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Decline with age of the respiratory chain activity in human skeletal muscle
Abstract
Mitochondrial respiratory systems have been screened in 63 orthopaedic patients of age ranging between 17 and 91 years. The results show a statistically significant definite decrease with ageing of mitochondrial respiratory activity with pyruvate plus malate, succinate and ascorbate plus TMPD. This pattern is associated with an equally significant decrease with age of the enzymatic activity of complex I, II and IV. No significant decrease with age is, on the contrary, observed in the mitochondrial content of cytochromes a+a3, and c+c1. Preliminary Western blot analysis indicates an altered polypeptide pattern in cytochrome c oxidase. This study provides evidence for a decline with age of mitochondrial respiratory activity in human skeletal muscle, affecting complex I, II and IV.
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“There have been many reports describing lower mitochondrial oxidative capacity with aging (6-11), however, the majority have not considered important covariates such as cardiorespiratory fitness (8,9) and BMI (7,8,11).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]
In the citing paper
“Moreover, most studies of mitochondrial respiration have not considered important covariates such as participant physical activity levels (9), adiposity (11), and fiber type percentage, which could confound the relationship between mitochondrial capacity and age (10,12,18,19).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]
In the citing paper
“Many have also used isolated mitochondria (6,9,11).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]
In the citing paper
“Furthermore, several of these investigations were performed in isolated mitochondria (6,9,11), which has been shown to exaggerate the observed deficit in mitochondrial function, when compared to measurements conducted on permeabilized myofibers (17).”
From Chronological Age Does not Influence Ex-vivo Mitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Schägger, H., & von Jagow, G. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90587-2 · Cited by 11,420
Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701
A MICROSPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF CYTOCHROME OXIDASE
Cooperstein, S. J., & Lazarow, A. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)44883-1 · Cited by 1,356
Diseases of the mitochondrial DNA
Wallace, D. C. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.005523 · Cited by 1,319
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
Linnane, A., Ozawa, T., Marzuki, S., & Tanaka, M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92145-4 · Cited by 983
Detection of a specific mitochondrial DNA deletion in tissues of older humans
Cortopassi, G. A., & Arnheim, N. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6927 · Cited by 788
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730
ATP synthesis by oxidative phosphorylation
Senior, A. E. (1988) · Physiological Reviews · doi:10.1152/physrev.1988.68.1.177 · Cited by 633
Horton, P., Ruban, A. V., Rees, D., Pascal, A. A., Noctor, G., & Young, A. J. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80819-o · Cited by 465
GENETICS OF MITOCHONDRIAL BIOGENESIS
Tzagoloff, A., & Myers, A. M. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.001341 · Cited by 428
The oxidation of citrate, isocitrate and cis-aconitate by isolated mitochondria
Chappell, J. (1964) · Biochemical Journal · doi:10.1042/bj0900225 · Cited by 392
Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence
Ikebe, S.-I., Tanaka, M., Ohno, K., Sato, W., Hattori, K., Kondo, T., Mizuno, Y., & Ozawa, T. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90497-b · Cited by 341
Corral‐Debrinski, M. (1991) · JAMA · doi:10.1001/jama.266.13.1812 · Cited by 341
Cooper, J. A. D., Mann, V. M., & Schapira, A. H. V. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90270-u · Cited by 335
Liver mitochondrial respiratory functions decline with age
Yen, T., Chen, Y.-S., King, K.-L., Yeh, S.-H., & Wei, Y. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92701-0 · Cited by 323
Müller‐Höcker, J. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90006-9 · Cited by 284
Müller‐Höcker, J. (1989) · PubMed Central · Cited by 280
Hattori, K., Tanaka, M., Sugiyama, S., Obayashi, T., Ito, T., Satake, T., Hanaki, Y., Asai, J., Nagano, M., & Ozawa, T. (1991) · American Heart Journal · doi:10.1016/0002-8703(91)90020-i · Cited by 264
Ageing-associated 5 kb deletion in human liver mitochondrial DNA
Yen, T.-C., Su, J.-H., King, K.-L., & Wei, Y.-H. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91788-e · Cited by 248
Simonetti, S., Chen, X., DiMauro, S., & Schon, E. A. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(92)90059-v · Cited by 242
Multiple mitochondrial DNA deletions in an elderly human individual
Zhang, C., Baumer, A., Maxwell, R. J., Linnane, A. W., & Nagley, P. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80321-7 · Cited by 214
