Rivastigmine
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Compared to oral pills, transdermal patches are more pleasant and provide a smaller dosage, leading to fewer side effects.
“Compared to oral pills, transdermal patches are more pleasant and provide a smaller dosage, which leads to fewer side effects.”
From Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease (2024) · cites this paper as [121]
Cites
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Protein aggregation and neurodegenerative disease
Ross, C. A., & Poirier, M. A. (2004) · Nature Medicine · doi:10.1038/nm1066 · Cited by 3,454 · see citing works
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works
Lane, C. A., Hardy, J., & Schott, J. M. (2018) · European Journal of Neurology · doi:10.1111/ene.13439 · Cited by 2,616 · see citing works
Rosler, M., Anand, R., Cicin-Sain, A., Gauthier, S., Agid, Y., Dal-Bianco, P., Stahelin, H. B., Hartman, R., Gharabawi, M., & Bayer, T. (1999) · BMJ · doi:10.1136/bmj.318.7184.633 · Cited by 943 · see citing works
Targeting acetylcholinesterase and butyrylcholinesterase in dementia
Lane, R. M., Potkin, S. G., & Enz, A. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005833 · Cited by 654 · see citing works
Gänger, S., & Schindowski, K. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030116 · Cited by 447 · see citing works
Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting
Fazil, M., Md, S., Haque, S., Kumar, M., Baboota, S., Sahni, J. K., & Ali, J. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.04.013 · Cited by 379 · see citing works
Farlow, M., Anand, R., Messina Jr, J., Hartman, R., & Veach, J. (2000) · European Neurology · doi:10.1159/000008243 · Cited by 332 · see citing works
Polinsky, R. J. (1998) · Clinical Therapeutics · doi:10.1016/s0149-2918(98)80127-6 · Cited by 323 · see citing works
Reading, P., Luce, A., & McKeith, I. G. (2001) · Movement Disorders · doi:10.1002/mds.1204 · Cited by 269 · see citing works
Potential medicinal plants for CNS disorders: an overview
Kumar, V. (2006) · Phytotherapy Research · doi:10.1002/ptr.1970 · Cited by 268 · see citing works
Advances in the Treatment of Alzheimer’s Disease: Benefits of Dual Cholinesterase Inhibition
Ballard, C. G. (2002) · European Neurology · doi:10.1159/000047952 · Cited by 261 · see citing works
Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
Mesulam, M. M., & Geula, C. (1994) · Annals of Neurology · doi:10.1002/ana.410360506 · Cited by 259 · see citing works
Rivastigmine for Alzheimer's disease
Birks, J., & Evans, J. G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001191.pub3 · Cited by 247 · see citing works
Shah, B. M., Khunt, D., Bhatt, H., Misra, M., & Padh, H. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.07.002 · Cited by 237 · see citing works
Kandiah, N., Pai, M.-C., Senanarong, V., Looi, I., Ampil, E. R., Park, K. W., Karanam, A. K., & Christopher, S. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s129145 · Cited by 232 · see citing works
Naber, P. A., & Witter, M. P. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980413)393:3 · Cited by 219 · see citing works
Spencer, C. M., & Noble, S. (1998) · Drugs & Aging · doi:10.2165/00002512-199813050-00005 · Cited by 187 · see citing works
Thomas, J., Thomas, C. J., Radcliffe, J., & Itsiopoulos, C. (2015) · BioMed Research International · doi:10.1155/2015/172801 · Cited by 173 · see citing works
Rivastigmine in the treatment of Alzheimer's disease: an update
Onor, M. L., Trevisiol, M., & Aguglia, E. (2007) · Clinical Interventions in Aging · doi:10.2147/ciia.2007.2.1.17 · Cited by 162 · see citing works
Castro, A., & Martı́nez, A. (2001) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557013406864 · Cited by 160 · see citing works
