Cited by 237Nicotinic Acetylcholine Receptors StudyMyasthenia Gravis and ThymomaMuscle Physiology and Disorders

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions

Reist, Noreen E., Werle, Michael J., McMahan, U.J.·1992·Neuron

Open this paper in CoChat — free account

Abstract

To test the hypothesis that agrin mediates motor neuron-induced aggregation of acetylcholine receptors (AChRs) in skeletal muscle fibers and to determine whether the agrin active in this process is released by motor neurons, we raised polyclonal antibodies to purified ray agrin that blocked its receptor aggregating activity. When the antibodies were applied to chick motor neuron--chick myotube cocultures, they inhibited the formation of AChR aggregates at and near neuromuscular contacts, demonstrating that agrin plays a role in the induction of the aggregates. Rat motor neurons, like chick motor neurons, induce AChR aggregates on chick myotubes. This effect was not inhibited by our antibodies, indicating that, although the antibodies inhibited the activity of chick agrin, they did not have a similar effect on rat agrin. We conclude that agrin released by rat motor neurons induced the chick myotubes to aggregate AChRs.

Integrity signals

Registry

Crossref · 10.1016/0896-6273(92)90200-w

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose
Ey, P. L., Prowse, S. J., & Jenkin, C. R. (1978) · Immunochemistry · doi:10.1016/0161-5890(78)90070-6 · Cited by 2,673
The Agrin HypothesisPreprint
McMahan, U. J. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.041 · Cited by 643
Self-citation
Identification of agrin, a synaptic organizing protein from Torpedo electric organ.
Nitkin, R. M., Smith, M. A., Magill, C., Fallon, J. R., Yao, Y. M., Wallace, B. G., & McMahan, U. J. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.6.2471 · Cited by 469
Self-citation
Synapse formation between dissociated nerve and muscle cells in low density cell cultures
Fischbach, G. D. (1972) · Developmental Biology · doi:10.1016/0012-1606(72)90023-1 · Cited by 458
Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve.
Burden, S. J., Sargent, P. B., & McMahan, U. J. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.82.2.412 · Cited by 355
Self-citation
Early events in neuromuscular junction formation in vitro: induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses.
Frank, E., & Fischbach, G. D. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.83.1.143 · Cited by 347
Structure and expression of a rat agrin
Rupp, F., Payan, D. G., Magill, C., Cowan, D. M., & Scheller, R. H. (1991) · Neuron · doi:10.1016/0896-6273(91)90177-2 · Cited by 306
The agrin gene codes for a family of basal lamina proteins that differ in function and distribution
Rüegg, M. A., Tsim, K. W. K., Horton, S. E., Kröger, S., Escher, G., Gensch, E. M., & McMahan, U. J. (1992) · Neuron · doi:10.1016/0896-6273(92)90090-z · Cited by 254
Self-citation
Development of Acetylcholine Receptor Clusters on Cultured Muscle Cells
Sytkowski, A. J., Vogel, Z., & Nirenberg, M. W. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.1.270 · Cited by 231
cDNA that encodes active agrin
Tsim, K. W. K., Rüegg, M. A., Escher, G., Kröger, S., & McMahan, U. J. (1992) · Neuron · doi:10.1016/0896-6273(92)90089-v · Cited by 200
Self-citation

