Adenosine Receptor Neurobiology: Overview

Ischemia and reperfusion—from mechanism to translation

Eltzschig, H. K., & Eckle, T. D. L. G. (2011) · Nature Medicine · doi:10.1038/nm.2507 · Cited by 3,468

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use

Fredholm, B. B., Bättig, K., Holmén, J., Nehlig, A., & Zvartau, E. E. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01396-6 · Cited by 2,624

International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors

Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585

Hypoxia and inflammation

Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061

The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist

Jaakola, V., Griffith, M. T., Hanson, M. A., Cherezov, V., Chien, E. Y. T., Lane, J. R., IJzerman, A. P., & Stevens, R. C. (2008) · Science · doi:10.1126/science.1164772 · Cited by 1,786

The Role and Regulation of Adenosine in the Central Nervous System

Dunwiddie, T. V., & Masino, S. A. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.31 · Cited by 1,669

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

van Calker, D., Müller, M., & Hamprecht, B. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb05236.x · Cited by 1,373

Astrocyte Control of Synaptic Transmission and Neurovascular Coupling

Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,371

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update

Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Linden, J. M., & Müller, C. E. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003285 · Cited by 1,307

Astrocytic Purinergic Signaling Coordinates Synaptic Networks

Pascual, O., Casper, K. B., Kubera, C., Zhang, J., Revilla-Sanchez, R., Sul, J.-Y., Takano, H., Moss, S. J., McCarthy, K., & Haydon, P. G. (2005) · Science · doi:10.1126/science.1116916 · Cited by 1,280

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

Haskó, G., Linden, J. M., Cronstein, B. N., & Pacher, P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2638 · Cited by 1,224

Dichotomous dopaminergic control of striatal synaptic plasticity

Shen, W., Flajolet, M., Greengard, P., & Surmeier, D. J. (2008) · Science · doi:10.1126/science.1160575 · Cited by 1,190

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120

Subclasses of external adenosine receptors.

Londos, C., Cooper, D. M. F., & Wolff, J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2551 · Cited by 1,083

Striatal Plasticity and Basal Ganglia Circuit Function

Kreitzer, A. C., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.005 · Cited by 1,071

The neurobiology and control of anxious states

Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 978

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

Liu, W., Chun, E., Thompson, A. A., Chubukov, P., Xu, F., Katritch, V., Han, G. W., Roth, C., Heitman, L. H., IJzerman, A. P., et al. (2012) · Science · doi:10.1126/science.1219218 · Cited by 952

Adenosine receptors as drug targets — what are the challenges?

Chen, J., Eltzschig, H. K., & Fredholm, B. B. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3955 · Cited by 923

Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918

Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes

Ventura, R. E., & Harris, K. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06897.1999 · Cited by 907

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

Lebon, G., Warne, T., Edwards, P. C., Bennett, K. A., Langmead, C. J., Leslie, A. G. W., & Tate, C. G. (2011) · Nature · doi:10.1038/nature10136 · Cited by 892

ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

Chen, Y., Corriden, R., Inoue, Y., Yip, L., Hashiguchi, N., Zinkernagel, A. S., Nizet, V., Insel, P. A., & JUNGER, W. G. (2006) · Science · doi:10.1126/science.1132559 · Cited by 882

Purinergic signalling in neuron–glia interactions

Fields, R. D., & Burnstock, G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1928 · Cited by 878

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S.-Y., Abel, T. G., Haydon, P. G., & Frank, M. G. (2009) · Neuron · doi:10.1016/j.neuron.2008.11.024 · Cited by 877

The tripartite synapse: roles for gliotransmission in health and disease

Halassa, M. M., Fellin, T., & Haydon, P. G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.005 · Cited by 852

Structure of an Agonist-Bound Human A 2A Adenosine Receptor

Xu, F., Wu, H., Katritch, V., Han, G. W., Jacobson, K. A., Gao, Z., Cherezov, V., & Stevens, R. C. (2011) · Science · doi:10.1126/science.1202793 · Cited by 820

Synaptic Islands Defined by the Territory of a Single Astrocyte

Halassa, M. M., Fellin, T., Takano, H., Dong, J.-H., & Haydon, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-07.2007 · Cited by 767

Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

Kreitzer, A. C., & Malenka, R. C. (2007) · Nature · doi:10.1038/nature05506 · Cited by 735

Adenosine, an endogenous distress signal, modulates tissue damage and repair

Fredholm, B. B. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402132 · Cited by 704

