Adenosine receptor neurobiology: overview

Ischemia and reperfusion—from mechanism to translation

Eltzschig, H. K., & Eckle, T. D. L. G. (2011) · Nature Medicine · doi:10.1038/nm.2507 · Cited by 3,389 · see citing works

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use

Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624 · see citing works

International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585 · see citing works

Hypoxia and inflammation

Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061 · see citing works

The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist

Jaakola, V., Griffith, M. T., Hanson, M. A., Cherezov, V., Chien, E. Y. T., Lane, J. R., IJzerman, A. P., & Stevens, R. C. (2008) · Science · doi:10.1126/science.1164772 · Cited by 1,786 · see citing works

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works

The Role and Regulation of Adenosine in the Central Nervous System

Dunwiddie, T. V., & Masino, S. A. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.31 · Cited by 1,624 · see citing works

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

van Calker, D., Müller, M., & Hamprecht, B. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb05236.x · Cited by 1,373 · see citing works

Astrocyte Control of Synaptic Transmission and Neurovascular Coupling

Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,326 · see citing works

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Linden, J. M., & Müller, C. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003285 · Cited by 1,307 · see citing works

Astrocytic Purinergic Signaling Coordinates Synaptic Networks

Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280 · see citing works

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

Haskó, G., Linden, J. M., Cronstein, B. N., & Pacher, P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2638 · Cited by 1,224 · see citing works

Dichotomous dopaminergic control of striatal synaptic plasticity

Shen, W., Flajolet, M., Greengard, P., & Surmeier, D. J. (2008) · Science · doi:10.1126/science.1160575 · Cited by 1,190 · see citing works

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120 · see citing works

Subclasses of external adenosine receptors.

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Striatal Plasticity and Basal Ganglia Circuit Function

Kreitzer, A. C., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.005 · Cited by 1,009 · see citing works

The neurobiology and control of anxious states

Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 963 · see citing works

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

Liu, W., Chun, E., Thompson, A. A., Chubukov, P., Xu, F., Katritch, V., Han, G. W., Roth, C., Heitman, L. H., IJzerman, A. P., et al. (2012) · Science · doi:10.1126/science.1219218 · Cited by 936 · see citing works

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918 · see citing works

Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes

Ventura, R., & Harris, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06897.1999 · Cited by 900 · see citing works

Adenosine receptors as drug targets — what are the challenges?

Chen, J., Eltzschig, H. K., & Fredholm, B. B. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3955 · Cited by 895 · see citing works

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Lebon, G., Warne, T., Edwards, P. C., Bennett, K. A., Langmead, C. J., Leslie, A. G. W., & Tate, C. G. (2011) · Nature · doi:10.1038/nature10136 · Cited by 877 · see citing works

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S.-Y., Abel, T. G., Haydon, P. G., & Frank, M. G. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.024 · Cited by 877 · see citing works

ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

Chen, Y., Corriden, R., Inoue, Y., Yip, L., Hashiguchi, N., Zinkernagel, A. S., Nizet, V., Insel, P. A., & JUNGER, W. G. (2006) · Science · doi:10.1126/science.1132559 · Cited by 858 · see citing works

The tripartite synapse: roles for gliotransmission in health and disease

Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852 · see citing works

Purinergic signalling in neuron–glia interactions

Fields, R. D., & Burnstock, G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1928 · Cited by 852 · see citing works

Structure of an Agonist-Bound Human A 2A Adenosine Receptor

Xu, F., Wu, H., Katritch, V., Han, G. W., Jacobson, K. A., Gao, Z., Cherezov, V., & Stevens, R. C. (2011) · Science · doi:10.1126/science.1202793 · Cited by 816 · see citing works

Synaptic Islands Defined by the Territory of a Single Astrocyte

Halassa, M. M., Fellin, T., Takano, H., Dong, J.-H., & Haydon, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-07.2007 · Cited by 767 · see citing works

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Kreitzer, A. C., & Malenka, R. C. (2007) · Nature · doi:10.1038/nature05506 · Cited by 735 · see citing works

Adenosine, an endogenous distress signal, modulates tissue damage and repair

Fredholm, B. B. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402132 · Cited by 689 · see citing works

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

Zhou, Q. Y., Li, C., Olah, M. E., Johnson, R. A., Stiles, G. L., & Civelli, O. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7432 · Cited by 659 · see citing works

Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum

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Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

