Cited by 1,509Photodynamic Therapy Research StudiesNonmelanoma Skin Cancer StudiesPorphyrin Metabolism and Disorders

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Photodynamic therapy with endogenous protoporphyrin

Kennedy, J.C., Pottier, R.H., Pross, D.C.·1990·Journal of Photochemistry and Photobiology B: Biology

Open this paper in CoChat — free account

Abstract

5-Aminolaevulinic acid (ALA) is a precursor of protoporphyrin IX (Pp IX) in the biosynthetic pathway for haem. Certain types of cells have a large capacity to synthesize Pp IX when exposed to an adequate concentration of exogenous ALA. Since the conversion of Pp IX into haem is relatively slow, such cells tend to accumulate photosensitizing concentrations of Pp IX. Pp IX photosensitization can be induced in cells of the epidermis and its appendages, but not in the dermis. Moreover, since ALA in aqueous solution passes readily through abnormal keratin, but not through normal keratin, the topical application of ALA in aqueous solution to actinic keratoses or superficial basal cell or squamous cell carcinomas induces Pp IX photosensitization that is restricted primarily to the abnormal epithelium. Subsequent exposure to photoactivating light selectively destroys such lesions. In our ongoing clinical trial of ALA-induced Pp IX photodynamic therapy, the response rate for basal cell carcinomas following a single treatment has been 90% complete response and 7.5% partial response for the first 80 lesions treated. The cosmetic results have been excellent, and patient acceptance has been very good.

Integrity signals

Registry

Crossref · 10.1016/1011-1344(90)85083-9

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

NON‐INVASIVE TECHNIQUE FOR OBTAINING FLUORESCENCE EXCITATION AND EMISSION SPECTRA IN VIVO
Pottier, R., Chow, Y. F. A., Laplante, J. P., Truscott, T. G., Kennedy, J. C., & Beiner, L. A. (1986) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1986.tb04726.x · Cited by 176
Self-citation
The metabolism of δ-aminolaevulic acid. 1. Normal pathways, studied with the aid of 15N
Berlin, N. I., Neuberger, A., & Scott, J. J. (1956) · Biochemical Journal · doi:10.1042/bj0640080 · Cited by 126
Experimental Porphyric Neuropathy: A Preliminary Report
Sima, A. A. F., Kennedy, J. C., Blakeslee, D., & Robertson, D. M. (1981) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100042992 · Cited by 72
Self-citation
The metabolism of δ-aminolaevulic acid. 2. Normal pathways, studied with the aid of 14C
Berlin, N. I., Neuberger, A., & Scott, J. J. (1956) · Biochemical Journal · doi:10.1042/bj0640090 · Cited by 54
Genetic, Metabolic, and Biochemical Aspects of the Porphyrias
Sassa, S., & Kappas, A. (1981) · Springer eBooks · doi:10.1007/978-1-4615-8303-5_3 · Cited by 42

Show all 5 references

Research works printed but not linked: 1

Divaris, 1990, Phototoxic damage to sebaceous glands and hair follicles of mice following systematic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence, Am. J. Pathol., 136

