MicroRNAs in Neurodegenerative Diseases
Abstract
MicroRNAs are small noncoding RNAs that regulate gene expression at the posttranscriptional level in a sequence-specific manner. After their discovery in 1993, mounting data have provided compelling evidence for their causal involvement in several human diseases, such as cancer and disorders of the brain. MicroRNAs have been described as the main regulator of homeostasis in neurons, and their dysregulation results in pathological conditions in the brain. In this review, we will focus on the role of MicroRNAs as novel drug targets and biomarkers of the three main neurodegenerative disorders (Alzheimer's disease, Parkinson's diseases, and Huntington's disease) and their role in other neurological disorders including traumatic brain injury and status epilepticus.
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Regulation via miRNA-mediated repression of gene expression is involved in nearly every physiological system and misregulation of miRNA biology is implicated in a broad spectrum of diseases.
“Regulation via miRNA-mediated repression of gene expression has been shown to be involved in nearly every physiological system and misregulation of miRNA biology has been implicated in a broad spectrum of diseases ranging from cancer to neurodegenerative diseases (Quinlan et al., 2017;Rupaimoole and Slack, 2017).”
From Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP (2022) · cites this paper as Quinlan et al., 2017
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Scalable and deep profiling of mRNA targets for individual microRNAs with chimeric eCLIP
Manakov, S. A., Shishkin, A. A., Yee, B. A., Shen, K. A., Cox, D. C., Park, S. S., Foster, H. M., Chapman, K. B., Yeo, G. W., & Van Nostrand, E. L. (2022) · doi:10.1101/2022.02.13.480296 · Cited by 43 · see citing works
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Mao, H., & Ding, L. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7853 · Cited by 12 · see citing works
- Authors
- Quinlan, S., Kenny, A., Medina, M., Engel, T., & Jimenez-Mateos, E. M.
- Affiliations
- Royal College of Surgeons in Ireland (IE)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Corresponding author
- Eva Maria Jimenez-Mateos
- Venue
- International Review of Cell and Molecular Biology
- Publisher
- Elsevier
- Published
- 2017
- Volume
- 334
- Pages
- 309-343
- ISSN
- 0074-7696 (ISSN-L)
- 1937-6448
- OpenAlex
- W2626587846
- Cited by
- 168
- References
- 12
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 15 · 2023: 16 · 2022: 19 · 2021: 17 · 2020: 42 · 2019: 23 · 2018: 16 · 2017: 3
- FWCI
- 18.48
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of cytology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microRNA, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, Huntington's disease, traumatic brain injury, status epilepticus, therapeutic target, biomarkers, post-transcriptional regulation, neuronal homeostasis
- MeSH terms
- Animals, Brain, Humans, Biomarkers, Neurodegenerative Diseases, MicroRNAs
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