Cited by 357Iron Metabolism and DisordersAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

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Ferritin as a source of iron for oxidative damage

Reif, David W.·1992·Free Radical Biology and Medicine

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Abstract

The generation of deleterious activated oxygen species capable of damaging DNA, lipids, and proteins requires a catalyst such as iron. Once released, ferritin iron is capable of catalyzing these reactions. Thus, agents that promote iron release may lead to increased oxidative damage. The superoxide anion formed enzymatically, radiolytically, via metal-catalyzed oxidations, or by redox cycling xenobiotics reductively mobilizes ferritin iron and promotes oxidative damage. In addition, a growing list of compounds capable of undergoing single electron oxidation/reduction reactions exemplified by paraquat, adriamycin, and alloxan have been reported to release iron from ferritin. Because the rapid removal of iron from ferritin requires reduction of the iron core, it is not surprising that the reduction potential of a compound is a primary factor that determines whether a compound will mobilize ferritin iron. The reduction potential does not, however, predict the rate of iron release. Therefore, ferritin-dependent oxidative damage may be involved in the pathogenesis of diseases where increased superoxide formation occurs and the toxicity of chemicals that increase superoxide production or have an adequate reduction potential to mobilize ferritin iron.

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Authors: Reif, D. W.
Corresponding author: Reif, David W.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 1992
Volume: 12
Issue: 5
Pages: 417-427
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/0891-5849(92)90091-t
OpenAlex: W1972164300
Cited by: 357
References: 95
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 7
FWCI: 11.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: ferritin, iron release, oxidative damage, superoxide, iron-catalyzed oxidation, redox potential, one-electron oxidation, paraquat, doxorubicin, alloxan, radiolysis, metal-catalyzed oxidation, DNA damage, lipid peroxidation, protein oxidation
MeSH terms: Animals, Ferritins, Humans, Iron, Nitric Oxide, Oxidation-Reduction, Oxygen, Superoxides, Lipid Peroxidation, Xenobiotics

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Ferritin as a source of iron for oxidative damage

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