Sorted by citations

Items 801–900 of 1,000

Lasers and Optical Technologies in Facial Plastic Surgery
Kuan, E. C., & Wong, B. J. F. (2008) · Archives of Facial Plastic Surgery · doi:10.1001/archfaci.10.6.381 · Cited by 19
A novel ATX‐S10(Na) photodynamic therapy for human skin tumors and benign hyperproliferative skin
Takahashi, H., Itoh, Y., Nakajima, S., Sakata, I., & Iizuka, H. (2004) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2004.00108.x · Cited by 19
Perspectives of Photodynamic Therapy for Skin Diseases
Colussi, V., Feyes, D. K., & Mukhtar, H. (1998) · Skin Pharmacology and Physiology · doi:10.1159/000029856 · Cited by 19
Tissue Diagnostics Using Lasers
Svanberg, S. R. (2001) · CRC Press eBooks · doi:10.1201/9781420040746.ch6 · Cited by 19
Spotlighting the Role of Photodynamic Therapy in Cutaneous Malignancy: An Update and Expansion
Ross, K., Cherpelis, B. S., Lien, M. H., & Fenske, N. A. (2013) · Dermatologic Surgery · doi:10.1111/dsu.12319 · Cited by 19
Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling
Dewalle, A. S., Betrouni, N., Tylcz, J., Vermandel, M., Mortier, L., & Mordon, S. R. (2015) · Journal of Biomedical Optics · doi:10.1117/1.jbo.20.5.058001 · Cited by 18
Topical 5-aminolevulinic acid photodynamic therapy for intra anal-rectal warts
Zhao, W., Shan, X.-F., Wang, C.-L., Liu, X.-Z., Li, Z., Xiao, H., Li, Z.-W., Zheng, R., Hou, J., & Tian, H. (2019) · Journal of Dermatological Treatment · doi:10.1080/09546634.2019.1594670 · Cited by 18
Combination of vitamin D and photodynamic therapy enhances immune responses in murine models of squamous cell skin cancer
Anand, S., Shen, A. S., Cheng, C.-E., Chen, J. H. K., Powers, J., Rayman, P. A., Diaz, M., Hasan, T. G., & Maytin, E. V. (2024) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2024.103983 · Cited by 18
Low irradiance compared with conventional photodynamic therapy in the treatment of actinic keratoses
Gholam, P., Bosselmann, I., Enk, A. H., & Dick, J. (2018) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12431 · Cited by 18
Fluorescence‐based discrimination of breast cancer cells by direct exposure to 5‐aminolevulinic acid
Morita, M., Tanaka, H., Kumamoto, Y., Nakamura, A., Harada, Y., Ogata, T., Sakaguchi, K., Taguchi, T., & Takamatsu, T. (2019) · Cancer Medicine · doi:10.1002/cam4.2466 · Cited by 18
Fluorometric quantification of protoporphyrin IX in biological skin samples from in vitro penetration/permeation studies
Rossetti, F. C., Depieri, L. V., Tedesco, A. C., & Bentley, M. V. L. B. (2010) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502010000400017 · Cited by 18
Influence of formulation factors on methyl-ALA-induced protoporphyrin IX accumulation in vivo
Donnelly, R. F., Juzenas, P., McCarron, P. A., Ma, L.-W., Woolfson, A. D., & Moan, J. E. (2006) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2006.03.007 · Cited by 18
Structural and Mutagenic Approach to Create Human Serum Albumin-Based Oxygen Carrier and Photosensitizer
Komatsu, T., Nakagawa, A., & Qu, X. (2009) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.24.287 · Cited by 18
Current and emerging treatment strategies for the treatment of actinic keratosis
Berlin, J. M. (2010) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s9910 · Cited by 18
Distribution of 5-aminolevulinic acid derivatives and induced porphyrin kinetics in mice tissues
Venosa, G. M. D., Batlle, A. M. D. C., Fukuda, H., MacRobert, A. J., & Casas, A. G. (2006) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-006-0186-9 · Cited by 18
Comparison of Aminolevulinic Acid– and Hexylester Aminolevulinate–Induced Protoporphyrin IX Fluorescence for the Detection of Ovarian Cancer in a Rat Model
Régis, C., Collinet, P., Farine, M. O., & Mordon, S. R. (2007) · Photomedicine and Laser Surgery · doi:10.1089/pho.2007.2057 · Cited by 18
Scavengers Protection of Cells Against ALA-based Photodynamic Therapy-induced Damage
Perotti, C., Casas, A. G., & Batlle, A. M. D. C. (2002) · Lasers in Medical Science · doi:10.1007/s101030200033 · Cited by 18
Potential Efficacy of a Delta 5-Aminolevulinic Acid Bioadhesive Gel Formulation for the Photodynamic Treatment of Lesions of the Gastrointestinal Tract in Mice