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

Zhou, Q. Y., Li, C., Olah, M. E., Johnson, R. A., Stiles, G. L., & Civelli, O. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7432 · Cited by 659

Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum

Fink, J. S., Weaver, D. R., Rivkees, S. A., Peterfreund, R. A., Pollack, A. E., Adler, E. M., & Reppert, S. M. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90173-9 · Cited by 649

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

Huang, Z.-L., Qu, W.-M., Eguchi, N., Chen, J.-F., Schwarzschild, M. A., Fredholm, B. B., Urade, Y., & Hayaishi, O. (2005) · Nature Neuroscience · doi:10.1038/nn1491 · Cited by 640

Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors

Cunha, R. A. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(00)00034-6 · Cited by 632

Adenosine and sleep–wake regulation

Basheer, R., Strecker, R. E., Thakkar, M. M., & McCarley, R. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.06.004 · Cited by 620

Neuroprotection by Caffeine and A 2A Adenosine Receptor Inactivation in a Model of Parkinson's Disease

Chen, J., Xu, K., Petzer, J. P., Staal, R. G. W., Xu, Y., Beilstein, M. A., Sonsalla, P. K., Castagnoli, K., Castagnoli, N. J., & Schwarzschild, M. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-j0001.2001 · Cited by 617

Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A 1 –A 2A Receptor Heteromers

Ciruela, F., Casadó, V., Rodrigues, R. J., Luján, R., Burgueño, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3574-05.2006 · Cited by 591

Structure and function of adenosine receptors and their genes

Fredholm, B. B., Arslan, G., Halldner, L., Kull, B., Schulte, G., & Wasserman, W. W. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000313 · Cited by 583

Tissue distribution of adenosine receptor mRNAs in the rat

Dixon, A. K., Gubitz, A. K., SIRINATHSINGHJI, D. J. S., Richardson, P. J., & Freeman, T. C. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15561.x · Cited by 566

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

Dore, A. S., Robertson, N. J., Errey, J. C., Ng, I. W., Hollenstein, K., Tehan, B. G., Hurrell, E., Bennett, K. A., Congreve, M., Magnani, F., et al. (2011) · Structure · doi:10.1016/j.str.2011.06.014 · Cited by 563

A2AAdenosine Receptor Deficiency Attenuates Brain Injury Induced by Transient Focal Ischemia in Mice

Chen, J., Huang, Z., Ma, J., Zhu, J., Moratalla, R., Standaert, D. G., Moskowitz, M. A., Fink, J. S., & Schwarzschild, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09192.1999 · Cited by 557

Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade

Cunha, R. A. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-0649-1 · Cited by 555

Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study

Schiffmann, S. N., Jacobs, O. E., & Vanderhaeghen, J. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb08257.x · Cited by 530

Regulated ATP release from astrocytes through lysosome exocytosis

Zhang, Z., Chen, G., Zhou, W., Song, A., Xu, T., Luo, Q., Wang, W., Gu, X., & Duan, S. (2007) · Nature Cell Biology · doi:10.1038/ncb1620 · Cited by 525

Adenosine receptors in the nervous system: pathophysiological implications

Ribeiro, J. A., Sebastião, A. M., & de Mendonça, A. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00155-7 · Cited by 521

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A 1 receptor

Johansson, B. A., Halldner, L., Dunwiddie, T. V., Masino, S. A., Poelchen, W., Giménez‐Llort, L., Escorihuela, R. M., Fernández‐Teruel, A., Wiesenfeld‐Hallin, Z., Xu, X.-J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161292398 · Cited by 506

Coaggregation, Cointernalization, and Codesensitization of Adenosine A2A Receptors and Dopamine D2Receptors

Hillion, J., Canals, M., Torvinen, M., Casadó, V., Scott, R. P., Terasmaa, A., Hansson, A. C., Watson, S. J., Olah, M. E., Mallol, J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107731200 · Cited by 499

Activation of Trk neurotrophin receptors in the absence of neurotrophins

Lee, F. S., & Chao, M. V. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061020198 · Cited by 484

Signalling from adenosine receptors to mitogen-activated protein kinases

Schulte, G., & Fredholm, B. B. (2003) · Cellular Signalling · doi:10.1016/s0898-6568(03)00058-5 · Cited by 483

The A3 adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells

Ramkumar, V., Stiles, G. L., Beaven, M. A., & Ali, H. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85277-8 · Cited by 448

Dopamine D 1 and adenosine A 1 receptors form functionally interacting heteromeric complexes

