The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
In vivo loss of telomeric repeats with age in humans
Open accessAbstract
Telomeric DNA in the skin cells of 21 human subjects aged between 0 and 92 years was quantified by determining the length of the telomeric smear and the relative amount of TTAGGG repeat sequences. Both telomere length and quantity of telomeric repeat sequences were found to decrease significantly with age. Telomere loss has previously been postulated to be a caused of cell senescence.
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“Telomere shortening also accompanies aging of mitotically active human tissues with high turnover, including blood, liver, skin, testis, and kidneys (Aikata et al., 2000; Friedrich et al., 2000; Lindsey et al., 1991; Takubo et al., 2000; Vaziri et al., 1993).”
From Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice (2010) · cites this paper as Lindsey et al., 1991
Citations
Cites
Telomeres shorten during ageing of human fibroblasts
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Telomere reduction in human colorectal carcinoma and with ageing
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Self-citationA mutant with a defect in telomere elongation leads to senescence in yeast
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THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES
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Self-citationHuman telomeres contain at least three types of G–rich repeat distributed non-randomly
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Variability at the Telomeres of the Human X/Y Pseudoautosomal Region
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Self-citationDynamics of telomere length variation in tetrahymena thermophila
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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227
Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10114 · Cited by 2,200
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349
Telomere elongation in immortal human cells without detectable telomerase activity
Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., & Reddel, R. R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00098.x · Cited by 1,279
Metadata
- Authors
- Lindsey, J., McGill, N. I., Lindsey, L. A., Green, D. K., & Cooke, H. J.
- Affiliations
- Western General Hospital (GB)
- Bangour Village Hospital (GB)
- Corresponding author
- Cooke, Howard J.
- Venue
- Mutation Research/DNAging
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 256
- Issue
- 1
- Pages
- 45-48
- ISSN
- 0921-8734 (ISSN-L)
- OpenAlex
- W1992520556
- Cited by
- 463
- References
- 12
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 5 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 13
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Mutation Research/DNAging (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- telomere length, telomeric repeats, aging, skin cells, TTAGGG repeats, cellular senescence, telomere loss
- MeSH terms
- Epidermal Cells, Adolescent, Adult, Aged, Aged, 80 and over, Aging, Child, Child, Preschool, Chromosomes, Humans, Infant, Infant, Newborn, Middle Aged, Repetitive Sequences, Nucleic Acid, Blotting, Southern, Telomere
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