · Cited by 29
AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease
Warnholtz, A., Ostad, M. A., Heitzer, T. A., Thuneke, F., Fröhlich, M., Tschentscher, P., Schwedhelm, E., Böger, R. H., Meinertz, T., & Münzel, T. F. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.034 · Cited by 29
Low-flow mediated constriction: the yin to FMD’s yang?
Humphreys, R. E., GREEN, D. J., Cable, N. T., Thijssen, D. H. J., & Dawson, E. A. (2014) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2014.909728 · Cited by 29
“Given that dilator responses show strong correlations between the coronary and brachial arteries [46,47], future studies should examine the potential for L-FMC as a surrogate marker of coronary artery constrictor responses.”
Background
Radial artery intima-media thickness predicts major cardiovascular events in patients with suspected coronary artery disease
Eklund, C., Ömerovic, E., Haraldsson, I., Friberg, P., & Gan, L. (2014) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jet285 · Cited by 28
“between the endothelial function of this peripheral vascular bed and the coronary arteries.(9) Based on these similarities, we hypothesized that rIMT may be a useful surrogate marker of atherosclerosis in the coronary artery.”
Background
Direct Association between C-reactive Protein Serum Levels and Endothelial Dysfunction in Patients with Claudication
Haro, J. D., Acín, F., López-Quintana, A., Medina, F. J., Martínez-Aguilar, E., Florez, A., & March, J. R. (2008) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.10.016 · Cited by 29
Rabbit models to study atherosclerosis and its complications – Transgenic vascular protein expression in vivo
Baumgartner, C., Brandl, J., Münch, G., & Ungerer, M. (2016) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2016.05.001 · Cited by 29
Endothelial and inflammatory responses to acute exercise in perimenopausal and late postmenopausal women
Serviente, C. F., Troy, L. M., de Jonge, M., Shill, D. D., Jenkins, N. T., & Witkowski, S. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00189.2016 · Cited by 29
Coronary endothelial function is better in healthy premenopausal women than in healthy older postmenopausal women and men
Mathews, L. M., Iantorno, M., Schär, M., Bonanno, G., Gerstenblith, G., Weiss, R. G., & Hays, A. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186448 · Cited by 30
A comparison of endothelial function in Caucasian and Chinese women before and after the menopause
McCrohon, J. A., Woo, K. S., & Celermajer, D. S. (2000) · Maturitas · doi:10.1016/s0378-5122(00)00102-x · Cited by 29
Relationship of asymmetric dimethylarginine with flow‐mediated dilatation in subjects with newly detected severe hypercholesterolemia
Vladimirova‐Kitova, L., Deneva, T., Angelova, E., Nikolov, F. P., Marinov, B. I., & Mateva, N. G. (2008) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2008.00825.x · Cited by 29
“There is convincing evidence that reduced percentage of FMD (%FMD) is a marker of coronary endothelial dysfunction (Anderson et al., 1995).”
Background
Modification of Vascular Function after Handgrip Exercise Training in 73- to90-yr-Old Men
Dobrosielski, D. A., Greenway, F. L., Welsh, D. A., Jazwinski, S. M., & Welsch, M. A. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318199bef4 · Cited by 29
“Measurement of brachial artery reactivity (BAR) in response to 5 min of forearm occlusion is a validated noninvasive tool to assess global vascular health and is associated with vasoreactivity of the coronary arteries (3,30).”
Method
Monitoring vascular health beyond blood pressure
Duprez, D. A., & Cohn, J. N. (2006) · Current Hypertension Reports · doi:10.1007/s11906-006-0066-z · Cited by 29
“A decrease in constitutive release of NO, which maintains low small-artery tone, may be the initial abnormality, but it is soon accompanied by a decrease in stimulated release of endothelial vasodilators, as manifested by a reduction in flow-mediated dilation of conduit arteries [21, 22 ].”
Background
Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients
Komai, N., Ohishi, M., Morishita, R., Moriguchi, A., Kaibe, M., Matsumoto, K., Rakugi, H., Higaki, J., & Ogihara, T. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(02)02274-4 · Cited by 29
The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia
Stein, J. H., Carlsson, C. M., Papcke-Benson, K., Aeschlimann, S. E., Bodemer, A. A., Carnes, M. L., & McBride, P. E. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01650-3 · Cited by 29
Small Artery Remodeling in Hypertension: Can It Be Corrected?
