The DOI matches its Crossref record; 119 of the 121 references it cites were found in a registry or an index.
New trends in photobiology
Abstract
A survey of the recent aspects of the main photoreactions induced by far-UV radiation in cellular DNA is reported. This mostly includes the formation of cyclobutadipyrimidines, pyrimidine(6-4)pyrimidone photoadducts and related Dewar valence isomers in various eukaryotic and prokaryotic cells, as monitored by using either specific or more general assays. Information is also provided on mechanistic aspects regarding the formation of 5,6-dihydro-5-(alpha-thyminyl) thymine, the so-called "spore photoproduct" within far-UV-irradiated bacterial spores. The second major topic of the review deals with the effects of near-UV radiation and visible light on cellular DNA which are mostly mediated by photosensitizers. The main photoreactions of furocoumarins with DNA, one major class of photosensitizers used in the phototherapy of skin diseases, involve a [2 + 2] cycloaddition to the thymine bases according to an oxygen-independent mechanism. In contrast a second type of photosensitized reaction which appears to play a major role in the genotoxic effects of both near-UV and visible light requires the presence of oxygen. The photodynamic effects which are mediated by either still unidentified endogenous photosensitizers or defined exogenous photosensitizers lead to the formation of a wide spectrum of DNA modifications including base damage, oligonucleotide strand breaks and DNA-protein cross-links.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Major mechanistic insights into the mechanisms of [2+2] photocycloaddition of furocoumarin derivatives to the 5,6-double bond of thymidine, the major target of these oxygen-independent photoreactions, have been gained from extensive model studies (35,(161)(162)(163).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [35]
In the citing paper
“While pyrone-side monoadducts to thymine are not photoreactive, UVA excitation of furan-side monoadducts may lead to the formation of harmful DNA interstrand cross-links (ICLs) through cycloaddition to opposite thymine at 5¢-TpA-3¢ sequences (Fig. 7) that are the preferential sites of photoreactions of most psoralen derivatives (35,(161)(162)(163).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [35]
In the citing paper
“While pyrone-side monoadducts to thymine are not photoreactive, UVA excitation of furan-side monoadducts may lead to the formation of harmful DNA interstrand cross-links (ICLs) through cycloaddition to opposite thymine at 5¢-TpA-3¢ sequences (Fig. 7) that are the preferential sites of photoreactions of most psoralen derivatives (35,(161)(162)(163).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [35]
In the citing paper
“While pyrone-side monoadducts to thymine are not photoreactive, UVA excitation of furan-side monoadducts may lead to the formation of harmful DNA interstrand cross-links (ICLs) through cycloaddition to opposite thymine at 5¢-TpA-3¢ sequences (Fig. 7) that are the preferential sites of photoreactions of most psoralen derivatives (35,(161)(162)(163).”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [35]
In the citing paper
“Essentially, the formation of two types of monoadducts as pairs of diastereomers through the implication of either the 4¢,5¢-double bond of the furan moiety or the 3,4-ethylenic bond of the pyrone ring has been reported.”
From Photoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions† (2012) · cites this paper as [35]
Citations
Cites
A role for sunlight in skin-cancer – UV-induced p53 mutations in squamous-cell carcinoma
Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., & Pontén, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10124 · Cited by 1,959
Definition of type I and type II photosensitized oxidation
Foote, C. S. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02071.x · Cited by 1,248
Treatment of Cutaneous T-Cell Lymphoma by Extracorporeal Photochemotherapy
Edelson, R. L., Berger, C. L., Gasparro, F. P., Jegasothy, B. V., HEALD, P. W., Wintroub, B. U., Vonderheid, E. C., Knobler, R., Wolff, K. S., Plewig, G., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702053160603 · Cited by 1,197
THE BIOLOGY OF THE (6–4) PHOTOPRODUCT
MITCHELL, D. L., & NAIRN, R. S. (1989) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1989.tb05578.x · Cited by 592
DNA precipitation assay: A rapid and simple method for detecting DNA damage in mammalian cells
Olive, P. L. (1988) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850110409 · Cited by 355
The Relative Cytotoxicity of (6-4) Photoproducts and Cyclobutane Dimers in Mammalian Cells
Mitchell, D. L. (1988) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1988.tb02785.x · Cited by 352
Freeman, S. E., Hacham, H., Gange, R. W., Maytum, D. J., Sutherland, J. C., & Sutherland, B. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5605 · Cited by 311
Devasagayam, T. P. A., Steenken, S., Obendorf, M. S. W., Schulz, W. A., & Sies, H. (1991) · Biochemistry · doi:10.1021/bi00239a029 · Cited by 304
Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a078 · Cited by 300
Self-citationMitchell, D. L., Haipek, C. A., & Clarkson, J. M. (1985) · Mutation Research Letters · doi:10.1016/s0165-7992(85)80018-x · Cited by 277
Research works printed but not linked: 10
- Carrier, 1989, UV-induced DNA damage differs quantitatively with cell type, Photochem. Photobiol., 49s, 29s
- Freeman, 1986, Action spectrum for pyrimidine formation in human skin, Photochem. Photobiol., 43s, 93s
- Douki, 1991, Measurement of the (6-4) photoproducts by a HPLC-fluorescence assay, Photochem. Photobiol., 53s, 27s
- Leadon, 1987, Production of thymine glycols by radiation and chemical carcinogens as detected by a monoclonal antibody, Br. J. Cancer, 55, 113
- Brankmann, 1989, UVA-induced 8-MOP binding to cells of Saccharomyces cerivisiae, J. Photochem. Photobiol. B. Biol., 3, 59
- Cadet, 1987, Monofunctional furocoumarins: photochemical reactions with DNA, photobiological effects and their implications in the photochemotherapy of psoriasis, IUPAC Publ. Sect., 9, 1
- Cadet, 1992, Oxidation reactions of the purine and pyrimidine moieties of DNA model compounds, Book of Abstracts, 6th Bienn. Meet. of The International Society for Free Radical Research, Torino
- Kasai, 1992, Photosensitized formation of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-hydroxy-2′-deoxyguanosine) in DNA by riboflavin, Book of Abstracts, 6th Bienn. Meet. of The International Society for Free Radical Research, Torino
- Mouret, 1991, Formation of adenine N1-oxide within human DNA upon exposure to UVA radiation, Photochem. Photobiol., 53s, 27s
- Rosenstein, 1988, Repair of solar UV-induced damages in normal human skin fibroblasts, Photochem. Photobiol., 47s, 27s
Cited by
Sorted by citations
Direct and indirect effects of UV radiation on DNA and its components
Ravanat, J.-L., Douki, T., & Cadet, J. (2001) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(01)00206-8 · Cited by 980
Self-citationEffects of ultraviolet radiation on plant cells
Hollósy, F. (2002) · Micron · doi:10.1016/s0968-4328(01)00011-7 · Cited by 574
Flavonoids Can Protect Maize DNA from the Induction of Ultraviolet Radiation Damage
Stapleton, A. E., & Walbot, V. (1994) · Plant Physiology · doi:10.1104/pp.105.3.881 · Cited by 420
Wondrak, G. T., Jacobson, M. K., & Jacobson, E. L. (2006) · Photochemical & Photobiological Sciences · doi:10.1039/b504573h · Cited by 411
Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation
Kvam, E. (1997) · Carcinogenesis · doi:10.1093/carcin/18.12.2379 · Cited by 344
Metadata
- Authors
- Cadet, J., Anselmino, C., Douki, T., & Voituriez, L.
- Affiliations
- CEA Grenoble (FR)
- Corresponding author
- Cadet, J.
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 15
- Issue
- 4
- Pages
- 277-298
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W2284627270
- Cited by
- 211
- References
- 121
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 8 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 9
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Keywords
- far-ultraviolet radiation, DNA photoproducts, spore photoproduct, bacterial spores, near-ultraviolet, visible light, photosensitizers, furocoumarins, [2+2] cycloaddition, photodynamic effect, genotoxicity, DNA strand breaks, DNA-protein crosslinks
- MeSH terms
- Animals, DNA, DNA Damage, Humans, Sunlight, Ultraviolet Rays
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
