Autophagy and related mechanisms of lysosome-mediated protein degradation

Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine

Kovács, A. L., Reith, A., & Seglen, P. O. (1982) · Experimental Cell Research · doi:10.1016/0014-4827(82)90020-9 · Cited by 163

Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors

HOLEN, I., GORDON, P. B., & SEGLEN, P. O. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18013.x · Cited by 88

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice

Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412022 · Cited by 2,331

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312

Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

Meléndez, A., Tallóczy, Z., Seaman, M., Eskelinen, E.-L., Hall, D. H., & Levine, B. (2003) · Science · doi:10.1126/science.1087782 · Cited by 1,270

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

Cuervo, A. M., & Dice, J. F. (1996) · Science · doi:10.1126/science.273.5274.501 · Cited by 979

Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast

Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00381 · Cited by 791

Autophagy, amyloidogenesis and Alzheimer disease

Nixon, R. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.019265 · Cited by 749

Ribosomal S6 Kinase Signaling and the Control of Translation

Dufner, A., & Thomas, G. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4683 · Cited by 676

Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway

Lee, H.-J., Khoshaghideh, F., Patel, S., & Lee, S.-J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3809-03.2004 · Cited by 445

Autophagy in chronically ischemic myocardium

Yan, L., Vatner, D. E., Kim, S.-J., Ge, H., Masurekar, M., Massover, W. H., Yang, G., Matsui, Y., Sadoshima, J., & Vatner, S. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506843102 · Cited by 430

Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1

Scarlatti, F., Bauvy, C., Ventruti, A., Sala, G., Cluzeaud, F., Vandewalle, A., Ghidoni, R., & Codogno, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313561200 · Cited by 388

Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)

Koike, M., Shibata, M., Waguri, S., Yoshimura, K., Tanida, I., Kominami, E., Gotow, T., Peters, C., von Figura, K., Mizushima, N., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61253-9 · Cited by 330

Role of LAMP-2 in Lysosome Biogenesis and Autophagy

Eskelinen, E.-L., Illert, A. L., Tanaka, Y., Schwarzmann, G., Blanz, J., von Figura, K., & Saftig, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0114 · Cited by 323

Two Distinct Pathways for Targeting Proteins from the Cytoplasm to the Vacuole/Lysosome

Baba, M., Osumi, M., Scott, S. V., Klionsky, D. J., & Ohsumi, Y. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1687 · Cited by 292

Convergence of Multiple Autophagy and Cytoplasm to Vacuole Targeting Components to a Perivacuolar Membrane Compartment Prior tode Novo Vesicle Formation

Kim, J., Huang, W.-P., Stromhaug, P. E., & Klionsky, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109134200 · Cited by 272

Chapter 10 Monitoring Autophagy by Electron Microscopy in Mammalian Cells

Ylä‐Anttila, P., Vihinen, H., Jokitalo, E., & Eskelinen, E. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(08)03610-0 · Cited by 257

Regulation of Autophagy by Sphingosine Kinase 1 and Its Role in Cell Survival during Nutrient Starvation

Lavieu, G., Scarlatti, F., Sala, G., Carpentier, S., Levade, T., Ghidoni, R., Botti, J., & Codogno, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506182200 · Cited by 225

Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris

Tuttle, D. L., & Dunn, W. A. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.1.25 · Cited by 206

AtATG Genes, Homologs of Yeast Autophagy Genes, are Involved in Constitutive Autophagy in Arabidopsis Root Tip Cells

Inoue, Y., Suzuki, T., Hattori, M., Yoshimoto, K., Ohsumi, Y., & Moriyasu, Y. (2006) · Plant and Cell Physiology · doi:10.1093/pcp/pcl031 · Cited by 189

Analysis of the Membrane Structures Involved in Autophagy in Yeast by Freeze-Replica Method.

