The DOI matches its Crossref record; 334 of the 336 references it cites were found in a registry or an index.
Adenosine Receptor Neurobiology: Overview
Abstract
Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the body as a metabolic intermediary. In the brain, adenosine functions as an important upstream neuromodulator of a broad spectrum of neurotransmitters, receptors, and signaling pathways. By acting through four G-protein-coupled receptors, adenosine contributes critically to homeostasis and neuromodulatory control of a variety of normal and abnormal brain functions, ranging from synaptic plasticity, to cognition, to sleep, to motor activity to neuroinflammation, and cell death. This review begun with an overview of the gene and genome structure and the expression pattern of adenosine receptors (ARs). We feature several new developments over the past decade in our understanding of AR functions in the brain, with special focus on the identification and characterization of canonical and noncanonical signaling pathways of ARs. We provide an update on functional insights from complementary genetic-knockout and pharmacological studies on the AR control of various brain functions. We also highlight several novel and recent developments of AR neurobiology, including (i) recent breakthrough in high resolution of three-dimension structure of adenosine A2A receptors (A2ARs) in several functional status, (ii) receptor-receptor heterodimerization, (iii) AR function in glial cells, and (iv) the druggability of AR. We concluded the review with the contention that these new developments extend and strengthen the support for A1 and A2ARs in brain as therapeutic targets for neurologic and psychiatric diseases.
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“Numerous preclinical studies have found that antagonizing adenosine receptors, including with caffeine, has neuroprotective effects during aging and in neurological disorders by slowing cognitive decline and the progression of the disorders [reviewed in Ref. (84, 85)].”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [84]
In the citing paper
“Several studies have reported a significant negative association between maternal caffeine consumption and birth weight (84, 85, 140–142).”
From The Safety of Ingested Caffeine: A Comprehensive Review (2017) · cites this paper as [84]
Citations
Cites
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The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
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Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
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The Safety of Ingested Caffeine: A Comprehensive Review
Temple, J. L., Bernard, C., Lipshultz, S. E., Czachor, J. D., Westphal, J. A., & Mestre, M. A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00080 · Cited by 557
Adenosine receptor targets for pain
Sawynok, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.031 · Cited by 204
Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex
Radnikow, G., & Feldmeyer, D. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00001 · Cited by 185
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment
Terrisse, S., Derosa, L., Iebba, V., Ghiringhelli, F., Vaz-Luis, I., Kroemer, G., Fidelle, M., Christodoulidis, S., Segata, N., Thomas, A. M., et al. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-021-00784-1 · Cited by 172
Tronel, C., Largeau, B., Ribeiro, M. J., Guilloteau, D., Dupont, A.-C., & Arlicot, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040802 · Cited by 161
Metadata
- Authors
- Chen, J.-F., Lee, C.-F., & Chern, Y.
- Affiliations
- Boston University (US)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- Venue
- International review of neurobiology
- Publisher
- Elsevier
- Published
- 2014
- Volume
- 119
- Pages
- 1-49
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W2123639506
- Cited by
- 119
- References
- 336
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 13 · 2022: 12 · 2021: 15 · 2020: 16 · 2019: 9 · 2018: 16 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 1
- FWCI
- 5.80
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS041083-10, R01NS041083, NS073947, R01NS073947)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- adenosine receptors, adenosine, G protein-coupled receptors, adenosine A1 receptor, adenosine A2A receptor, adenosine A2B receptor, A3 adenosine receptor, receptor signaling pathways, receptor heterodimerization, glial cells, neuromodulation, synaptic plasticity, sleep, neuroinflammation, neurodegeneration, therapeutic target, knockout mice
- MeSH terms
- Animals, Humans, Neurobiology, Receptors, Purinergic P1
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