Cited by 213MicroRNA in disease regulationCancer-related molecular mechanisms researchPlant Molecular Biology Research

Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128

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Adlakha, Yogita K, Saini, Neeru·2014·Molecular Cancer

Abstract

MicroRNAs, the non-coding single-stranded RNA of 19-25 nucleotides are emerging as robust players of gene regulation. Plethora of evidences support that the ability of microRNAs to regulate several genes of a pathway or even multiple cross talking pathways have significant impact on a complex regulatory network and ultimately the physiological processes and diseases. Brain being a complex organ with several cell types, expresses more distinct miRNAs than any other tissues. This review aims to discuss about the microRNAs in brain development, function and their dysfunction in brain tumors. We also provide a comprehensive summary of targets of brain specific and brain enriched miRNAs that contribute to the diversity and plasticity of the brain. In particular, we uncover recent findings on miRNA-128, a brain-enriched microRNA that is induced during neuronal differentiation and whose aberrant expression has been reported in several cancers. This review describes the wide spectrum of targets of miRNA-128 that have been identified till date with potential roles in apoptosis, angiogenesis, proliferation, cholesterol metabolism, self renewal, invasion and cancer progression and how this knowledge might be exploited for the development of future miRNA-128 based therapies for the treatment of cancer as well as metabolic diseases.

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  • Cites a retracted work: 10.3892/mmr.2013.1814

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    The cited work was retracted on 2023-12-27 (notice 10.3892/mmr.2023.13154), not before this paper was published (2014).

    Cited work 10.3892/mmr.2013.1814 · retracted 2023-12-27 · notice 10.3892/mmr.2023.13154 · this paper published 2014

  • Cites a retracted work: 10.1371/journal.pone.0055008

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    The cited work was retracted on 2020-01-23 (notice 10.1371/journal.pone.0228340), not before this paper was published (2014).

    Cited work 10.1371/journal.pone.0055008 · retracted 2020-01-23 · notice 10.1371/journal.pone.0228340 · this paper published 2014

  • Cites a retracted work: 10.1016/j.stem.2007.04.001

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    The cited work was retracted on 2023-06-01 (notice 10.1016/j.stem.2023.05.009), not before this paper was published (2014).

    Cited work 10.1016/j.stem.2007.04.001 · retracted 2023-06-01 · notice 10.1016/j.stem.2023.05.009 · this paper published 2014

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Authors
Adlakha, Y. K., & Saini, N.
Affiliations
Institute of Genomics and Integrative Biology (IN)
Corresponding author
Saini, Neeru
Venue
Molecular Cancer
Published
2014
Volume
13
Issue
1
Pages
33
ISSN
1476-4598 (ISSN-L)
OpenAlex
W2151668353
Cited by
213
References
287
Citations by year
2026: 7 · 2025: 14 · 2024: 14 · 2023: 23 · 2022: 23 · 2021: 13 · 2020: 31 · 2019: 20 · 2018: 14 · 2017: 23 · 2016: 21 · 2015: 9 · 2014: 1
FWCI
1.90
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Molecular Cancer (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Council of Scientific and Industrial Research, India (BSC 0123)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
microRNA, brain development, brain tumors, neuronal differentiation, miRNA target genes, apoptosis, angiogenesis, tumor progression, cholesterol metabolism, self-renewal, tumor invasion, miRNA-based therapy, metabolic disorders
MeSH terms
Animals, Brain, Gene Expression Regulation, Humans, Neoplasms, Apoptosis, MicroRNAs

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