An update on the safety of current therapies for Alzheimer’s disease: focus on rivastigmine
Khoury, R., Rajamanickam, J., & Grossberg, G. T. (2018) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098617750555 · Cited by 156 · see citing works
Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months
Darreh‐Shori, T., Almkvist, O., Guan, Z. Z., Garlind, A., Strandberg, B., Svensson, A., Soreq, H., Hellström‐Lindahl, E., & Nordberg, A. K. (2002) · Neurology · doi:10.1212/wnl.59.4.563 · Cited by 154 · see citing works
Design, Synthesis, and Biological Evaluation of Conformationally Restricted Rivastigmine Analogues
Bolognesi, M. L., Bartolini, M., Cavalli, A., Andrisano, V., Rosini, M., Minarini, A., & Melchiorre, C. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049782n · Cited by 150 · see citing works
Shah, B. M., Misra, M., Shishoo, C. J., & Padh, H. (2014) · Drug Delivery · doi:10.3109/10717544.2013.878857 · Cited by 136 · see citing works
Treatment Options in Alzheimer’s Disease: Maximizing Benefit, Managing Expectations
Farlow, M. R., Miller, M. L., & Pejović, V. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000122962 · Cited by 130 · see citing works
Genetic markers for diagnosis and pathogenesis of Alzheimer's disease
Kim, D., Yeo, S. H., Park, J.-M., Choi, J. Y., Lee, T.-H., Park, S. Y., Ock, M. S., Eo, J., Kim, H., & Cha, H. (2014) · Gene · doi:10.1016/j.gene.2014.05.031 · Cited by 128 · see citing works
Cholinergic activity and amyloid precursor protein metabolism
Roberson, M. R. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00016-7 · Cited by 127 · see citing works
Dose-dependent CSF acetylcholinesterase inhibition by SDZ ENA 713 in Alzheimer's disease
Cutler, N. R., Polinsky, R. J., Srarnek, J. J., Enz, A., Jhee, S. S., Mancione, L., Hourani, J., & Zolnouni, P. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1998.tb00645.x · Cited by 123 · see citing works
A review of rivastigmine: A reversible cholinesterase inhibitor
Williams, B. R., Nazarians, A., & Gill, M. A. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80160-1 · Cited by 122 · see citing works
Singh, B., Sharma, B., Jaggi, A. S., & Singh, N. (2012) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320312459977 · Cited by 117 · see citing works
Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.04.024 · Cited by 116 · see citing works
Plaque-associated lipids in Alzheimer’s diseased brain tissue visualized by nonlinear microscopy
Kiškis, J., Fink, H., Nyberg, L. K., Thyr, J., Li, J., & Enejder, A. M. K. (2015) · Scientific Reports · doi:10.1038/srep13489 · Cited by 113 · see citing works
Mesulam, M., & Geula, C. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903060202 · Cited by 105 · see citing works
Abouhussein, D. M. N., Khattab, A., Bayoumi, N. A., Mahmoud, A. F., & Sakr, T. M. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.09.021 · Cited by 105 · see citing works
Winblad, B. G., Kawata, A. K., Beusterien, K. M., Thomas, S. K., Wimo, A. B., Lane, R. M., Fillit, H. M., & Blesa, R. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1806 · Cited by 101 · see citing works
Darreh‐Shori, T., Hellström‐Lindahl, E., Flores‐Flores, C., Guan, Z. Z., Soreq, H., & Nordberg, A. K. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02230.x · Cited by 92 · see citing works
Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer’s disease
Bastiat, G., Plourde, F., Motulsky, A., Fürtös, A., Dumont, Y., Quirion, R., Fuhrmann, G., & Leroux, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.009 · Cited by 87 · see citing works
Simon, A., Amaro, M. I., Cabral, L. M., Healy, A. M., & de Sousa, V. P. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.066 · Cited by 84 · see citing works
Poirier, J. (2002) · PubMed · Cited by 74 · see citing works
