Structure and function of the natural-resistance-associated macrophage protein (Nramp1), a candidate protein for infectious and autoimmune disease susceptibility
Abstract
The ability of macrophages to become activated is central to antimicrobial immunity. Microbial stimuli can elicit a cascade of gene-inductive events mediating inflammation, elimination of the invading organism and induction of T-cell memory against reinvasion. Nramp1, a gene originally identified as Ity/Lsh/Bcg for its role in controlling Salmonella typhimurium, Leishmania donovani and Mycobacterium bovis infections in mice, regulates this cascade. Here we examine how the structure of the Nramp1 protein might relate to its function, and how variable expression of the human homologue (NRAMP1) might mediate enhanced resistance to infection but cause susceptibility to autoimmune disease.
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Nramp1 is a phagolysosomal transporter with homology to Dmt1 (Nramp2).
“A phagolysosomal transporter with homology to Dmt1 (Nramp2) is Nramp1 [8, 20, 71, 75].”
From “Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels (2017) · cites this paper as [20]
Cites
Schreck, R., Albermann, K., & Baeuerle, P. A. (1992) · Free Radical Research Communications · doi:10.3109/10715769209079515 · Cited by 1,411 · see citing works
Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria
McGuire, W. L., Hill, A. V. S., Allsopp, C. E. M., Greenwood, B. M., & Kwiatkowski, D. P. (1994) · Nature · doi:10.1038/371508a0 · Cited by 1,166 · see citing works
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104 · see citing works
Jaks and Stats in signaling by the cytokine receptor superfamily.
Ihle, J., & Kerr, I. (1995) · Trends in Genetics · doi:10.1016/s0168-9525(00)89000-9 · Cited by 953 · see citing works
High pressure effects on protein structure and function
Mozhaev, V. V., Heremans, K., Jzn, J. F., Masson, P., & Balny, C. (1996) · Proteins Structure Function and Bioinformatics · doi:10.1002/(sici)1097-0134(199601)24:1 · Cited by 716 · see citing works
Vidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603 · see citing works
Schulze‐Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., & Fiers, W. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05978.x · Cited by 566 · see citing works
Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis.
Cabrera, M., Shaw, M., Sharples, C. E., Williams, H. B., Castés, M., Convit, J., & Blackwell, J. M. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1259 · Cited by 452 · see citing works
Self-citationSignalling through SH2 and SH3 domains
Mayer, B. J., & Baltimore, D. (1993) · Trends in Cell Biology · doi:10.1016/0962-8924(93)90194-6 · Cited by 354 · see citing works
Nramp defines a family of membrane proteins.
Cellier, M. F., Privé, G. G., Belouchi, A., Kwan, T., Rodrigues, V., Chia, W., & Gros, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10089 · Cited by 349 · see citing works
Nonspecific defence mechanism: the role of nitric oxide
Liew, F. Y., & Cox, F. E. G. (1991) · Immunology Today · doi:10.1016/s0167-5699(05)80006-4 · Cited by 328 · see citing works
Identification and characterization of a second mouse Nramp gene
Gruenheid, S., Cellier, M. F., Vidal, S. M., & Gros, P. (1995) · Genomics · doi:10.1016/0888-7543(95)80053-o · Cited by 287 · see citing works
Cellier, M. F., Govoni, G. R., Vidal, S. M., Kwan, T., Groulx, N., Liu, J., Sanchez, F., Skamene, E., Schurr, E., & Gros, P. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1741 · Cited by 245 · see citing works
Focal adhesion kinase: an integrin-linked protein tyrosine kinase
Schaller, M. D., & Parsons, J. T. (1993) · Trends in Cell Biology · doi:10.1016/0962-8924(93)90053-4 · Cited by 177 · see citing works
