The DOI matches its Crossref record; 29 of the 30 references it cites were found in a registry or an index.
Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat
Abstract
A hippocampal poly(A) RNA, pADHC-9, was cloned by differential screening of a human hippocampal cDNA library. By RNA blot analysis, pADHC-9 was elevated 2-fold in Alzheimer's disease hippocampus. In situ analyses identified pADHC-9 expression in pyramidal and non-pyramidal cells of the hippocampus and entorhinal cortex. Nucleotide sequence analysis identified pADHC-9 as a potential human homolog of rat sulfated glycoprotein 2 (SGP-2). SGP-2 expression increased in rat hippocampus following experimental lesions that mimic intrinsic neuronal loss and/or deafferentation. The function of pADHC-9 in brain has not been defined, but in serum, a similar protein inhibits complement-dependent cytolysis. Increased expression of pADHC-9 in Alzheimer's disease hippocampus may be a compensatory response mounted to retard a complement-driven neurodegenerative cascade.
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“CLU was first associated with Alzheimer’s disease (AD) in 1990 when it was found to be increased in the hippocampi of AD patients (May, et al., 1990)”
From A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin (2016) · cites this paper as May, et al., 1990
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Metadata
- Authors
- May, P. C., Lampert-Etchells, M., Johnson, S. A., Poirier, J., Masters, J. N., & Finch, C. E.
- Affiliations
- University of Southern California (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 5
- Issue
- 6
- Pages
- 831-839
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2004102314
- Cited by
- 339
- References
- 30
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 11 · 2013: 10 · 2012: 12
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 05142, P50AG005142)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, hippocampus, gene expression, sulfated glycoprotein-2, polyadenylated RNA, entorhinal cortex, experimental brain lesions, deafferentation, neuronal loss, complement-dependent cytotoxicity, neurodegeneration, compensatory response
- MeSH terms
- Alzheimer Disease, Autoradiography, Cloning, Molecular, Denervation, DNA, Glycoproteins, Hippocampus, Humans, Male, Nucleic Acid Hybridization, RNA, Transcription, Genetic, DNA Probes, Gene Expression, Molecular Chaperones, Clusterin
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