Cited by 2,033Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin EffectsCardiovascular Function and Risk Factors

The DOI matches its Crossref record; 21 of the 24 references it cites were found in a registry or an index.

Close relation of endothelial function in the human coronary and peripheral circulations

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Anderson, Todd J., Uehata, Akimi, Gerhard, Marie D., Meredith, Ian T., Knab, Sarah, Delagrange, Danielle, Lieberman, Eric H., Ganz, Peter, Creager, Mark A., Yeung, Alan C., Selwyn, Andrew P.·1995·Journal of the American College of Cardiology

DOI 10.1016/0735-1097(95)00327-4

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Abstract

Objectives The relation between endothelium-dependent vasodilator function in the brachial and coronary arteries was determined in the same subjects.Background Coronary artery endothelial dysfunction precedes the development of overt atherosclerosis and is important in its pathogenesis. A noninvasive assessment of endothelial function in a peripheral conduit vessel, the brachial artery, was recently described, but the relation between brachial artery function and coronary artery vasodilator function has not been explored.Methods In 50 patients referred to the catheterization laboratory for the evaluation of coronary artery disease (mean age +/- SD 56 +/- 10 years), the coronary vasomotor response to serial intracoronary infusions of the endothelium-dependent agonist acetylcholine (10(-8) to 10(-6) mol/liter), was studied. Endothelium-dependent vasodilation was also assessed in the brachial artery by measuring the change in brachial artery diameter in response to reactive hyperemia.Results Patients with coronary artery endothelial dysfunction manifested as vasoconstriction in response to acetylcholine had significantly impaired flow-mediated vasodilation in the brachial artery compared with that of patients with normal coronary endothelial function (4.8 +/- 5.5% vs. 10.8 +/- 7.6%, p < 0.01). Patients with coronary artery disease also had an attenuated brachial artery vasodilator response compared with that of patients with angiographically smooth coronary arteries (4.5 +/- 4.6% vs. 9.7 +/- 8.1%, p < 0.02). By multivariate analysis, the strongest predictors of reduced brachial dilator responses to flow were baseline brachial artery diameter (p < 0.001), coronary endothelial dysfunction (p = 0.003), the presence of coronary artery disease (p = 0.007) and cigarette smoking (p = 0.016). The brachial artery vasodilator response to sublingual nitroglycerin was independent of coronary endothelial responses or the presence of coronary artery disease. The positive predictive value of abnormal brachial dilation ( < 3%) in predicting coronary endothelial dysfunction is 95%.Conclusions This study demonstrated a close relation between coronary artery endothelium-dependent vasomotor responses to acetylcholine and flow-mediated vasodilation in the brachial artery. This noninvasive method may become a useful surrogate in assessing the predisposition to atherosclerosis in patients with cardiac risk factors.