Baba, M., Osumi, M., & Ohsumi, Y. (1995) · Cell Structure and Function · doi:10.1247/csf.20.465 · Cited by 151

Cell “Self‐Eating” (Autophagy) Mechanism in Alzheimer's Disease

Funderburk, S. F., Marcellino, B. K., & Yue, Z. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20161 · Cited by 139

SKD1 AAA ATPase-Dependent Endosomal Transport is Involved in Autolysosome Formation.

Nara, A., Mizushima, N., Yamamoto, A., Kabeya, Y., Ohsumi, Y., & Yoshimori, T. (2002) · Cell Structure and Function · doi:10.1247/csf.27.29 · Cited by 144

Inhibition of Hepatocytic Autophagy by Adenosine, Aminoimidazole-4-carboxamide Riboside, and N 6-Mercaptopurine Riboside

Samari, H. R., & Seglen, P. O. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.37.23758 · Cited by 125

Modulation of intracellular calcium homeostasis blocks autophagosome formation

Engedal, N., Torgersen, M. L., Guldvik, I. J., Barfeld, S. J., Bakula, D., Sætre, F., Hagen, L. K., Patterson, J. B., Proikas-Cezanne, T., Seglen, P. O., et al. (2013) · Autophagy · doi:10.4161/auto.25900 · Cited by 104

mVps34 Deletion in Podocytes Causes Glomerulosclerosis by Disrupting Intracellular Vesicle Trafficking

Chen, J., Chen, M. X., Fogo, A. B., Harris, R. C., & Chen, J.-K. (2013) · Journal of the American Society of Nephrology · doi:10.1681/asn.2012010101 · Cited by 82

The correlation between cell and nucleus size is explained by an eukaryotic cell growth model

Wu, Y., Pegoraro, A. F., Weitz, D. A., Janmey, P., & Sun, S. X. (2022) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009400 · Cited by 72

TMEM74, a lysosome and autophagosome protein, regulates autophagy

Yu, C., Wang, L., Lv, B., Lu, Y., Zeng, L., Chen, Y., Ma, D., Shi, T., & Wang, L. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.055 · Cited by 66

SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy

Lippai, M., Csikós, G., Maróy, P., Lukácsovich, T., Juhász, G., & Sass, M. (2008) · Autophagy · doi:10.4161/auto.5719 · Cited by 56

Autophagy in the epithelial cells of murine seminal vesicle in vitro

Kovács, A. L., Réz, G., Pálfia, Z., & Kovács, J. (2000) · Cell and Tissue Research · doi:10.1007/s004410000275 · Cited by 53

Autolysosomal Membrane-associated Betaine Homocysteine Methyltransferase

Ueno, T., Ishidoh, K., Mineki, R., Tanida, I., Murayama, K., Kadowaki, M., & Kominami, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15222 · Cited by 50

Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas

Tóth, S., Nagy, K., Pálfia, Z., & Réz, G. (2002) · Cell and Tissue Research · doi:10.1007/s00441-001-0506-7 · Cited by 44

Altered signal transduction pathways and induction of autophagy in human myotonic dystrophy type 1 myoblasts

Beffy, P., Del Carratore, R., Masini, M., Furling, D., Puymirat, J., Masiello, P., & Simili, M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.010 · Cited by 42

Small Molecular Weight Soybean Protein-Derived Peptides Nutriment Attenuates Rat Burn Injury-Induced Muscle Atrophy by Modulation of Ubiquitin-Proteasome System and Autophagy Signaling Pathway

Zhao, F., Yu, Y., Liu, W., Zhang, J., Liu, X., Liu, L., & Yin, H. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05387 · Cited by 41

The effects of acute aerobic and resistance exercise on mTOR signaling and autophagy markers in untrained human skeletal muscle

Mazo, C. E., D’Lugos, A. C., Sweeney, K. R., Haus, J. M., Angadi, S. S., Carroll, C. C., & Dickinson, J. M. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04758-6 · Cited by 36

Macroautophagy in Mammalian Cells

Eskelinen, E.-L. (2007) · Lysosomes · doi:10.1007/0-387-28957-7_14 · Cited by 4