Liu, J., Fujiwara, T., Buu, N., Sánchez, F. O. N., Cellier, M. F., Paradis, A. J., Frappier, D., Skamene, E., Gros, P., & Morgan, K. (1995) · PubMed Central · Cited by 171 · see citing works
Genetic susceptibility to leishmanial infections: studies in mice and man
Blackwell, J. M. (1996) · Parasitology · doi:10.1017/s0031182000076678 · Cited by 167 · see citing works
Self-citationFuortes, M. G., Jin, W. W., & Nathan, C. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.3.777 · Cited by 148 · see citing works
Blackwell, J. M., Barton, C. H., White, J. K., Searle, S., Baker, A.-M., Williams, H. P., & Shaw, M. (1995) · Molecular Medicine · doi:10.1007/bf03401567 · Cited by 143 · see citing works
Self-citationRoach, T. I. A., Kiderlen, A. F., & Blackwell, J. M. (1991) · Infection and Immunity · doi:10.1128/iai.59.11.3935-3944.1991 · Cited by 138 · see citing works
Self-citationRodrigues, V., Cheah, P. Y., Ray, K., & Chia, W. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07303.x · Cited by 136 · see citing works
Barton, C. H., Whitehead, S. H., & Blackwell, J. M. (1995) · Molecular Medicine · doi:10.1007/bf03401551 · Cited by 129 · see citing works
Self-citationTumor necrosis factor α in autoimmunity: pretty girl or old witch?
Jacob, C. O. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90107-i · Cited by 129 · see citing works
MacNaul, K. L., Hutchinson, N. I., Parsons, J. N., Bayne, E. K., & Tocci, M. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.12.4154 · Cited by 114 · see citing works
Govoni, G. R., Vidal, S. M., Cellier, M. F., Lepage, P., Malo, D., & Gros, P. (1995) · Genomics · doi:10.1006/geno.1995.1002 · Cited by 104 · see citing works
Ziegler, S. F., Wilson, C. B., & Perlmutter, R. M. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.5.1801 · Cited by 98 · see citing works
Blackwell, J. M., Barton, C. H., White, J. K., Roach, T. I. A., Shaw, M., Whitehead, S. H., Mock, B. A., Searle, S., Williams, H. P., & Baker, A.-M. (1994) · Immunology Letters · doi:10.1016/0165-2478(94)00161-8 · Cited by 98 · see citing works
Self-citationBarton, C. H., White, J. K., Roach, T. I. A., & Blackwell, J. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.5.1683 · Cited by 92 · see citing works
Self-citationLinkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.
Shaw, M., Clayton, D. G., Atkinson, S. E., Williams, H. B., Miller, N., Sibthorpe, D., & Blackwell, J. M. (1996) · Journal of Medical Genetics · doi:10.1136/jmg.33.8.672 · Cited by 86 · see citing works
Self-citationThe macrophage resistance gene Lsh/Ity/Bcg
Blackwell, J. M. (1989) · Research in Immunology · doi:10.1016/0923-2494(89)90029-1 · Cited by 81 · see citing works
Self-citationCorticosteroids enhance the binding of recombinant interferon-gamma to cultured human monocytes.
Strickland, R. W., WAHL, L. M., & Finbloom, D. S. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.5.1577 · Cited by 76 · see citing works
Roach, T. I. A., Chatterjee, D., & Blackwell, J. M. (1994) · Infection and Immunity · doi:10.1128/iai.62.4.1176-1184.1994 · Cited by 76 · see citing works
Self-citationWest, A. H., Clark, D. J., Martin, J., Neupert, W., Hartl, F. U., & Horwich, A. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35810-1 · Cited by 72 · see citing works
Barrera, L. F., Kramnik, I., Skamene, E., & Radzioch, D. (1994) · PubMed Central · Cited by 57 · see citing works
White, J. K., Shaw, M., Barton, C. H., Cerretti, D. P., Williams, H. P., Mock, B. A., Carter, N. P., Peacock, C. S., & Blackwell, J. M. (1994) · Genomics · doi:10.1006/geno.1994.1619 · Cited by 55 · see citing works
Self-citationBrown, D., Lafuse, W. P., & Zwilling, B. S. (1995) · Infection and Immunity · doi:10.1128/iai.63.8.2983-2988.1995 · Cited by 50 · see citing works
Formica, S., Roach, T. I. A., & Blackwell, J. M. (1994) · PubMed · Cited by 40 · see citing works
Self-citationMolecular mechanisms of natural resistance to mycobacterial infections.