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Method
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Background
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Background
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Background
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“function in the coronary arteries (2).”
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Result
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Background
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“Several studies have shown that brachial FMD is impaired by cardiovascular risk factors such as aging, male sex, smoking, hypercholesterolemia and diabetes mellitus, and is correlated with invasive coronary results (Anderson et al., 1995; Celermajer et al., 1996; Levenson et al., 2001; Chironi et al., 2008).”
Background
Folic acid treatment of hyperhomocysteinemia in peritoneal dialysis patients: no change in endothelial function after long-term therapy.
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“It parallels endothelial dysfunction of the coronary arteries and correlates with the extent of atherosclerotic vascular disease.(33,34) In fact, reduced bioavailability of endotheliumderived NO plays an important and early role in the pathogenesis of atherosclerosis.”
Background
Population-Based Twin Study of the Effects of Migration From Finland to Sweden on Endothelial Function and Intima-Media Thickness
Jartti, L., Rönnemaa, T., Kaprio, J. A., Järvisalo, M. J., Toikka, J., Marniemi, J., Hammar, N., Alfredsson, L. S., Saraste, M., Hartiala, J., et al. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013313.70875.a7 · Cited by 65
Endothelial dysfunction in endocrine disease
Abdu, T. A. M. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00425-8 · Cited by 64
Sex Differences in Cardiovascular Aging and Heart Failure
Oneglia, A. P., Nelson, M. D., & Merz, C. N. B. (2020) · Current Heart Failure Reports · doi:10.1007/s11897-020-00487-7 · Cited by 65
No differences of carotid intima–media thickness between young patients with ankylosing spondylitis and healthy controls
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Evidence that cranberry juice may improve augmentation index in overweight men
Ruel, G., Lapointe, A., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.11.002 · Cited by 66
“endothelium-dependent vasodilation response as previously reported [51–54].”
Background
The role of oxidative stress in postprandial endothelial dysfunction
Lacroix, S., Rosiers, C. D., Tardif, J., & Nigam, A. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422412000182 · Cited by 65
“Endothelial function is often evaluated by ultrasonography of the brachial artery and is expressed as a percentage of endothelium-dependent vasodilation in response to transient ischaemia (flow-mediated dilatation)((5,6)).”
Background
Aldosterone and the Vasculature: Mechanisms Mediating Resistant Hypertension
Duprez, D. A. (2007) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2007.06367.x · Cited by 63
Relationship between brachial artery flow-mediated dilation and coronary flow reserve in patients with peripheral artery disease.
Pellegrino, T., Storto, G., Filardi, P. P., Sorrentino, A. R., Silvestro, A., Petretta, M., Brevetti, G., Massimo Chiariello, A., Salvatore, M., & Cuocolo, A. (2005) · PubMed · Cited by 64
How to assess endothelial function in human blood vessels
Vanhoutte, P. M. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917080-00001 · Cited by 64
Inter-relationships of indices of endothelial damage/dysfunction [circulating endothelial cells, von Willebrand factor and flow-mediated dilatation] to tissue factor and interleukin-6 in acute coronary syndromes
Lee, K. W., Blann, A. D., & Lip, G. Y. H. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.10.014 · Cited by 63
“coagulation) [7–9] are elevated in patients with ACS, whilst FMD is impaired [19,24], and all predict recurrent coronary events.”
Background
Blood pressure and cardiovascular risk: What about cocoa and chocolate?
Grassi, D., Desideri, G., & Ferri, C. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.05.020 · Cited by 64
Impact of Bed Rest on Conduit Artery Remodeling
van Duijnhoven, N. T. L., GREEN, D. J., Felsenberg, D., Belavý, D. L., Hopman, M. T. E., & Thijssen, D. H. J. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.152868 · Cited by 63
Imaging of subclinical atherosclerosis in children and young adults
Raitakari, O. T. (1999) · Annals of Medicine · doi:10.1080/07853890.1999.11904397 · Cited by 63
Endothelial function in HIV-infected patients receiving protease inhibitor therapy: does immune competence affect cardiovascular risk?
Nolan, D. A., Watts, G. F., Herrmann, S., French, M. A., John, M., & Mallal, S. A. (2003) · QJM · doi:10.1093/qjmed/hcg145 · Cited by 63
Isoflavones improve vascular reactivity in post-menopausal women with hypercholesterolemia
Lissin, L. W., Oka, R. K., Lakshmi, S., & Cooke, J. P. (2004) · Vascular Medicine · doi:10.1191/1358863x04vm531oa · Cited by 63
Dissecting the genetic architecture of the cardiovascular and renal stress response
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“…or brachial arteries to reactive hyperemia has been associated with elevated resting BP, smoking, hypercholesterolemia and has differentiated individuals with and without CVD or EH (Anderson and Armstead, 1995; Anderson et al., 1995; Celermajer et al., 1994a,b, 1992; Luscher and Vanhoutte, 1990).”