Ginés, S., Hillion, J., Torvinen, M., Crom, S. L., Casadó, V., Canela, E. I., Rondin, S., Lew, J. Y., Watson, S. J., Zoli, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150241097 · Cited by 444

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

Daly, J. W., Butts-Lamb, P., & Padgett, W. L. (1983) · Cellular and Molecular Neurobiology · doi:10.1007/bf00734999 · Cited by 443

Targeting adenosine A2A receptors in Parkinson's disease

Schwarzschild, M. A., Agnati, L. F., Fuxé, K., Chen, J., & Morelli, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.004 · Cited by 441

Recent developments in adenosine receptor ligands and their potential as novel drugs

Müller, C. E., & Jacobson, K. A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.12.017 · Cited by 431

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells11Abbreviations: cAMP, cyclic adenosine 3′,5′-monophosphate; CHO, Chinese hamster ovary; NBMPR, nitrobenzylthioinosine; and NECA, 5′-N-ethyl carboxamido adenosine.

Fredholm, B. B., Irenius, E., Kull, B., & Schulte, G. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00570-0 · Cited by 430

Molecular cloning and characterization of the human A3 adenosine receptor.

Salvatore, C., Jacobson, M. A., Taylor, H. E., Linden, J. M., & Johnson, R. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10365 · Cited by 426

Adenosine receptors and brain diseases: neuroprotection and neurodegeneration

Gomes, C. V., Kaster, M. P., Tomé, A. R., Agostinho, P. M., & Cunha, R. A. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.12.001 · Cited by 419

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes

Kirsch, G. E., Codina, J., Birnbaumer, L., & Brown, A. M. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.3.h820 · Cited by 401

Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system

Rosin, D. L., Robeva, A., Woodard, R. L., Guyenet, P. G., & Linden, J. M. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981116)401:2 · Cited by 395

Adenosine A2A receptors and basal ganglia physiology

Schiffmann, S. N., Fisone, G., Moresco, R. M., Cunha, R. A., & Ferré, S. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.05.001 · Cited by 393

Caffeine and adenosine A2a receptor antagonists prevent β-amyloid (25–35)-induced cognitive deficits in mice

Dall'Igna, O. P. P., Neto, P. F., Gomes, M. W. S., Souza, D. O., Cunha, R. A., & Lara, D. R. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.08.008 · Cited by 372

Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma.

Feoktistov, I., & Biaggioni, I. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118245 · Cited by 367

ACTIONS OF ADENOSINE AT ITS RECEPTORS IN THE CNS: Insights from Knockouts and Drugs

Fredholm, B. B., Chen, J., Masino, S. A., & Vaugeois, J. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095731 · Cited by 365

Adenosine A2AReceptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by β-Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway

Canas, P. M., Porciúncula, L. O., Cunha, G. M. A., Silva, C. G., Machado, N. J., Oliveira, J. M. A., Oliveira, C. R., & Cunha, R. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3728-09.2009 · Cited by 358

Adenosine Inhibition of Mesopontine Cholinergic Neurons: Implications for EEG Arousal

Rainnie, D. G., Grunze, H., McCarley, R. W., & Greene, R. W. (1994) · Science · doi:10.1126/science.8303279 · Cited by 341

Association between A2a receptor gene polymorphisms and caffeine-induced anxiety

Alsene, K., Deckert, J., Sand, P., & de Wit, H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300232 · Cited by 334

Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens

Lazarus, M., Shen, H.-Y., Cherasse, Y., Qu, W.-M., Huang, Z.-L., Bass, C. E., Winsky-Sommerer, R., Semba, K., Fredholm, B. B., Boison, D., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6730-10.2011 · Cited by 327

The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A 2A receptors

Yacoubi, M. E., Ledent, C. A., Ménard, J.-F., Parmentier, M., Costentin, J., & Vaugeois, J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703170 · Cited by 307

Signaling from cAMP/PKA to MAPK and Synaptic Plasticity

Waltereit, R., & Weller, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:99 · Cited by 303

Adenosine A2 receptor-mediated excitatory actions on the nervous system

Sebastião, A. M. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00035-6 · Cited by 303

Increased susceptibility to sporadic Parkinson's disease by a certain combined ?-synuclein/apolipoprotein E genotype

Krüger, R., Vieira-Saecker, A. M. M., Kuhn, W., Berg, D., M�ller, T., K�hnl, N., Fuchs, G., Storch, A., Hungs, M., Woitalla, D., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 281