Radzioch, D., Kramnik, I., & Skamene, E. (1994) · PubMed · Cited by 27 · see citing works
HLA‐DR4, mycobacteria, heat‐shock proteins, and rheumatoid arthritis
Rook, G. A. W., & McCulloch, J. (1992) · Arthritis & Rheumatism · doi:10.1002/art.1780351202 · Cited by 12 · see citing works
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Variations in the NRAMP1 Gene and Susceptibility to Tuberculosis in West Africans
Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P. W. J., Whittle, H. C., & Hill, A. V. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199803053381002 · Cited by 731 · see citing works
Leishmaniasis: Current Status of Vaccine Development
Handman, E. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.2.229-243.2001 · Cited by 595 · see citing works
Gruenheid, S., Pinner, E., Desjardins, M., & Gros, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.717 · Cited by 428 · see citing works
The Host Immune Response to Tuberculosis
Schluger, N. W., & Rom, W. N. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.3.9708002 · Cited by 420 · see citing works
Natural Resistance to Intracellular Infections
Jabado, N., Jankowski, A., Dougaparsad, S., Picard, V., Grinstein, S., & Gros, P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1237 · Cited by 372 · see citing works
Mycobacterium boviss Infection and Tuberculosis in Cattle
Pollock, J. M., & Neill, S. D. (2002) · The Veterinary Journal · doi:10.1053/tvjl.2001.0655 · Cited by 296 · see citing works
Searle, S., & Blackwell, J. M. (1999) · Journal of Medical Genetics · doi:10.1136/jmg.36.4.295 · Cited by 220 · see citing works
Self-citationThe Host Response to Leishmania Infection
Solbach, W., & Laskay, T. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60912-8 · Cited by 204 · see citing works
“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
Nairz, M., Theurl, I., Swirski, F. K., & Weiss, G. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1944-8 · Cited by 178 · see citing works
Mannose-Binding Protein B Allele Confers Protection against Tuberculous Meningitis
Hoal, E. G., Epstein, J. E., Victor, T. C., Hon, D., Lewis, L., Beyers, N., Zurakowski, D., Ezekowitz, R. A. B., & van Helden, P. D. (1999) · Pediatric Research · doi:10.1203/00006450-199904010-00002 · Cited by 165 · see citing works
Signaling Role of Intracellular Iron in NF-κB Activation
Xiong, S., She, H., Takeuchi, H., Han, B., Engelhardt, J. F., Barton, C. H., Zandi, E., Giulivi, C., & Tsukamoto, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210905200 · Cited by 161 · see citing works
Understanding the multiple functions of Nramp1
Blackwell, J. M., Searle, S., Goswami, T., & Miller, E. N. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00295-1 · Cited by 136 · see citing works
Self-citationShaw, M., Collins, A. R., Peacock, C. S., Miller, E. N., Black, G. F., Sibthorpe, D., Lins-Lainson, Z., Shaw, J. J., Ramos, F., Sílveira, F. T., et al. (1997) · Tubercle and Lung Disease · doi:10.1016/s0962-8479(97)90014-9 · Cited by 135 · see citing works
Self-citationGenetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg)
Blackwell, J. M., & Searle, S. (1999) · Immunology Letters · doi:10.1016/s0165-2478(98)00127-8 · Cited by 102 · see citing works
Self-citationPasetti, M. F., Levine, M. M., & Sztein, M. B. (2003) · Vaccine · doi:10.1016/s0264-410x(02)00472-3 · Cited by 99 · see citing works
Genetic resistance to bacterial diseases of animals
Adams, L. G., & Templeton, J. W. (1998) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.17.1.1085 · Cited by 97 · see citing works
