Chemical Characteristics and Functional Properties of Chitosan

Chitin and chitosan: Properties and applications

Rinaudo, M. (2006) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2006.06.001 · Cited by 8,259

Antimicrobial properties of chitosan and mode of action: a state of the art review

Kong, M., Chen, X. G., Xing, K., & Park, H. J. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.09.012 · Cited by 3,037

Chitosan Chemistry and Pharmaceutical Perspectives

Kumar, M. N. V. R., Müzzarelli, R. A. A., Muzzarelli, C., Sashiwa, H., & Domb, A. J. (2004) · Chemical Reviews · doi:10.1021/cr030441b · Cited by 2,987

Chitin and chitosan polymers: Chemistry, solubility and fiber formation

Pillai, C. K. S., Paul, W., & Sharma, C. P. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.04.001 · Cited by 2,745

Recent advances on chitosan-based micro- and nanoparticles in drug delivery

Agnihotri, S. A., Mallikarjuna, N. N., & Aminabhavi, T. M. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.010 · Cited by 2,586

Chitosan-based hydrogels for controlled, localized drug delivery

Bhattarai, N., Gunn, J., & Zhang, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.07.019 · Cited by 2,500

Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications

Berger, J., Reist, M., Mayer, J. M., Felt, O., Peppas, N. A., & Gurny, R. (2003) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00161-9 · Cited by 2,200

Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review

Francis Suh, J.-K., & Matthew, H. W. T. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00126-5 · Cited by 1,997

Biodegradation, biodistribution and toxicity of chitosan

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Food applications of chitin and chitosans

Shahidi, F., Arachchi, J. K. V., & Jeon, Y.-J. (1999) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(99)00017-5 · Cited by 1,826

Implantable applications of chitin and chitosan

Khor, E., & Lim, L. Y. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00026-7 · Cited by 1,695

Chitosan: A versatile biopolymer for orthopaedic tissue-engineering

Di Martino, A., Sittinger, M., & Risbud, M. V. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.03.016 · Cited by 1,634

An infrared investigation in relation with chitin and chitosan characterization

Brugnerotto, J., Lizardi, J., Goycoolea, F. M., Argüelles-Monal, W., Desbrières, J., & Rinaudo, M. (2001) · Polymer · doi:10.1016/s0032-3861(00)00713-8 · Cited by 1,531

Biodegradable polymers

Chandra, R. (1998) · Progress in Polymer Science · doi:10.1016/s0079-6700(97)00039-7 · Cited by 1,462

Perspectives for chitosan based antimicrobial films in food applications

Dutta, P. K., Tripathi, S., Mehrotra, G. K., & Dutta, J. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2008.11.047 · Cited by 1,454

Biomedical applications of chitin and chitosan based nanomaterials—A short review

Jayakumar, R., Menon, D., Manzoor, K., Nair, S. V., & Tamura, H. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.04.074 · Cited by 1,284

Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)

Vert, M., Doi, Y., Hellwich, K.-H., Hess, M., Hodge, P., Kubisa, P., Rinaudo, M., & Schué, F. (2012) · Pure and Applied Chemistry · doi:10.1351/pac-rec-10-12-04 · Cited by 1,273

Chitosan based edible films and coatings: A review

Elsabee, M. Z., & Abdou, E. S. (2013) · Materials Science and Engineering: C · doi:10.1016/j.msec.2013.01.010 · Cited by 1,216

Metal complexation by chitosan and its derivatives: a review

Varma, A. J., Deshpande, S. V., & Kennedy, J. F. (2004) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2003.08.005 · Cited by 1,174

Chitin — The Undisputed Biomolecule of Great Potential

Tharanathan, R. N., & Kittur, F. S. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826455 · Cited by 996

Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications

Berger, J., Reist, M., Mayer, J. M., Felt, O., & Gurny, R. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00160-7 · Cited by 987

Chitosan for coagulation/flocculation processes – An eco-friendly approach

Renault, F., Sancey, B., Badot, P.-M., & Crini, G. (2009) · European Polymer Journal · doi:10.1016/j.eurpolymj.2008.12.027 · Cited by 966

Controlled functionalization of the polysaccharide chitin

Kurita, K. (2001) · Progress in Polymer Science · doi:10.1016/s0079-6700(01)00007-7 · Cited by 900