Vonarx, V., Eléouet, S., Carré, J., Iooss, P., Gouyette, A., Leray, A. M., Merle, C., Lajat, Y., & Patrice, T. (1997) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1997.tb06087.x · Cited by 19
New developments in laser medicine
Svanberg, S. R. (1997) · Physica Scripta · doi:10.1088/0031-8949/1997/t72/009 · Cited by 18
Photodynamic Endometrial Ablation in the Nonhuman Primate
Vugt, D. V., Krzemien, A., Roy, B. N., Fletcher, W. A., Foster, W., Lundahl, S., Marcus, S. L., & Reid, R. L. (2000) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(00)00037-x · Cited by 18
Købner reaction induced by photodynamic therapy using delta-aminolevulinic acid. A case report.
Stender, I., & Wulf, H. C. (1996) · Acta Dermato Venereologica · doi:10.2340/0001555576392393 · Cited by 18
Iron chelation promotes 5-aminolaevulinic acid-based photodynamic therapy against oral tongue squamous cell carcinoma
Qin, J., Zhou, C., Zhu, M., Shi, S., Zhang, L., Zhao, Y., Li, C., Wang, Y., & Wang, Y. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101907 · Cited by 17
Ablation efficacy of 5-aminolevulinic acid-mediated photodynamic therapy on human glioma stem cells
Omura, N., Nonoguchi, N., Fujishiro, T., Park, Y., Ikeda, N., Kajimoto, Y., Hosomi, R., Yagi, R., Hiramatsu, R., Furuse, M., et al. (2022) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2022.103119 · Cited by 17
Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells
Chung, C., Kim, C. H., Lee, H. M., Kim, D. H., Kwak, T.-W., Chung, K. D., Jeong, Y., & Kang, D. H. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.01.022 · Cited by 17
Antitumor activity of photodynamic therapy with a chlorin derivative in vitro and in vivo
Wang, L., Li, J.-W., Huang, J., Li, J., Zhang, L., O’Shea, D. F., & Chen, Z. (2015) · Tumor Biology · doi:10.1007/s13277-015-3395-1 · Cited by 17
In vivo and in vitro evaluation of the cytotoxic effects of Photosan-loaded hollow silica nanoparticles on liver cancer
Liu, Z.-T., Xiong, L., Liu, Z.-P., Miao, X., Lin, L., & Wen, Y. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-319 · Cited by 17
Plum-blossom needling enhanced the effect of photodynamic therapy on basal cell carcinoma
Mu, X. L., Wang, L., Wang, L., Ge, R., Dang, H., & Mou, K. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.08.001 · Cited by 17
Current and New Treatments of Photodamaged Skin
Shamban, A. T. (2009) · Facial Plastic Surgery · doi:10.1055/s-0029-1243083 · Cited by 17
Photodynamic therapy of non-melanoma skin cancers
Ikram, M., Khan, R. U., Firdous, S., Atif, M. M., & Nawaz, M. Y. (2011) · Laser Physics · doi:10.1134/s1054660x11030042 · Cited by 17
Correlation of death modes of photosensitized cells with intracellular ATP concentration
Kirvelienė, V., Sadauskaite, A., Kadziauskas, J., Sasnauskienė, S., & Juodka, B. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01014-7 · Cited by 17
Skin-photosensitizing properties of Zn(II)-2(3), 9(10), 16(17), 23(24)-tetrakis-(4-oxy-N-methylpiperidinyl) phthalocyanine topically administered to mice
Kassab, K., Fabris, C., Filippis, M. P. D., Dei, D., Fantetti, L., Roncucci, G., Reddi, E., & Jori, G. (2000) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(00)00034-8 · Cited by 17
In vivo fluorescence kinetics of porphyrins following intravesical instillation of 5-aminolaevulinic acid in normal and tumour-bearing rat bladders
Heil, P., Stocker, S., Sroka, R. C., & Baumgärtner, R. (1997) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(96)07443-x · Cited by 17
Topical treatment of actinic keratoses with low‐dose 5‐fluorouracil in combination with salicylic acid – pilot study
Schlaak, M. S., & Simon, J. C. (2009) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2009.07293.x · Cited by 17
Significance of Fluorescence Cystoscopy for Diagnosis of Superficial Bladder Cancer after Intravesical Instillation of Delta Aminolevulinic Acid
Ehsan, A., Sommer, F. O., Haupt, G., & Engelmann, U. H. (2001) · Urologia Internationalis · doi:10.1159/000051007 · Cited by 17
The modern paradigm of phototherapy
Zanolli, M. D. (2003) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2003.08.005 · Cited by 17
Effectiveness of photodynamic ablation for destruction of endometrial explants in a rat endometriosis model