Moore, M. A., & Schiffrin, E. L. (2001) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200107000-00002 · Cited by 29
Endothelial function is more impaired in hemodialysis patients than renal transplant recipients
Oflaz, H., Püşüroğlu, H., Gençhallaç, H., Demirel, Ş., Buğra, Z., Sever, M. Ş., & Yıldız, A. (2003) · Clinical Transplantation · doi:10.1046/j.1399-0012.2003.00100.x · Cited by 29
“Endothelial dysfunction (ED) is an early abnormality for development of atherosclerosis and a good correlation between coronary and peripheral arterial ED has been reported in patients with ischemic heart disease (2).”
Background
Elevated Plasma Concentration of Asymmetric Dimethylarginine That Is Reduced by Single Dose Testosterone Administration in Idiopathic Hypogonadotropic Hypogonadism Patients
Cakir, E., Ozcan, O., Yaman, H., Akgul, E. O., Bilgi, C., Erbil, M. K., & Yesilova, Z. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2045 · Cited by 28
EFFECT OF HIGH-INTENSITY EXERCISE ON ENDOTHELIAL FUNCTION IN PATIENTS WITH T2DM
da Silva, C. A., Vasconcelos-Filho, F. S. L., Serafim, M., Botura, E., da Rocha-e-Silva, R. C., Pacheco, C., Marques, F. A. O., & Melo, S. I. L. (2016) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-869220162202151254 · Cited by 28
Do incretins improve endothelial function?
Oyama, J., Higashi, Y., & Node, K. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-21 · Cited by 31
Association of Thyroid-stimulating Hormone and Cardiovascular Risk Factors
Sun, X., Sun, Y., Li, W., Chen, C.-Y., Chiu, Y.-H., Chien, H.-Y., & Wang, Y. (2015) · Internal Medicine · doi:10.2169/internalmedicine.54.4514 · Cited by 29
“Endothelial dysfunction, a common pre-atherosclerosis condition (46), has been detected in both the SH and OH patients, thus suggesting that hypothyroidism may play a role in this disease (50, 51).”
Background
Effects of dipeptidyl peptidase-4 inhibitors on cardiac and endothelial function in type 2 diabetes mellitus: A pilot study
Leung, M., Leung, D. Y., & Wong, V. W. (2016) · Diabetes and Vascular Disease Research · doi:10.1177/1479164116629352 · Cited by 27
Reactive hyperemia test: methods of analysis, mechanisms of reaction and prospects
Сагайдачный, А. А. (2018) · Regional blood circulation and microcirculation · doi:10.24884/1682-6655-2018-17-3-5-22 · Cited by 31
Relationship between heart rate variability and endothelial function in healthy subjects
Pintér, A., Horváth, T., Sárközi, A., & Kollai, M. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.05.005 · Cited by 28
“Specifically, we aimed to determine the relationship of vagal heart rate variability indices to brachial artery flowmediated dilatation, a generally accepted systemic measure of endothelial function (Anderson et al., 1995; Debbabi et al., 2010).”
Background
Tributyltin chloride disrupts aortic vascular reactivity and increases reactive oxygen species production in female rats
Ximenes, C. F., Rodrigues, S. M. L., Podratz, P. L., Merlo, E., de Araújo, J. F. P., Rodrigues, L. C. M., Coitinho, J. B., Vassallo, D. V., Graceli, J. B., & Stefanon, I. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-0061-8 · Cited by 31
Prostaglandin E1 Improves Endothelial Function in Critical Limb Ischemia
Marchesi, S., Pasqualini, L., Lombardini, R., Vaudo, G., Lupattelli, G., Pirro, M., Schillaci, G., & Mannarino, E. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200302000-00014 · Cited by 28
“There is a close relation between brachial artery and coronary artery endothelial function (19).”