Show all 21 references

Sorted by citations

Items 101–200 of 237

Neuregulin-1 Potentiates Agrin-Induced Acetylcholine Receptor Clustering via Muscle Specific Kinase Phosphorylation
Ngo, S. T., Cole, R. N., Sunn, N., Phillips, W. D., & Noakes, P. G. (2012) · Journal of Cell Science · doi:10.1242/jcs.095109 · Cited by 49
Limb Salvage With Major Nerve Injury: Current Management and Future Directions
Kang, J. R., Zamorano, D. P., & Gupta, R. (2011) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-201102001-00006 · Cited by 49
Identification of a Novel Alternatively Spliced Agrin mRNA That Is Preferentially Expressed in Non-neuronal Cells
Tsen, G., Napier, A., Halfter, W. M., & Cole, G. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.27.15934 · Cited by 49
Phosphorylation reactions in activity-dependent synapse modification at the neuromuscular junction during development
Nelson, P. G., Lanuza, M. A., Jia, M., Li, M., & Tomàs, J. M. (2003) · Journal of Neurocytology · doi:10.1023/b:neur.0000020625.70284.a6 · Cited by 48
The many roles of dystroglycan in nervous system development and function
Jahncke, J. N., & Wright, K. M. (2022) · Developmental Dynamics · doi:10.1002/dvdy.516 · Cited by 47
Evidence That Agrin directly Influences Presynaptic Differentiation at Neuromuscular Junctions In Vitro
Campagna, J. A., Rüegg, M. A., & Bixby, J. L. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01645.x · Cited by 47
Agrin-induced clustering of acetylcholine receptors: a cytoskeletal link.
Hoch, W., Campanelli, J. T., & Scheller, R. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.1 · Cited by 47
Human motor endplate remodeling after traumatic nerve injury
Gupta, R., Chan, J. P., Uong, J., Palispis, W. A., Wright, D. J., Shah, S. B., Ward, S. R., Lee, T. Q., & Steward, O. (2020) · Journal of neurosurgery · doi:10.3171/2020.8.jns201461 · Cited by 46
What controls the position, number, size, and distribution of neuromuscular junctions on rat muscle fibers?
Lømo, T. (2003) · Journal of Neurocytology · doi:10.1023/b:neur.0000020627.18156.b1 · Cited by 46
Heparan sulfates in skeletal muscle development and physiology
Jenniskens, G. J., Veerkamp, J. H., & Kuppevelt, T. H. V. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20450 · Cited by 47
Why so many forms of acetylcholinesterase?
Legay, C. (2000) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(20000401)49:1 · Cited by 90
Differential Distribution of Agrin Isoforms in the Developing and Adult Avian Retina
Kröger, S. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0651 · Cited by 45
Agrin Receptors at the Skeletal Neuromuscular Junction
Sanes, J. R., Apel, E. D., Gautam, M., GLASS, D., Grady, R. M., Martin, P. T., Nichol, M. C., & Yancopoulos, G. D. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10905.x · Cited by 44
Synapse-specific gene expression
Burden, S. J. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90066-q · Cited by 43
Induction of Anti-agrin Antibodies Causes Myasthenia Gravis in Mice
Yan, M., Liu, Z., Fei, E., Chen, W., Lai, X., Luo, B., Chen, P., Jing, H., Pan, J., Rivner, M. H., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.015 · Cited by 42
The Role of an Agrin–Growth Factor Interaction in ACh Receptor Clustering
Daggett, D. F., Cohen, M. W., Stone, D. M., Nikolics, K., Rauvala, H., & Peng, H. B. (1996) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0063 · Cited by 42
Characterization of the tyrosine phosphorylation and distribution of dystrobrevin isoforms
Balasubramanian, S., Fung, E. T., & Huganir, R. L. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00804-7 · Cited by 42
AChR phosphorylation and aggregation induced by an agrin fragment that lacks the binding domain for alpha‐dystroglycan.
Meier, T., Gesemann, M., Cavalli, V., Rüegg, M. A., & Wallace, B. G. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00622.x · Cited by 41