Krzemien, A. A., Vugt, D. A. V., Fletcher, W. A., & Reid, R. L. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(02)03151-5 · Cited by 17
Effect of photodynamic therapy using 5-aminolevulinic acid on 4-nitroquinoline-1-oxide-induced premalignant and malignant lesions of mouse tongue
Ma, G., Ikeda, H., Inokuchi, T., & Sano, K. (1999) · Oral Oncology · doi:10.1016/s1368-8375(98)00066-9 · Cited by 17
Cystoscopic Diagnosis of Bladder Cancer by Intravesical Instillation of 5-Aminolevulinic Acid Induced Porphyrin Fluorescence—The Singapore Experience
Cheng, C., Lau, W. K. O., Tan, P. H., & Olivo, M. (2000) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v29n2p153 · Cited by 17
The optical properties of skin tumours measured during superficial photodynamic therapy
Hudson, E. J., Stringer, M. R., Cairnduff, F., Ash, D., & Smith, M. A. (1994) · Lasers in Medical Science · doi:10.1007/bf02590357 · Cited by 17
Effect of Mammalian Cell Differentiation on Response to Exogenous 5-Aminolevulinic Acid
Li, G., Szewczuk, M. R., Pottier, R., & Kennedy, J. C. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb03279.x · Cited by 17
Self-citation
Photodynamic therapy and laser-based diagnostic studies of malignant tumours
Wang, I. (1999) · Lund University Publications (Lund University) · Cited by 17
Enhancement of Delta Aminolevulinic Acid–Photodynamic Therapy In Vivo by Decreasing Tumor pH With Glucose and Amiloride
Piot, B., Rousset, N., Lenz, P., Eléouet, S., Carré, J., Vonarx, V., Bourré, L., & Patrice, T. (2001) · The Laryngoscope · doi:10.1097/00005537-200112000-00026 · Cited by 17
Fractional 1,927 nm Thulium Laser Plus Photodynamic Therapy Compared and Combined for Photodamaged Décolleté Skin: A Side‐by‐Side Randomized Controlled Trial
Hendel, K., Mogensen, M., Wenande, E. C., Dierickx, C. C., Hædersdal, M., & Togsverd‐Bo, K. (2019) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23194 · Cited by 16
A Review of the Dermatologic Clinical Applications of Topical Photodynamic Therapy
Luo, O. D., Bose, R., Bawazir, M. A., Thuraisingam, T., & Ghazawi, F. M. (2024) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/12034754231216969 · Cited by 16
Epigenetically Enhanced Photodynamic Therapy ( e PDT ) is Superior to Conventional Photodynamic Therapy for Inducing Apoptosis in Cutaneous T‐Cell Lymphoma
Salva, K. A., & Wood, G. S. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12521 · Cited by 16
Changes in actin and E-cadherin expression induced by 5-aminolevulinic acid photodynamic therapy in normal and Ras-transfected human mammary cell lines
Venosa, G. M. D., Rodríguez, L., Mamone, L. A., Gándara, L., Rossetti, M. V., Batlle, A. M. D. C., & Casas, A. G. (2011) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2011.10.002 · Cited by 16
Nonsurgical Treatment Modalities for Primary Cutaneous Malignancies
Tull, S., Nunley, K. S., & Sengelmann, R. D. (2008) · Dermatologic Surgery · doi:10.1097/00042728-200807000-00001 · Cited by 16
Improved 5-Aminolevulinic Acid Production with Recombinant Escherichia coli by a Short-term Dissolved Oxygen Shock in Fed-batch Fermentation
Yang, J. M., Zhu, L., Fu, W., Lin, Y., Lin, J., & Cen, P. (2013) · Chinese Journal of Chemical Engineering · doi:10.1016/s1004-9541(13)60627-8 · Cited by 16
5-Aminolevulinic acid-induced fluorescence in bronchial tumours: dependency on the patterns of tumour invasion
Gamarra, F., Lingk, P., Marmarova, A., Edelmann, M., Haŭtmann, H., Stepp, H. G., Baumgärtner, R., & Huber, R. M. (2003) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2003.09.009 · Cited by 16
Physical Modalities (Devices) in the Management of Acne
Nestor, M. S., Swenson, N., & Macrì, A. (2016) · Dermatologic Clinics · doi:10.1016/j.det.2015.11.003 · Cited by 16
Treatment of multiple scalp basal cell carcinomas by photodynamic therapy
Morton, C. A., & Burden, A. D. (2001) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2001.00755.x · Cited by 16
Effects of levulinic acid on 5-aminolevulinic acid production in heterotrophic cultures of Chlorella regularis YA-603
Ano, A., Funahashi, H., Nakao, K., & Nishizawa, Y. (2000) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(00)88733-2 · Cited by 16
