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Cited by 158Cognitive Functions and MemoryTranscranial Magnetic Stimulation StudiesNeuroscience and Neuropharmacology Research

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Principles of Neuroplasticity-Based Rehabilitation

Nahum, Mor, Lee, Hyunkyu, Merzenich, Michael M.·2013·Progress in Brain Research
DOI 10.1016/b978-0-444-63327-9.00009-6
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Abstract

The purpose of this review is to summarize how our perspective about the neuroscience of brain plasticity, informed by perceptual, experimental, and cognitive psychology, has led to the designs of a new class of therapeutic tools developed to drive functionally distorted and damaged brains in corrective directions. How does neuroplasticity science inform us about optimal therapeutic program designs? How do we apply that science, using modern technology, to drive neurological changes that address both the neurobehavioral distortions and the resulting behavioral deficits that are expressed in specific neurological and psychiatric disorders? By what strategies can we achieve the strongest and most complete rehabilitative corrections? These are questions that we have extensively explored in our efforts to establish new medical applications of neuroplasticity-based therapeutics. Here, we summarize the state of this rapidly emerging area of translational neuroscience, beginning with an explanation of the scientific premises and strategies, then describing their implementation in therapeutic software to address two human illnesses: the treatment of social cognition deficits in chronic schizophrenia and in autism; and the amelioration of age-related functional decline using strategies designed to delay the onset of--and potentially prevent--Alzheimer's Disease and related causes of dementia in aging.

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References 115 · Cited by 158