Close relationship between the vasodilator response to acetylcholine in the brachial and coronary artery in suspected coronary artery disease
Takase, B., Hamabe, A., Satomura, K., Akima, T., Uehata, A., Ohsuzu, F., Ishihara, M., & Kurita, A. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.12.021 · Cited by 63
The value of ECG and echocardiography during stress testing for identifying systemic endothelial dysfunction and epicardial artery stenosis
Pálinkás, A. (2002) · European Heart Journal · doi:10.1053/euhj.2002.3170 · Cited by 63
“Via Moruzzi, 1 56126 Pisa, Italy. function [5] [6] and can be evaluated non-invasively with brachial ultrasound [7] [8] .”
Background
The Arterial System in Human Hypertension
Duprez, D. A., & Cohn, J. N. (2007) · Elsevier eBooks · doi:10.1016/b978-0-323-03961-1.50015-5 · Cited by 63
Altered Endothelial Function in Asymptomatic Male Adolescents with Type 1 Diabetes
Mahmud, F. H., Earing, M. G., Lee, R. A., Lteif, A. N., Driscoll, D. J. O., & Lerman, A. (2006) · Congenital Heart Disease · doi:10.1111/j.1747-0803.2006.00015.x · Cited by 61
Physiological testosterone replacement and arterial endothelial function in men
Sader, M. A., Griffiths, K. A., Skilton, M. R., Wishart, S. M., Handelsman, D. J., & Celermajer, D. S. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01796.x · Cited by 62
“Arterial FMD measurements reflect predominantly nitric oxide release (Joannides et al., 1995) and correlate significantly with coronary endothelial function (Anderson et al., 1995) and coronary atherosclerosis (Neunteufl et al., 1997).”
Background
Vascular Protective Effects of Angiotensin Converting Enzyme Inhibitors and their Relation to Clinical Events
Enseleit, F., Hürlimann, D., & Lüscher, T. F. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200109011-00004 · Cited by 63
“Endothelium-dependent vasodilation in the human forearm and coronary vascular beds are strongly correlated (75,76).”
Background
A comparison of flow-mediated dilatation and von Willebrand factor as markers of endothelial cell function in health and in hypertension
Felmeden, D. C., Blann, A. D., Spencer, C., Beevers, D. G., & Lip, G. Y. H. (2003) · Blood Coagulation & Fibrinolysis · doi:10.1097/00001721-200307000-00001 · Cited by 62
Ticagrelor Improves Peripheral Arterial Function in Patients with a Previous Acute Coronary Syndrome
Törngren, K., Öhman, J. N., Salmi, H., Larsson, J., & Erlinge, D. (2013) · Cardiology · doi:10.1159/000347122 · Cited by 62
Postprandial Improvement of Endothelial Function by Red Wine and Olive Oil Antioxidants: A Synergistic Effect of Components of the Mediterranean Diet
Karatzi, K., Papamichael, C. M., Karatzis, E. N., Papaioannou, T. G., Voidonikola, P. T., Vamvakou, G. D., Lekakis, J. P., & Zampelas, A. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719724 · Cited by 61
“The method we used (FMD) is a non-invasive, easy to perform method to assess endothelial function, it is closely related to coronary endothelial function [22] and it has been related with several established risk factors [23].”
Method
Endothelial dysfunction, intima–media thickness and coronary reserve in relation to risk factors and Framingham score in patients without clinical atherosclerosis
Campuzano, R., Moya, J. L., García‐Lledó, A., Tomas, J. P., Ruíz, S., Megı́as, A., Balaguer, J., & Asín, E. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000239294.17636.27 · Cited by 61
Vasculopathy Related to Manic/Hypomanic Symptom Burden and First-Generation Antipsychotics in a Sub-Sample from the Collaborative Depression Study
Fiedorowicz, J. G., Coryell, W. H., Rice, J. P., Warren, L. L., & Haynes, W. G. (2012) · Psychotherapy and Psychosomatics · doi:10.1159/000334779 · Cited by 62
Relation of Brachial Artery Flow-Mediated Vasodilation to Significant Coronary Artery Disease in Patients With Peripheral Arterial Disease
Filardi, P. P., Cuocolo, A., Brevetti, G., Silvestro, A., Storto, G., Dellegrottaglie, S., Corrado, L., Cafiero, M., Camerino, R., Polimeno, M., et al. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.06.084 · Cited by 61
Limb-specific differences in flow-mediated dilation: the role of shear rate
Nishiyama, S. K., Wray, D. W., Berkstresser, K. A., Ramaswamy, M., & Richardson, R. S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00273.2007 · Cited by 61
“Predominantly employed in the brachial artery (BA), FMD testing has been widely used as an index of global vascular health and coronary vasoreactivity (1, 33, 34).”
Method
The role of endothelial dysfunction in the pathophysiology of erectile dysfunction in diabetes and in determining response to treatment
Pegge, N. C., Twomey, A. M., Vaughton, K. C., Gravenor, M. B., Ramsey, M. W., & Price, D. E. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01911.x · Cited by 61
Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia
Søndergaard, E. V., Møller, J. E., & Egstrup, K. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00078-4 · Cited by 61
Measuring FMD in the brachial artery: how important is QRS gating?
Kizhakekuttu, T. J., Gutterman, D. D., Phillips, S. A., Jurva, J. W., Arthur, E. I. L., Das, E., & Widlansky, M. E. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00532.2010 · Cited by 60
