The DOI matches its Crossref record; 136 of the 137 references it cites were found in a registry or an index.
Central control of autonomic function and involvement in neurodegenerative disorders
Abstract
The central autonomic network includes the insular cortex, anterior cingulate cortex, amygdala, hypothalamus, periaqueductal gray, parabrachial nucleus, nucleus of the solitary tract, ventrolateral reticular formation of the medulla, and medullary raphe. These areas: are reciprocally interconnected; receive converging visceral and somatosensory information; generate stimulus-specific patterns of autonomic, endocrine, and motor responses; and are regulated according to the behavioral state, including the sleep-wake cycle. Several components of the central autonomic networks are affected in neurodegenerative disorders characterized by the presence of intracellular inclusions containing α-synuclein. These include multiple system atrophy (MSA), characterized by accumulation of glial cytoplasmic inclusions, and Lewy body disorders, including Parkinson disease (PD), dementia with Lewy bodies, and the so-called "pure" autonomic failure. In MSA, involvement of the rostral ventrolateral medulla may be primarily responsible for orthostatic hypotension; involvement in the pontine micturition area, sacral preganglionic nucleus, and Onuf nucleus is responsible for neurogenic bladder; and involvement of the pre-Bötzinger complex and medullary raphe may contribute to sleep-related respiratory abnormalities. In contrast, Lewy body disorders are characterized by early involvement of the enteric nervous system and cardiac sympathetic ganglia. The dorsal motor nucleus of the vagus is affected b…
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“Additionally, the c-ICNs have also been associated with autonomic nervous system (ANS) modulation [45–50] possibly helping to explain the ANS dysfunction consistently reported across psychopathologies [51, 52].”
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Cites
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318
Second consensus statement on the diagnosis of multiple system atrophy
Gilman, S., Wenning, G. K., Low, P. A., Brooks, D. J., Mathias, C. J., Trojanowski, J. Q., Wood, N. W., Colosimo, C., Dürr, A., Fowler, C. J., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000324625.00404.15 · Cited by 3,140
Interoception: the sense of the physiological condition of the body
(Bud) Craig, A. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00090-4 · Cited by 2,556
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
The sympathetic control of blood pressure
Guyenet, P. G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1902 · Cited by 1,863
Braak, H., R�b, U., Gai, W. P., & Del Tredici, K. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0808-2 · Cited by 1,683
The neural control of micturition
Fowler, C. J., GRIFFITHS, D. J., & de Groat, W. C. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2401 · Cited by 1,492
LeDoux, J. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.005 · Cited by 1,281
Neural mechanisms of autonomic, affective, and cognitive integration
Critchley, H. D. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20749 · Cited by 1,214
Research works printed but not linked: 1
- Jean, 1991, The nucleus tractus solitarius: neuroanatomic, neurochemical and functional aspects, Arch Int Physiol Biochim Biophys, 99, A3
Cited by
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Items 101–129 of 129
Clinical Implications of the Enlarged Autonomic Nervous System
Cardinali, D. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-57571-1_7 · Cited by 2
Interpreting Heart Rate Variability in Sleep: Why, When, and How?
Pagani, M., Guaraldi, P., Baschieri, F., Lucini, D., & Cortelli, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-62263-3_10 · Cited by 2
Impact of Early Blood Pressure Lowering in Patients Presenting with Acute Ischemic Stroke
Maud, A., Rodriguez, G. J., Vellipuram, A., Sheriff, F. G., Ghatali, M., Gupta, V. S., Khatri, R., & Cruz‐Flores, S. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01497-0 · Cited by 2
Nomoto, S., Oeda, T., Tomii, Y., Kasahara, N., Uchizumi, H., Ishihara, T., Kohsaka, M., Toda, S., Umemura, A., Park, K., et al. (2026) · BMJ Neurology Open · doi:10.1136/bmjno-2025-001497 · Cited by 1
Crispino, M., D’Angelo, S., Ranciati, S., & Mira, A. (2018) · Springer proceedings in mathematics & statistics · doi:10.1007/978-3-030-00039-4_1 · Cited by 1
Sweating as a presentation of focal epilepsy: clinical case report
López-Bravo, A., Sanchinel, A. A. S., Gracia, M. M., & Viloria‐Alebesque, A. (2021) · Neurología (English Edition) · doi:10.1016/j.nrleng.2020.06.009 · Cited by 1
Autonomic failure: Clinicopathologic, physiologic, and genetic aspects
Younger, D. S. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-98818-6.00020-0 · Cited by 1
Kocsis, B., & Topchiy, I. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02687-7 · Cited by 1
Central autonomic dysfunction in multiple system atrophy: can we measure it with MRI?