Research works printed but not linked: 88

  1. Addington, 1998, Facial affect recognition and information processing in schizophrenia and bipolar disorder, Schizophr. Res., 32, 171, 10.1016/S0920-9964(98)00042-5 · DOI
  2. Addington, 2006, Influence of social perception and social knowledge on cognitive and social functioning in early psychosis, Br. J. Psychiatry, 189, 373, 10.1192/bjp.bp.105.021022 · DOI · Paper page
  3. Adolphs, 1999, Social cognition and the human brain, Trends Cogn. Sci., 3, 469, 10.1016/S1364-6613(99)01399-6 · DOI · Paper page
  4. Ahissar, 2009, Reverse hierarchies and sensory learning, Philos. Trans. R Soc. Lond. B Biol. Sci., 364, 285, 10.1098/rstb.2008.0253 · DOI
  5. Aston-Jones, 2005, An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance, Annu. Rev. Neurosci., 28, 403, 10.1146/annurev.neuro.28.061604.135709 · DOI · Paper page
  6. Ball, 2007, The impact of speed of processing training on cognitive and everyday functions, J. Gerontol. B Psychol. Soc. Sci., 62, 19, 10.1093/geronb/62.special_issue_1.19 · DOI
  7. Bao, 2001, Cortical remodeling induced by activity of ventral tegmental dopamine neurons, Nature, 412, 79, 10.1038/35083586 · DOI · Paper page
  8. Bao, 2002, Suppression of cortical representation through backward conditioning, Proc. Natl. Acad. Sci. U. S. A., 100, 1405, 10.1073/pnas.0337527100 · DOI
  9. Bartholomeusz, 2012, Neurocognitive and social cognitive approaches for improving functional outcome in early psychosis: theoretical considerations and current state of evidence, Schizophr. Res. Treatment, 2012, 815315, 10.1155/2012/815315 · DOI
  10. Bell, 2009, Neurocognition, social cognition, perceived social discomfort, and vocational outcomes in schizophrenia, Schizophr. Bull., 35, 738, 10.1093/schbul/sbm169 · DOI
  11. Berry, 2010, The influence of perceptual training on working memory in older adults, PLoS One, 5, 311537, 10.1371/journal.pone.0011537 · DOI
  12. Billeke, 2013, Social cognition in schizophrenia: from social stimuli processing to social e engagement, Front. Psychiatry, 4, 4, 10.3389/fpsyt.2013.00004 · DOI
  13. Botvinick, 2005, Viewing facial expressions of pain engages cortical areas involved in the direct experience of pain, Neuroimage, 25, 312, 10.1016/j.neuroimage.2004.11.043 · DOI
  14. Bredesen, 2010, Importance of the caspase cleavage site in amyloid-B protein precursor, J. Alzheimers Dis., 22, 57, 10.3233/JAD-2010-100537 · DOI
  15. Brothers, 1990, The neural basis of primate social communication, Motiv. Emot., 14, 81, 10.1007/BF00991637 · DOI
  16. Brothers, 1990, The social brain: a project for integrating primate behavior and neurophysiology in a new domain, Concepts Neurosci., 1, 27
  17. Brune, 2007, Mental state attribution, neurocognitive functioning, and psychopathology: what predicts poor social competence in schizophrenia best?, Schizophr. Res., 92, 151, 10.1016/j.schres.2007.01.006 · DOI
  18. Choi, 2009, Social cognition training for individuals with schizophrenia: a review of targeted interventions, Clin. Psychopharm. Neurosci., 27, 29
  19. Compte, 2003, Temporally irregular mnemonic persistent activity in prefrontal neurons of monkeys during a delayed response task, J. Neurophysiol., 90, 3441, 10.1152/jn.00949.2002 · DOI
  20. Couture, 2006, The functional significance of social cognition in schizophrenia: a review, Schizophr. Bull., 32, S44, 10.1093/schbul/sbl029 · DOI
  21. de Villers-Sidani, 2011, Lifelong plasticity in the rat auditory cortex: basic mechanisms and role of sensory experience, Prog. Brain Res., 191, 119, 10.1016/B978-0-444-53752-2.00009-6 · DOI
  22. de Villers-Sidani, 2010, Recovery of functional and structural age-related changes in the rat primary auditory cortex with operant training, Proc. Natl. Acad. Sci. U. S. A., 107, 13900, 10.1073/pnas.1007885107 · DOI
  23. Edwards, 2002, Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review, Clin. Psychol. Rev., 22, 789, 10.1016/S0272-7358(02)00130-7 · DOI