Rosuvastatin treatment in stable chronic obstructive pulmonary disease ( RODEO ): a randomized controlled trial
Neukamm, A. M. C., Høiseth, A. D., Einvik, G., Lehmann, S., Hagve, T., Søyseth, V., & Omland, T. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12337 · Cited by 60
Vasoprotective endothelial effects of a standardized grape product in humans
Chaves, A., Joshi, M. S., Coyle, C. M., Brady, J. E., Dech, S. J., Schanbacher, B. L., Baliga, R. S., Basuray, A., & Bauer, J. A. (2008) · Vascular Pharmacology · doi:10.1016/j.vph.2008.08.004 · Cited by 60
ACE Inhibition and Endothelial Function: Main Findings of PERFECT, a Sub-Study of the EUROPA Trial
Bots, M. L., Remme, W. J., Lüscher, T. F., Fox, K. M., Bertrand, M. E., Ferrari, R., Simoons, M. L., Grobbee, D. E., & EUROPA-PERFECT Investigators (2007) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-007-6041-3 · Cited by 61
“It had been argued that in clinical trials the number of subjects needed should be such that at least a 2% difference in FMD is detectable [23].”
Background
Targeting Endothelial Function to Treat Heart Failure with Preserved Ejection Fraction: The Promise of Exercise Training
Gevaert, A. B., Lemmens, K., Vrints, C. J., & Craenenbroeck, E. M. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4865756 · Cited by 60
“The peripheral circulation is the preferred organ system for measuring endothelial-dependent vasodilation, because of the easy, noninvasive measurement and the good correlation with “gold standard” invasive coronary vasodilation [60].”
Background
Home‐hit improves muscle capillarisation and eNOS/NAD(P)Hoxidase protein ratio in obese individuals with elevated cardiovascular disease risk
Scott, S. N., Shepherd, S. O., Hopkins, N. D., Dawson, E. A., Strauss, J. A., Wright, D. J., Cooper, R. G., Kumar, P., Wagenmakers, A. J. M., & Cocks, M. S. (2019) · The Journal of Physiology · doi:10.1113/jp278062 · Cited by 65
“2011) and is a surrogate of coronary artery endothelial function (Anderson et al. 1995).”
Background
Assessment of Vascular Endothelial Function With Peripheral Arterial Tonometry
Patvardhan, E. A., Heffernan, K. S., Ruan, J., Soffler, M. I., Karas, R. H., & Kuvin, J. T. (2009) · Cardiology in Review · doi:10.1097/crd.0b013e3181c46a15 · Cited by 60
“Numerous studies have shown that endothelial dysfunction is a diffuse disease process, including coronary and peripheral arteries, and it occurs in patients with cardiovascular risk factors, even in the absence of clinically significant atherosclerotic plaque deposition.(5,6) Neunteufl et al have also shown that perip…”
Background
Urinary albumin excretion is associated with impaired flow- and nitroglycerin-mediated brachial artery dilatation in hypertensive adults
Malik, A. R., Sultan, S., Turner, S. T., & Kullo, I. J. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002143 · Cited by 59
Flow-mediated dilation in brachial artery in the second half of pregnancy and prediction of pre-eclampsia
Takase, B., Goto, T., Hamabe, A., Uehata, A., Kuroda, K., Satomura, K., Ohsuzu, F., & Kurita, A. (2003) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001599 · Cited by 58
Evaluación no invasiva de la función endotelial en la práctica clínica
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Folic acid improves endothelial function in children and adolescents with type 1 diabetes
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The impact of heavy passive smoking on arterial endothelial function in modernized Chinese
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Authors: Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., & Selwyn, A. P.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Anderson, Todd J.
Meredith, Ian T.
Ganz, Peter
Creager, Mark A.
Yeung, Alan C.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 1995-11
Volume: 26
Issue: 5
Pages: 1235-1241
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/0735-1097(95)00327-4
OpenAlex: W1980445357
Cited by: 2,033
References: 24
Citations by year: 2026: 10 · 2025: 18 · 2024: 26 · 2023: 30 · 2022: 25 · 2021: 50 · 2020: 47 · 2019: 42 · 2018: 41 · 2017: 61 · 2016: 67 · 2015: 72 · 2014: 82 · 2013: 75 · 2012: 66
FWCI: 25.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6467 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k04hl002566-04, 5k08hl002787-05, 5k07hl002663-02)
National Heart, Lung, and Blood Institute (HL02663, 1K04-HL-02566, 1K08 HL-02787)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords: endothelial dysfunction, coronary artery disease, brachial artery flow-mediated dilation, coronary vasodilation, acetylcholine, reactive hyperemia, cigarette smoking, nitroglycerin, atherosclerosis risk prediction, coronary artery disease screening, brachial artery diameter, vasoconstriction
MeSH terms: Acetylcholine, Adult, Aged, Brachial Artery, Coronary Artery Disease, Coronary Vessels, Endothelium, Vascular, Female, Nitroglycerin, Cardiac Catheterization, Humans, Male, Middle Aged, Predictive Value of Tests, Vasodilation, Vasodilator Agents

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Close relation of endothelial function in the human coronary and peripheral circulations

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