TEIXEIRA, V. H., Olaso, R., Martin‐Magniette, M., Lasbleiz, S., Jacq, L., Oliveira, C. R., Hilliquin, P., Gut, I. G., Cornélis, F., & Petit, É. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006803 · Cited by 96 · see citing works
The role of iron in T cell development and autoimmunity
Bowlus, C. L. (2003) · Autoimmunity Reviews · doi:10.1016/s1568-9972(02)00143-x · Cited by 95 · see citing works
Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study
Blackwell, J. M., Black, G. F., Peacock, C. S., Miller, E. N., Sibthorpe, D., Gnananandha, D., Shaw, J. J., Sílveira, F. T., Lins-Lainson, Z., Ramos, F., et al. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0118 · Cited by 96 · see citing works
Self-citationGenetic factors in the pathogenesis of primary biliary cirrhosis
Jones, D. E. J., & Donaldson, P. T. (2003) · Clinics in Liver Disease · doi:10.1016/s1089-3261(03)00095-3 · Cited by 81 · see citing works
The Pathogenesis of Tuberculosis
Schluger, N. W. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f293 · Cited by 76 · see citing works
Lang, T., Prina, E., Sibthorpe, D., & Blackwell, J. M. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.380-386.1997 · Cited by 75 · see citing works
Self-citationATKINSON, & Barton (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00672.x · Cited by 74 · see citing works
Nramp1 drives an accelerated inflammatory response duringSalmonella-induced colitis in mice
Valdez, Y., Graßl, G. A., Guttman, J. A., Coburn, B. A., Gros, P., Vallance, B. A., & Finlay, B. B. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01258.x · Cited by 74 · see citing works
Arias, M. A., Rojas, M., Zabaleta, J., Rodríguez, J., París, S. C., Barrera, L. F., & García, L. F. (1997) · The Journal of Infectious Diseases · doi:10.1086/514154 · Cited by 74 · see citing works
Kotze, M. J., de Villiers, J. N. P., Rooney, R. N., Grobbelaar, J. J., Mansvelt, E. P. G., Bouwens, C. S. H., Carr, J. A., Stander, I. A., & du Plessis, L. (2001) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2000.0349 · Cited by 72 · see citing works
Altet, L., Francino, O., Solano‐Gallego, L., Renier, C. M., & Sánchez, A. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.2763-2771.2002 · Cited by 71 · see citing works
Intraarticular injection of hyaluronan as treatment for knee osteoarthritis: What is the evidence?
Brandt, K. D., Smith, G. N., & Simon, L. S. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200006)43:6 · Cited by 204 · see citing works
Self-citationSoo, S.-S., Villarreal‐Ramos, B., Khan, C. M. A., Hormaeche, C. E., & Blackwell, J. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1910-1917.1998 · Cited by 68 · see citing works
Self-citationEctopic expression of Nramp1 in COS‐1 cells modulates iron accumulation
Atkinson, P. G. P., & Barton, C. H. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00236-1 · Cited by 67 · see citing works
Genetic and familial considerations of primary biliary cirrhosis
Tanaka, A., Borchers, A. T., Ishibashi, H., Ansari, A. A., Keen, C. L., & Gershwin, M. E. (2001) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(00)02239-5 · Cited by 65 · see citing works
Host responses to pathogenic Salmonella infection.Preprint
Jones, B. D. (1997) · Genes & Development · doi:10.1101/gad.11.6.679 · Cited by 62 · see citing works
Pareyn, M., Alves, F. P., Burza, S., Chakravarty, J., Alvar, J., Diro, E., Kaye, P. M., & van Griensven, J. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00663-w · Cited by 60 · see citing works
