Optimization of brain targeted chitosan nanoparticles of Rivastigmine for improved efficacy and safety
Abstract
The study aims at formulation and optimization brain targeted nanoparticles (NP) of Rivastigmine (RT) to improve its therapeutic potential and to verify its safety profile. The NP were optimized using a two factor three level (3(2)) central composite design aiming to minimize particle size; maximize zeta potential and drug entrapment efficiency of NP. The optimized formulation (cRTNP) was evaluated using in vitro drug release study; in vivo behavioral, and biochemical and maximum tolerated dose (MTD) study. The optimized formulation evidenced a significant reversal of scopolamine-induced amnesia by Tween 80(®) coated nanoparticles as compared to both pure RT as well as uncoated nanoparticles. The MTD of RT was increased by 10% by formulating them as cRTNP. Thus, formulation of RT as cRTNP improved the therapeutic and safety profile of RT.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
RT-loaded chitosan NPs improved memory function with reduced toxicity in a mouse model.
“Furthermore, RT-loaded chitosan NPs also improved memory function with reduced toxicity in a mouse model.102”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [102]
Cites
International Journal of Nanomedicine
(2020) · International Journal of Nanomedicine · doi:10.2147/ijn · Cited by 2,760 · see citing works
Irwin, S. (1968) · Psychopharmacology · doi:10.1007/bf00401402 · Cited by 1,240 · see citing works
Iranian Journal of Pharmaceutical Research
(2022) · Iranian journal of pharmaceutical research · doi:10.5812/ijpr · Cited by 1,229 · see citing works
Pardridge, W. M. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2006.10.013 · Cited by 1,191 · see citing works
Chitosan Nanoparticles: A Promising System in Novel Drug Delivery
Nagpal, K., Singh, S. K., & Mishra, D. N. (2010) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.58.1423 · Cited by 661 · see citing works
Self-citationZensi, A., Begley, D., Pontikis, C., Legros, C., Mihoreanu, L., Wagner, S., Büchel, C., von Briesen, H., & Kreuter, J. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.03.002 · Cited by 438 · see citing works
New Acetylcholinesterase Inhibitors for Alzheimer's Disease
Mehta, M., Adem, A., & Sabbagh, M. N. (2011) · International Journal of Alzheimer s Disease · doi:10.1155/2012/728983 · Cited by 436 · see citing works
Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting
Fazil, M., Md, S., Haque, S., Kumar, M., Baboota, S., Sahni, J. K., & Ali, J. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.04.013 · Cited by 379 · see citing works
Nerurkar, M. M., Burton, P. S., & Borchardt, R. T. (1996) · Pharmaceutical Research · doi:10.1023/a:1016033702220 · Cited by 287 · see citing works
Wagner, S., Zensi, A., Wien, S., Tschickardt, S., Maier, W., Vogel, T., Worek, F., Pietrzik, C. U., Kreuter, J., & von Briesen, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032568 · Cited by 260 · see citing works
Joshi, S. A., Chavhan, S. S., & Sawant, K. K. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.07.007 · Cited by 235 · see citing works
Lin, X., Tian, Wei, Feng, Huang, Wang, Ren, R., & Diao (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s16570 · Cited by 189 · see citing works
Fodale, V., Santamaria, L. B., Schifilliti, D., & Mandal, P. K. (2010) · Anaesthesia · doi:10.1111/j.1365-2044.2010.06244.x · Cited by 169 · see citing works
Chitosan‐Based Systems for Biopharmaceuticals
(2012) · Wiley eBooks · doi:10.1002/9781119962977 · Cited by 134 · see citing works
Cardiac Toxicity of Antineoplastic Anthracyclines
Zucchi, R., & Danesi, R. (2003) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011033353434 · Cited by 129 · see citing works
Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.762354 · Cited by 115 · see citing works
Self-citationRisk assessment for glucosamine and chondroitin sulfate