N-Acetyllactosamine and the CT Carbohydrate Antigen Mediate Agrin-Dependent Activation of MuSK and Acetylcholine Receptor Clustering in Skeletal Muscle
Parkhomovskiy, N., Kammesheidt, A., & Martin, P. T. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0835 · Cited by 41
The agrin receptor. Localization in the postsynaptic membrane, interaction with agrin, and relationship to the acetylcholine receptor.
Ma, J., Nastuk, M. A., McKechnie, B. A., & Fallon, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74576-1 · Cited by 40
Resistance training‐induced adaptations in the neuromuscular system: Physiological mechanisms and implications for human performance
Lecce, E., Amoruso, P., Felici, F., & Bazzucchi, I. (2025) · The Journal of Physiology · doi:10.1113/jp289716 · Cited by 56
Matrix Topography Regulates Synaptic Transmission at the Neuromuscular Junction
Ko, E. C., Yu, S. J., Pagan‐Diaz, G. J., Mahmassani, Z. S., Boppart, M. D., Im, S. G., Bashir, R., & Kong, H. (2019) · Advanced Science · doi:10.1002/advs.201801521 · Cited by 38
Expression, distribution and ultrastructural localization of the synapse‐organizing molecule agrin in the mature avian retina
Koulen, P., Honig, L. S., Fletcher, E. L., & Kröger, S. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00848.x · Cited by 37
Selective Regulation of Agrin mRNA Induction and Alternative Splicing in PC12 Cells by Ras-dependent Actions of Nerve Growth Factor
Smith, M. A., Fanger, G. R., O’Connor, L. T., Bridle, P., & Maue, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15675 · Cited by 37
Electrical stimulation enhances the acetylcholine receptors available for neuromuscular junction formation
Lozano, R., Gilmore, K. J., Thompson, B. C., Stewart, E. M., Waters, A. M., Romero‐Ortega, M. I., & Wallace, G. G. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.08.006 · Cited by 35
Increased expression of the 43-kD protein disrupts acetylcholine receptor clustering in myotubes
Yoshihara, C., & Hall, Z. W. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.169 · Cited by 35
Functional innervation of cultured human skeletal muscle proceeds by two modes with regard to agrin effects
Marš, T., King, M. P., Miranda, A. F., Walker, W. F., Miš, K., & Grubič, Z. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00765-0 · Cited by 34
BMP4 Is a Peripherally-Derived Factor for Motor Neurons and Attenuates Glutamate-Induced Excitotoxicity In Vitro
Chou, H.-J., Lai, D., Huang, C.-W., McLennan, I. S., Wang, H., & Wang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058441 · Cited by 34
Agrin mRNA variants are differentially regulated in developing chick embryo spinal cord and sensory ganglia
Ma, E., Morgan, R. G., & Godfrey, E. W. (1995) · Journal of Neurobiology · doi:10.1002/neu.480260411 · Cited by 34
Neuritic deposition of agrin on culture substrate: implications for nerve-muscle synaptogenesis
Cohen, M., Moody‐Corbett, F., & Godfrey, E. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03293.1994 · Cited by 33
Nitric Oxide Is a Downstream Mediator of Agrin-Induced Acetylcholine Receptor Aggregation
Jones, M. A., & Werle, M. J. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0901 · Cited by 32
Self-citation
The Signaling Pathways Mediated by P2Y Nucleotide Receptors in the Formation and Maintenance of the Skeletal Neuromuscular Junction
Tsim, K. W. K., & Barnard, E. A. (2002) · Neurosignals · doi:10.1159/000057322 · Cited by 31
Neural Agrin Activates a High-Affinity Receptor in C2 Muscle Cells that Is Unresponsive to Muscle Agrin
Bowen, D. C., Sugiyama, J. E., Ferns, M., & Hall, Z. W. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03791.1996 · Cited by 30
Recruitment of a Nicotinic Acetylcholine Receptor Mutant Lacking Cytoplasmic Tyrosine Residues in Its β Subunit into Agrin-Induced Aggregates