Archer, N., Nassif, N. T., & O’Brien, B. A. (2015) · Genes and Immunity · doi:10.1038/gene.2015.8 · Cited by 52 · see citing works
Variants of the HumanNRAMP1Gene and Altered Human Immunodeficiency Virus Infection Susceptibility
Marquet, S., Sánchez, F. O. N., Arias, M. A., Rodríguez, J., París, S. C., Skamene, E., Schurr, E., & García, L. F. (1999) · The Journal of Infectious Diseases · doi:10.1086/315091 · Cited by 51 · see citing works
Ateş, Ö., Dalyan, L., Müsellim, B., Hatemi, G., Türker, H., Öngen, G., Hamuryudan, V., & Topal-Sarikaya, A. (2008) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2008.00814.x · Cited by 49 · see citing works
Expression of the SLC11A1 (NRAMP1) 5′-(GT) repeat: Opposite effect in the presence of −237C→T
Zaahl, M. G., Robson, K., Warnich, L., & Kotze, M. J. (2004) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2004.04.003 · Cited by 48 · see citing works
Tumour Necrosis Factor alpha and Mucocutaneous Leishmaniasis
Blackwell, J. M. (1999) · Parasitology Today · doi:10.1016/s0169-4758(98)01355-6 · Cited by 45 · see citing works
Self-citationZhang, G., Wu, H., Ross, C. R., Minton, J. E., & Blecha, F. (2000) · Infection and Immunity · doi:10.1128/iai.68.3.1086-1093.2000 · Cited by 45 · see citing works
Valdez, Y., Diehl, G. E., Vallance, B. A., Graßl, G. A., Guttman, J. A., Brown, N. F., Rosenberger, C. M., Littman, D. R., Gros, P., & Finlay, B. B. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01155.x · Cited by 43 · see citing works
Dai, Y. D., Marrero, I. G., Gros, P., Zaghouani, H., Wicker, L. S., & Sercarz, E. E. (2009) · Diabetes · doi:10.2337/db07-1608 · Cited by 41 · see citing works
Typhoid Fever and Genetic Polymorphisms at the Natural Resistance–Associated Macrophage Protein 1
Dunstan, S. J., Ho, V. A., Duc, C. M., Lanh, M. N., Phuong, C. X. T., Luxemburger, C., Wain, J. R., Dudbridge, F., Peacock, C. S., House, D., et al. (2001) · The Journal of Infectious Diseases · doi:10.1086/319289 · Cited by 41 · see citing works
Self-citationGRAHAM, A. M., DOLLINGER, M. M., Howie, S., & HARRISON, D. J. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.150 · Cited by 41 · see citing works
The CAG repeat within the androgen receptor gene in male breast cancer patients
Young, I., Kurian, K. M., MACKENZIE, M. A. F., KUNKLER, I. H., COHEN, B. B., HOOPER, M. L., WYLLIE, A. H., & STEEL, C. M. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.139 · Cited by 39 · see citing works
Nramp1 is expressed in neurons and is associated with behavioural and immune responses to stress
Evans, C. A., Harbuz, M. S., Ostenfeld, T., Norrish, A. R., & Blackwell, J. M. (2001) · Neurogenetics · doi:10.1007/s100480100105 · Cited by 37 · see citing works
Self-citationRamírez, C., Díaz-Toro, Y., Téllez, J., Castilho, T. M., Rojas, R., Ettinger, N., Tikhonova, I., Alexander, N. D. E., Valderrama, L., Hager, J., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001866 · Cited by 37 · see citing works
Evidence of association with type 1 diabetes in the SLC11A1 gene region
Yang, J. H. M., Downes, K., Howson, J. M. M., Nutland, S. L., Stevens, H. E., Walker, N. M., & Todd, J. A. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-59 · Cited by 33 · see citing works
Helden, E. G. H., Hon, D., Lewis, L., Beyers, N., & van Helden, P. D. (2001) · Cell Biology International · doi:10.1006/cbir.2000.0679 · Cited by 31 · see citing works
A negative autoregulatory link between Nramp 1 function and expression