Hathcock, J. N., & Shao, A. E. (2006) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2006.07.004 · Cited by 106 · see citing works
Kinetics of transport of doxorubicin bound to nanoparticles across the blood–brain barrier
Wohlfart, S., Khalansky, A. S., Gelperina, S. E., Begley, D. J., & Kreuter, J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.05.010 · Cited by 100 · see citing works
Lee, Y. K., Yuk, D. Y., Kim, T. I., Kim, Y. H., Kim, K., Kim, K. H., Lee, B. J., Nam, S.-Y., & Hong, J. T. (2009) · Journal of Natural Medicines · doi:10.1007/s11418-009-0330-z · Cited by 97 · see citing works
Delivery of nanoparticles to the brain detected by fluorescence microscopy
Reimold, I., Domke, D., Bender, J., Seyfried, C. A., Radunz, H.-E., & Fricker, G. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.05.007 · Cited by 89 · see citing works
Asparagus recemosus enhances memory and protects against amnesia in rodent models
Ojha, R., Sahu, A. N., Muruganandam, A. V., Singh, G. K., & Krishnamurthy, S. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2010.05.009 · Cited by 84 · see citing works
Переверзева, Э. Р., Трещалин, И. Д., Бодягин, Д. А., Максименко, О. О., Langer, K., Dreis, S., Asmussen, B., Kreuter, J., & Gelperina, S. E. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.01.031 · Cited by 76 · see citing works
Wilson, B., Samanta, M. K., Muthu, M. S., & Vinothapooshan, G. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.21 · Cited by 74 · see citing works
Current Medicinal Chemistry - Anti-Cancer Agents
(2019) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/cmcaca-15680118-662 · Cited by 71 · see citing works
Wei, F., Tian, T., Wei, F., Wang, T., Wang, P., Lin, X., Wang, J., Wang, D., & Ren, L. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s26541 · Cited by 67 · see citing works
Nagpal, K., Singh, S. K., & Mishra, D. N. (2012) · Drug Delivery · doi:10.3109/10717544.2012.738437 · Cited by 64 · see citing works
Self-citationBiochemical Differentiation of Cholinesterases from Normal and Alzheimers Disease Cortex
Ciro, A., Park, J., Burkhard, G., Yan, N., & Geula, C. (2012) · Current Alzheimer Research · doi:10.2174/156720512799015127 · Cited by 58 · see citing works
Ricci‐Júnior, E., dos Santos, E. P., de Brito‐Gitirana, L., Volta, Oliveira, Moreno, & Holandino, C. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s15860 · Cited by 52 · see citing works
Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.c12-00732 · Cited by 41 · see citing works
Self-citationRaut, S., Kirthivasan, B., Bommana, M. M., Squillante, E., & Sadoqi, M. (2010) · Nanotechnology · doi:10.1088/0957-4484/21/39/395102 · Cited by 35 · see citing works
Optimization of brain targeted gallic acid nanoparticles for improved antianxiety-like activity
Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.03.022 · Cited by 30 · see citing works
Self-citationAmini, H., & Ahmadiani, A. (2010) · Europe PMC (PubMed Central) · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Chitosan in nasal delivery systems for therapeutic drugs
Casettari, L., & Illum, L. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.003 · Cited by 448 · see citing works
Elnaggar, Y. S. R., Etman, S. M., Abdelmonsif, D. A., & Abdallah, O. Y. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24557 · Cited by 327 · see citing works
Jurcău, M. C., Andronie-Cioara, F. L., Jurcău, A., Marcu, F., Ţiț, D. M., Pașcalău, N., & Nistor-Cseppentö, D. C. (2022) · Antioxidants · doi:10.3390/antiox11112167 · Cited by 226 · see citing works
Bugnicourt, L., & Ladavière, C. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.06.002 · Cited by 202 · see citing works
Potential of Chitosan and Its Derivatives for Biomedical Applications in the Central Nervous System
Ojeda-Hernández, D. D., Canales-Aguirre, A. A., Matías‐Guiu, J., Gómez‐Pinedo, U., & Mateos‐Díaz, J. C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00389 · Cited by 172 · see citing works