Background
Flow‐Mediated Dilation and Gender in Patients with Coronary Artery Disease: Arterial Size Influences Gender Differences in Flow‐Mediated Dilation
Mizia‐Stec, K., Gąsior, Z., Mizia, M., Haberka, M., Holecki, M. T., Zwolińska, W., Katarzyna, K., & Skowerski, M. (2007) · Echocardiography · doi:10.1111/j.1540-8175.2007.00531.x · Cited by 28
Endothelial dysfunction in coronary heart disease is more than a systemic process
Ganz, P., & Hsue, P. Y. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht199 · Cited by 28
The Female Athlete Triad and Endothelial Dysfunction
Lanser, E. M., Zach, K. N., & Hoch, A. Z. (2011) · PM&R · doi:10.1016/j.pmrj.2010.12.024 · Cited by 26
Obesity, Metabolic Syndrome and Disorders of Energy Balance
Han, J. C., & Weiss, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00024-5 · Cited by 27
Where Are We Heading with Noninvasive Clinical Vascular Physiology? Why and How Should We Assess Endothelial Function?
Ellins, E. A., & Halcox, J. (2011) · Cardiology Research and Practice · doi:10.4061/2011/870132 · Cited by 27
“Why and How Should We Assess”
Arterial stiffening and systemic endothelial activation induced by smoking
Vlachopoulos, C. V., Aznaouridis, K. A., Bratsas, A., Ioakeimidis, N., Dima, I., Xaplanteris, P., Stefanadis, C., & Tousoulis, D. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.029 · Cited by 27
The Influence of Insulin Resistance, Obesity, and Diabetes Mellitus on Vascular Tone and Myocardial Blood Flow
Valenta, I., Dilsizian, V., Quercioli, A., Schelbert, H. R., & Schindler, T. H. (2011) · Current Cardiology Reports · doi:10.1007/s11886-011-0240-z · Cited by 27
“01) [19], the overall data discourage extrapolation of data between the two vascular beds [20–22].”
Background
Hypothyroidism is associated with signs of endothelial dysfunction despite 1‐year replacement therapy with levothyroxine
Clausen, P., Mersebach, H., Nielsen, B., Feldt‐Rasmussen, B., & Feldt‐Rasmussen, U. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03410.x · Cited by 27
Neuropsychological Performance Is Associated With Vascular Function in Patients With Atherosclerotic Vascular Disease
Moser, D. J., Robinson, R. G., Hynes, S. M., Reese, R. L., Arndt, S. V., Paulsen, J. S., & Haynes, W. G. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000250973.93401.2d · Cited by 27
Inhibition of endocytosis exacerbates TNF-α-induced endothelial dysfunction via enhanced JNK and p38 activation
Choi, H., Nguyen, H. N., & Lamb, F. S. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00885.2013 · Cited by 26
Effects of long-term and reduced-dose hormone replacement therapy on endothelial function and intima-media thickness in postmenopausal women
Hashimoto, M., Miyao, M., Akishita, M., Hosoi, T., Toba, K., Kozaki, K., Yoshizumi, M., & Ouchi, Y. (2002) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200201000-00009 · Cited by 27
New risk factors for coronary heart disease in Asia
Woo, K. S., Chook, P., Young, R., & Sanderson, J. (1997) · International Journal of Cardiology · doi:10.1016/s0167-5273(97)00211-8 · Cited by 27
Effects of thyroxine replacement on lipid profile and endothelial function after thyroidectomy
Erbil, Y., Özbey, N., Giriş, M., Salmaslıoğlu, A., Özarmağan, S., & Tezelman, S. (2007) · British journal of surgery · doi:10.1002/bjs.5915 · Cited by 27
Nitric oxide and vascular reactivity in African American patients with hypertension*1
Vita, J. A. (2003) · Journal of Cardiac Failure · doi:10.1054/s1071-9164(03)00588-8 · Cited by 27
Endothelial Dysfunction in Hypertension
Kiowski, W. (1999) · Clinical and Experimental Hypertension · doi:10.3109/10641969909060995 · Cited by 27
Vascular Endothelium in Health and Disease: Structure, Function, Assessment and Role in Metabolic Disorders
Pluta, W. W., Lubkowska, A., & Dudzińska, W. (2025) · Vascular Health and Risk Management · doi:10.2147/vhrm.s519426 · Cited by 35
“46 The demonstration of the relationship between the functioning of the VE in the coronary arteries and the function in the peripheral arteries 47 made it possible to adapt the technique to the much more easily accessible brachial artery.”
Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy
Philpott, A. C., Hubacek, J., Sun, Y., Hillard, D., & Anderson, T. J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.10.067 · Cited by 26
The Clinical Relevance of the Percentage Flow-Mediated Dilation Index
Atkinson, G., & Batterham, A. M. (2015) · Current Hypertension Reports · doi:10.1007/s11906-014-0514-0 · Cited by 26
Acute lower leg hot water immersion protects macrovascular dilator function following ischaemia–reperfusion injury in humans
Engelland, R. E., Hemingway, H. W., Tomasco, O. G., Olivencia‐Yurvati, A. H., & Romero, S. A. (2019) · Experimental Physiology · doi:10.1113/ep088154 · Cited by 27
“Importantly, the brachial artery can be used as a surrogate for the coronary artery given the strong relationship between brachial and coronary vasodilator function (Anderson et al., 1995; Takase et al., 1998, 2005; Vallbracht-Israng, Morguet, & Schwimmbeck, 2007).”
Method
Platelet Inhibition, Endothelial Function, and Clinical Outcome in Patients Presenting With ST‐Segment–Elevation Myocardial Infarction Randomized to Ticagrelor Versus Prasugrel Maintenance Therapy: Long‐Term Follow‐Up of the REDUCE‐MVI Trial
van der Hoeven, N. W., Janssens, G. N., Everaars, H., Nap, A., Lemkes, J. S., de Waard, G. A., van de Ven, P. M., van Rossum, A. C., Escaned, J., Mejía-Rentería, H. D., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014411 · Cited by 26
“CK-MB (μg/L), median (IQR) 86 (28-207) 102 (37-216) 0.”
Effect of atorvastatin on peripheral endothelial function and systemic inflammatory markers in patients with stable coronary artery disease
Alber, H. F., Frick, M., Suessenbacher, A., Dörler, J., Dichtl, W., Stocker, E.-M., Pachinger, O. M., & Weidinger, F. F. (2007) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-007-0377-y · Cited by 26
“Peripheral endothelial function, determined non-invasively by the ultrasonographic assessment of brachial artery flow-mediated vasodilation (FMD) [1], is related to coronary endothelial function [ 2 ], coronary risk factors [3] as well as circulating inflammatory markers [4, 5] and may serve as a surrogate parameter f…”
Progesterone does not influence vascular function in postmenopausal women
Honisett, S. Y., Pang, B., Stojanovska, L., Sudhir, K., & Komesaroff, P. A. (2003) · Journal of Hypertension · doi:10.1097/00004872-200306000-00014 · Cited by 26
Comparison of Coronary Microcirculation in Female Nurses After Day-Time Versus Night-Time Shifts
Kubo, T., Fukuda, S., Hirata, K., Shimada, K., Maeda, K., Komukai, K., Kono, Y., Miyahana, R., Nakanishi, K., Otsuka, K., et al. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.07.028 · Cited by 26
Evidence for a Greater Elevation in Vascular Shear Stress after Morning Exercise
Jones, H., GREEN, D. J., George, K., Black, M. A., & Atkinson, G. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318195109c · Cited by 26
Endothelial Dysfunction in Patients With Coronary Artery Disease
Manganaro, A., Ciracì, L., Andrè, L., Trio, O., Manganaro, R., Saporito, F., Oreto, G., & Andò, G. (2014) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029614524620 · Cited by 26
Analysis of endothelial precursor cells in chronic migraine: A case-control study
Oterino, A., Toriello, M., Palacio, E., González‐Quintanilla, V., Ruiz‐Lavilla, N., Montes, S., de la Vega, M. S., Martínez-Nieto, R., Castillo, J., & Pascual, J. (2012) · Cephalalgia · doi:10.1177/0333102412469737 · Cited by 26
Simultaneous Noninvasive Assessment of Systemic and Coronary Endothelial Function
Iantorno, M., Hays, A. G., Schär, M., Krishnaswamy, R. R., Soleimanifard, S., Steinberg, A. M., Stuber, M., Gerstenblith, G., & Weiss, R. G. (2016) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.115.003954 · Cited by 27