5-Aminolevulinic acid ester?induced protoporphyrin IX in a murine melanoma cell line
Vena, F. C. B., Turchiello, R. F., Laville, I., Pigaglio, S., Blais, J., & Tedesco, A. C. (2004) · Lasers in Medical Science · doi:10.1007/s10103-004-0313-y · Cited by 16
Photodynamic therapy using direct‐current pulsed iontophoresis for 5‐aminolevulinic acid application
Mizutani, K., Watanabe, D., Akita, Y., Akimoto, M., Tamada, Y., & Matsumoto, Y. (2009) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2009.00456.x · Cited by 16
Topical application of ALA and ALA hexyl ester on a subcutaneous murine mammary adenocarcinoma: tissue distribution
Perotti, C., Casas, A. G., Fukuda, H., SACCA, P. A., & Batlle, A. M. D. C. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6600665 · Cited by 16
Systemic Component of Protoporphyrin IX Production in Nude Mouse Skin upon Topical Application of Aminolevulinic Acid Depends on the Application Conditions¶
van den Akker, J. T. H. M., Iani, V., Star, W. M., Sterenborg, H. J. C. M., & Moan, J. E. (2002) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2002)0750172scopip2.0.co2 · Cited by 16
Routine experimental system for defining conditions used in photodynamic therapy and fluorescence photodetection of (non-) neoplastic epithelia
Lange, N., Vaucher, L., Marti, A., Etter, A. L., Gerber, P., van den Bergh, H., Jichlinski, P., & Kučera, P. (2001) · Journal of Biomedical Optics · doi:10.1117/1.1352751 · Cited by 16
Photodynamic Therapy in Daylight for Actinic Keratoses
Wulf, H. C. (2016) · JAMA Dermatology · doi:10.1001/jamadermatol.2015.5979 · Cited by 16
Fluorescence spectroscopy of exogenous, exogenously-induced and endogenous fluorophores for the photodetection and photodynamic therapy of cancer
Zellweger, M. (2000) · Infoscience (Ecole Polytechnique Fédérale de Lausanne) · doi:10.5075/epfl-thesis-2126 · Cited by 15
Terapia fotodinâmica com ftalocianina de zinco tópica: avaliação da intensidade de fluorescência, absorção cutânea, alterações histológicas e imuno-histoquímicas na pele do modelo animal
Tomazini, M. V., Souza, C. D. S., Garcia, S. B., & Tedesco, A. C. (2007) · Anais Brasileiros de Dermatologia · doi:10.1590/s0365-05962007000600006 · Cited by 15
Laser spectroscopy in medical diagnostics
Svanberg, S. R. (2013) · Elsevier eBooks · doi:10.1533/9780857097545.3.286 · Cited by 15
Increased cutaneous oxygen availability by topical application of hydrogen peroxide cream enhances the photodynamic reaction to topical 5-aminolevulinic acid-methyl ester
Manifold, R. N., & Anderson, C. D. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1128-x · Cited by 15
Synthesis and Evaluation of New Potential Benzo[a]phenoxazinium Photosensitizers for Anticancer Photodynamic Therapy
Zhang, J., Júnior, W. T. D. S., da Silva, V. C. M., Rodrigues, M. C., Morais, J. A. V., Song, J.-L., Cheng, Z., Longo, J. P. F., Azevedo, R. B., Jiang, C., et al. (2018) · Molecules · doi:10.3390/molecules23061436 · Cited by 15
Light Patch: Preliminary Report of a Novel Form of Blue Light Delivery for the Treatment of Actinic Keratosis
Zelickson, B. D., Counters, J., Coles, C. M., & Selim, M. M. (2006) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2005.31094 · Cited by 15
Deletion of Alloantigen-Activated Cells by Aminolevulinic Acid-Based Photodynamic Therapy
Hryhorenko, E. A., Oseroff, A. R., Morgan, J., & Rittenhouse‐Olson, K. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb03327.x · Cited by 15
Introduction to Photodynamic Therapy: Early Experience
Gold, M. H. (2007) · Dermatologic Clinics · doi:10.1016/j.det.2006.09.004 · Cited by 15
Fluorescence diagnosis of cervical squamous intraepithelial lesions: A clinical feasability study
Collinet, P., Delemer-Lefebvre, M., Jouve, E., Régis, C., Farine, M. O., Vinatier, D., Cosson, M., & Mordon, S. R. (2006) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2006.10.003 · Cited by 15
Photochemical internalization in bladder cancer–development of an orthotopic in vivo model
Gederaas, O. A., Johnsson, A., Berg, K., Manandhar, R., Shrestha, C., Skåre, D. G., Ekroll, I. K., Høgset, A., & Hjelde, A. (2017) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00176b · Cited by 15