Meyer, G. R. Y. D., & Wallace, B. G. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0689 · Cited by 30
Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro
Fukazawa, T., Matsumoto, M., Imura, T., Khalesi, E., Kajiume, T., Kawahara, Y., Tanimoto, K., & Yuge, L. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.04.006 · Cited by 29
The synaptic cleft of the neuromuscular junction
Sanes, J. R. (1995) · Seminars in Developmental Biology · doi:10.1016/s1044-5781(06)80026-5 · Cited by 29
R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5
Nakashima, H., Ohkawara, B., Ishigaki, S., Fukudome, T., Ito, K., Tsushima, M., Konishi, H., Okuno, T., Yoshimura, T., Ito, M., et al. (2016) · Scientific Reports · doi:10.1038/srep28512 · Cited by 28
Heparin Inhibits Acetylcholine Receptor Aggregation at Two Distinct Steps in the Agrin‐induced Pathway
Hopf, C., & Hoch, W. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01471.x · Cited by 28
Transcriptome analysis provides insights into the molecular mechanisms responsible for evisceration behavior in the sea cucumber Apostichopus japonicus
Ding, K., Zhang, L., Sun, L., Lin, C., Feng, Q., Zhang, S., Yang, H., Brinkman, R., Lin, G., & Huang, Z. J. (2019) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2019.02.008 · Cited by 27
Utrophin mRNA Expression in Muscle Is Not Restricted to the Neuromuscular Junction
Vater, R., Young, C., Anderson, L. V. B., Lindsay, S., Blake, D. J., Davies, K. E., Zuellig, R. A., & Slater, C. R. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0661 · Cited by 27
Development of the neuromuscular synapse
Jennings, C. G. B., & Burden, S. J. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90038-z · Cited by 27
Regulation of agrin expression in hippocampal neurons by cell contact and electrical activity
Lesuisse, C., Qiu, D., Böse, C., Nakaso, K., & Rupp, F. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00161-3 · Cited by 26
Upstream sequences of the myogenin gene convey responsiveness to skeletal muscle denervation in transgenic mice
Buonanno, A., Edmondson, D. G., & Hayes, W. P. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.24.5684 · Cited by 24
Synaptic differentiation: the role of agrin in the formation and maintenance of the neuromuscular junction
Denzer, A. J., Hauser, D. M., Gesemann, M., & Rüegg, M. A. (1997) · Cell and Tissue Research · doi:10.1007/s004410050941 · Cited by 24
Accumulation of acetylcholine receptors is a necessary condition for normal accumulation of acetylcholinesterase during in vitro neuromuscular synaptogenesis
De, S., Porte, L., Chaubourt, E., Fabre, F., Poulas, K. A., Chapron, J., Eymard, B., Tzartos, S. J., & Koenig, J. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00165.x · Cited by 24
Direct conversion of adult human skin fibroblasts into functional Schwann cells that achieve robust recovery of the severed peripheral nerve in rats
Kitada, M., Murakami, T., Wakao, S., Li, G., & Dezawa, M. (2019) · Glia · doi:10.1002/glia.23582 · Cited by 21
Intercellular communication that mediates formation of the neuromuscular junction
Daniels, M. P. (1997) · Molecular Neurobiology · doi:10.1007/bf02740654 · Cited by 23
Antisense Agrin cDNA Transfection Blocks Neuroblastoma Cell-Induced Acetylcholine Receptor Aggregation When Co-cultured with Myotubes
Pun, S., & Tsim, K. W. K. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0637 · Cited by 22
Regulation of the Size and Distribution of Agrin-Induced Postsynaptic-like Apparatus in Adult Skeletal Muscle by Electrical Muscle Activity
Mathiesen, I., Rimer, M., Ashtari, O., Cohen, I., McMahan, U. J., & Lømo, T. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0744 · Cited by 21
Self-citation
Acetylcholine Receptors Enable the Transport of Rapsyn from the Golgi Complex to the Plasma Membrane
