Cited by 90Treatment of Major DepressionOpioid Use Disorder TreatmentElectroconvulsive Therapy Studies

Opiate Treatment in Depression Refractory to Antidepressants and Electroconvulsive Therapy

Nyhuis, Peter W., Gastpar, Markus, Scherbaum, Norbert·2008·Journal of Clinical Psychopharmacology

Abstract

*Departments of Psychiatry, and Psychotherapy, and †Addictive Behavior and, Addiction Medicine, Rhine State Hospital, University Duisburg-Essen, Essen, Germany [email protected]

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Crossref · 10.1097/jcp.0b013e31818638a4

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11 of 11 references verified0 citation errors · 0 not checkable

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  • Buprenorphine shows antidepressant effects in both opioid use disorder and treatment-resistant depression.

    “Buprenorphine has antidepressant effects when used for both opioid use disorder and treatment-resistant depression (279-284)”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [280]

  • Six clinical trials, one clinical case, and three additional studies investigating opiate-dependent patients were included, with 216 subjects with treatment-resistant depression treated with buprenorphine in monotherapy or with an opioid antagonist.

    “Overall, six clinical trials [41,42,43,44,45,46]—of which three were randomized, double-blind and placebo controlled studies [41,44,45]—and one clinical case [47], including a total of 216 subjects with TRD treated with BUP in mono-therapy or together with an opioid antagonist (naloxone or samidorphan) were included.”
  • Nyhuis et al. observed improvement of depressive symptoms in six nonpsychotic treatment-resistant depression patients after seven days of buprenorphine monotherapy at a medium dose of 1.2 mg/day.

    “Nyhuis and colleagues [46] observed in six nonpsychotic TRD patients an improvement of depressive symptoms after seven days of BUP treatment, as a monotherapy, at a medium dose of 1.2 mg/day.”
  • Buprenorphine has a rapid antidepressant and anti-suicidal action, acting in about a week after the first administration.

    “Taken together, according to the included studies, BUP has a rapid antidepressant and anti-suicidal action: in fact, this psychoactive compound seems to act in about a week after the first administration [41,42,43,44,46,47,48,52].”
  • The short duration of some study designs (one week or a few days more) may be insufficient to observe long-term efficacy or emergence of adverse effects of buprenorphine.

    “Unfortunately, a period of one week [41,44,46], or a few days more [52], may be not sufficient to observe the long-term efficacy or the emergence of some adverse effects related to this agent.”

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Authors
Nyhuis, P. W., Gastpar, M., & Scherbaum, N.
Affiliations
University of Duisburg-Essen (DE)
Corresponding author
  • Nyhuis, Peter W.
  • Gastpar, Markus
Venue
Journal of Clinical Psychopharmacology
Published
2008-10
Volume
28
Issue
5
Pages
593-595
ISSN
0271-0749 (ISSN-L)
OpenAlex
W1994125953
Cited by
90
References
11
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 7 · 2018: 14 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 5 · 2013: 1 · 2012: 2
FWCI
1.63
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Clinical Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
opioid therapy, treatment-resistant depression, antidepressant-refractory depression, antidepressant resistance
MeSH terms
Adult, Aged, Analgesics, Opioid, Antidepressive Agents, Buprenorphine, Major Depressive Disorder, Electroconvulsive Therapy, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Treatment Outcome

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