Cunha, S., Costa, C. P., Loureiro, J. A., Alves, J., Peixoto, A. F. R. O., Forbes, B., Lobo, J. M. S., & Silva, A. C. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070599 · Cited by 156 · see citing works
Ursolic acid liposomes with chitosan modification: Promising antitumor drug delivery and efficacy
Wang, M., Zhao, T., Liu, Y., Wang, Q., Xing, S., Li, L., Wang, L., Liu, L., & Gao, D. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.11.014 · Cited by 136 · see citing works
Rajput, A., & Butani, S. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.01.040 · Cited by 114 · see citing works
Overcoming the Blood-Brain Barrier: Functionalised Chitosan Nanocarriers
Caprifico, A. E., Foot, P. J. S., Polycarpou, E., & Calabrese, G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111013 · Cited by 108 · see citing works
Chitosan-Based Nanocarriers for Nose to Brain Delivery
Aderibigbe, B. A., & Naki, T. (2019) · Applied Sciences · doi:10.3390/app9112219 · Cited by 104 · see citing works
Leyva-Gómez, G., Cortés, H., Magaña, J. J., Leyva-García, N., Quintanar-Guerrero, D., & Florán, B. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.02.009 · Cited by 102 · see citing works
Al‐Nemrawi, N. K., Alsharif, S. S. M., & Dave, R. H. (2018) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2018v10i5.26375 · Cited by 97 · see citing works
Use of Biodegradable, Chitosan-Based Nanoparticles in the Treatment of Alzheimer’s Disease
Manek, E., Darvas, F., & Petroianu, G. A. (2020) · Molecules · doi:10.3390/molecules25204866 · Cited by 97 · see citing works
Gutiérrez-Ruíz, S. C., Cortés, H., González‐Torres, M., Almarhoon, Z. M., Gürer, E. S., Sharifi‐Rad, J., & Leyva‐Gómez, G. (2024) · Journal of Biological Engineering · doi:10.1186/s13036-024-00403-w · Cited by 94 · see citing works
Pinto, M., Silva, V., Barreiro, S., Silva, R. V. D. S., Remião, F., Borges, F., & Fernandes, C. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101658 · Cited by 94 · see citing works
Abdel‐Moneim, A., El‐Shahawy, A. A. G., Yousef, A. I., El-Twab, S. M. A., Elden, Z. E., & Taha, M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.031 · Cited by 86 · see citing works
Simon, A., Amaro, M. I., Cabral, L. M., Healy, A. M., & de Sousa, V. P. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.01.066 · Cited by 84 · see citing works
Rajput, A., Bariya, A. H., Allam, A. A., Othman, S. I., & Butani, S. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-0540-6 · Cited by 83 · see citing works
Shehabeldine, A. M., & Hasanin, M. S. (2019) · Environmental Nanotechnology Monitoring & Management · doi:10.1016/j.enmm.2019.100252 · Cited by 76 · see citing works
Haider, M. F., Khan, S., Gaba, B., Alam, T., Baboota, S., Ali, J., & Ali, A. (2018) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2018.01.123 · Cited by 68 · see citing works
Nanoparticle-mediated growth factor delivery systems: A new way to treat Alzheimer's disease
Lauzon, M.-A., Daviau, A., Marcos, B., & Faucheux, N. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.024 · Cited by 65 · see citing works
The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders
Ngowi, E. E., Wang, Y., Qian, L., Helmy, Y. A. S. H., Anyomi, B. K., Li, T., Zheng, M., Jiang, E., Duan, S., Wei, J., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.629832 · Cited by 68 · see citing works
Kaur, H., Ghosh, S., Kumar, P., Basu, B., & Nagpal, K. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119927 · Cited by 59 · see citing works
Self-citationAdvances in Nanomedicine for the Treatment of Alzheimer’s and Parkinson’s Diseases
Hernando, S., Gartziandia, O., Herrán, E., Pedraz, J. L., Igartúa, M., & Hernández, R. M. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0019 · Cited by 48 · see citing works
Salwa, & Kumar, L. (2023) · Microchemical Journal · doi:10.1016/j.microc.2023.108944 · Cited by 47 · see citing works
Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go
Prasanna, P., & Upadhyay, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00224 · Cited by 46 · see citing works
