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Cited by 3,535Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and MetabolismNicotinic Acetylcholine Receptors Study

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Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

Monyer, Hannah, Burnashev, Nail, Laurie, David J., Sakmann, Bert, Seeburg, Peter H.·1994·Neuron
DOI 10.1016/0896-6273(94)90210-0
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Abstract

An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts display distinct expression patterns. NR2B and NR2D mRNAs occur prenatally, whereas NR2A and NR2C mRNAs are first detected near birth. All transcripts except NR2D peak around P20. NR2D mRNA, present mainly in midbrain structures, peaks around P7 and thereafter decreases to adult levels. Postnatally, NR2B and NR2C transcript levels change in opposite directions in the cerebellar internal granule cell layer. In the adult hippocampus, NR2A and NR2B mRNAs are prominent in CA1 and CA3 pyramidal cells, but NR2C and NR2D mRNAs occur in different subsets of interneurons. Recombinant binary NR1-NR2 channels show comparable Ca2+ permeabilities, but marked differences in voltage-dependent Mg2+ block and in offset decay time constants. Thus, the distinct expression profiles and functional properties of NR2 subunits provide a basis for NMDA channel heterogeneity in the brain.

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Citations

Cites

Research works printed but not linked: 29

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Metadata

Authors
Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H.
Affiliations
  • Heidelberg University (DE)
  • Max Planck Society (DE)
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
1994-03
Volume
12
Issue
3
Pages
529-540
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/0896-6273(94)90210-0
OpenAlex
W2065169750
Cited by
3,535
References
4
Citations by year
2026: 45 · 2025: 66 · 2024: 66 · 2023: 94 · 2022: 97 · 2021: 91 · 2020: 88 · 2019: 106 · 2018: 112 · 2017: 100 · 2016: 116 · 2015: 105 · 2014: 123 · 2013: 113 · 2012: 137
FWCI
36.77
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords
NMDA receptor, NR1 subunit, NR2 subunits, NR2A, NR2B, NR2C, NR2D, gene expression, postnatal brain development, regional expression, hippocampus, interneurons, calcium permeability, magnesium block, channel heterogeneity, rats
MeSH terms
Animals, Animals, Newborn, Base Sequence, Brain, Cerebellum, Granulocytes, Hippocampus, Humans, Ion Channels, Molecular Sequence Data, Neurons, Recombinant Proteins, RNA, Messenger, Molecular Probes, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Rats

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