Huang, Z.-L., Qu, W.-M., Eguchi, N., Chen, J.-F., Schwarzschild, M. A., Fredholm, B. B., Urade, Y., & Hayaishi, O. (2005) · Nature Neuroscience · doi:10.1038/nn1491 · Cited by 640 · see citing works

Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors

Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 632 · see citing works

Neuroprotection by Caffeine and A 2A Adenosine Receptor Inactivation in a Model of Parkinson's Disease

Chen, J., Xu, K., Petzer, J. P., Staal, R. G. W., Xu, Y., Beilstein, M. A., Sonsalla, P. K., Castagnoli, K., Castagnoli, N. J., & Schwarzschild, M. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-j0001.2001 · Cited by 608 · see citing works

Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A 1 –A 2A Receptor Heteromers

Ciruela, F., Casadó, V., Rodrigues, R. J., Luján, R., Burgueño, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3574-05.2006 · Cited by 591 · see citing works

Adenosine and sleep–wake regulation

Basheer, R., Strecker, R. E., Thakkar, M. M., & McCarley, R. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.004 · Cited by 589 · see citing works

Structure and function of adenosine receptors and their genes

Fredholm, B. B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. W. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000313 · Cited by 583 · see citing works

Tissue distribution of adenosine receptor mRNAs in the rat

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Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

Dore, A. S., Robertson, N. J., Errey, J. C., Ng, I. W., Hollenstein, K., Tehan, B. G., Hurrell, E., Bennett, K. A., Congreve, M., Magnani, F., et al. (2011) · Structure · doi:10.1016/j.str.2011.06.014 · Cited by 557 · see citing works

A2AAdenosine Receptor Deficiency Attenuates Brain Injury Induced by Transient Focal Ischemia in Mice

Chen, J., Huang, Z., Ma, J., Zhu, J., Moratalla, R., Standaert, D. G., Moskowitz, M. A., Fink, J. S., & Schwarzschild, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09192.1999 · Cited by 557 · see citing works

Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade

Cunha, R. A. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-0649-1 · Cited by 540 · see citing works

Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study

Schiffmann, S. N., Jacobs, O. E., & Vanderhaeghen, J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08257.x · Cited by 530 · see citing works

Regulated ATP release from astrocytes through lysosome exocytosis

Zhang, Z., Chen, G., Zhou, W., Song, A., Xu, T., Luo, Q., Wang, W., Gu, X., & Duan, S. (2007) · Nature Cell Biology · doi:10.1038/ncb1620 · Cited by 525 · see citing works

Adenosine receptors in the nervous system: pathophysiological implications

Ribeiro, J. A., Sebastião, A. M., & de Mendonça, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00155-7 · Cited by 509 · see citing works

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor

Johansson, B. A., Halldner, L., Dunwiddie, T. V., Masino, S. A., Poelchen, W., Giménez‐Llort, L., Escorihuela, R. M., Fernández‐Teruel, A., Wiesenfeld‐Hallin, Z., Xu, X.-J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161292398 · Cited by 506 · see citing works

Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors

Hillion, J., Canals, M., Torvinen, M., Casadó, V., Scott, R. P., Terasmaa, A., Hansson, A. C., Watson, S. J., Olah, M. E., Mallol, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107731200 · Cited by 499 · see citing works

Activation of Trk neurotrophin receptors in the absence of neurotrophins

Lee, F. S., & Chao, M. V. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061020198 · Cited by 484 · see citing works

Signalling from adenosine receptors to mitogen-activated protein kinases

Schulte, G., & Fredholm, B. B. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00058-5 · Cited by 470 · see citing works

The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells

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Dopamine D 1 and adenosine A 1 receptors form functionally interacting heteromeric complexes

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Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

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Targeting adenosine A2A receptors in Parkinson's disease

Schwarzschild, M. A., Agnati, L. F., Fuxé, K., Chen, J., & Morelli, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.004 · Cited by 433 · see citing works

Recent developments in adenosine receptor ligands and their potential as novel drugs

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Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells11Abbreviations: cAMP, cyclic adenosine 3′,5′-monophosphate; CHO, Chinese hamster ovary; NBMPR, nitrobenzylthioinosine; and NECA, 5′-N-ethyl carboxamido adenosine.

Fredholm, B. B., Irenius, E., Kull, B., & Schulte, G. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00570-0 · Cited by 430 · see citing works

Molecular cloning and characterization of the human A3 adenosine receptor.