“Patients with coronary artery disease (CAD), in fact, manifest a paradoxical coronary artery vasoconstrictor response to endothelial-dependent stressors that normally cause vasodilatation,(11) whereas the brachial arteries of patients with CAD vasodilate less in response to endothelial dependent stressors than do thos…”
BackgroundMethodResultInfluential
Brief Exposure to Secondhand Smoke Reversibly Impairs Endothelial Vasodilatory Function
Pinnamaneni, K., Sievers, R. E., Sharma, R., Selchau, A. M., Gutierrez, G., Nordsieck, E. J., Su, R., An, S., Chen, Q., Wang, X., et al. (2013) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntt189 · Cited by 26
HIV-Infektion, antiretrovirale Therapie und Endothel
Hürlimann, D., Weber, R. K., Enseleit, F., & Lüscher, T. F. (2005) · Herz · doi:10.1007/s00059-005-2740-3 · Cited by 26
“In-vitro-Daten zeigen, dass das HIV-Oberflächenprotein gp120 die Expres- 8 7 6 5 4 3 2 1 0 M yo ka rd in fa rk tin zi de nz / 1 00 0 P J (9 5% -”
BackgroundInfluential
Acute effect of oral vitamin C on coronary circulation in young healthy smokers
Teramoto, K., Daimon, M., Hasegawa, R., Toyoda, T., Sekine, T., Kawata, T., Yoshida, K., & Komuro, I. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.03.006 · Cited by 26
Pyridoxine improves endothelial function in cardiac transplant recipients
Miner, S. E. S., Cole, D. E. C., Evrovski, J., Forrest, Q., Hutchison, S. J., Holmes, K., & Ross, H. J. (2001) · The Journal of Heart and Lung Transplantation · doi:10.1016/s1053-2498(01)00293-5 · Cited by 26
Assessing risk for coronary heart disease: beyond Framingham
Cobb, F. R., Kraus, W. E., Root, M. M., & Allen, J. D. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00500-3 · Cited by 26
Brachial artery ultrasound: A noninvasive tool in the assessment of triglyceride-rich lipoproteins
Vogel, R. A. (1999) · Clinical Cardiology · doi:10.1002/clc.4960221407 · Cited by 26
Role of endothelial dysfunction in determining angina after percutaneous coronary intervention: Learning from pathophysiology to optimize treatment
Mangiacapra, F., Buono, M. G. D., Abbate, A., Gori, T., Barbato, E., Montone, R. A., Crea, F., & Niccoli, G. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.02.009 · Cited by 25
Prognostic role of brachial reactivity in patients with ST myocardial infarction after percutaneous coronary intervention
Wang, X., Guo, F., Li, G., Cao, Y., & Fu, H. (2009) · Coronary Artery Disease · doi:10.1097/mca.0b013e32832e5c61 · Cited by 25
Effects of acute consumption of a fruit and vegetable purée-based drink on vasodilation and oxidative status
George, T. W., Waroonphan, S., Niwat, C., Gordon, M. H., & Lovegrove, J. A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003315 · Cited by 25
“Laser Doppler imaging coupled with iontophoresis (LDI) is one such method of investigating the vasodilation of the peripheral microvasculature by delivering vasodilator agents across the skin under the influence of an applied electrical field((7)).”
Method
Possible association between non-invasive parameter of flow-mediated dilatation in brachial artery and whole coronary plaque vulnerability in patients with coronary artery disease
Sawada, T., Emoto, T., Motoji, Y., Hashimoto, M., Kageyama, H., Terashita, D., Mizoguchi, T., Mizuguchi, T., Iwasaki, M., Taira, K., et al. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.11.101 · Cited by 25
Evaluation of the Impact of Treatment on Endothelial Function and Cardiac Performance in Acromegaly
Akgul, E., Tokgozoglu, S. L., Erbas, T. A., Kabakçı, G., Aytemir, K., Haznedaroğlu, İ. C., Oto, A., & Kes, S. (2010) · Echocardiography · doi:10.1111/j.1540-8175.2010.01179.x · Cited by 25
Cerebrovascular mental stress reactivity is impaired in hypertension
Naqvi, T. Z., & Hyuhn, H. K. (2009) · Cardiovascular Ultrasound · doi:10.1186/1476-7120-7-32 · Cited by 25
“Brachial artery reactivity (BART) in response to shear stress assesses endothelial function by measuring arterial dilation [11,12] and is abnormal in patients with coronary artery disease [13-15], and its risk factors [4-12].”