Photodynamic therapy versus cryosurgery of basal cell carcinomas; results of a phase III randomized clinical trial
Wang, I., Svanberg, K., Bendsøe, N., af Klinteberg, C., Enejder, A. M. K., Andersson‐Engels, S., & Svanberg, S. R. (1999) · Biomedical optics · doi:10.1364/bio.1999.ctua3 · Cited by 15
Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified δ-aminolevulinic acid
Thompson, M. S., Gustafsson, L., Pålsson, S., Bendsøe, N., Stenberg, M., af Klinteberg, C., Andersson‐Engels, S., & Svanberg, K. (2001) · Journal of Porphyrins and Phthalocyanines · doi:10.1002/jpp.325 · Cited by 15
The Use of Photodynamic Therapy for Skin Cancer
Karrer, S., Szeimies, R., Abels, C., & Landthaler, M. (1998) · Oncology Research and Treatment · doi:10.1159/000026783 · Cited by 15
Response of a Rodent Fibrosarcoma to Photodynamic Therapy Using 5-aminolaevulinic Acid or Polyhaematoporphyrin
Cairnduff, F., Roberts, D. J., Dixon, B., & Brown, S. B. (1995) · International Journal of Radiation Biology · doi:10.1080/09553009514550121 · Cited by 15
Kinetics of 5-Aminolevulinic Acid-Induced Fluorescence in Organ Cultures of Bronchial Epithelium and Tumor
Gamarra, F., Wagner, S., Al-Batran, S. E., Maier, I., Castro, M., Haŭtmann, H., Bergner, A., Baumgartner, R., & Huber, R. M. (2002) · Respiration · doi:10.1159/000064008 · Cited by 15
The effect of photodynamic therapy on rat urinary bladder with orthotopic urothelial carcinoma
Grönlund‐Pakkanen, S., Wahlfors, J., Talja, M., Kosma, V. ‐., Pakkanen, T. M., Ala‐Opas, M., Alhava, E., & Moore, R. B. (2003) · BJU International · doi:10.1046/j.1464-410x.2003.04290.x · Cited by 14
Mechanistic insights into the design of fluorogenic molecules for wash-free biological applications
Huang, R., Abedi, S. A. A., Jiang, G., Wang, C., Peng, L., Shen, T., Mroweh, N., Fang, Y., & Liu, X. (2026) · Chemical Society Reviews · doi:10.1039/d5cs01519g · Cited by 14
Advances in 5-aminoketovaleric acid(5-ALA) nanoparticle delivery system based on cancer photodynamic therapy
Zhang, C., Zhao, X., Li, D., Ji, F., Dong, A., Chen, X., Zhang, J., Wang, X., Zhao, Y., & Chen, X. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103933 · Cited by 15
Treatment of nonmelanoma skin cancer with pro‐differentiation agents and photodynamic therapy: Preclinical and clinical studies (Review)
Anand, S., Hasan, T. G., & Maytin, E. V. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13914 · Cited by 14
Unveiling the Spatiotemporal and Dose Responses within a Single Live Cancer Cell to Photoswitchable Upconversion Nanoparticle Therapeutics Using Hybrid Hyperspectral Stimulated Raman Scattering and Transient Absorption Microscopy
Xin, L., Luo, Z., Liu, X., & Huang, Z. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.3c04898 · Cited by 14
Photodynamic Therapy of Human Undifferentiated Thyroid Carcinoma–Bearing Nude Mice Using Topical 5-Aminolevulinic Acid
Al-Watban, F. A. H., & Zhang, X. (2005) · Photomedicine and Laser Surgery · doi:10.1089/pho.2005.23.206 · Cited by 14
Tratamiento de queilitis actínicas con terapia fotodinámica
Castaño, E., Comunión, A., Arias, D., Miñano, R., Romero, A., & Borbujo, J. M. (2009) · Actas Dermo-Sifiliográficas · doi:10.1016/s0001-7310(09)72919-9 · Cited by 14
Epigenetically Enhanced PDT Induces Significantly Higher Levels of Multiple Extrinsic Pathway Apoptotic Factors than Standard PDT , Resulting in Greater Extrinsic and Overall Apoptosis of Cutaneous T‐cell Lymphoma
Salva, K. A., Kim, Y. H., Rahbar, Z., & Wood, G. S. (2018) · Photochemistry and Photobiology · doi:10.1111/php.12925 · Cited by 14
In vitro bactericidal activity of 465–470 nm blue light phototherapy and aminolevulinic acid on Staphylococcus pseudintermedius
Bae, S., & Oh, T. (2018) · Veterinary Dermatology · doi:10.1111/vde.12651 · Cited by 14
A xanthene derivative, free or associated to nanoparticles, as a new potential agent for anticancer photodynamic therapy
Wang, K., Zhang, J., Júnior, W. T. D. S., da Silva, V. C. M., Rodrigues, M. C., Morais, J. A. V., Jiang, C., Longo, J. P. F., Azevedo, R. B., & Muehlmann, L. A. (2020) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2020.1788370 · Cited by 14
Clinical assessment of a low-cost, hand-held, smartphone-attached intraoral imaging probe for 5-aminolevulinic acid photodynamic therapy monitoring and guidance
