Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128
Open accessAbstract
MicroRNAs, the non-coding single-stranded RNA of 19-25 nucleotides are emerging as robust players of gene regulation. Plethora of evidences support that the ability of microRNAs to regulate several genes of a pathway or even multiple cross talking pathways have significant impact on a complex regulatory network and ultimately the physiological processes and diseases. Brain being a complex organ with several cell types, expresses more distinct miRNAs than any other tissues. This review aims to discuss about the microRNAs in brain development, function and their dysfunction in brain tumors. We also provide a comprehensive summary of targets of brain specific and brain enriched miRNAs that contribute to the diversity and plasticity of the brain. In particular, we uncover recent findings on miRNA-128, a brain-enriched microRNA that is induced during neuronal differentiation and whose aberrant expression has been reported in several cancers. This review describes the wide spectrum of targets of miRNA-128 that have been identified till date with potential roles in apoptosis, angiogenesis, proliferation, cholesterol metabolism, self renewal, invasion and cancer progression and how this knowledge might be exploited for the development of future miRNA-128 based therapies for the treatment of cancer as well as metabolic diseases.
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Cites a retracted work: 10.3892/mmr.2013.1814
InfoThe cited work was retracted on 2023-12-27 (notice 10.3892/mmr.2023.13154), not before this paper was published (2014).
Cited work 10.3892/mmr.2013.1814 · retracted 2023-12-27 · notice 10.3892/mmr.2023.13154 · this paper published 2014
Cites a retracted work: 10.1371/journal.pone.0055008
InfoThe cited work was retracted on 2020-01-23 (notice 10.1371/journal.pone.0228340), not before this paper was published (2014).
Cited work 10.1371/journal.pone.0055008 · retracted 2020-01-23 · notice 10.1371/journal.pone.0228340 · this paper published 2014
“10.1371/journal.pone.0055008”
Cites a retracted work: 10.1016/j.stem.2007.04.001
InfoThe cited work was retracted on 2023-06-01 (notice 10.1016/j.stem.2023.05.009), not before this paper was published (2014).
Cited work 10.1016/j.stem.2007.04.001 · retracted 2023-06-01 · notice 10.1016/j.stem.2023.05.009 · this paper published 2014
“10.1016/j.stem.2007.04.001”
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- Authors
- Adlakha, Y. K., & Saini, N.
- Affiliations
- Institute of Genomics and Integrative Biology (IN)
- Corresponding author
- Saini, Neeru
- Venue
- Molecular Cancer
- Published
- 2014
- Volume
- 13
- Issue
- 1
- Pages
- 33
- ISSN
- 1476-4598 (ISSN-L)
- PMC
- PMC3936914
- OpenAlex
- W2151668353
- Semantic Scholar
- 5e2e0380167b8a7d1673392477a8315e67cd3687
- Cited by
- 213
- References
- 287
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 14 · 2023: 23 · 2022: 23 · 2021: 13 · 2020: 31 · 2019: 20 · 2018: 14 · 2017: 23 · 2016: 21 · 2015: 9 · 2014: 1
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India (BSC 0123)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, brain development, brain tumors, neuronal differentiation, miRNA target genes, apoptosis, angiogenesis, tumor progression, cholesterol metabolism, self-renewal, tumor invasion, miRNA-based therapy, metabolic disorders
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Humans, Neoplasms, Apoptosis, MicroRNAs
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