An Angiogenic Switch in Macrophages Involving Synergy between Toll-Like Receptors 2, 4, 7, and 9 and Adenosine A2A Receptors

Pinhal-Enfield, G., Ramanathan, M., Hasko, G., Vogel, S. N., Salzman, A. L., Boons, G.-J., & Leibovich, S. J. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63698-x · Cited by 278

Nucleoside transporters: from scavengers to novel therapeutic targets

King, A. E., Ackley, M. A., Cass, C. E., Young, J. D., & Baldwin, S. A. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.06.004 · Cited by 278

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

Pin, J., Neubig, R. R., Bouvier, M., Devi, L. A., Filizola, M., Javitch, J. A., Lohse, M. J., Milligan, G., Palczewski, K., Parmentier, M., et al. (2007) · Pharmacological Reviews · doi:10.1124/pr.59.1.5 · Cited by 276

Adenosine Receptor Signaling Modulates Permeability of the Blood–Brain Barrier

Carman, A. J., Mills, J. H., Krenz, A., Kim, D.-G., & Bynoe, M. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3337-11.2011 · Cited by 276

Differential Expression of Adenosine Receptors in Human Endothelial Cells

Feoktistov, I., Goldstein, A. E., Ryzhov, S. V., Zeng, D., Belardinelli, L., Voyno-Yasenetskaya, T., & Biaggioni, I. (2002) · Circulation Research · doi:10.1161/01.res.0000012203.21416.14 · Cited by 271

Adenosine Receptors and the Central Nervous System

Sebastião, A. M., & Ribeiro, J. A. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-89615-9_16 · Cited by 271

An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons

Scammell, T. E., Gerashchenko, D., Mochizuki, T., McCarthy, M. T., Estabrooke, I. V., Sears, C., Saper, C. B., Urade, Y., & Hayaishi, O. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00383-9 · Cited by 269

Striatal Adenosine A2A and Cannabinoid CB1 Receptors Form Functional Heteromeric Complexes that Mediate the Motor Effects of Cannabinoids

Carriba, P., Ortiz, O., Patkar, K. A., Justinová, Z., Stroik, J., Themann, A., Müller, C. E., Woods, A. S., Hope, B. T., Ciruela, F., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301375 · Cited by 260

Purinergic approaches in experimental therapeutics

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An Update on Adenosine A2A-Dopamine D2 Receptor Interactions: Implications for the Function of G Protein-Coupled Receptors

Ferré, S., Quiroz, C., Woods, A. S., Cunha, R. A., Popoli, P., Ciruela, F., Lluı́s, C., Franco, R., Azdad, K., & Schiffmann, S. N. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784480108 · Cited by 254

Adenosine: An Old Drug Newly Discovered

Eltzschig, H. K., Warner, D. S., & Warner, M. A. A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b060f2 · Cited by 253

Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats

Prediger, R. D., Batista, L. C., & Takahashi, R. N. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.08.012 · Cited by 251

Adenosine: does it have a neuroprotective role after all?

de Mendonça, A., Sebastião, A. M., & Ribeiro, J. A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00033-3 · Cited by 248

Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease

Xu, K., Bastia, E., & Schwarzschild, M. A. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.10.007 · Cited by 245

Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation

Chen, J., Sonsalla, P. K., Pedata, F., Melani, A., Domenici, M. R., Popoli, P., Geiger, J. D., Lopes, L. V., & de Mendonça, A. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.09.002 · Cited by 242

Cloning and expression of an A1 adenosine receptor from rat brain.

Mahan, L. C., McVittie, L. D., Smyk-Randall, E. M., Nakata, H., Monsma, F. J., Gerfen, C. R., & Sibley, D. R. (1991) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12833-2 · Cited by 238

Adenosine A2A and Dopamine D2 Heteromeric Receptor Complexes and Their Function

Fuxé, K., Ferré, S., Canals, M., Torvinen, M., Terasmaa, A., Marcellino, D. J., Goldberg, S. R., Staines, W. A., Jacobsen, K. X., Lluís, C., et al. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:2-3:209 · Cited by 234

Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells

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Adenosine Promotes Wound Healing and Mediates Angiogenesis in Response to Tissue Injury Via Occupancy of A2A Receptors

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Region‐dependent difference in the sleep‐promoting potency of an adenosine A2A receptor agonist

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Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

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Evidence for functional adenosine A3 receptors in microglia cells

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