van Eimeren, T. (2020) · Clinical Autonomic Research · doi:10.1007/s10286-020-00695-0 · Cited by 1
Dysautonomia: From the Brain Disorders to Neuropathies and Including Diabetes
Flotats, A., & Carrió, I. (2016) · Springer eBooks · doi:10.1007/978-3-319-45800-7_9
Eldahan, K. C. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.064
Effect of cold oral stimulation on orthostatic hypotension in multiple system atrophy: a case study
Uzawa, H., Takeuchi, S., & Nishida, Y. (2020) · Journal of Physical Therapy Science · doi:10.1589/jpts.32.473
Neurological Red Flags in Common Neurological Conditions Associated with PoTS
Theochari, E. G. (2020) · Springer eBooks · doi:10.1007/978-3-030-54165-1_11
Shinoda, L., Rodrigues, L. D., Freitas, L., Cravo, S. L. D., Campos, R. R., Scorza, C. A., Scorza, F. A., & Faber, J. (2021) · Research Square · doi:10.21203/rs.3.rs-745726/v1
Schettino, M., Parrillo, C., Gazzellini, S., Cairone, L., Baldassari, G., Thayer, J. F., Giove, F., Napolitano, A., & Ottaviani, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3015876/v1
Multiple System Atrophy With Intractable Fever: A Case ReportPreprint
yu, D., Li, H., Tang, W., & Wang, W. (2023) · Research Square · doi:10.21203/rs.3.rs-3146254/v1
Ollari, J., Deschle, F., Rubiño, V., Blanco, R., Ciufia, N., & Delembert, W. (2023) · Vertex Revista Argentina de Psiquiatría · doi:10.53680/vertex.v34i161.487
Characteristics of brain network after cardiopulmonary phase synchronization enhancement
Ren, Y., Xie, L., Wang, X., & Zhang, J. (2025) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2025.104396
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Clark, I. H., Heinmiller, A., Zhu, W., Zhu, X.-H., Strell, P., Roushdy, Z., Vernekar, M., Johnson, S. T., Natera-Rodriguez, D. E., Sun, K. Y., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.31.645325
Connectivity-based localization and mapping of central epilepsy semiology
Zhu, M., Song, J., Shi, X., Shen, K., Wang, L., Wang, Z., Liu, L., Wu, Y., Guo, Y., Xiao-lin, Y., et al. (2025) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2025.110662
Tarisawa, M., Matsushima, M., Kudo, A., Nomura, T., Uwatoko, H., Shirai, S., Takahashi‐Iwata, I., Sakushima, K., Yaguchi, H., Yokota, I., et al. (2025) · The Cerebellum · doi:10.1007/s12311-025-01905-z
Syncope Unveiling a Diagnosis of Adult-Onset Leukoencephalomyelopathy: A case reportPreprint
Kasemsantitham, A., Singtokum, N., Taychargumpoo, C., Amornvit, J., Chokesuwattanaskul, R., & Jakchairoongruang, K. (2025) · Research Square · doi:10.21203/rs.3.rs-7445286/v1
Linard, M., Bousiges, O., Mondino, M., Sanna, L., Cretin, B., Muller, C., Anthony, P., Demynck, C., Philippi, N., & Blanc, F. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01935-z
Stasiak, J. E., Wang, J., Dundon, N. M., Rizor, E. J., Barandon, P. L., Villanueva, C. M., Babenko, V., Li, T. L., Sabugo, K. M., Grafton, S. T., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.23.707545
Vieillissement cognitif réussi : système nerveux autonome, sommeil et interactions sociales
Martin, M. S. (2014) · theses.fr (ABES) · doi:10.70675/35437193z315bz403cza20dz5c3eb6890517
Brainstem-cortical dynamics of Parkinson’s disease autonomic failurePreprint
Dhanis, H., Dore, C., Smith, N., Sheehan, G., Yadav, P., & Lambert, C. (2026) · medRxiv · doi:10.64898/2026.05.07.26352636
Pattanayak, S., Srivastava, N. K., Kumar, D. A., Joshi, D., Roy, A., Singh, S. K., Prasad, R., Tripathi, S., Verma, A., Ojha, R., et al. (2026) · Brain and Behavior · doi:10.1002/brb3.71624
Jin, B., Lee, Y., Lee, S., Yoon, B., Jeong, Y. J., & Cheon, S. (2026) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.70817
Sakatani, H., Ueda, R., Tha, K. K., Murakami, K., 北川, 真., Kubota, S. I., Kono, M., Murakami, M., & Hotomi, M. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112185
Metadata
- Authors
- Cersosimo, M. G., & Benarroch, E. E.
- Affiliations
- Universidad de Buenos Aires (AR)
- Mayo Clinic (US)
- Corresponding author
- Eduardo Elias Benarroch
- Venue
- Handbook of Clinical Neurology
- Publisher
- Elsevier
- Published
- 2013
- Volume
- 117
- Pages
- 45-57
- ISSN
- 0072-9752 (ISSN-L)
- OpenAlex
- W104100557
- Cited by
- 129
- References
- 137
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 9 · 2023: 13 · 2022: 7 · 2021: 18 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 12 · 2016: 8 · 2015: 12 · 2014: 7
- FWCI
- 24.87
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Handbook of clinical neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- central autonomic network, autonomic dysfunction, neurodegenerative diseases, alpha-synuclein, multiple system atrophy, Lewy body disease, Parkinson's disease, dementia with Lewy bodies, pure autonomic failure, orthostatic hypotension, neurogenic bladder, dorsal motor nucleus of the vagus, enteric nervous system, rostral ventrolateral medulla, pre-Bötzinger complex, medullary raphe, sleep-wake cycle
- MeSH terms
- Afferent Pathways, Animals, Autonomic Nervous System, Autonomic Nervous System Diseases, Brain, Humans, Neurodegenerative Diseases
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