The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Techniques to Monitor Glycolysis
Open accessAbstract
An increased flux through glycolysis supports the proliferation of cancer cells by providing additional energy in the form of ATP as well as glucose-derived metabolic intermediates for nucleotide, lipid, and protein biosynthesis. Thus, glycolysis and other metabolic pathways that control cell proliferation may represent valuable targets for therapeutic interventions and diagnostic procedures. In this context, the measurement of glucose uptake and lactate excretion by malignant cells may be useful to detect shifts in glucose catabolism, while determining the activity of rate-limiting glycolytic enzymes can provide insights into points of metabolic regulation. Moreover, metabolomic studies can be used to generate large, integrated datasets to track changes in carbon flux through glycolysis and its collateral anabolic pathways. As discussed here, these approaches can reveal and quantify the metabolic alterations that underlie malignant cell proliferation.
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The pentose phosphate pathway in health and disease
TeSlaa, T., Ralser, M., Fan, J., & Rabinowitz, J. D. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00863-2 · Cited by 650
Self-citationLDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Arra, M., Swarnkar, G., Ke, K., Otero, J. E., Ying, J., Duan, X., Maruyama, T., Rai, M. F., O’Keefe, R. J., Mbalaviele, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17242-0 · Cited by 412
Metabolic reprogramming in tumors: Contributions of the tumor microenvironment
Lane, A. N., Higashi, R. M., & Fan, T. W.-M. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2019.10.007 · Cited by 91
Grzych, G., Defauwes, I., de Tullio, P., Pekar, J. D., Brousseau, T., Lippi, G., & Cavalier, E. (2025) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2025.2533855 · Cited by 4
Metadata
- Authors
- TeSlaa, T., & Teitell, M. A.
- Venue
- Methods in Enzymology
- Publisher
- Elsevier
- Published
- 2014
- Volume
- 542
- Pages
- 91-114
- ISSN
- 0076-6879 (ISSN-L)
- OpenAlex
- W1867360977
- Cited by
- 273
- References
- 51
- FWCI
- 14.65
- Type
- book chapter
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