  24. Edwards, 2001, Facial affect and affective prosody recognition in first episode schizophrenia, Schizophr. Res., 48, 235, 10.1016/S0920-9964(00)00099-2 · DOI
  25. Edwards, 2009, The longitudinal impact of cognitive speed of processing training on driving mobility, Gerontologist, 49, 485, 10.1093/geront/gnp042 · DOI
  26. Engineer, 2012, Inverted-U function relating cortical plasticity and task difficulty, Neuroscience, 205, 81, 10.1016/j.neuroscience.2011.12.056 · DOI
  27. Frith, 1996, Exploring 'theory of mind' in people with schizophrenia, Psychol. Med., 26, 521, 10.1017/S0033291700035601 · DOI
  28. Froemke, 2007, A synaptic memory trace for cortical receptive field plasticity, Nature, 450, 425, 10.1038/nature06289 · DOI · Paper page
  29. Froemke, 2013, Long-term modification of cortical synapses improves sensory perception, Nat. Neurosci., 16, 79, 10.1038/nn.3274 · DOI
  30. Goldman Rakic, 1995, Cellular basis of working memory, Neuron, 14, 477, 10.1016/0896-6273(95)90304-6 · DOI · Paper page
  31. Green, 2012, Social cognition in schizophrenia, Part 1: performance across phase of illness, Schizophr. Bull., 38, 854, 10.1093/schbul/sbq171 · DOI
  32. Green, 2006, Cognitive impairment and functional outcome in schizophrenia and bipolar disorder, J. Clin. Psychiatry, 67, 3
  33. Green, 2007, Stimulating the development of drug treatments to improve cognition in schizophrenia, Annu. Rev. Clin. Psychol., 3, 159, 10.1146/annurev.clinpsy.3.022806.091529 · DOI
  34. Gur, 2002, An fMRI study of facial emotion processing in patients with schizophrenia, Am. J. Psychiatry, 159, 1992, 10.1176/appi.ajp.159.12.1992 · DOI
  35. Hahn, 2013, Selectively and progressively disrupted structural connectivity of functional brain networks in Alzheimer’s Disease revealed by a novel framework to analyze edge distributions of networks detecting disruptions with strong statistical evidence, Neuroimage, 81, 96, 10.1016/j.neuroimage.2013.05.011 · DOI
  36. Harrington, 2005, Theory of mind in schizophrenia: a critical review, Cogn. Neuropsychiatry, 10, 249, 10.1080/13546800444000056 · DOI
  37. Heister, 2011, Predicting MCI outcome with clinically available MRI and CSF biomarkers, Neurology, 77, 1619, 10.1212/WNL.0b013e3182343314 · DOI
  38. Heneka, 2010, Locus ceruleus controls Alzheimer’s disease pathology by modulating microglial functions through norepinephrine, Proc. Natl. Acad. Sci. U. S. A., 107, 6058, 10.1073/pnas.0909586107 · DOI
  39. Hochstein, 2002, View from the top: hierarchies and reverse hierarchies in the visual system, Neuron, 36, 791, 10.1016/S0896-6273(02)01091-7 · DOI
  40. Horan, 2012, Social cognition in schizophrenia, Part 2: 12-month stability and prediction of functional outcome in first-episode patients, Schizophr. Bull., 38, 865, 10.1093/schbul/sbr001 · DOI
  41. Jagust, 2013, Vulnerable neural systems and the borderland of brain aging and neurodegeneration, Neuron, 77, 219, 10.1016/j.neuron.2013.01.002 · DOI
  42. Jardanhazi-Kurtz, 2009, Distinct adrenergic system changes and neuroinflammation in response to induced locus ceruleus degeneration in A APP/PS1 transgenic mice, Neuroscience, 276, 396
  43. Kenny, 2012, Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer’s disease, Brain, 135, 569, 10.1093/brain/awr327 · DOI
  44. Kilgard, 1998, Cortical map reorganization enabled by nucleus basalis activity, Science, 279, 1714, 10.1126/science.279.5357.1714 · DOI
  45. Knudsen, 2002, Instructed learning in the auditory localization pathway of the barn owl, Nature, 417, 322, 10.1038/417322a · DOI · Paper page
  46. Koffie, 2011, Alzheimer’s disease: synapses gone cold, Mol. Neurodegener., 6, 63, 10.1186/1750-1326-6-63 · DOI
  47. Kohler, 2010, Facial emotion perception in schizophrenia: a meta-analytic review, Schizophr. Bull., 36, 1009, 10.1093/schbul/sbn192 · DOI
  48. Kurtz, 2012, Social cognitive training for schizophrenia: a meta-analytic investigation of controlled research, Schizophr. Bull., 38, 1092, 10.1093/schbul/sbr036 · DOI · Paper page