Park, J.-Y., Ikeda, H., Ikenaga, T., & Ono, F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0397-12.2012 · Cited by 21
The Efficacy and Duration of Onabotulinum Toxin A in Improving Upper Facial Expression Lines With 64-Unit Dose Optimization: A Systematic Review and Meta-Analysis With Trial Sequential Analysis of the Randomized Controlled Trials
Rahman, E., Mosahebi, A., CARRUTHERS, J. D. A., & CARRUTHERS, A. J. (2022) · Aesthetic Surgery Journal · doi:10.1093/asj/sjac253 · Cited by 21
Cell‐to‐Cell Signaling at the Neuromuscular Junction
Werle, M. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1405.035 · Cited by 20
Self-citation
Role of the target organ in determining susceptibility to experimental autoimmune myasthenia gravis
Hoedemaekers, A. C. W. E., Bessereau, J., Graus, Y., Guyon, T., Changeux, J., Berrih‐Aknin, S., Vriesman, P. J. C. V. B., & Baets, M. H. D. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00126-x · Cited by 20
Endosomal trafficking of the receptor tyrosine kinase MuSK proceeds via clathrin‐dependent pathways, A rf6 and actin
Luiskandl, S., Woller, B., Schlauf, M., Schmid, J. A., & Herbst, R. (2013) · FEBS Journal · doi:10.1111/febs.12309 · Cited by 19
In Vitro Innervation as an Experimental Model to Study the Expression and Functions of Acetylcholinesterase and Agrin in Human Skeletal Muscle
Miš, K., Grubič, Z., Lorenzon, P., Sciancalepore, M., Marš, T., & Pirkmajer, S. (2017) · Molecules · doi:10.3390/molecules22091418 · Cited by 19
Phosphoinositide 3‐kinase acts through RAC and Cdc42 during agrin‐induced acetylcholine receptor clustering
Nizhynska, V., Neumueller, R., & Herbst, R. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20371 · Cited by 19
Synapse Formation and Agrin Expression in Stratospheroid Cultures from Embryonic Chick Retina
Hering, H., & Kröger, S. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9410 · Cited by 18
Nitric oxide synthase activity is required for postsynaptic differentiation of the embryonic neuromuscular junction
Schwarte, R. C., & Godfrey, E. W. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.06.003 · Cited by 17
A novel epitope of entactin is present at the mammalian neuromuscular junction
Chiu, A., & Ko, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02809.1994 · Cited by 17
Subnanosecond polarized fluorescence photobleaching: rotational diffusion of acetylcholine receptors on developing muscle cells
Yuan, Y., & Axelrod, D. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)79944-1 · Cited by 17
Engineering skeletal muscle - from two to three dimensions
Ngan, C., Quigley, A. F., Kapsa, R. M. I., & Choong, P. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2265 · Cited by 16
Laminin β2 (S-Laminin): a New Player at the Synapse
Hall, Z. W. (1995) · Science · doi:10.1126/science.7618101 · Cited by 16
Motor neurons and endothelial cells additively promote development and fusion of human iPSC-derived skeletal myocytes
Das, S., Hilman, M. C., Yang, F., Mourkioti, F., Yang, W., & Cullen, D. K. (2024) · Skeletal Muscle · doi:10.1186/s13395-024-00336-4 · Cited by 15
Enhanced reinnervation after neurotization with Schwann cell transplantation
Fukuda, A., Hirata, H., Akeda, K., Morita, A., Nagakura, T., Tsujii, M., & Uchida, A. (2004) · Muscle & Nerve · doi:10.1002/mus.20254 · Cited by 15
Neuromuscular Adaptation
Edgerton, V. R., Bodine, S. C., Roy, R. R., Ishihara, A., & Hodgson, J. A. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120102 · Cited by 15
■ REVIEW : Postsynaptic Anchoring of Receptors: A Cellular Approach to Neuronal and Muscular Sensitivity
Kirsch, J., & Kröger, S. (1996) · The Neuroscientist · doi:10.1177/107385849600200211 · Cited by 14
Examination of the human motor endplate after brachial plexus injury with two‐photon microscopy
Chan, J. P., Clune, J. E., Shah, S. B., Ward, S. R., Kocsis, J. D., Mozaffar, T., Steward, O., & Gupta, R. (2019) · Muscle & Nerve · doi:10.1002/mus.26778 · Cited by 13
