Cited by 237Nicotinic Acetylcholine Receptors StudyMyasthenia Gravis and ThymomaMuscle Physiology and Disorders

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Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions

Reist, Noreen E., Werle, Michael J., McMahan, U.J.·1992·Neuron

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Abstract

To test the hypothesis that agrin mediates motor neuron-induced aggregation of acetylcholine receptors (AChRs) in skeletal muscle fibers and to determine whether the agrin active in this process is released by motor neurons, we raised polyclonal antibodies to purified ray agrin that blocked its receptor aggregating activity. When the antibodies were applied to chick motor neuron--chick myotube cocultures, they inhibited the formation of AChR aggregates at and near neuromuscular contacts, demonstrating that agrin plays a role in the induction of the aggregates. Rat motor neurons, like chick motor neurons, induce AChR aggregates on chick myotubes. This effect was not inhibited by our antibodies, indicating that, although the antibodies inhibited the activity of chick agrin, they did not have a similar effect on rat agrin. We conclude that agrin released by rat motor neurons induced the chick myotubes to aggregate AChRs.

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Authors: Reist, N. E., Werle, M. J., & McMahan, U. J.
Affiliations: Stanford Medicine (US)
ORCID: Reist, Noreen E.
Venue: Neuron
Publisher: Elsevier BV
Published: 1992-05
Volume: 8
Issue: 5
Pages: 865-868
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/0896-6273(92)90200-w
OpenAlex: W2068836997
Cited by: 237
References: 21
Citations by year: 2026: 3 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 6 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 7 · 2012: 5
FWCI: 8.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Clinical Neurology › Myasthenia Gravis and Thymoma
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: agrin, acetylcholine receptor aggregation, neuromuscular junction, motor neurons, polyclonal antibodies, skeletal muscle
MeSH terms: Animals, Antibodies, Cells, Cultured, Chickens, Motor Neurons, Nerve Tissue Proteins, Neuromuscular Junction, Receptors, Cholinergic, Agrin, Macromolecular Substances, Rats

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Agrin released by motor neurons induces the aggregation of acetylcholine receptors at neuromuscular junctions

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