Nanomedicines in the Management of Alzheimer’s Disease: Current View and Future Prospects
Chopra, H., Bibi, S., Singh, I., Kamal, M. A., Islam, F., Alhumaydhi, F. A., Emran, T. B., & Cavalu, S. D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.879114 · Cited by 47 · see citing works
Khodaverdi, K., Bakhshi, A., Mozafari, M. R., & Naghib, S. M. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134962 · Cited by 45 · see citing works
El-Hameed, A. M. A. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00699-7 · Cited by 43 · see citing works
Kaur, R., Rajput, R., Nag, P., Kumar, S., Rachana, R., & Singh, M. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.04.030 · Cited by 40 · see citing works
Liu, S., & Ho, P. C. (2017) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12797 · Cited by 39 · see citing works
Amini, M., & Abdolmaleki, Z. (2021) · Neuropsychobiology · doi:10.1159/000519534 · Cited by 36 · see citing works
Natural biomaterials in brain repair: A focus on collagen
Uçar, B. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105033 · Cited by 34 · see citing works
Lauzon, M.-A., Marcos, B., & Faucheux, N. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.11.075 · Cited by 31 · see citing works
Significance of Algal Polymer in Designing Amphotericin B Nanoparticles
Bhatia, S., Kumar, V., Sharma, K., Nagpal, K., & Bera, T. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/564573 · Cited by 27 · see citing works
Self-citationJamshidnejad-Tosaramandani, T., Kashanian, S., Karimi, I., & Schiöth, H. B. (2024) · Polymers · doi:10.3390/polym16040510 · Cited by 28 · see citing works
El-Hameed, A. M. A., Yousef, A. I., El-Twab, S. M. A., El‐Shahawy, A. A. G., & Abdel‐Moneim, A. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921020061 · Cited by 26 · see citing works
Grosso, C., Silva, A., Delerue-Matos, C. M., & Barroso, M. F. (2023) · Pharmaceuticals · doi:10.3390/ph16121721 · Cited by 24 · see citing works
Kumar, G. V., Su, C., & Velusamy, P. (2016) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2016.05.054 · Cited by 23 · see citing works
Abomosallam, M., Hendam, B. M., Abdallah, A. A., Refaat, R., Elshatory, A., & El-Hak, H. N. G. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01151-x · Cited by 22 · see citing works
Rajamanickam, G., & Manju, S. L. (2023) · Macromolecular Research · doi:10.1007/s13233-023-00114-z · Cited by 22 · see citing works
Carbohydrate Nanoparticles for Brain Delivery
Lalatsa, A., & Barbu, E. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.05.004 · Cited by 22 · see citing works
Drug Delivery Systems and Strategies to Overcome the Barriers of Brain
Garg, Y., Kapoor, D. N., Sharma, A. K., & Bhatia, A. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612828666211222163025 · Cited by 20 · see citing works
Elawad, M. A., Ayaz, M., Mosa, O. F., Usman, A., Hamdoon, A. A. E., Almawash, S., Salim, L. H. M., Ahmed, A., & Elkhalifa, M. E. M. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400525 · Cited by 20 · see citing works
Gascon, S., Solano, A. G., Kheir, W. E., Therriault, H., Berthelin, P., Cattier, B., Marcos, B., Virgilio, N., Paquette, B., Faucheux, N., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12040356 · Cited by 20 · see citing works
Nanomedicine against Alzheimer’s and Parkinson’s Disease
Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666201021140904 · Cited by 19 · see citing works
Self-citationChitosan based nanocarriers as a promising tool in treatment and management of inflammatory diseases
Goyal, S., Thirumal, D., Rana, J., Gupta, A. K., Kumar, A., Babu, M. A., Kumar, P., & Sindhu, R. K. (2024) · Carbohydrate Polymer Technologies and Applications · doi:10.1016/j.carpta.2024.100442 · Cited by 19 · see citing works
Li, L., Wang, Q., Zhang, X., Luo, L., He, Y., Zhu, R., & Gao, D. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0115 · Cited by 18 · see citing works
Alternative methods for the pilot-scale production and characterization of chitosan nanoparticles
Alves, H. J., Gasparrini, L. J., Silva, F. E. B., Caciano, L., de Muñiz, G. I. B., Ballester, E. L. C., Cremonez, P. A., & Arantes, M. K. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11343-5 · Cited by 17 · see citing works
Amaro, M. I., Simon, A., Cabral, L. M., de Sousa, V. P., & Healy, A. M. (2015) · Solid State Sciences · doi:10.1016/j.solidstatesciences.2015.09.004 · Cited by 17 · see citing works
Treatment of Alzheimer's Disease: Classical Therapeutic Approach
Bajić, V., Sudar-Milovanovic, E. M., Spremo‐Potparević, B., Živković, L., Milicevic, Z., Stanimirović, J., Bogdanović, N., & Isenović, E. R. (2015) · Current Pharmaceutical Analysis · doi:10.2174/1573412911666150611184740 · Cited by 16 · see citing works
Nanotechnology‐empowered therapeutics targeting neurodegenerative diseases
Wang, Z., Gonzalez, K. M., Cordova, L. E., & Lu, J. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1907 · Cited by 18 · see citing works
Liu, C., Wu, K.-Z., Gao, H. X., Li, J., & Xu, X. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s380550 · Cited by 15 · see citing works
An applied quantum-chemical model for genipin-crosslinked chitosan (GCS) nanocarrier
Nasrabadi, M., Morsali, A., & Beyramabadi, S. A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.013 · Cited by 15 · see citing works
Toxicological study of the Primaquine phosphate loaded chitosan nanoparticles in mice
Rajera, R., Nagpal, K., Singh, S. K., & Mishra, D. N. (2013) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2013.08.019 · Cited by 15 · see citing works
Self-citationSheweita, S. A., Alian, D. M. E., Haroun, M., Nounou, M. I., Patel, A. A., & El-Khordagui, L. K. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/9944985 · Cited by 14 · see citing works
Alzheimer hastalığı tedavisinde nano boyutlu ilaç taşıyıcı sistemlerin kullanımı
GÜN, D. N. (2016) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.1501/eczfak_0000000579 · Cited by 13 · see citing works
Shamami, M. S., Ekhlaspour, M., Sulaiman, J. M. A., Kareem, R. A., Alsultany, N. M. A., Nasiri, K., & Shenasa, N. (2025) · Nanotoxicology · doi:10.1080/17435390.2025.2484002 · Cited by 11 · see citing works
Narayan, S., Gupta, P. K., & Nagpal, K. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00062 · Cited by 12 · see citing works
Self-citationIbrahim, R. M., Teaima, M. H. M., El-Nabarawi, M. A., & Badawi, N. M. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105885 · Cited by 10 · see citing works
Polyphenol-conjugated polysaccharide nanoplatforms for enhanced therapeutic efficacy
Narayan, S., Nagpal, K., & Kumar, P. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2514714 · Cited by 10 · see citing works
Self-citationMangia, L. H. R., Ferraz, H. C., de Souza, R. S., Pereira, M. C. D. S., & Pinto, J. C. (2021) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2021.126776 · Cited by 10 · see citing works
Formulation and Characterization of Propranolol Nanoparticles for Transmucosal Nasal Drug Delivery
Nag, P., Rajput, R., Dhaliwal, S., Kumar, S., Prajapat, D., & Singh, M. (2015) · Macromolecular Symposia · doi:10.1002/masy.201400051 · Cited by 9 · see citing works
Design and Development of Lomustine Loaded Chitosan Nanoparticles for Efficient Brain Targeting
Anand, A., Iyer, B. R., Ponnusamy, C., Pandiyan, R., & Sugumaran, A. (2020) · Cardiovascular & Hematological Agents in Medicinal Chemistry · doi:10.2174/1871525718666200203112502 · Cited by 9 · see citing works
Huda, N. H., Gauri, B., Benson, H. A., & Chen, Y. (2018) · Journal of Analytical Methods in Chemistry · doi:10.1155/2018/1841937 · Cited by 9 · see citing works
Minocycline encapsulated chitosan nanoparticles for central antinociceptive activity
Nagpal, K., Singh, S. K., & Mishra, D. N. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.07.055 · Cited by 8 · see citing works
Self-citationNanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease
Choubdar, N., & Avizheh, S. (2019) · Nanoscience & Nanotechnology-Asia · doi:10.2174/2210681209666190228143636 · Cited by 7 · see citing works
