Cited by 979Autophagy in Disease and TherapyCellular transport and secretionUbiquitin and proteasome pathways

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

Cuervo, Ana Maria, Dice, J. Fred·1996·Science

Abstract

Multiple pathways of protein degradation operate within cells. A selective protein import pathway exists for the uptake and degradation of particular cytosolic proteins by lysosomes. Here, the lysosomal membrane glycoprotein LGP96 was identified as a receptor for the selective import and degradation of proteins within lysosomes. Specific substrates of this proteolytic pathway bound to the cytosolic tail of a 96-kilodalton lysosomal membrane protein in two different binding assays. Overexpression of human LGP96 in Chinese hamster ovary cells increased the activity of the selective lysosomal proteolytic pathway in vivo and in vitro.

Integrity signals

Registry

Crossref · 10.1126/science.273.5274.501

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cited by

Sorted by citations

Authors
Cuervo, A. M., & Dice, J. F.
Affiliations
  • Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA.
  • Tufts University (US)
Corresponding author
Dice, J. Fred
Venue
Science
Published
1996-07-26
Volume
273
Issue
5274
Pages
501-503
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1968322176
Cited by
979
References
0
Citations by year
2026: 28 · 2025: 37 · 2024: 49 · 2023: 41 · 2022: 53 · 2021: 54 · 2020: 49 · 2019: 53 · 2018: 56 · 2017: 43 · 2016: 50 · 2015: 49 · 2014: 27 · 2013: 46 · 2012: 37
FWCI
14.92
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG-06116)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
lysosomal membrane glycoprotein, lysosomal protein degradation, selective autophagy, receptor identification, lysosomal proteolysis, protein binding
MeSH terms
Amino Acid Sequence, Animals, Glyceraldehyde-3-Phosphate Dehydrogenases, Cricetinae, Heat-Shock Proteins, Humans, Intracellular Membranes, Lysosomes, Membrane Glycoproteins, Molecular Sequence Data, Proteins, Ribonuclease, Pancreatic, Transfection, Antigens, CD, CHO Cells, HSP70 Heat-Shock Proteins, HSC70 Heat-Shock Proteins, Rats, Lysosomal Membrane Proteins, Lysosomal-Associated Membrane Protein 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review