Common peripheral nerve injuries in sport: diagnosis and management
Lolis, A., Falsone, S., & Berić, A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63954-7.00038-0 · Cited by 13
Agrin-like proteins of the neuromuscular junction
Patthy, L., & Nikolics, K. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90108-2 · Cited by 13
Synapse formation molecules in muscle and autonomic ganglia: the dual constraint hypothesis
Bennett, M. R. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00043-4 · Cited by 13
The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function
Reshetniak, S., Bogaciu, C. A., Bonn, S., Brose, N., Cooper, B. H., D’Este, E., Fauth, M. J., Fernández‐Busnadiego, R., Fiošins, M., Fischer, A., et al. (2024) · The Journal of Physiology · doi:10.1113/jp286400 · Cited by 15
Agrin and neuregulin, expanding roles and implications for therapeutics
Williams, S., Ryan, C., & Jacobson, C. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.11.003 · Cited by 12
Neuronal MT1-MMP mediates ECM clearance and Lrp4 cleavage for agrin deposition and signaling in presynaptic development
Oentaryo, M. J., Tse, A. C.-K., & Lee, C. W. (2020) · Journal of Cell Science · doi:10.1242/jcs.246710 · Cited by 12
Agrin-induced AChR aggregate formation requires cGMP and aggregate maturation requires activation of cGMP-dependent protein kinase
Jones, M. A., & Werle, M. J. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.013 · Cited by 12
Self-citation
Basement Membrane Molecules in Vertebrate Nervous System
Sanes, J. R. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-593165-6.50010-3 · Cited by 12
Neuromuscular Contacts Induce Nitric Oxide Signals in Skeletal Myotubes in vitro
Püttmann, B., Gerlach, E., Kruger, M. G., & Blottner, D. (2005) · Neurosignals · doi:10.1159/000086290 · Cited by 11
Neurotoxins in the study of neural regulation of membrane proteins in skeletal muscle
Bambrick, L. L., & Gordon, T. (1994) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/1056-8719(94)90066-3 · Cited by 11
Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function
Vicidomini, R., & Serpe, M. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.04.001 · Cited by 10
Agrin Influences Botulinum Neurotoxin A-Induced Nerve Sprouting via miR-144-agrin-MuSK Signaling
Ma, L., Pan, L., Liu, W., Liu, Y., Xiang, X., Pan, Y., Zhang, X., & Jin, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00015 · Cited by 10
Inhibition of agrin‐mediated acetylcholine receptor clustering by utrophin C‐terminal peptides
Namba, T., Scheller, R. H., & Hirokawa, N. (1996) · Genes to Cells · doi:10.1111/j.1365-2443.1996.tb00015.x · Cited by 10
Non-neural agrin codistributes with acetylcholine receptors during early differentiation of Torpedo electrocytes
Cartaud, A., Ludosky, M., Haasemann, M., Jung, D., Campbell, K. P., & Cartaud, J. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.7.1837 · Cited by 10
Cerebellar granule cells express a specific isoform of agrin that lacks the acetylcholine receptor aggregating activity
So, K.-L., Pun, S., Wan, D. C., & Tsim, K. W. K. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01486-1 · Cited by 9
The Synaptic Basis of Activity-Dependent Eye-Specific Competition
Zhang, C., Yadav, S., & Speer, C. M. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112085 · Cited by 9
An explant muscle model to examine the refinement of the synaptic landscape
Hanson, M. G., & Niswander, L. A. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.09.013 · Cited by 9
Collagen synthesis inhibition reduces clustering of heparan sulfate proteoglycan and acetylcholine receptors but not agrin or p65, at neuromuscular contacts in vitro
Bixby, J. L. (1995) · Journal of Neurobiology · doi:10.1002/neu.480260210 · Cited by 9