  49. Lamm, 2007, The neural substrate of human empathy: effects of perspective-taking and cognitive appraisal, J. Cogn. Neurosci., 19, 42, 10.1162/jocn.2007.19.1.42 · DOI · Paper page
  50. Levitt, 1971, Transformed up-down methods in psychoacoustics, J. Acoust. Soc. Am., 49
  51. Lo, 2011, Longitudinal change of biomarkers in cognitive decline, Arch. Neurol., 68, 1257, 10.1001/archneurol.2011.123 · DOI
  52. Mahncke, 2006, Brain plasticity and functional losses in the aged: scientific bases for a novel intervention, Prog. Brain Res., 157, 81, 10.1016/S0079-6123(06)57006-2 · DOI
  53. Mandal, 1998, Facial expressions of emotions and schizophrenia: a review, Schizophr. Bull., 24, 399, 10.1093/oxfordjournals.schbul.a033335 · DOI
  54. Mishra, 2012, Attention distributed across sensory modalities enhances perceptual performance, J. Neurosci., 32, 12294, 10.1523/JNEUROSCI.0867-12.2012 · DOI
  55. Mufson, 2002, Loss of balal forebrain P75 immunoreactivity in subjects with mild cognitive impairment and Alzheimer’s disease, J. Comp. Neurol., 443, 136, 10.1002/cne.10122 · DOI
  56. Penn, 2008, Social cognition in schizophrenia: an overview, Schizophr. Bull., 34, 408, 10.1093/schbul/sbn014 · DOI · Paper page
  57. Pinkham, 2003, Implications for the neural basis of social cognition for the study of schizophrenia, Am. J. Psychiatry, 160, 815, 10.1176/appi.ajp.160.5.815 · DOI
  58. Pinkham, 2008, Implications for the neural basis of social cognition for the study of schizophrenia, Am. J. Psychiatry, 160, 815, 10.1176/appi.ajp.160.5.815 · DOI
  59. Pinkham, 2007, Emotion perception and social skill over the course of psychosis: a comparison of individuals “at-risk” for psychosis and individuals with early and chronic schizophrenia spectrum illness, Cogn. Neuropsychiatry, 12, 198, 10.1080/13546800600985557 · DOI
  60. Pinkham, 2008, An investigation of the relationship between activation of a social cognitive neural network and social functioning, Schizophr. Bull., 34, 688, 10.1093/schbul/sbn031 · DOI
  61. Reitz, 2011, Epidemiology of Alzheimer disease, Nat. Rev. Neurol., 7, 137, 10.1038/nrneurol.2011.2 · DOI · Paper page
  62. Russell, 2000, Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attribution, Am. J. Psychiatry, 157, 2040, 10.1176/appi.ajp.157.12.2040 · DOI
  63. Sacks, 2013, Combining computerized social cognitive training with neuroplasticity-based auditory training in schizophrenia, Clin. Schizophr. Relat. Psychoses, 7, 78, 10.3371/CSRP.SAFI.012513 · DOI
  64. Sara, 2012, Orienting and reorienting: the locus coeruleus mediates cognition through arousal, Neuron, 76, 130, 10.1016/j.neuron.2012.09.011 · DOI · Paper page
  65. Sarter, 2006, More attention must be paid: the neurobiology of attentional effort, Brain Res. Rev., 51, 145, 10.1016/j.brainresrev.2005.11.002 · DOI · Paper page
  66. Sarter, 2001, The cognitive neuroscience of sustained attention: where top-down meets bottom-up, Brain Res. Rev., 35, 146, 10.1016/S0165-0173(01)00044-3 · DOI · Paper page
  67. Schneider, 1998, Differential amygdala activation in schizophrenia during sadness, Schizophr. Res., 34, 133, 10.1016/S0920-9964(98)00085-1 · DOI
  68. Sergi, 2007, Social cognition in schizophrenia: relationships with neurocognition and negative symptoms, Schizophr. Res., 90, 316, 10.1016/j.schres.2006.09.028 · DOI
  69. Shamay-Tsoory, 2005, The neural correlates of understanding the other's distress: a positron emission tomography investigation of accurate empathy, Neuroimage, 27, 468, 10.1016/j.neuroimage.2005.05.012 · DOI
  70. Sheng, 2013, Altered volume and lateralization of language-related regions in first-episode schizophrenia, Schizophr. Res., 148, 168, 10.1016/j.schres.2013.05.021 · DOI
  71. Stevens, 2008, Neural mechanisms of selective auditory attention are enhanced by computerized training: electrophysiological evidence from language-impaired and typically developing children, Brain Res., 1205, 55, 10.1016/j.brainres.2007.10.108 · DOI · Paper page
  72. Straube, 2013, Superior temporal sulcus disconnectivity during processing of metaphoric gestures in schizophrenia, Schizophr. Bull., 10.1093/schbul/sbt110 · DOI
  73. Vauth, 2004, Does social cognition influence the relation between neurocognitive deficits and vocational functioning in schizophrenia?, Psychiatry Res., 128, 155, 10.1016/j.psychres.2004.05.018 · DOI
  74. Wang, 2004, Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory, Proc. Natl. Acad. Sci. U. S. A., 101, 1368, 10.1073/pnas.0305337101 · DOI
  75. Weinberger, 2004, Specific long-term memory traces in primary auditory cortex, Nat. Rev. Neurosci., 5, 279, 10.1038/nrn1366 · DOI
  76. Wicker, 2003, Both of us disgusted in My insula: the common neural basis of seeing and feeling disgust, Neuron, 40, 655, 10.1016/S0896-6273(03)00679-2 · DOI · Paper page
  77. Weiner, 2013, The Alzheimer’s disease neuroimaging initiative, Alzheimers Dement., 9, 111, 10.1016/j.jalz.2013.05.1769 · DOI
  78. Williams, 2003, Emotion perception in schizophrenia: an eye movement study comparing the effectiveness of risperidone vs. haloperidol, Psychiatry Res., 120, 13, 10.1016/S0165-1781(03)00166-5 · DOI
  79. Wolinsky, 2006, The ACTIVE cognitive training trial and health-related quality of life: protection that lasts for 5 years, J. Gerontol. A Biol. Sci. Med. Sci., 61, 1324, 10.1093/gerona/61.12.1324 · DOI · Paper page
  80. Wolinsky, 2009, The ACTIVE cognitive training interventions and the onset of and recovery from suspected clinical depression, J. Gerontol. B Psychol. Sci. Soc. Sci., 65, 577, 10.1093/geronb/gbp061 · DOI
  81. Wolinsky, 2010, Does cognitive training improve internal locus of control among older adults, J. Gerontol. B Psychol. Sci. Soc. Sci., 65, 491
  82. Wolinsky, 2010, Speed of processing training protects self-rated health in older adults: enduring effects observed in the multi=site ACTIVE randomized controlled trial, Int. Psychogeriatr., 22, 470, 10.1017/S1041610209991281 · DOI
  83. Wolinsky, 2013, A randomized controlled trial of cognitive training using a visual speed of processing intervention in middle aged and older adults, PLoS One, 8, e61624, 10.1371/journal.pone.0061624 · DOI
  84. Wright, 2010, Enhancing perceptual learning by combining practice with periods of additional sensory stimulation, J. Neurosci., 30, 2868, 10.1523/JNEUROSCI.0487-10.2010 · DOI
  85. Zarow, 2003, Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases, JAMA Neurol., i60, 337
  86. Zelinski, 2011, Improvement in memory with plasticity-based adaptive cognitive training: results of the 3-month follow-up, J. Am. Geriatr. Soc., 59, 258, 10.1111/j.1532-5415.2010.03277.x · DOI · Paper page
  87. Zhou, 2010, Successive-signal biasing for a learned sound sequence, Proc. Natl. Acad. Sci. U. S. A., 107, 14839, 10.1073/pnas.1009433107 · DOI
  88. Zhou, 2011, Natural restoration of critical period plasticity in the juvenile and adult primary auditory cortex, J. Neurosci., 31, 5625, 10.1523/JNEUROSCI.6470-10.2011 · DOI

Metadata

Authors
Nahum, M., Lee, H., & Merzenich, M. M.
Affiliations
Posit Science (United States) (US)
Corresponding author
Merzenich, Michael M.
ORCID
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2013
Volume
207
Pages
141-171
ISSN
0079-6123 (ISSN-L)
DOI
10.1016/b978-0-444-63327-9.00009-6
OpenAlex
W2417753533
Cited by
158
References
115
Citations by year
2026: 10 · 2025: 23 · 2024: 15 · 2023: 12 · 2022: 25 · 2021: 14 · 2020: 11 · 2019: 12 · 2018: 6 · 2017: 13 · 2016: 8 · 2015: 4 · 2014: 4 · 2013: 1
FWCI
20.57
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuroplasticity, rehabilitation, social cognition deficits, chronic schizophrenia, autism spectrum disorder, Alzheimer's disease, dementia prevention, age-related cognitive decline, behavioral deficits, translational neuroscience
MeSH terms
Mental Disorders, Brain, Brain Diseases, Humans, Neuronal Plasticity

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