Cited by 11Enzyme Structure and FunctionViral Infections and Immunology ResearchProtein Structure and Dynamics

Functional aspects of the capsid structure of mengo virus

Scraba, Douglas G.·1990·Journal of Structural Biology

Abstract

The three-dimensional structure of the Mengo virus capsid has been determined at a resolution of 3.0 A. This achievement is discussed in an historical context, and the general features of picornavirus capsid design are presented. The dynamic functional aspects of the Mengo virus capsid--namely its ability to interact with specific receptors on host cells, to dissociate and release the viral genomic RNA into the cellular cytoplasm, to assemble with progeny RNA molecules and form new virions, and to alter its external surface in order to evade neutralization by circulating antibodies--are discussed. Comparisons with other picornaviruses whose capsid structures have also been elucidated (poliovirus serotype 1 and 3, human rhinovirus types 14 and 1A, and foot-and-mouth disease virus type O) illustrate both the similarities and the distinctive features of capsid design found within this family of mammalian viruses.

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Crossref · 10.1016/1047-8477(90)90057-j

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56 of 56 references verified0 citation errors · 0 not checkable

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  • The two-steps dissociation process seems not to fully apply to cardioviruses since contacts between their pentamers are less extensive than for PV.

    “However this two-steps dissociation process seems not to fully apply to cardioviruses since contacts between their pentamers are less extensive than for PV.21”

    From The encephalomyocarditis virus (2012) · cites this paper as [21]

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Authors
Scraba, D. G.
Affiliations
University of Alberta (CA)
Corresponding author
Scraba, Douglas G.
Venue
Journal of Structural Biology
Publisher
Elsevier BV
Published
1990-07
Volume
104
Issue
1-3
Pages
52-62
ISSN
1047-8477 (ISSN-L)
OpenAlex
W2055333003
Cited by
11
References
56
Citations by year
2022: 1 · 2018: 1 · 2012: 1
FWCI
0.05
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Structural Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Keywords
mengovirus, capsid structure, receptor binding, viral RNA release, viral assembly, poliovirus, human rhinovirus, foot-and-mouth disease virus
MeSH terms
Animals, Capsid, Mengovirus, Microscopy, Electron, Models, Structural, Picornaviridae, Receptors, Virus, Virion, X-Ray Diffraction

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