The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.
Tryptophan in health and disease
Abstract
Tryptophan (TRP), an essential amino acid in mammals, is involved in several physiological processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is metabolized via the kynurenine and serotonin pathways, leading to the generation of biologically active compounds, such as serotonin, melatonin and niacin. In addition to endogenous TRP metabolism, resident gut microbiota also contributes to the production of specific TRP metabolites and indirectly influences host physiology. The variety of physiologic functions regulated by TRP reflects the complex pattern of diseases associated with altered homeostasis. Indeed, an imbalance in the synthesis of TRP metabolites has been associated with pathophysiologic mechanisms occurring in neurologic and psychiatric disorders, in chronic immune activation and in the immune escape of cancer. In this chapter, the role of TRP metabolism in health and disease is presented. Disorders involving the central nervous system, malignancy, inflammatory bowel and cardiovascular disease are discussed.
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Cites
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Cited by
Gut microbiota-derived metabolites as central regulators in metabolic disorders
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“These metabolites are significantly associated with the appearance, development, and outcomes of various neuropsychiatric disorders [1].”
BackgroundAmino acid metabolism, redox balance and epigenetic regulation in cancer
Li, X., & Zhang, H. (2024) · The FEBS Journal · doi:10.1111/febs.16803 · Cited by 90
Bian, X., Wang, Q., Wang, Y., & Lou, S. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1305208 · Cited by 15
Chehadi, A. C., Pereira de Lima, E., Detregiachi, C. R. P., Santos de Argollo Haber, R., Catharin, V. M. C. S., Fornari Laurindo, L., Engracia Valenti, V., Machado Galhardi, C., Tanaka, M., & Maria Barbalho, S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27010465 · Cited by 8
Metadata
- Venue
- Advances in Clinical Chemistry
- Publisher
- Elsevier
- Published
- 2020
- Volume
- 95
- Pages
- 165-218
- ISSN
- 0065-2423 (ISSN-L)
- OpenAlex
- W3007631121
- Cited by
- 294
- References
- 242
- FWCI
- 19.52
- Type
- book chapter
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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