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Cited by 239Antioxidant Activity and Oxidative StressNutrition and Health StudiesCarcinogens and Genotoxicity Assessment

The DOI matches its Crossref record; 85 of the 86 references it cites were found in a registry or an index.

Tolerance and safety of vitamin E: A toxicological position report

Kappus, H·1992·Free Radical Biology and Medicine
DOI 10.1016/0891-5849(92)90166-e
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Abstract

From numerous publications on the "prophylactic" and "therapeutic" use of vitamin E, it may be concluded that the toxicity of vitamin E is very low. It has been demonstrated in animal experiments that vitamin E has neither mutagenic, teratogenic nor carcinogenic properties. Based on studies in humans, a daily dosage of 100-300 mg vitamin E can be considered harmless from a toxicological point of view. Using double-blind studies involving a large number of subjects, it has been demonstrated that large oral doses of up to 3,200 USP-Units/day led to no consistent adverse effects. From a large body of published data, dosage ranges have been deduced which can be characterized as safe for human subjects even where their use extends over a long period of time. It should, however, be noted that oral intake of high levels of vitamin E can exacerbate the blood coagulation defect of vitamin K deficiency caused by malabsorption or anticoagulant therapy. High levels of vitamin E intake are, therefore, contraindicated in these subjects.

Overview

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Crossref · 10.1016/0891-5849(92)90166-e

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85 of 85 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Kappus, H.
Affiliations
Freie Universität Berlin (DE)
Corresponding author
Kappus, H
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
1992-07
Volume
13
Issue
1
Pages
55-74
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/0891-5849(92)90166-e
OpenAlex
W1983748680
Cited by
239
References
86
Citations by year
2026: 1 · 2025: 9 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 8
FWCI
5.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords
vitamin E, alpha-tocopherol, toxicity, safety, mutagenicity, teratogenicity, carcinogenicity, high-dose vitamin E, coagulation, vitamin K deficiency, malabsorption, anticoagulation, tolerable daily intake
MeSH terms
Animals, Drug Tolerance, Free Radicals, Humans, Safety, Vitamin E

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