Agrin‐Deficient Myotube Retains Its Acetylcholine Receptor Aggregation Ability when Challenged with Agrin
Pun, S., Ng, Y. P., Yang, J. F., Ip, N. Y., & Tsim, K. W. K. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062555.x · Cited by 9
Target‐dependent regulation of acetylcholine secretion at developing motoneurons in Xenopus cell cultures
Liou, J., Chen, Y., & Fu, W. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0721s.x · Cited by 9
Exploring Missense Mutations in Tyrosine Kinases Implicated with Neurodegeneration
Sami, N., Kumar, V., Islam, A., Ali, S., Ahmad, F., & Hassan, M. I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0046-5 · Cited by 9
Agrin: Toward a Molecular Understanding of Synapse Regeneration
Deyst, K. A., Ma, J., & Fallon, J. R. (1995) · Neurosurgery · doi:10.1227/00006123-199507000-00011 · Cited by 8
Trophic Factors as Therapeutic Agents for Diseases Characterized by Neuronal Death
Koliatsos, V. E., & Mocchetti, I. (1999) · Humana Press eBooks · doi:10.1007/978-1-4612-1602-5_28 · Cited by 8
Isoform Pattern and AChR Aggregation Activity of Agrin Expressed by Embryonic Chick Retinal Ganglion Neurons
Annies, M. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1125 · Cited by 8
Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos
Hanson, M. G., & Niswander, L. A. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.05.018 · Cited by 7
L‐type calcium channels mediate acetylcholine receptor aggregation on cultured muscle
Milholland, R. B. R., Dulla, C. G., & Gordon, H. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20397 · Cited by 7
An Emerging Picture of Synapse Formation: A Balance of Two Opposing Pathways
Ono, F. (2008) · Science Signaling · doi:10.1126/stke.12pe3 · Cited by 7
α-Galactosidase Stimulates Acetylcholine Receptor Aggregation in Skeletal Muscle Cells via PNA-Binding Carbohydrates
Parkhomovskiy, N., & Martin, P. T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2521 · Cited by 7
Synaptic activity and connective tissue remodeling in denervated frog muscle.
Connor, E. A., Qin, K., Yankelev, H., & DeStefano, D. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.5.1435 · Cited by 7
Development of the neuromuscular junction and neuromuscular blocking agents in neonates, infants and children
Saldien, V., Veyckemans, F., & Hansen, T. G. (2025) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000002270 · Cited by 6
Agrin signals at the junction
Slater, C. R. (1996) · Nature · doi:10.1038/381478a0 · Cited by 5
Neuronal precursors of the adult rat subependymal zone persist into senescence, with no decline in spatial extent or response to BDNF
Goldman, S. A., Kirschenbaum, B., Harrison‐Restelli, C., & Thaler, H. T. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19970605)32:6 · Cited by 81
Polarity in skeletal muscle cells is induced by innervation
Burden, S. J., Jo, S. A., Tang, J., Zhu, X., Yeadon, J. E., & Simon, A. M. (1995) · Seminars in Developmental Biology · doi:10.1016/s1044-5781(06)80085-x · Cited by 5

Authors: Reist, N. E., Werle, M. J., & McMahan, U. J.
Affiliations: Stanford Medicine (US)
ORCID: Reist, Noreen E.
Venue: Neuron
Publisher: Elsevier BV
Published: 1992-05
Volume: 8
Issue: 5
Pages: 865-868
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(92)90200-w
OpenAlex: W2068836997
Cited by: 237
References: 21
Citations by year: 2026: 3 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 6 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 5
FWCI: 8.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: agrin, acetylcholine receptor aggregation, neuromuscular junction, motor neurons, polyclonal antibodies, skeletal muscle
MeSH terms: Animals, Antibodies, Cells, Cultured, Chickens, Motor Neurons, Nerve Tissue Proteins, Neuromuscular Junction, Receptors, Cholinergic, Agrin, Macromolecular Substances, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks