The DOI matches its Crossref record; 411 of the 411 references it cites were found in a registry or an index.
Organokines in disease
Abstract
Studies have linked obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and dementia. Their relationship to the incidence and progression of these disease states suggests an interconnected pathogenesis involving chronic low-grade inflammation and oxidative stress. Metabolic syndrome represents comorbidities of central obesity, insulin resistance, dyslipidemia, hypertension and hyperglycemia associated with increased risk of type 2 diabetes, NAFLD, atherosclerotic CVD and neurodegenerative disease. As the socioeconomic burden for these diseases has grown signficantly with an increasing elderly population, new and alternative pharmacologic solutions for these cardiometabolic diseases are required. Adipose tissue, skeletal muscle and liver are central endocrine organs that regulate inflammation, energy and metabolic homeostasis, and the neuroendocrine axis through synthesis and secretion of adipokines, myokines, and hepatokines, respectively. These organokines affect each other and communicate through various endocrine, paracrine and autocrine pathways. The ultimate goal of this review is to provide a comprehensive understanding of organ crosstalk. This will include the roles of novel organokines in normal physiologic regulation and their pathophysiological effect in obesity, metabolic syndrome, type 2 diabetes, CVD, NAFLD and neurodegenerative disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It also stimulates insulin release by increasing the expression of the glucagon-1-like peptide (GLP-1) [11,59].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [59]
In the citing paper
“These cytokines, especially TNF-α and leptin, seem to aggravate hypertension, which, together with visceral obesity, dyslipidemia, and hyperglycemia, configure the metabolic syndrome scenario [59,93].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [59]
Citations
Cites
1 retracted
Items 401–411 of 411
Sahebkar, A. (2013) · Metabolism · doi:10.1016/j.metabol.2013.08.017 · Cited by 21
Development of Neurotrophic Molecules for Treatment of Neurode-generation
Chen, Z.-Y., Cao, L. H., Wang, L., et al. (2001) · Current Protein and Peptide Science · doi:10.2174/1389203013381125 · Cited by 21
Emerging Human Fetuin A Assays for Biomedical Diagnostics
Vashist, S. K., Schneider, E. M., Venkatesh, A. G., & Luong, J. H. T. (2017) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.12.006 · Cited by 21
Phrommintikul, A., Sa‐nguanmoo, P., Sripetchwandee, J., Vathesatogkit, P., Chattipakorn, N., & Chattipakorn, S. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-23550-9 · Cited by 21
Decreased serum alfa2-HS-glycoprotein concentration in patients with primary biliary cirrhosis
Kalabay, L., Szalay, F., Nemesánszky, E., et al. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80483-7 · Cited by 17
Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes
Chung, H. S., Lee, H. J., Hwang, S. Y., Choi, J.-H., Yoo, H. J., Seo, J. A., Kim, S. G., Kim, N. H., Choi, D. S., Baik, S. H., et al. (2018) · International Journal of Endocrinology · doi:10.1155/2018/7918714 · Cited by 17
Self-citationPark, C. Y., Moon, J., Jo, G., Lee, J., Kim, O. Y., Oh, H., Lim, H., & Shin, M. (2019) · Scientific Reports · doi:10.1038/s41598-018-36581-z · Cited by 17
Nestel, P. J., & Mensink, R. P. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835c0834 · Cited by 16
Jiang, S., Zhang, R., Li, H., Fang, Q., Jiang, F., Hou, X., Hu, C., & Jia, W. (2014) · Lifestyle Genomics · doi:10.1159/000367943 · Cited by 16
‘Proactive’ use of cue-context congruence for building reinforcement learning’s reward function
Zsuga, J., Bíró, K., Tajti, G., Szilasi, M. E., Papp, C., Juhász, B., & Gesztelyi, R. (2016) · BMC Neuroscience · doi:10.1186/s12868-016-0302-7 · Cited by 13
Fraga, V. G., Guimarães, H. C., Teixeira, A. L., Barbosa, M. T., Mateo, E. C. C., Ferriani, M. D. G. C., Caramelli, P., & Gomes, K. B. (2015) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20150137 · Cited by 10
Flagged first, then by citations
Cited by
Sorted by citations
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189
Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications
Barbalho, S. M., Flato, U. A. P., Tofano, R. J., Goulart, R. D. A., Guiguer, E. L., Detregiachi, C. R. P., Buchaim, D. V., Araújo, A. C., Buchaim, R. L., Reina, F. T. R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103607 · Cited by 156
Metadata
- Authors
- Chung, H. S., & Choi, K. M.
- Affiliations
- Hallym University (KR)
- Korea University (KR)
- Corresponding author
- Kyung Mook Choi
- Venue
- Advances in clinical chemistry
- Publisher
- Elsevier
- Published
- 2020
- Volume
- 94
- Pages
- 261-321
- ISSN
- 0065-2423 (ISSN-L)
- OpenAlex
- W2967080190
- Cited by
- 46
- References
- 411
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 3
- FWCI
- 17.66
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in clinical chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, myokines, hepatokines, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, dementia, neurodegenerative diseases, low-grade inflammation, oxidative stress, organ crosstalk, insulin resistance, adipose tissue, skeletal muscle, liver, cardiometabolic disease
- MeSH terms
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Obesity, Neurodegenerative Diseases, Metabolic Syndrome, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
