Cited by 239Antioxidant Activity and Oxidative StressNutrition and Health StudiesCarcinogens and Genotoxicity Assessment

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Tolerance and safety of vitamin E: A toxicological position report

Kappus, H·1992·Free Radical Biology and Medicine

DOI 10.1016/0891-5849(92)90166-e

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Abstract

From numerous publications on the "prophylactic" and "therapeutic" use of vitamin E, it may be concluded that the toxicity of vitamin E is very low. It has been demonstrated in animal experiments that vitamin E has neither mutagenic, teratogenic nor carcinogenic properties. Based on studies in humans, a daily dosage of 100-300 mg vitamin E can be considered harmless from a toxicological point of view. Using double-blind studies involving a large number of subjects, it has been demonstrated that large oral doses of up to 3,200 USP-Units/day led to no consistent adverse effects. From a large body of published data, dosage ranges have been deduced which can be characterized as safe for human subjects even where their use extends over a long period of time. It should, however, be noted that oral intake of high levels of vitamin E can exacerbate the blood coagulation defect of vitamin K deficiency caused by malabsorption or anticoagulant therapy. High levels of vitamin E intake are, therefore, contraindicated in these subjects.

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Authors: Kappus, H.
Affiliations: Freie Universität Berlin (DE)
Corresponding author: Kappus, H
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 1992-07
Volume: 13
Issue: 1
Pages: 55-74
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/0891-5849(92)90166-e
OpenAlex: W1983748680
Cited by: 239
References: 86
Citations by year: 2026: 1 · 2025: 9 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 8
FWCI: 5.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: vitamin E, alpha-tocopherol, toxicity, safety, mutagenicity, teratogenicity, carcinogenicity, high-dose vitamin E, coagulation, vitamin K deficiency, malabsorption, anticoagulation, tolerable daily intake
MeSH terms: Animals, Drug Tolerance, Free Radicals, Humans, Safety, Vitamin E

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Tolerance and safety of vitamin E: A toxicological position report

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