Baker, S. T., Barton, C. H., & Biggs, T. E. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.4.501 · Cited by 30 · see citing works
Susceptibility to JRA/JIA: complementing general autoimmune and arthritis traits
Phelan, J. D., Thompson, S. D., & Glass, D. N. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364273 · Cited by 28 · see citing works
Chen, Z.-M., & Jenkins, M. K. (1999) · Infection and Immunity · doi:10.1128/iai.67.4.2025-2029.1999 · Cited by 27 · see citing works
Nishino, M., Ikegami, H., Fujisawa, T., Kawaguchi, Y., Kawabata, Y., Shintani, M., Ono, M., & Ogihara, T. (2005) · Metabolism · doi:10.1016/j.metabol.2004.12.006 · Cited by 25 · see citing works
Extent and distribution of linkage disequilibrium around the SLC11A1 locus
Yip, S. P., Leung, K. H., & Lin, C. K. (2003) · Genes and Immunity · doi:10.1038/sj.gene.6363944 · Cited by 22 · see citing works
Caron, J., Larivière, L., Nacache, M., Tam, M., Stevenson, M. M., McKerly, C., Gros, P., & Malo, D. (2006) · Infection and Immunity · doi:10.1128/iai.74.5.2787-2802.2006 · Cited by 22 · see citing works
Bahuau, M., Laurendeau, I., Pelet, A., Assouline, B., LAMIREAU, T., TAINE, L., BAIL, B. L., VERGNES, P., GALLET, S., Vidaud, M., et al. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.146 · Cited by 22 · see citing works
Chromosomal localisation and genetic variation of the SLC11A1 gene in goats (Capra hircus)
Vacca, G. M., Pazzola, M., Pisano, C., Carcangiu, V., Diaz, M. L., Nieddu, M., Robledo, R., Mezzanotte, R., & Dettori, M. L. (2010) · The Veterinary Journal · doi:10.1016/j.tvjl.2010.09.028 · Cited by 20 · see citing works
Wardrop, S. L., Wells, C. A., Ravasi, T., Hume, D. A., & Richardson, D. R. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.1.99 · Cited by 19 · see citing works
Smit, J. J., Loveren, H. V., Hoekstra, M. O., Nijkamp, F. P., & Bloksma, N. (2003) · The FASEB Journal · doi:10.1096/fj.02-0985fje · Cited by 20 · see citing works
O’Brien, B. A., Archer, N., Simpson, A. M., Torpy, F. R., & Nassif, N. T. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.02.002 · Cited by 19 · see citing works
The Slc11a1 ( Nramp1 ) Gene Controls Efficacy of Mycobacterial Treatment of Allergic Asthma
Smit, J. J., Loveren, H. V., Hoekstra, M. O., Karimi, K., Folkerts, G., & Nijkamp, F. P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.754 · Cited by 19 · see citing works
Lin, X., Hamilton‐Williams, E. E., Rainbow, D. B., Hunter, K. M. D., Dai, Y. D., Cheung, J., Peterson, L. B., Wicker, L. S., & Sherman, L. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203422 · Cited by 18 · see citing works
Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis
Yen, J., Lin, C., TSAI, W., Ou, T.-L., WU, C., Hu, C., & Liu, H. (2005) · Immunology Letters · doi:10.1016/j.imlet.2005.07.008 · Cited by 17 · see citing works
Renal angiomyolipomata and learning difficulty in tuberous sclerosis complex
O'Callaghan, F. J., NOAKES, M., & OSBORNE, J. P. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.156 · Cited by 17 · see citing works
Blackwell, J. M., Black, G. F., Sharples, C. E., Soo, S.-S., Peacock, C. S., & Miller, E. N. (1999) · Microbes and Infection · doi:10.1016/s1286-4579(99)80020-3 · Cited by 16 · see citing works
Self-citationRucker, U., & El‐Matbouli, M. (2007) · Diseases of Aquatic Organisms · doi:10.3354/dao076223 · Cited by 15 · see citing works
Niño-Moreno, P., Turrubiartes-Martínez, E., Oceguera-Maldonado, B., Baltazar-Benítez, N., Negrete-González, C., Oliva-Ramírez, B., Baranda, L., & González‐Amaro, R. (2017) · Revista de investigaci�n Cl�nica · doi:10.24875/ric.17002152 · Cited by 14 · see citing works