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Adenosine receptors and brain diseases: neuroprotection and neurodegeneration

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Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

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Adenosine A2A receptors and basal ganglia physiology

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Caffeine and adenosine A2a receptor antagonists prevent β-amyloid (25–35)-induced cognitive deficits in mice

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Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma.

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Adenosine A2AReceptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by β-Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

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ACTIONS OF ADENOSINE AT ITS RECEPTORS IN THE CNS: Insights from Knockouts and Drugs

Fredholm, B. B., Chen, J., Masino, S. A., & Vaugeois, J. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095731 · Cited by 354 · see citing works

Adenosine Inhibition of Mesopontine Cholinergic Neurons: Implications for EEG Arousal

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Association between A2a receptor gene polymorphisms and caffeine-induced anxiety

Alsene, K., Deckert, J., Sand, P., & de Wit, H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300232 · Cited by 334 · see citing works

Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens

Lazarus, M., Shen, H.-Y., Cherasse, Y., Qu, W.-M., Huang, Z.-L., Bass, C. E., Winsky-Sommerer, R., Semba, K., Fredholm, B. B., Boison, D., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6730-10.2011 · Cited by 327 · see citing works

The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A 2A receptors

Yacoubi, M. E., Ledent, C. A., Ménard, J.-F., Parmentier, M., Costentin, J., & Vaugeois, J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703170 · Cited by 307 · see citing works

Adenosine A2 receptor-mediated excitatory actions on the nervous system

Sebastião, A. M. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00035-6 · Cited by 303 · see citing works

Signaling from cAMP/PKA to MAPK and Synaptic Plasticity

Waltereit, R., & Weller, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:99 · Cited by 300 · see citing works

Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys

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An Angiogenic Switch in Macrophages Involving Synergy between Toll-Like Receptors 2, 4, 7, and 9 and Adenosine A2A Receptors

Pinhal-Enfield, G., Ramanathan, M., Hasko, G., Vogel, S. N., Salzman, A. L., Boons, G.-J., & Leibovich, S. J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63698-x · Cited by 278 · see citing works

Nucleoside transporters: from scavengers to novel therapeutic targets

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International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

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Adenosine Receptor Signaling Modulates Permeability of the Blood–Brain Barrier

Carman, A. J., Mills, J. H., Krenz, A., Kim, D.-G., & Bynoe, M. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3337-11.2011 · Cited by 276 · see citing works

Differential Expression of Adenosine Receptors in Human Endothelial Cells

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Adenosine Receptors and the Central Nervous System

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An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons

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Striatal Adenosine A2A and Cannabinoid CB1 Receptors Form Functional Heteromeric Complexes that Mediate the Motor Effects of Cannabinoids

Carriba, P., Ortiz, O., Patkar, K. A., Justinová, Z., Stroik, J., Themann, A., Müller, C. E., Woods, A. S., Hope, B. T., Ciruela, F., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301375 · Cited by 260 · see citing works

Purinergic approaches in experimental therapeutics

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An Update on Adenosine A2A-Dopamine D2 Receptor Interactions: Implications for the Function of G Protein-Coupled Receptors

Ferré, S., Quiroz, C., Woods, A. S., Cunha, R. A., Popoli, P., Ciruela, F., Lluı́s, C., Franco, R., Azdad, K., & Schiffmann, S. N. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784480108 · Cited by 254 · see citing works

Adenosine: does it have a neuroprotective role after all?

de Mendonça, A., Sebastião, A. M., & Ribeiro, J. A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00033-3 · Cited by 248 · see citing works

Adenosine: An Old Drug Newly Discovered

Eltzschig, H. K., Warner, D. S., & Warner, M. A. A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b060f2 · Cited by 247 · see citing works

Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease

Xu, K., Bastia, E., & Schwarzschild, M. A. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.10.007 · Cited by 244 · see citing works

Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats

Prediger, R. D., Batista, L. C., & Takahashi, R. N. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.08.012 · Cited by 240 · see citing works

Cloning and expression of an A1 adenosine receptor from rat brain.

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Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation

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Adenosine A2A and Dopamine D2 Heteromeric Receptor Complexes and Their Function

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Purinergic Signaling in the Vertebrate Olfactory System

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Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia–Reperfusion via Adenosine A1 Receptors in Rats

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Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy

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