Chitosan application for active bio-based films production and potential in the food industry: Review

Aider, M. (2010) · LWT - Food Science and Technology · doi:10.1016/j.lwt.2010.01.021 · Cited by 881

Biological activities of chitosan and chitooligosaccharides

Xia, W., Liu, P., Zhang, J., & Chen, J. (2011) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2010.03.003 · Cited by 836

Topical formulations and wound healing applications of chitosan

Ueno, H., Mori, T., & Fujinaga, T. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00189-2 · Cited by 811

Production, Properties, and Some New Applications of Chitin and Its Derivatives

Synowiecki, J., & Al-Khateeb, N. A. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826473 · Cited by 783

Application of Chitosan for the Removal of Metals From Wastewaters by Adsorption—Mechanisms and Models Review

Gerente, C., Lee, V. K. C., Cloirec, P. L., & McKay, G. (2007) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380600729089 · Cited by 781

Biofabrication with Chitosan

Yi, H., Wu, L.-Q., Bentley, W. E., Ghodssi, R., Rubloff, G. W., Culver, J. N., & Payne, G. F. (2005) · Biomacromolecules · doi:10.1021/bm050410l · Cited by 759

Bioactive compounds from marine processing byproducts – A review

Kim, S.-K., & Mendis, E. (2006) · Food Research International · doi:10.1016/j.foodres.2005.10.010 · Cited by 737

Chitosan as a potential natural compound to control pre and postharvest diseases of horticultural commodities

Bautista-Baños, S., Hernández-Lauzardo, A. N., Velázquez-del Valle, M. G., Hernández-López, M., Ait Barka, E., Bosquez-Molina, E., & Wilson, C. L. (2006) · Crop Protection · doi:10.1016/j.cropro.2005.03.010 · Cited by 729

A validated 1H NMR method for the determination of the degree of deacetylation of chitosan

Lavertu, M., Xia, Z., Serreqi, A. N., Berrada, M., Rodrigues, A., Wang, D., Buschmann, M. D., & Gupta, A. (2003) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(03)00155-9 · Cited by 691

Characterization of chitosan. Influence of ionic strength and degree of acetylation on chain expansion

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Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems

Hamman, J. H. (2010) · Marine Drugs · doi:10.3390/md8041305 · Cited by 569

Chitosan-gelatin composites and bi-layer films with potential antimicrobial activity

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Biotechnological aspects of chitinolytic enzymes: a review

Dahiya, N., Tewari, R., & Hoondal, G. S. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0183-7 · Cited by 544

Potential applications of chitosan in veterinary medicine

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Human enzymatic activities related to the therapeutic administration of chitin derivatives

Muzzarelli, R. A. A. (1997) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000584 · Cited by 516

A review of several reported procedures to determine the degree of N-acetylation for chitin and chitosan using infrared spectroscopy

KASAAI, M. (2008) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.07.009 · Cited by 465

Preparation and Characterization of Chitin and Chitosan—A Review

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An optimised method to determine the degree of acetylation of chitin and chitosan by FTIR spectroscopy

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A Biopolymer Chitosan and Its Derivatives as Promising Antimicrobial Agents against Plant Pathogens and Their Applications in Crop Protection

Badawy, M. E. I., & Rabea, E. I. (2011) · International Journal of Carbohydrate Chemistry · doi:10.1155/2011/460381 · Cited by 428

Chitin-chitosan: Properties, benefits and risks

Koide, S. S. (1998) · Nutrition Research · doi:10.1016/s0271-5317(98)00091-8 · Cited by 411

Studies on chitin, 2. Effect of deacetylation on solubility

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Typical Physicochemical Behaviors of Chitosan in Aqueous Solution

Schatz, C., Viton, C., Delair, T., Pichot, C., & Domard, A. (2003) · Biomacromolecules · doi:10.1021/bm025724c · Cited by 396

Chitin deacetylases: new, versatile tools in biotechnology

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Review Paper: Chitosan Derivatives as Promising Materials for Controlled Drug Delivery

Prabaharan, M. (2008) · Journal of Biomaterials Applications · doi:10.1177/0885328208091562 · Cited by 371

Determination of the degree of N-acetylation for chitin and chitosan by various NMR spectroscopy techniques: A review

Kasaai, M. R. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.10.051 · Cited by 369

Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications

Chen, T., Embree, H. D., Brown, E. M., Taylor, M. M., & Payne, G. F. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00096-6 · Cited by 359

Chitosan-based drug nanocarriers: Where do we stand?