Teebi, A. S. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.145 · Cited by 14 · see citing works
Lack of association between NRAMP1 gene polymorphisms and Trypanosoma cruzi infection
Calzada, J. E., Nieto, A., López‐Nevot, M. Á., & Martin, J. J. (2001) · Tissue Antigens · doi:10.1034/j.1399-0039.2001.057004353.x · Cited by 13 · see citing works
Ates, Ö., Müsellim, B., Öngen, G., & Topal-Sarikaya, A. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9134-7 · Cited by 13 · see citing works
Clinical geneticists' attitudes and practice towards testing for breast cancer susceptibility genes
Lucassen, A., & Houlston, R. S. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.157 · Cited by 13 · see citing works
Wu, H., Cheng, D., & Wang, L. (2008) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(08)60014-4 · Cited by 10 · see citing works
Nath, M., Woolliams, J. A., & Bishop, S. C. (2004) · Journal of Animal Science · doi:10.1093/ansci/82.2.384 · Cited by 10 · see citing works
HASTINGS, R. J., SVENNEVIK, E. C., SETTERFIELD, B., Wells, D., Delhanty, J. D. A., & MACKINNON, H. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.141 · Cited by 10 · see citing works
Genetic analysis of SLC11A1 polymorphisms in multiple sclerosis patients
Comabella, M., Altet, L., Peris, F., Villoslada, P., Sánchez, A., & Montalbán, X. (2004) · Multiple Sclerosis Journal · doi:10.1191/1352458504ms1097oa · Cited by 9 · see citing works
Genetic polymorphism of Nramp1 gene and correlation with mastitis in Holstein cattle
Hai-Chuan, H. U., Wang, H., Li, J., Wang, C., Lai, S., Li, Q., & Zhong, J. (2009) · Hereditas (Beijing) · doi:10.3724/sp.j.1005.2009.00057 · Cited by 9 · see citing works
Solute Carrier Family 11 Member A1 Gene Polymorphisms in Reactive Arthritis
Chen, Y., Lin, C., Ou, T., Wu, C., Tsai, W., Liu, H., & Yen, J. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-006-9050-2 · Cited by 7 · see citing works
Feng, Y., & Cohen, S. N. (2013) · Infection and Immunity · doi:10.1128/iai.01177-12 · Cited by 7 · see citing works
Nramp1 gene expression in different tissues of Meishan piglets from newborn to weaning
Dai, C., Wu, J., Zhao, C., Yu, L., Bao, W., & Wu, S. (2017) · Genetics and Molecular Research · doi:10.4238/gmr16019288 · Cited by 6 · see citing works
No evidence for imprinting in distal 18q
Maiwald, R., OVERHAUSER, J., & Laccone, F. A. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.152 · Cited by 6 · see citing works
Wang, H., Libo, Z., Ming-hai, H., Wang, C., Wang, L., Sun, T., & Zhong, J. (2011) · Zhongguo nongye Kexue · Cited by 5 · see citing works
Prospects of Vaccine in Leishmaniasis
Salam, M. A. (2010) · Bangladesh Journal of Medical Microbiology · doi:10.3329/bjmm.v3i2.5327 · Cited by 5 · see citing works
Sequencing and phylogenetic analysis of theSLC11A1gene in pigs
Devi, B., Laskar, S., Borah, P., Hussain, I., & Bharti, P. K. (2016) · Journal of Applied Animal Research · doi:10.1080/09712119.2016.1218885 · Cited by 4 · see citing works
Tohidi, R., Idris, I., Panandam, J. M., & Bejo, M. H. (2011) · Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) · doi:10.5897/ajb10.829 · Cited by 4 · see citing works
Stress and the pathogenesis of tuberculosis
Boomershine, C. S., & Zwilling, B. S. (2000) · Clinical Microbiology Newsletter · doi:10.1016/s0196-4399(00)80028-8 · Cited by 4 · see citing works
[Immunology and BCG therapeutics].
