Absence of relationship between the level of electron transport chain activities and aging in human skeletal muscle
Abstract
We investigated the relationship between age and respiratory chain function of skeletal muscle mitochondria in 132 control individuals (15 to 95 years old). Muscle mitochondria were studied polarographically and spectrophotometrically. By regression analysis, we found a significant inverse correlation between age and oxygen uptake linked to substrate oxidation (succinate, glutamate-malate or ascorbate-TMPD). However, this significance disappeared after including physical activity and tobacco consumption as confounding variables in a multivariate statistical analysis. Similarly, the activity of respiratory chain complexes individually measured did not decline with age. It therefore appears that respiratory chain activity in human skeletal muscle mitochondria is substantially undamaged during the aging process.
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It has been suggested that age-related reduction in ETC function is not related to aging per se, but due to confounding factors including physical inactivity.
“However, it has also been suggested that the age-related reduction in ETC function, reduced mitochondrial complex I, II, III, and IV activity, is not related to the aging process per se, but rather due to other confounding factors, including physical inactivity (23).”
From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [23]
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- Authors
- Barrientos, A., Casademont, J., Rötig, A., Miró, Ò., Urbano-Márquez, Á., Rustin, P., & Cardellach, F.
- Affiliations
- Universitat de Barcelona (ES)
- Inserm (FR)
- Corresponding author
- Cardellach, Francesc
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 229
- Issue
- 2
- Pages
- 536-539
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W1997970054
- Cited by
- 95
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- aging, skeletal muscle, mitochondrial respiratory chain, electron transport chain, mitochondrial function, oxygen consumption, succinate oxidation, respiratory chain complexes, physical activity, smoking
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Electron Transport, Humans, Middle Aged, Mitochondria, Muscle, Muscle, Skeletal
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