Covalent Modification of DNA by Natural Products

Gates, Kent S.

doi:10.1016/b978-0-08-091283-7.00074-6

Cited by 44DNA and Nucleic Acid ChemistryBioactive Compounds and Antitumor AgentsCarcinogens and Genotoxicity Assessment

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Covalent Modification of DNA by Natural Products

Gates, Kent S.·1999·Comprehensive Natural Products Chemistry

DOI 10.1016/b978-0-08-091283-7.00074-6

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Under disturbed redox metal homeostasis, free metal ions can catalyze heterolytic cleavage of hydrogen peroxide, resulting in hydroxyl radicals and OH− (Fenton reaction).
“Under the conditions of disturbed redox metal homeostasis (e.g. Alzheimer’s diseases and some cancers), free (unbound) metal ions can catalyze heterolytic cleavage of hydrogen peroxide (formed by the SOD-catalyzed dismutation reaction), resulting in the formation of hydroxyl radicals (·OH) and OH−. This reaction is termed the Fenton reaction (Valko et al. 2005; Gates 1999)7”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Gates 1999

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Authors: Gates, K. S.
Affiliations: University of Missouri (US)
Corresponding author: Gates, Kent S.
ORCID: Gates, Kent S.
Venue: Comprehensive Natural Products Chemistry
Publisher: Elsevier
Published: 1999
Pages: 491-552
DOI: 10.1016/b978-0-08-091283-7.00074-6
OpenAlex: W2951334876
Cited by: 44
References: 351
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 3 · 2014: 1 · 2012: 1
FWCI: 1.56
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Elsevier eBooks (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords: natural products, DNA adducts, DNA damage, genotoxicity

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