Chen, Z., Digiacomo, M., Tu, Y., Gu, Q., Wang, S., Yang, X., Chu, J., Chen, Q., Han, Y., Chen, J., et al. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.09.052 · Cited by 74 · see citing works
Preferential Cerebrospinal Fluid Acetylcholinesterase Inhibition by Rivastigmine in Humans
Kennedy, J. S., Polinsky, R. J., Johnson, B. W., Loosen, P. T., Enz, A., Laplanche, R., Schmidt, D. E., Mancione, L., Parris, W. C. V., & Ebert, M. H. (1999) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199912000-00005 · Cited by 73 · see citing works
Salatin, S., Barar, J., Barzegar-Jalali, M., Adibkia, K., & Jelvehgari, M. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.08.031 · Cited by 72 · see citing works
Three years survival in patients with a clinical diagnosis of dementia with Lewy bodies
Walker, Z., Allen, R. L., Shergill, S. S., Mullan, E., & Katona, C. (2000) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(200003)15:3 · Cited by 71 · see citing works
Haider, M. F., Khan, S., Gaba, B., Alam, T., Baboota, S., Ali, J., & Ali, A. (2018) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2018.01.123 · Cited by 68 · see citing works
Empirical evidence of neuroprotection by dual cholinesterase inhibition in Alzheimer??s disease
Venneri, A., McGeown, W. J., & Shanks, M. F. (2005) · Neuroreport · doi:10.1097/00001756-200502080-00006 · Cited by 65 · see citing works
Wang, L., Wang, Y., Tian, Y., Shang, J., Sun, X., Chen, H., Wang, H., & Tan, W. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.11.002 · Cited by 63 · see citing works
Almkvist, O., Darreh‐Shori, T., Stefanova, E. D., Spiegel, R., & Nordberg, A. K. (2004) · European Journal of Neurology · doi:10.1046/j.1468-1331.2003.00757.x · Cited by 55 · see citing works
Alzheimer´s Disease associated with Psychiatric Comorbidities
Garcez, M. L., Falchetti, A. C. B., Mina, F., & Budni, J. (2015) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201520140716 · Cited by 55 · see citing works
Karimipour, M., Esfandiary, E., Mardani, M., Ghanadian, M., Alaei, H., Mohammadnejad, D., & Esmaeili, A. (2015) · Advanced Biomedical Research · doi:10.4103/2277-9175.161512 · Cited by 52 · see citing works
Improved chemoenzymatic asymmetric synthesis of (S)-Rivastigmine
Fuchs, M., Koszelewski, D., Tauber, K., Sattler, J. H., Banko, W., Holzer, A. K., Pickl, M., Kroutil, W., & Faber, K. (2012) · Tetrahedron · doi:10.1016/j.tet.2012.06.031 · Cited by 52 · see citing works
An open-label, comparative study of rivastigmine, donepezil and galantamine in a real-world setting
Aguglia, E., Onor, M. L., Saina, M., & Maso, E. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904x6273 · Cited by 52 · see citing works
Amenta, F., Tayebati, S. K., Vitali, D., & Tullio, M. A. D. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.09.017 · Cited by 48 · see citing works
Adler, G., Mueller, B., & Articus, K. (2014) · International Journal of Clinical Practice · doi:10.1111/ijcp.12374 · Cited by 47 · see citing works
Malaiya, M. K., Jain, A., Hurkat, P., Jain, A., & Jain, D. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.03.030 · Cited by 43 · see citing works
Pousa, S. L., Estrada, A. T., Garre‐Olmo, J., Nierga, I. P., Gallego, M. L., Vilalta-Franch, M., Hernández-Ferràndiz, M., Muñoz, V. M., Isern-Vila, A., Gelada-Batlle, E., et al. (2005) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000083498 · Cited by 40 · see citing works
Anand, A., Arya, M., Kaithwas, G., Singh, G., & Saraf, S. A. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.11.021 · Cited by 35 · see citing works
Amat-ur-Rasool, H., & Ahmed, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136509 · Cited by 30 · see citing works
Nesi, G., Chen, Q., Sestito, S., Digiacomo, M., Yang, X., Wang, S., Pi, R., & Rapposelli, S. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.006 · Cited by 27 · see citing works
