Depressive symptoms during buprenorphine treatment of opioid abusers
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Among 40 opioid addicts treated as outpatients with sublingual buprenorphine (2-8 mg daily) for a month, depressive symptoms significantly decreased in the 19 who were depressed at intake to treatment.
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Three additional studies investigating the course of depressive symptoms in opiate dependence patients treated with buprenorphine included a total of 248 patients.
“Three additional studies investigating the course of depressive symptoms in opiate dependence patients treated with BUP were also considered in addition to the Striebel case (a total of 248 patients) [48,49,50].”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [48]
Buprenorphine has a rapid antidepressant and anti-suicidal action, acting in about a week after the first administration.
“Taken together, according to the included studies, BUP has a rapid antidepressant and anti-suicidal action: in fact, this psychoactive compound seems to act in about a week after the first administration [41,42,43,44,46,47,48,52].”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [48]
Kosten et al. found a good response in 47% of the sample; 75% of responders showed the largest improvement during the first week of buprenorphine treatment.
“Kosten et al. [48] found a good response in 47% of the sample; in particular, 75% of responders showed the largest improvement during the first week of BUP treatment.”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [48]
In some studies, the antidepressant action of buprenorphine is prolonged for up to one to three months.
“On the other hand, there are also studies [42,47,48,50,51] suggesting that this action is prolonged in time up to one to three months.”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [48]
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- Authors
- Kosten, T. R., Morgan, C., & Kosten, T. A.
- Affiliations
- Yale University (US)
- Corresponding author
- Kosten, Thomas R.
- Venue
- Journal of Substance Abuse Treatment
- Publisher
- Elsevier BV
- Published
- 1990
- Volume
- 7
- Issue
- 1
- Pages
- 51-54
- ISSN
- 0740-5472 (ISSN-L)
- OpenAlex
- W2101525777
- Cited by
- 110
- References
- 26
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 2
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Substance Abuse Treatment (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k02da000112-09, 5p50da004060-13)
- National Institute on Drug Abuse (KO2-DA00112, P50-DA04060, R01-DA05626, R01DA005626)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- depressive symptoms, buprenorphine, opioid use disorder, opioid dependence treatment, sublingual buprenorphine, outpatient care, depression remission
- MeSH terms
- Adult, Buprenorphine, Cocaine, Combined Modality Therapy, Depressive Disorder, Female, Follow-Up Studies, Humans, Male, Methadone, Opioid-Related Disorders, Personality Tests, Substance-Related Disorders
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