Functional aspects of the capsid structure of mengo virus
Abstract
The three-dimensional structure of the Mengo virus capsid has been determined at a resolution of 3.0 A. This achievement is discussed in an historical context, and the general features of picornavirus capsid design are presented. The dynamic functional aspects of the Mengo virus capsid--namely its ability to interact with specific receptors on host cells, to dissociate and release the viral genomic RNA into the cellular cytoplasm, to assemble with progeny RNA molecules and form new virions, and to alter its external surface in order to evade neutralization by circulating antibodies--are discussed. Comparisons with other picornaviruses whose capsid structures have also been elucidated (poliovirus serotype 1 and 3, human rhinovirus types 14 and 1A, and foot-and-mouth disease virus type O) illustrate both the similarities and the distinctive features of capsid design found within this family of mammalian viruses.
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The two-steps dissociation process seems not to fully apply to cardioviruses since contacts between their pentamers are less extensive than for PV.
“However this two-steps dissociation process seems not to fully apply to cardioviruses since contacts between their pentamers are less extensive than for PV.21”
From The encephalomyocarditis virus (2012) · cites this paper as [21]
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The encephalomyocarditis virus
Carocci, M., & Bakkali-Kassimi, L. (2012) · Virulence · doi:10.4161/viru.20573 · Cited by 231 · see citing works
- Authors
- Scraba, D. G.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Scraba, Douglas G.
- Venue
- Journal of Structural Biology
- Publisher
- Elsevier BV
- Published
- 1990-07
- Volume
- 104
- Issue
- 1-3
- Pages
- 52-62
- ISSN
- 1047-8477 (ISSN-L)
- OpenAlex
- W2055333003
- Cited by
- 11
- References
- 56
- Citations by year
- 2022: 1 · 2018: 1 · 2012: 1
- FWCI
- 0.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Structural Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- mengovirus, capsid structure, receptor binding, viral RNA release, viral assembly, poliovirus, human rhinovirus, foot-and-mouth disease virus
- MeSH terms
- Animals, Capsid, Mengovirus, Microscopy, Electron, Models, Structural, Picornaviridae, Receptors, Virus, Virion, X-Ray Diffraction
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