Ozawa, T., Tanaka, M., Ikebe, S.-I., Ohno, K., Kondo, T., & Mizuno, Y. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90698-m · Cited by 187
Münscher, C., Rieger, T., Müller‐Höcker, J., & Kadenbach, B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81484-h · Cited by 143
Bookelman, H., Trijbels, J. M. F., Sengers, R. C. A., & Janssen, A. J. M. (1978) · Biochemical Medicine · doi:10.1016/0006-2944(78)90037-6 · Cited by 137
Müller‐Höcker, J. (1992) · Brain Pathology · doi:10.1111/j.1750-3639.1992.tb00683.x · Cited by 103
Paradies, G., & Ruggiero, F. M. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90304-2 · Cited by 88
Fischer, J., Ruitenbeek, W., Stadhouders, A. M., Trijbels, J. M. F., Sengers, R. C. A., Janssen, A. J. M., & Veerkamp, J. H. (1985) · Clinica Chimica Acta · doi:10.1016/0009-8981(85)90022-1 · Cited by 72
Reconstitution of Respiratory Chain Enzyme Systems
King, T. E., & Takemori, S. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97759-8 · Cited by 47
DECLINE IN SKELETAL MUSCLE MITOCHONDRIAL RESPIRATION CHAIN FUNCTION WITH AGEING
Cardellach, F., Galofré, J., Cussó, R., & Urbano-Márquez, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90282-1 · Cited by 43
Zanotti, F., GUERRIERI, F., Capozza, G., Houštěk, J., Ronchi, S., & Papa, S. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80161-3 · Cited by 42
Self-citationAge-dependent changes in the mitochondrial F0F1 ATP synthase
GUERRIERI, F., Capozza, G., Kalous, M., Zanotti, F., Drahota, Z., & Papa, S. (1992) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(92)90029-4 · Cited by 38
Self-citationIsoforms of human cytochrome‐c oxidase
Kuilenburg, A. B. P., Dekker, H. L., den Bogert, C. V., NIEBOER, P., GELDER, B. F. V., & Muijsers, A. O. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16162.x · Cited by 35
On the Mechanism of Action of Alkylguanidines on Oxidative Phosphorylation in Mitochondria
Papa, S., de Gómez‐Puyou, M. T., & Gómez‐Puyou, A. (1975) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1975.tb02131.x · Cited by 35
Self-citationOxidative energy failure in post-mitotic cells: a major factor in senescence.
Byrne, E., Dennett, X., & Trounce, I. A. (1991) · PubMed · Cited by 35
Organelles in eukaryotic cells : molecular structure and interactions
Tager, J. M. (1989) · Plenum Press eBooks · Cited by 30
Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform
Kuilenburg, A. B. P., BEEUMEN, J. V., Demol, H., den Bogert, C. V., Schouten, I., & Muijsers, A. O. (1992) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(92)90395-t · Cited by 12
Corral-Debrinski, M. (1991) · JAMA · doi:10.1001/jama.1991.03470130092035 · Cited by 1
Research works printed but not linked: 11
- Müller-Hocker, 1989, Am. J. Pathol., 134, 1167
- Byrne, 1991, Rev. Neurol., 147, 6
- Byrne, 1991, Rev. Neurol., 147, 532
- Linnane, 1990, Biochem. Int., 22, 1067
- Fisher, 1985, Clin. Chim. Acta, 145, 89, 10.1016/0009-8981(85)90022-1 · DOI
- Chance, 1956, Adv. Enzymol. Relat. Subj. Biochem., 17, 65
- Bookelman, 1978, Bioch. Med., 19, 366, 10.1016/0006-2944(78)90037-6 · DOI
- Hatefi, 1961, J. Biol. Chem., 237, 1620
- Ewart, 1991, FEBS Lett., 292, 2
- Ewart, 1991, FEBS Lett., 79
- Paradies, 1990, B.B.A., 1016, 207
Cited by
Sorted by citations
Oxidative damage and mitochondrial decay in aging.
Shigenaga, M. K., Hagen, T. M., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10771 · Cited by 2,055
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
Chan, D. C. (2006) · Cell · doi:10.1016/j.cell.2006.06.010 · Cited by 1,987
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Aging, energy, and oxidative stress in neurodegenerative diseases
Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434
Johnson, F. B., Sinclair, D. A., & Guarente, L. (1999) · Cell · doi:10.1016/s0092-8674(00)80567-x · Cited by 844
Metadata
- Authors
- Boffoli, D., Scacco, S. C., Vergari, R., Solarino, G., Santacroce, G., & Papa, S.
- Affiliations
- University of Bari Aldo Moro (IT)
- Corresponding author
- Papa, S.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 1994-04
- Volume
- 1226
- Issue
- 1
- Pages
- 73-82
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2135792486
- Cited by
- 341
- References
- 38
- Citations by year
- 2026: 1 · 2025: 14 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 13 · 2013: 12 · 2012: 10
- FWCI
- 4.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- mitochondrial respiratory chain, aging, skeletal muscle, complex I, complex II, cytochrome c oxidase, cytochrome aa3, respiratory chain activity, orthopedic patients
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Ascorbic Acid, Electron Transport Complex IV, Cytochromes, Humans, Malates, Middle Aged, Mitochondria, Muscle, Multienzyme Complexes, Oxidation-Reduction, Oxidoreductases, Pyruvates, Succinate Dehydrogenase, Succinates, NAD(P)H Dehydrogenase (Quinone), Pyruvic Acid, Succinic Acid, Electron Transport Complex II
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