Kalra, V., Silakari, O., & Tiwary, A. K. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125635 · Cited by 6 · see citing works
Abdul‐Hamid, M., Galaly, S. R., Mohamed, H. M., Mostafa, F., & Abdel‐Moneim, A. (2023) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-023-00441-1 · Cited by 6 · see citing works
Biopolymers as promising vehicles for drug delivery to the brain
Mythri, R. B., & Aishwarya, M. (2023) · Drug Metabolism Reviews · doi:10.1080/03602532.2023.2281855 · Cited by 6 · see citing works
Advances in Neurotherapeutic Delivery Technologies
Mr Pradeep, K. (2015) · OMICS International eBooks · doi:10.4172/978-1-63278-036-2-037 · Cited by 6 · see citing works
Acetylcholinesterase inhibitors and nanoparticles on Alzheimer’s disease: a review
Silva, S., Almeida, A. J., & Vale, N. (2021) · Journal of Nanoparticle Research · doi:10.1007/s11051-020-05118-9 · Cited by 6 · see citing works
Nanoparticle-mediated delivery of AChE inhibitors for the treatment of Alzheimer’s disease
Namdeo, P., Mathew, J., & Garg, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85544-0.00004-6 · Cited by 5 · see citing works
Extravaganza of Nanobiotechnology in the Diagnosis and Treatment of Dementia Patients
Bhattacharya, S. (2022) · Current Pharmaceutical Biotechnology · doi:10.2174/1385272827666221027103050 · Cited by 6 · see citing works
Ezzat, S. M., Salem, M. A., El Mahdy, N. M., & Ragab, M. F. (2021) · Naturally Occurring Chemicals Against Alzheimer's Disease · doi:10.1016/b978-0-12-819212-2.00007-4 · Cited by 4 · see citing works
Nanotechnology Based Approaches for Neurodegenerative Disorders: Diagnosis and Treatment
Hernando, S., Herrán, E., Pedraz, J. L., Igartúa, M., & Hernández, R. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-57696-1_3 · Cited by 4 · see citing works
Nanopolymer Chitosan in Cancer and Alzheimer Biomedical Application
Putri, A. D., Murti, B. T., Sabela, M. I., Kanchi, S., & Bisetty, K. (2017) · doi:10.1002/9781119364849.ch12 · Cited by 4 · see citing works
Dey, P., Narayan, S., & Nagpal, K. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00611 · Cited by 3 · see citing works
Self-citationA Medico-Biological Approach to Chitosan Bionanocomposites
Khanna, N., Chatterji, T., Singh, S., & Khanna, N. (2023) · Biological and medical physics, biomedical engineering · doi:10.1007/978-981-19-9646-7_3 · Cited by 3 · see citing works
Self-citationChitosan-based nanoparticles for the treatment of neurological disorders
Enejiyon, S. O., Komolafe, L. I., Ahmad, N. H., Muhammad, F. E., Okoye, U. M., Oyewole, O. A., & Adetunji, C. O. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13997-0.00014-x · Cited by 3 · see citing works
Polymeric nanoparticles as drug delivery systems for dementia
Esteruelas, G., Souto, E. B., Cano, A. C., Ettcheto, M., Espina, M., Camins, A., García, M. L., & Sánchez‐López, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824331-2.00006-6 · Cited by 3 · see citing works
Nanoengineering and nanotechnology for diagnosis and treatment of CNS and neurological diseases
Kumar, P., Dwivedi, A., Plaimas, K., Sagar, K., & Chauhan, L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91182-5.00006-1 · Cited by 3 · see citing works
Polymeric nanosystems for neurological therapeutics
Noah, N. M., & Ndangili, P. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85656-0.00010-3 · Cited by 3 · see citing works
Nano chitosan anchored copper-ferrite: a smart magnetic nanocomposite agent for drug delivery
Adebayo, A. O., Alli, Y. A., Bamisaye, A., & Adewuyi, S. (2023) · Emergent Materials · doi:10.1007/s42247-023-00584-y · Cited by 3 · see citing works
Assaf, S. M., Almnayyes, A. I., Obaidat, R., & Maaroof, K. T. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107803 · Cited by 2 · see citing works
Aslam, S., Tulain, U. R., Zahid, F., Ali, Z., Erum, A., Alamri, A. H., Fatease, A. M. A., Amin, M., Wan, G., & Din, F. U. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151998 · Cited by 2 · see citing works