Khan, S., Song, B., Mallidi, S., Li, S., Liu, H., Hussain, M. A. B., Siddiqui, S., Khan, A. P., Akhtar, K., Siddiqui, S. A., et al. (2023) · Journal of Biomedical Optics · doi:10.1117/1.jbo.28.8.082809 · Cited by 14
Photodynamic effect of 5-aminolevulinic acid-loaded nanoparticles on bladder cancer cells: A preliminary investigation
Yan, X., Al‐Hayek, S., Huang, H., Zhu, Z., Zhu, W., & Guo, H. (2013) · Scandinavian Journal of Urology · doi:10.3109/00365599.2012.713000 · Cited by 14
Photodynamic Therapy
Chamberlain, A. J., & Kurwa, H. A. (2003) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200304030-00001 · Cited by 14
Modifications of protoporphyrin IX fluorescence during ALA-based photodynamic therapy of endometriosis
König, K., Wyss-Desserich, M.-T., Tadir, Y., Haller, U., Tromberg, B. J., Berns, M. W., & Wyss, P. A. (2006) · Medical Laser Application · doi:10.1016/j.mla.2006.07.003 · Cited by 14
Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid
Li, G., Szewczuk, M. R., Raptis, L. H., Johnson, J. G., Weagle, G. E., Pottier, R., & Kennedy, J. C. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690409 · Cited by 14
Self-citation
Visualisierung von Karzinomen der Mundhöhle durch Stimulierung der Synthese von fluoreszierendem Protoporphyrin IX
Zenk, W., Dietel, W., Schleier, P., & Günzel, S. (1999) · Oral and Maxillofacial Surgery · doi:10.1007/s100060050131 · Cited by 14
Licht-/Laser-/PDT-Therapie bei Akne
Borelli, C., Merk, K., Plewig, G., & Degitz, K. (2005) · Der Hautarzt · doi:10.1007/s00105-005-1036-0 · Cited by 14
Photodynamic therapy for Bowen's disease and squamous cell carcinoma of the skin
Haddad, R., Nesher, E., Weiss, J., Skornick, Y. G., & Kashtan, H. (2004) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/s1572-1000(04)00048-1 · Cited by 14
The Influence of UV Exposure on 5-Aminolevulinic Acid-induced Protoporphyrin IX Production in Skin¶
von Beckerath, M., Juzenas, P., Ma, L., Iani, V., Lofgren, L. A., & Moan, J. E. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740825tioueo2.0.co2 · Cited by 14
Mechanistic studies on δ-aminolevulinic acid uptake and efflux in a mammary adenocarcinoma cell line
Garcı́a, S. C., Casas, A. G., Perotti, C., Batlle, A. M. D. C., & Moretti, M. B. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601066 · Cited by 14
ATX-S10(Na)-photodynamic therapy is less carcinogenic for mouse skin compared with ultraviolet B irradiation
Takahashi, H., Nakajima, S., Sakata, I., Ishida‐Yamamoto, A., & Iizuka, H. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06937.x · Cited by 14
Chlorin-Type Photosensitizers Photochemically Derived from Vinyl Porphyrins¶
Brault, D., Aveline, B. M., Delgado, O., & Martin, M. T. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0730331ctppdf2.0.co2 · Cited by 14
The morphological changes in rat bladder after photodynamic therapy with 5‐aminolaevulinic acid‐induced protoporphyrin IX
Grönlund-Pakkanen, S., Pakkanen, T. M., Talja, M. T., Kosma, V., Ala‐Opas, M., & ALHAVA, E. M. (2000) · British Journal of Urology · doi:10.1046/j.1464-410x.2000.00718.x · Cited by 14
Photodynamic therapy of experimental colonic tumours with 5-aminolevulinic-acid-induced endogenous porphyrins
Orth, K., K�nig, K., Genze, F., & R�ck, A. (1994) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01245377 · Cited by 14
Photodynamic Therapy for Gastrointestinal Tumors
Wilson, J. H. P., van Hillegersberg, R., van den Berg, J. W. O., Kort, W. J., & Terpstra, O. T. (1991) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529109111225 · Cited by 14
The History and Advancement of Light, Lasers, and Energy-Based Devices in Dermatologic Surgery
Dover, J. S., Liu, C., Watchmaker, J. D., Wang, J. V., Geronemus, R. G., Arndt, K. A., & Anderson, R. R. (2025) · Dermatologic Surgery · doi:10.1097/dss.0000000000004542 · Cited by 13
Aminolevulinic Acid‐Photodynamic Therapy Combined with Topically Applied Vascular Disrupting Agent Vadimezan Leads to Enhanced Antitumor Responses
Marrero, A. M., Becker, T. L., Sunar, U., Morgan, J., & Bellnier, D. A. (2011) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2011.00943.x · Cited by 13