Asymmetric synthesis of an enantiomerically pure rivastigmine intermediate using ketoreductase
Sethi, M. K., Bhandya, S. R., Maddur, N., Shukla, R., Kumar, A., & Mittapalli, V. S. N. J. (2013) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2013.01.023 · Cited by 21 · see citing works
In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus
Trabace, L., Coluccia, A. M. L., Gaetani, S., Tattoli, M., Cagiano, R., Pietra, C., Kendrick, K. M., & Cuomo, V. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02266-6 · Cited by 21 · see citing works
Rivastigmine as a Modulator of the Neuronal Glutamate Transporter rEAAC1 mRNA Expression
Andin, J., Enz, A., Gentsch, C., & Marcusson, J. O. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000080966 · Cited by 20 · see citing works
Treatment of cognitive impairment in Alzheimer's disease
Burns, A. S. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.1/aburns · Cited by 20 · see citing works
Xie, P., Zhou, X., & Zheng, L. (2018) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2018.11.016 · Cited by 16 · see citing works
Blesa, R., Boada, M., Parra, C. M., Saladié, D. G. I., Almagro, C. A., & Vázquez, A. L. G. (2011) · Neurología · doi:10.1016/j.nrl.2010.10.007 · Cited by 10 · see citing works
Kim, G. H., Jeon, S., Seo, S. W., Kim, M.-J., Kim, J. H., Roh, J. H., Shin, J. S., Kim, C. H., Im, K., Lee, M.-J., et al. (2011) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2011.10.013 · Cited by 10 · see citing works
Chang, C., Chou, T., Chang, C., Chen, T., Hu, C., Fuh, J., Wang, W., Chen, C., Hsu, W., & Huang, C. (2018) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.013 · Cited by 10 · see citing works
Modulation of human motor cortex excitability by the cholinesterase inhibitor rivastigmine
Langguth, B., Bauer, E., Feix, S., Landgrebe, M., Binder, H., Sand, P. G., Hajak, G., & Eichhammer, P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.01.008 · Cited by 9 · see citing works
Penhasi, A., & Gomberg, M. (2018) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2018.08.009 · Cited by 7 · see citing works
Mulley, G. P., & Jones, R. W. (2003) · Clinical Medicine · doi:10.7861/clinmedicine.3-5-404 · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 73 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Yoo, J., Lee, J., Ahn, B., Han, J., & Lim, M. H. (2025) · Chemical Science · doi:10.1039/d4sc06762b · Cited by 74 · see citing works
Recent Advances in Therapeutics for the Treatment of Alzheimer’s Disease
Thawabteh, A. M., Ghanem, A. W., AbuMadi, S., Thaher, D., Jaghama, W., Karaman, D., & Karaman, R. (2024) · Molecules · doi:10.3390/molecules29215131 · Cited by 56 · see citing works
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., & Harrington, C. R. (2022) · Biomedicines · doi:10.3390/biomedicines10040867 · Cited by 8 · see citing works
Ismail, M. F., & Al-Gawhari, F. J. (2025) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v9i2.2460 · Cited by 1 · see citing works
- Authors
- Ezzat, S. M., Salem, M. A., El Mahdy, N. M., & Ragab, M. F.
- Affiliations
- Cairo University (EG)
- Menoufia University (EG)
- October University of Modern Sciences and Arts (EG)
- Venue
- Naturally Occurring Chemicals Against Alzheimer's Disease
- Publisher
- Elsevier
- Published
- 2021
- Pages
- 93-108
- OpenAlex
- W4236733791
- Cited by
- 4
- References
- 73
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1
- FWCI
- 0.59
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Elsevier eBooks (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- rivastigmine, Alzheimer's disease, acetylcholinesterase inhibitors, acetylcholine, cholinergic neurotransmission, cognitive impairment, dementia treatment, cholinesterase inhibition
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review