Cited by 211DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentPhotodynamic Therapy Research Studies

The DOI matches its Crossref record; 119 of the 121 references it cites were found in a registry or an index.

New trends in photobiology

Cadet, J., Anselmino, C., Douki, T., Voituriez, L.·1992·Journal of Photochemistry and Photobiology B: Biology

Abstract

A survey of the recent aspects of the main photoreactions induced by far-UV radiation in cellular DNA is reported. This mostly includes the formation of cyclobutadipyrimidines, pyrimidine(6-4)pyrimidone photoadducts and related Dewar valence isomers in various eukaryotic and prokaryotic cells, as monitored by using either specific or more general assays. Information is also provided on mechanistic aspects regarding the formation of 5,6-dihydro-5-(alpha-thyminyl) thymine, the so-called "spore photoproduct" within far-UV-irradiated bacterial spores. The second major topic of the review deals with the effects of near-UV radiation and visible light on cellular DNA which are mostly mediated by photosensitizers. The main photoreactions of furocoumarins with DNA, one major class of photosensitizers used in the phototherapy of skin diseases, involve a [2 + 2] cycloaddition to the thymine bases according to an oxygen-independent mechanism. In contrast a second type of photosensitized reaction which appears to play a major role in the genotoxic effects of both near-UV and visible light requires the presence of oxygen. The photodynamic effects which are mediated by either still unidentified endogenous photosensitizers or defined exogenous photosensitizers lead to the formation of a wide spectrum of DNA modifications including base damage, oligonucleotide strand breaks and DNA-protein cross-links.

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Crossref · 10.1016/1011-1344(92)85135-h

Cites

119 of 119 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 121 references

Research works printed but not linked: 10

  1. Carrier, 1989, UV-induced DNA damage differs quantitatively with cell type, Photochem. Photobiol., 49s, 29s
  2. Freeman, 1986, Action spectrum for pyrimidine formation in human skin, Photochem. Photobiol., 43s, 93s
  3. Douki, 1991, Measurement of the (6-4) photoproducts by a HPLC-fluorescence assay, Photochem. Photobiol., 53s, 27s
  4. Leadon, 1987, Production of thymine glycols by radiation and chemical carcinogens as detected by a monoclonal antibody, Br. J. Cancer, 55, 113
  5. Brankmann, 1989, UVA-induced 8-MOP binding to cells of Saccharomyces cerivisiae, J. Photochem. Photobiol. B. Biol., 3, 59
  6. Cadet, 1987, Monofunctional furocoumarins: photochemical reactions with DNA, photobiological effects and their implications in the photochemotherapy of psoriasis, IUPAC Publ. Sect., 9, 1
  7. Cadet, 1992, Oxidation reactions of the purine and pyrimidine moieties of DNA model compounds, Book of Abstracts, 6th Bienn. Meet. of The International Society for Free Radical Research, Torino
  8. Kasai, 1992, Photosensitized formation of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-hydroxy-2′-deoxyguanosine) in DNA by riboflavin, Book of Abstracts, 6th Bienn. Meet. of The International Society for Free Radical Research, Torino
  9. Mouret, 1991, Formation of adenine N1-oxide within human DNA upon exposure to UVA radiation, Photochem. Photobiol., 53s, 27s
  10. Rosenstein, 1988, Repair of solar UV-induced damages in normal human skin fibroblasts, Photochem. Photobiol., 47s, 27s

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Metadata

Authors
Cadet, J., Anselmino, C., Douki, T., & Voituriez, L.
Affiliations
CEA Grenoble (FR)
Corresponding author
Cadet, J.
Venue
Journal of Photochemistry and Photobiology B: Biology
Publisher
Elsevier BV
Published
1992-09
Volume
15
Issue
4
Pages
277-298
ISSN
1011-1344 (ISSN-L)
OpenAlex
W2284627270
Cited by
211
References
121
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 9
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Photochemistry and Photobiology B Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Keywords
far-ultraviolet radiation, DNA photoproducts, spore photoproduct, bacterial spores, near-ultraviolet, visible light, photosensitizers, furocoumarins, [2+2] cycloaddition, photodynamic effect, genotoxicity, DNA strand breaks, DNA-protein crosslinks
MeSH terms
Animals, DNA, DNA Damage, Humans, Sunlight, Ultraviolet Rays

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