García-Fuentes, M., & Alonso, M. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.017 · Cited by 354

Elicitation of plants and microbial cell systems

Radman, R., Saez, T., Bucke, C., & Keshavarz, T. (2003) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20020118 · Cited by 342

Chitosan based nanofibers, review

Elsabee, M. Z., Naguib, H. F., & Morsi, R. E. (2012) · Materials Science and Engineering C · doi:10.1016/j.msec.2012.05.009 · Cited by 334

Calculation of Mark–Houwink–Sakurada (MHS) equation viscometric constants for chitosan in any solvent–temperature system using experimental reported viscometric constants data

Kasaai, M. R. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2006.11.006 · Cited by 321

Preparation and properties evaluation of chitosan-coated cassava starch films

Bangyekan, C., Aht-Ong, D., & Srikulkit, K. (2006) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2005.07.032 · Cited by 318

Preparation and Characterization of Chitosan-Based Nanoparticles

Bodnar, M., Hartmann, J. F., & Borbely, J. (2005) · Biomacromolecules · doi:10.1021/bm0502258 · Cited by 307

Enzymic preparation of water-soluble chitosan and their antitumor activity

Qin, C., Du, Y., Xiao, L., Li, Z., & Gao, X. (2002) · International Journal of Biological Macromolecules · doi:10.1016/s0141-8130(02)00064-8 · Cited by 307

Effect of abiotic factors on the antibacterial activity of chitosan against waterborne pathogens

Chung, Y. (2003) · Bioresource Technology · doi:10.1016/s0960-8524(03)00002-6 · Cited by 302

Three D structures of chitosan

Ogawa, K., Yui, T., & Okuyama, K. (2004) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2003.11.002 · Cited by 301

Chitosan Derivatives with Antimicrobial, Antitumour and Antioxidant Activities - a Review

Vinsova, J., & Vavrikova, E. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798194468 · Cited by 294

Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials

Molinaro, G., Leroux, J.-C., Damas, J., & Adam, A. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00004-2 · Cited by 294

Chitin-based tubes for tissue engineering in the nervous system

Freier, T., Montenegro, R., Koh, H. S., & Shoichet, M. S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.040 · Cited by 290

The Antiviral Activity of Chitosan (Review)

Chirkov, S. N. (2002) · Applied Biochemistry and Microbiology · doi:10.1023/a:1013206517442 · Cited by 289

Chitosan as a promising natural compound to enhance potential physiological responses in plant: a review

Katiyar, D., Hemantaranjan, A., & Singh, B. (2015) · Indian Journal of Plant Physiology · doi:10.1007/s40502-015-0139-6 · Cited by 283

A simple preparation of half N-acetylated chitosan highly soluble in water and aqueous organic solvents

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Acid hydrolysis of chitosans

Vårum, K. (2001) · Carbohydrate Polymers · doi:10.1016/s0144-8617(00)00288-5 · Cited by 269

Applications of Chitosan in the Seafood Industry and Aquaculture: A Review

Alishahi, A., & Aïder, M. (2012) · Food and Bioprocess Technology · doi:10.1007/s11947-011-0664-x · Cited by 268

Physicochemical Characteristics and Functional Properties of Various Commercial Chitin and Chitosan Products

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Fungal chitosan production and its characterization

Pochanavanich, P., & Suntornsuk, W. (2002) · Letters in Applied Microbiology · doi:10.1046/j.1472-765x.2002.01118.x · Cited by 267

Physicochemical Properties and Bioactivity of Fungal Chitin and Chitosan

Wu, T., Zivanovic, S., Draughon, F. A., Conway, W. S., & Sams, C. E. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048202s · Cited by 260

Preparation and Solubility in Acid and Water of Partially Deacetylated Chitins

Cho, Y.-W., Jang, J., Park, C. R., & Ko, S.-W. (2000) · Biomacromolecules · doi:10.1021/bm000036j · Cited by 260

Insulin-Loaded Nanoparticles are Prepared by Alginate Ionotropic Pre-Gelation Followed by Chitosan Polyelectrolyte Complexation