Olivas, M. A. S., Zavala, M. P. V., Montes, J. M., Olivas, J. A. S., & Méndez, I. F. (2008) · PubMed · Cited by 3 · see citing works
Genetic diversity of NRAMP1 3’-UTR microsatellite in cattle breeds reared in Sardinia
Pazzola, M., Dettori, M. L., Atzeni, M., Balia, D., & Vacca, G. M. (2009) · Italian Journal of Animal Science · doi:10.4081/ijas.2009.s2.126 · Cited by 3 · see citing works
Larcombe, L., Mookherjee, N., & Lodge, A. M. (2015) · Mycobacterial Diseases · doi:10.4172/2161-1068.1000193 · Cited by 3 · see citing works
Detection and Analysis of Antidiarrheal Genes and Immune Factors in Various Shanghai Pig Breeds
Zhou, J., Liu, F., He, M., Gao, J. L., Wu, C., Gan, Y., Bian, Y., Wei, J., Zhang, W., Zhang, W., et al. (2024) · Biomolecules · doi:10.3390/biom14050595 · Cited by 2 · see citing works
Angeborene Mechanismen der Infektabwehr
Sprenger, H., & Gemsa, D. (1999) · Springer eBooks · doi:10.1007/978-3-662-07865-5_10 · Cited by 2 · see citing works
Kala azar one of the diseases that play role in autoimmune Thyroid diseases
Muhammed, H. J., Mahmood, M. M., & Admon, A. (2011) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.v10i2.302 · Cited by 1 · see citing works
Martínez, M. D. C. J., Saldaña, R. B., Linares, M., Sánchez, R. C., Lascuraín, R., & Galindo, E. (2001) · Revista del Instituto Nacional de Enfermedades Respiratorias · Cited by 1 · see citing works
Macrophage Antimycobacterial Activity, Effects of Stress on
Boomershine, C. S., & Zwilling, B. S. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6.00243-9
Factors genètics de la leishmaniosi canina: caracterització del Nramp1 com a gen candidat
Altet, L. (2003) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Polymorphism of SLC11A1 gene in Doom pigs of Asom
DEVI, B., Laskar, S. K., Borah, P., KALITA, D. J., Zaman, G. U., Ferdoci, A. M., & Hussain, I. (2015) · The Indian Journal of Animal Sciences · doi:10.56093/ijans.v85i4.47853
Tlaskalová‐Hogenová, H. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1165181.628110
- Authors
- Blackwell, J. M.
- Affiliations
- Addenbrooke's Hospital (GB)
- Corresponding author
- Blackwell, Jenefer M.
- Venue
- Molecular Medicine Today
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 2
- Issue
- 5
- Pages
- 205-211
- ISSN
- 1357-4310 (ISSN-L)
- OpenAlex
- W2042578860
- Cited by
- 97
- References
- 38
- Citations by year
- 2025: 1 · 2024: 1 · 2017: 3 · 2016: 1 · 2015: 3 · 2013: 2 · 2012: 1
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Medicine Today (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Keywords
- NRAMP1, NRAMP, macrophage activation, antimicrobial immunity, Salmonella typhimurium, Leishmania donovani, Mycobacterium bovis, protein structure-function relationship, infection susceptibility, autoimmune disease susceptibility
- MeSH terms
- Natural Resistance-associated Macrophage Protein 1, Animals, Autoimmune Diseases, Carrier Proteins, Humans, Immunity, Innate, Infections, Macrophages, Membrane Proteins, Structure-Activity Relationship, Genetic Predisposition to Disease, Cation Transport Proteins, Mice
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