Kumar, D., Kondaveeti, S. B., Agrawal, M., Kumar, A., Awasthi, A., Mahmood, S., Singh, T. G., & Kumar, M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05857-1 · Cited by 2 · see citing works
Hou, X., Xu, J., He, S., Bai, J., Guan, Y., Pan, X., Yang, J., Zhang, N., Yang, S., Hu, J., et al. (2023) · Polymers for Advanced Technologies · doi:10.1002/pat.6120 · Cited by 2 · see citing works
Nose-to-Brain Drug Delivery Strategies for the Treatment of Neurological Disorders
Prabakaran, A., Bhatane, D., & Alexander, A. (2023) · Springer eBooks · doi:10.1007/978-981-99-6807-7_17 · Cited by 2 · see citing works
Thyme oil-loaded chitosan microparticles: an antibacterial approach against pathogenic bacteria
Thakur, A., & Sharma, K. (2025) · 3 Biotech · doi:10.1007/s13205-025-04301-w · Cited by 2 · see citing works
Brisbin, R., Bartolo, M., Leveille, M. P., Rajan, A. K., Jahan, B., McCloskey, K. E., Gopinathan, A., Ghosh, S., & Baxter, R. D. (2022) · Scientific Reports · doi:10.1038/s41598-022-04851-6 · Cited by 2 · see citing works
Amin, O. M., Khalifa, M. K. A., El-Fattah, M. A. A., Allam, A., Aboutaleb, A. S., & Al‐Najjar, A. H. (2025) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2025.2592102 · Cited by 1 · see citing works
Ismail, S. M., Eldin, Z. E., Elbakkay, M. H., Abdel‐Moneim, A., El‐Shahawy, A. A. G., & Zanaty, M. I. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10595-x · Cited by 1 · see citing works
Nanoparticulate systems for sustained delivery of paracrine factors
Arabi, L., Ho, J. Q., Javdani, N., Jones, S. M., Chen, I., Sharaf, M., Aieneravaie, M., Georgala, P., Sepand, M. R., Rafat, M., et al. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817434-0.00011-8 · Cited by 1 · see citing works
Biological nanodrugs for brain targeting
Jovčevska, I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90773-6.00028-2 · Cited by 1 · see citing works
Neuroprotection through nanotechnology
Kaur, J., Khan, F. D., & Naqvi, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00080-4 · Cited by 1 · see citing works
Nanotechnological Drug Delivery Strategies in Epilepsy
Esteruelas, G., Bonilla-Vidal, L., Ettcheto, M., Haro, I., Gomara, M. J., Souto, E. B., Espina, M., Camins, A., García, M. L., Sánchez‐López, E., et al. (2023) · Springer eBooks · doi:10.1007/978-981-99-6807-7_14 · Cited by 1 · see citing works
Mohammed, S. R., Abdel‐Moneim, A., Abdel-Reheim, E., Ramadan, H., Eldin, Z. E., El‐Shahawy, A. A. G., & Yousef, A. I. (2024) · Journal of Optoelectronic and Biomedical Materials · doi:10.15251/jobm.2024.162.73 · Cited by 1 · see citing works
Biomarker detection of Parkinson’s disease: therapy and treatment using nanomaterials
Nanda, R., Panda, P., & Mishra, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817923-9.00017-1 · Cited by 1 · see citing works
- Authors
- Nagpal, K., Singh, S. K., & Mishra, D. N.
- Affiliations
- Guru Jambheshwar University of Science and Technology (IN)
- Corresponding author
- Nagpal, Kalpana
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 59
- Pages
- 72-83
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2024268060
- Cited by
- 116
- References
- 32
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 16 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 1
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- rivastigmine, chitosan nanoparticles, brain drug delivery, central composite design, scopolamine-induced amnesia, maximum tolerated dose, encapsulation efficiency, zeta potential, particle size, in vitro drug release, Alzheimer's disease
- MeSH terms
- Rivastigmine, Amnesia, Animals, Behavior, Animal, Body Weight, Brain, Dose-Response Relationship, Drug, Drug Carriers, Drug Compounding, Drug Evaluation, Preclinical, Factor Analysis, Statistical, Male, Memory, Polysorbates, Scopolamine, Treatment Outcome, Neuroprotective Agents, Maze Learning, Chitosan, Phenylcarbamates, Mice, Rats, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review