MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

Hébert, Sébastien S.; Horré, Katrien; Nicolaï, Laura; Bergmans, Bruno; Papadopoulou, Aikaterini S.; Delacourte, André; De Strooper, Bart

doi:10.1016/j.nbd.2008.11.009

Cited by 436Alzheimer's disease research and treatmentsMicroRNA in disease regulationNeuroinflammation and Neurodegeneration Mechanisms

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

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Hébert, Sébastien S., Horré, Katrien, Nicolaï, Laura, Bergmans, Bruno, Papadopoulou, Aikaterini S., Delacourte, André, De Strooper, Bart·2009·Neurobiology of Disease

DOI 10.1016/j.nbd.2008.11.009

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Abstract

Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in gene transcriptional control, could be involved in the development of sporadic Alzheimer's disease (AD). We therefore investigated whether miRNAs could participate in the regulation of APP gene expression. We show that miRNAs belonging to the miR-20a family (that is, miR-20a, miR-17-5p and miR-106b) could regulate APP expression in vitro and at the endogenous level in neuronal cell lines. A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. We thus identify miRNAs as novel endogenous regulators of APP expression, suggesting that variations in miRNA expression could contribute to changes in APP expression in the brain during development and disease. This possibility is further corroborated by the observation that a statistically significant decrease in miR-106b expression was found in sporadic AD patients.

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miR-106b-5p also targets APP in the HeLa cell line.
“Notably, miR-106b-5p also targets APP in the HeLa cell line [117].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [117]

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Self-citation

Authors: Hébert, S. S., Horré, K., Nicolaï, L., Bergmans, B., Papadopoulou, A. S., Delacourte, A., & De Strooper, B.
Affiliations: KU Leuven (BE)
Inserm (FR)
ORCID: Hébert, Sébastien S.
Horré, Katrien
Bergmans, Bruno
Papadopoulou, Aikaterini S.
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2009-03
Volume: 33
Issue: 3
Pages: 422-428
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2008.11.009
OpenAlex: W2072484559
Cited by: 436
References: 39
Citations by year: 2026: 7 · 2025: 27 · 2024: 19 · 2023: 24 · 2022: 22 · 2021: 29 · 2020: 19 · 2019: 24 · 2018: 16 · 2017: 21 · 2016: 26 · 2015: 26 · 2014: 27 · 2013: 39 · 2012: 25
FWCI: 19.22
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neurobiology of Disease (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
UCL Discovery (University College London) (submittedVersion)
Lirias (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: microRNA, amyloid precursor protein, Alzheimer's disease, miR-20a, miR-17-5p, miR-106b, gene expression regulation, neuronal differentiation, brain development, sporadic Alzheimer's disease, familial Alzheimer's disease
MeSH terms: Actins, Animals, Brain, Cell Line, Cells, Cultured, Densitometry, Gene Expression Regulation, Humans, Neurons, Receptors, Cell Surface, RNA, Messenger, Transfection, Blotting, Northern, Blotting, Western, Amyloid beta-Protein Precursor, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Neurogenesis, Protease Nexins

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MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

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