Cited by 309Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

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Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine

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Dani, John A.·2015·International Review of Neurobiology

DOI 10.1016/bs.irn.2015.07.001PMC PMC4795468

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Abstract

Nicotinic acetylcholine receptors (nAChRs) belong to the "Cys-loop" superfamily of ligand-gated ion channels that includes GABAA, glycine, and serotonin (5-HT3) receptors. There are 16 homologous mammalian nAChR subunits encoded by a multigene family. These subunits combine to form many different nAChR subtypes with various expression patterns, diverse functional properties, and differing pharmacological characteristics. Because cholinergic innervation is pervasive and nAChR expression is extremely broad, practically every area of the brain is impinged upon by nicotinic mechanisms. This review briefly examines the structural and functional properties of the receptor/channel complex itself. The review also summarizes activation and desensitization of nAChRs by the low nicotine concentrations obtained from tobacco. Knowledge of the three-dimensional structure and the structural characteristics of channel gating has reached an advanced stage. Likewise, the basic functional properties of the channel also are reasonably well understood. It is these receptor/channel properties that underlie the participation of nAChRs in nearly every anatomical region of the mammalian brain.

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“…its effects via nicotinic cholinergic receptors (nAChRs), pentameric ligand-gated ion channels that are widely distributed throughout the brain (Dani, 2015; Zoli et al., 2015). nAChRs consist of pentameric arrays of homomeric (α7–α10) or heteromeric of α (α2–α7) and β (β2–β4) subunits, giving…”
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Authors: Dani, J. A.
Affiliations: University of Pennsylvania (US)
Corresponding author: Dani, John A.
ORCID: Dani, John A.
Venue: International Review of Neurobiology
Publisher: Elsevier
Published: 2015
Volume: 124
Pages: 3-19
ISSN: 0074-7742 (ISSN-L)
DOI: 10.1016/bs.irn.2015.07.001
PMC: PMC4795468
OpenAlex: W2427261560
Cited by: 309
References: 69
Citations by year: 2026: 24 · 2025: 28 · 2024: 41 · 2023: 38 · 2022: 27 · 2021: 46 · 2020: 41 · 2019: 28 · 2018: 22 · 2017: 10 · 2016: 4
FWCI: 19.11
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International review of neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (DA09411, R01DA009411, R01DA036572)
National Institute of Neurological Disorders and Stroke (NS 21229, R37NS021229, R01NS021229)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: nicotinic acetylcholine receptors, Cys-loop ligand-gated ion channels, receptor structure, channel gating, receptor desensitization, nAChR subtypes
MeSH terms: Animals, Humans, Models, Molecular, Nicotine, Receptors, Nicotinic, Ion Channel Gating, Protein Subunits

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Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine

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