The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Ultrastructure of the human vomeronasal organ
Abstract
Virtually all vertebrates have a vomeronasal system whose involvement in pheromone detection plays a crucial role in reproduction. In humans, the vomeronasal organ has been assumed to be vestigial or absent and without functional significance. In the present study involving over 400 subjects, vomeronasal pits were observed in all individuals except those with pathological conditions affecting the septum. Electron microscopy of the adult human vomeronasal organ indicates the presence of two potential receptor elements in the pseudostratified epithelial lining: microvillar cells, and unmyelinated, intraepithelial axons. In addition, unmyelinated axons are common in the lamina propria surrounding the organ. They appear to constitute the components essential for a functional chemosensory system, and may thus provide the basis for a pheromone detection system as in other animals.
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In the citing paper
“The epithelium lining the human VNO is unlike that of VNOs in other species and unlike that of olfactory or respiratory epithelium in humans (Moran et al., 1991;Stensaas et al., 1991).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991
In the citing paper
“The human vomeronasal epithelium differs in appearance from both the sensory and non-sensory epithelia in the VNOs of other species and from nasal 'respiratory' epithelium (Moran et al., 1991;Stensaas et al., 1991).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991
In the citing paper
“There are axons within the human VNO and Schwann cell-wrapped bundles of axons underlying it (Stensaas et al., 1991;Jahnke and Merker, 2000), so it is somewhat surprising that Trotier et al. did not find S100 expression close to the VNO (Trotier et al., 2000).”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991
In the citing paper
“Axons are observed in the epithelium (Stensaas et al., 1991), but not in continuity or in synaptic contact with epithelial cells.”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991
In the citing paper
“Axon bundles are reported in the submucosa (Stensaas et al., 1991), but do not appear to arise from axon bundles penetrating the lamina propria in the same way as in vomeronasal epithelia of other species.”
From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Stensaas et al., 1991
Citations
Cites
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The Organization and Function of the Vomeronasal System
Halpern, M. (1987) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.10.030187.001545 · Cited by 732
Neurobehavioral evidence for the involvement of the vomeronasal system in mammalian reproduction.
Wysocki, C. (1979) · Neuroscience and Biobehavioral Reviews · doi:10.1016/0149-7634(79)90015-0 · Cited by 478
Vomeronasal Organ: Critical Role in Mediating Sexual Behavior of the Male Hamster
Powers, J. B., & Winans, S. S. (1975) · Science · doi:10.1126/science.1145182 · Cited by 351
THE ROLE OF THE VOMERONASAL ORGAN IN MAMMALIAN REPRODUCTION
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Morphology of the human olfactory epithelium
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The fine structure of the olfactory mucosa in man
Moran, D. T., Rowley, J. C., Jafek, B. W., & Lovell, M. A. (1982) · Journal of Neurocytology · doi:10.1007/bf01153516 · Cited by 280
Crosby, E. C., & Humphrey, T. (1941) · The Journal of Comparative Neurology · doi:10.1002/cne.900740209 · Cited by 275
Electron microscopy of human olfactory epithelium reveals a new cell type: The microvillar cell
Moran, D. T., Rowley, J. C., & Jafek, B. W. (1982) · Brain Research · doi:10.1016/0006-8993(82)90671-0 · Cited by 150
The alveolar brush cell in rat lung—a third pneumonocyte
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Cited by
Sorted by citations
A novel family of genes encoding putative pheromone receptors in mammals
Dulac, C., & Axel, R. (1995) · Cell · doi:10.1016/0092-8674(95)90161-2 · Cited by 1,001
Molecular detection of pheromone signals in mammals: from genes to behaviour
Dulac, C. G., & Torello, A. T. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1140 · Cited by 662
Structure and function of the vomeronasal system: an update
Halpern, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00103-5 · Cited by 639
Tirindelli, R., Dibattista, M., Pifferi, S., & Menini, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2008 · Cited by 393
Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases
Meredith, M. (2001) · Chemical Senses · doi:10.1093/chemse/26.4.433 · Cited by 280
Metadata
- Authors
- Stensaas, L. J., Lavker, R. M., Monti-Bloch, L., Grosser, B. I., & Berliner, D. L.
- Affiliations
- University of Utah (US)
- University of Pennsylvania (US)
- Corresponding author
- Stensaas, Larry J.
- ORCID
- Lavker, Robert M.
- Venue
- The Journal of Steroid Biochemistry and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1991-10
- Volume
- 39
- Issue
- 4
- Pages
- 553-560
- ISSN
- 0960-0760 (ISSN-L)
- OpenAlex
- W2081035242
- Cited by
- 118
- References
- 31
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 1 · 2013: 3
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Steroid Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- vomeronasal organ, pheromone detection, lamina propria, pseudostratified epithelium, chemosensory system, human reproduction, ultrastructure
- MeSH terms
- Adult, Autopsy, Axons, Chemoreceptor Cells, Epithelium, Fetus, Humans, Microscopy, Microscopy, Electron, Nasal Septum, Olfactory Pathways
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