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Chitosan-Alginate Blended Nanoparticles as Carriers for the Transmucosal Delivery of Macromolecules

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Physicochemical Behavior of Homogeneous Series of Acetylated Chitosans in Aqueous Solution: Role of Various Structural Parameters

Lamarque, G., Lucas, J. ‐., Viton, C., & Domard, A. (2004) · Biomacromolecules · doi:10.1021/bm0496357 · Cited by 233

A Pathway of Chitosan Formation in Mucor rouxii

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Chitosan as an ingredient for domestic animal feeds

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Studies on Glutaraldehyde Crosslinked Chitosan Hydrogel Properties for Drug Delivery Systems

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Binding of ions to chitosan—selectivity studies

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Chitosan as a Lipid Binder: A Langmuir Monolayer Study of Chitosan−Lipid Interactions

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Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen

Dhiman, H. K., Ray, A. R., & Panda, A. K. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.012 · Cited by 206

Effects of dietary chitosan and Bacillus subtilis on the growth performance, non-specific immunity and disease resistance of cobia, Rachycentron canadum

Geng, X., Dong, X., Tan, B., Yang, Q., Chi, S., Liu, H., & Liu, X. (2011) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2011.06.006 · Cited by 204

Chitosan oligosaccharides, dp 2–8, have prebiotic effect on the Bifidobacterium bifidium and Lactobacillus sp.

Lee, H.-W., Park, Y., Jung, J.-S., & Shin, W. (2002) · Anaerobe · doi:10.1016/s1075-9964(03)00030-1 · Cited by 199

Vascular cell responses to polysaccharide materials:

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Characterization of chitosan by steric exclusion chromatography

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Chitin and ChitosanValue-Added Products from Mushroom Waste

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Pseudo‐first‐order kinetic studies of the sorption of acid dyes onto chitosan

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Viscosity of Semiflexible Chitosan Solutions: Influence of Concentration, Temperature, and Role of Intermolecular Interactions

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Pyrene fluorescence study of chitosan self-association in aqueous solution

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Effects of molecular weight, degree of acetylation and ionic strength on surface tension of chitosan in dilute solution

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Adsorption of Gold(III) Ions onto Chitosan and N-Carboxymethyl Chitosan: Equilibrium Studies

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Structural diversity of chitosan and its complexes

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Chitin production by arthropods in the hydrosphere

Cauchie, H. (2002) · Hydrobiologia · doi:10.1023/a:1015615819301 · Cited by 161

Effects of ultrasonic conditions and storage in acidic solutions on changes in molecular weight and polydispersity of treated chitosan

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Adsorption of heavy metal ions, dyes and proteins by chitosan composites and derivatives — A review

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Physico-chemical studies of the gelation of chitosan in a hydroalcoholic medium

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Chitosan–poly(vinyl pyrrolidone) blends as membranes for direct methanol fuel cell applications

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Optimal routine conditions for the determination of the degree of acetylation of chitosan by 1H-NMR

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Glyoxal crosslinking of cell-seeded chitosan/collagen hydrogels for bone regeneration

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Preparative and analytical size-exclusion chromatography of chitosans

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Chitosan nanoparticles: a contribution to nanomedicine

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Chitosan for overweight or obesity

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A Glucomannan and Chitosan Fiber Supplement Decreases Plasma Cholesterol and Increases Cholesterol Excretion in Overweight Normocholesterolemic Humans

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Relation between Solution Properties and Degree of Acetylation of Chitosan: Role of Aging

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Chitosan molecular structure as a function of N ‐acetylation

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Dietary oligochitosan supplementation enhances immune status of broilers

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Chitin: a biomaterial in waiting

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Jumbo squid (Dosidicus gigas) mantle collagen: Extraction, characterization, and potential application in the preparation of chitosan–collagen biofilms

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Standards and Guidelines for Biopolymers in Tissue‐Engineered Medical Products

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Effect of organic and inorganic acids on concentrated chitosan solutions and gels

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Salt-assisted acid hydrolysis of chitosan to oligomers under microwave irradiation

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Physical chemistry of macromolecules: basic principles and issues

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Detection and characterization of chitinases and other chitin-modifying enzymes

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Rheological study of the chitosan/glutaraldehyde chemical gel system

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