Endothelial dysfunction in insulin-resistant rats is associated with oxidative stress and COX pathway dysregulation
Oudot, A., Behr‐Roussel, D., Compagnie, S., Caisey, S., Coz, O. L., Gorny, D., Alexandre, L., & Giuliano, F. (2009) · Physiological Research · doi:10.33549/physiolres.931583 · Cited by 25
Ovarian hormones modulate endothelin‐1 receptor responses in young women
Sebzda, K. N., Kuczmarski, A. V., Pohlig, R. T., Lennon, S. L., Edwards, D. G., & Wenner, M. M. (2018) · Microcirculation · doi:10.1111/micc.12490 · Cited by 27
Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
Sumpio, B. J., Citoni, G., Chin, J. A., & Sumpio, B. E. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.03.463 · Cited by 25
Impaired peripheral vasodilation during graded systemic hypoxia in healthy older adults: role of the sympathoadrenal system
Richards, J. C., Crecelius, A. R., Larson, D. G., Luckasen, G. J., & Dinenno, F. A. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00794.2016 · Cited by 25
“The forearm was chosen, not only to isolate the local effects of our pharmacological agents, but also because of the significant correlation between endothelial function assessed in the forearm and coronary vasculature (1).”
The interrelation of endothelial function and microvascular reactivity in different vascular beds, and risk assessment in hypertension: results from the Doxazosin–ramipril study
Jekell, A., Kalani, M., & Kahan, T. (2018) · Heart and Vessels · doi:10.1007/s00380-018-1265-7 · Cited by 25
Vascular, cardiac and renal target organ damage associated to arterial hypertension: which noninvasive tools for detection?
Cortese, F., Cecere, A., Cortese, A. M., Andriani, A., Truncellito, L., Valente, F., Giordano, P., & Ciccone, M. M. (2020) · Journal of Human Hypertension · doi:10.1038/s41371-020-0307-7 · Cited by 25
The Acute Effect of Aerobic Exercise on Brachial Artery Endothelial Function in Renal Transplant Recipients
Cosío-Lima, L., Thompson, P. D., REYNOLDS, K. L., Headley, S., Winter, C. R., Manos, T. M., Lagasse, M. A., Todorovich, J. R., & Germain, M. (2006) · Preventive Cardiology · doi:10.1111/j.1520-037x.2006.05408.x · Cited by 25
Impaired endothelial function in hypertensive patients with target organ damage
Xu, J., Zhang, Y., Wu, S., Niu, W.-Q., Zhu, D.-L., & Gao, P.-J. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.10 · Cited by 25
Assessment of vascular and endothelial dysfunction in nutritional studies
Ray, S., Miglio, C., Eden, T., & Rio, D. D. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.03.011 · Cited by 25
Endothelial dysfunction occurs in peripheral circulation patients with acute and stable coronary artery disease
Thanyasiri, P., Celermajer, D. S., & Adams, M. R. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01086.2004 · Cited by 25
“A number of other measures of endothelial physiology were not assessed such as t-PA activity or plasminogen activator inhibitor-1 levels; however, recent studies have demonstrated that these measures correlated well with the factors measured (3, 19).”
Background

Authors: Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., & Selwyn, A. P.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Anderson, Todd J.
Meredith, Ian T.
Ganz, Peter
Creager, Mark A.
Yeung, Alan C.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 1995-11
Volume: 26
Issue: 5
Pages: 1235-1241
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/0735-1097(95)00327-4
OpenAlex: W1980445357
Cited by: 2,033
References: 24
Citations by year: 2026: 10 · 2025: 18 · 2024: 26 · 2023: 30 · 2022: 25 · 2021: 50 · 2020: 47 · 2019: 42 · 2018: 41 · 2017: 61 · 2016: 67 · 2015: 72 · 2014: 82 · 2013: 75 · 2012: 66
FWCI: 25.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6467 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k04hl002566-04, 5k08hl002787-05, 5k07hl002663-02)
National Heart, Lung, and Blood Institute (HL02663, 1K04-HL-02566, 1K08 HL-02787)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: endothelial dysfunction, coronary artery disease, brachial artery flow-mediated dilation, coronary vasodilation, acetylcholine, reactive hyperemia, cigarette smoking, nitroglycerin, atherosclerosis risk prediction, coronary artery disease screening, brachial artery diameter, vasoconstriction
MeSH terms: Acetylcholine, Adult, Aged, Brachial Artery, Coronary Artery Disease, Coronary Vessels, Endothelium, Vascular, Female, Nitroglycerin, Cardiac Catheterization, Humans, Male, Middle Aged, Predictive Value of Tests, Vasodilation, Vasodilator Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Close relation of endothelial function in the human coronary and peripheral circulations

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks