CoChat
Sign Up
Cited by 28Trace Elements in HealthHeavy Metal Exposure and ToxicityMagnesium in Health and Disease

Serum zinc and serum lipid profiles in 778 adults

Open access
Hiller, Rita, Seigel, Daniel, Sperduto, Robert D., Blair, Norman, Burton, Thomas C., Farber, Marilyn D., Gragoudas, Evangelos S., Gunter, Elaine W. +4 more·1995·Annals of Epidemiology
DOI 10.1016/1047-2797(95)00066-6
Open this paper in CoChat — free account

Abstract

There has been increasing use of high-dosage zinc supplementation in the population, in particular as a potential treatment for age-related macular degeneration. We examined the relationship between fasting serum zinc and serum lipid levels in 778 adults, aged 22 to 80 years, who were control subjects in a multicenter, clinic-based case-control study. The samples were taken during 1987 to 1990, a time when vitamin/mineral supplementation was becoming increasingly common. We found that higher serum zinc levels, most notably those above the highest quintile, were associated with higher levels of total serum cholesterol, low-density-lipoprotein cholesterol, and triglycerides. No significant trend was noted for high-density-lipoprotein cholesterol. Previous studies demonstrated that high-dosage zinc supplements raise serum zinc levels. The possibility that use of such supplements can adversely affect serum lipid profiles suggests that chronic ingestion of such supplements should not be done without adequate medical supervision.

Integrity signals

Registry

Crossref · 10.1016/1047-2797(95)00066-6

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Women who proceed with an unapproved pregnancy in China are known to be reluctant to use antenatal and obstetric services because they fear they will face pressure to have an abortion or fines for violating the one-child policy.

    “Women who proceed with an unapproved pregnancy are known to be reluctant to use antenatal and obstetric services because they fear they will face pressure to have an abortion or fines for violating the one-child policy. 9,10”

    From The Effect of China's One-Child Family Policy after 25 Years (2005) · cites this paper as [9]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Hiller, R., Seigel, D., Sperduto, R. D., Blair, N., Burton, T. C., Farber, M. D., Gragoudas, E. S., Gunter, E. W., Haller, J., Seddon, J. M., Sowell, A. L., & Yannuzzi, L. A.
Affiliations
  • National Institutes of Health (US)
  • University of Illinois Chicago (US)
  • Medical College of Wisconsin (US)
  • Massachusetts Eye and Ear Infirmary (US)
  • Centers for Disease Control and Prevention (US)
  • Manhattan Eye, Ear and Throat Hospital (US)
Corresponding author
Hiller, Rita
ORCID
Venue
Annals of Epidemiology
Publisher
Elsevier BV
Published
1995-11
Volume
5
Issue
6
Pages
490-496
ISSN
1047-2797 (ISSN-L)
DOI
10.1016/1047-2797(95)00066-6
OpenAlex
W1991375792
Cited by
28
References
48
Citations by year
2025: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2015: 1 · 2014: 1
FWCI
0.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Annals of Epidemiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Eye Institute (EY-5-2109, EY-5-2111, EY-5-2110)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
Keywords
serum zinc, lipid profile, zinc supplementation, total cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, age-related macular degeneration, vitamin and mineral supplementation, adverse effects of supplements
MeSH terms
Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Humans, Lipids, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Triglycerides, Zinc, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review