Authors: Kennedy, J. C., Pottier, R. H., & Pross, D. C.
Affiliations: Queen's University (CA)
Corresponding author: Kennedy, J.C.
Venue: Journal of Photochemistry and Photobiology B: Biology
Publisher: Elsevier BV
Published: 1990-06
Volume: 6
Issue: 1-2
Pages: 143-148
ISSN: 1011-1344 (ISSN-L)
DOI: 10.1016/1011-1344(90)85083-9
OpenAlex: W1506108633
Cited by: 1,509
References: 5
Citations by year: 2026: 18 · 2025: 20 · 2024: 39 · 2023: 35 · 2022: 30 · 2021: 20 · 2020: 42 · 2019: 33 · 2018: 37 · 2017: 25 · 2016: 44 · 2015: 39 · 2014: 45 · 2013: 38 · 2012: 49
FWCI: 22.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Photochemistry and Photobiology B Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Keywords: photodynamic therapy, protoporphyrin IX, 5-aminolevulinic acid, heme biosynthesis, photosensitization, basal cell carcinoma, actinic keratosis, squamous cell carcinoma, topical application, cosmetic outcome
MeSH terms: Aminolevulinic Acid, Animals, Carcinoma, Basal Cell, Basal Cell Carcinoma, Carcinoma, Squamous Cell, Humans, Keratosis, Photochemotherapy, Prodrugs, Protoporphyrins, Radiation-Sensitizing Agents, Skin Neoplasms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Photodynamic therapy with endogenous protoporphyrin

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks