Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine

Mammalian nicotinic acetylcholine receptors: from structure to function

Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

Unwin, P. N. T. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.031 · Cited by 1,677

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System

Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197

Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors

McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947

Emerging structure of the Nicotinic Acetylcholine receptors

Karlin, A. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn731 · Cited by 924

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

Celie, P. H. N., van Rossum-Fikkert, S. E., van Dijk, W. J., Brejc, K., Smit, A. B., & Sixma, T. K. (2004) · Neuron · doi:10.1016/s0896-6273(04)00115-1 · Cited by 781

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

Taly, A., Corringer, P., Guédin, D., Lestage, P. J., & Changeux, J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2927 · Cited by 743

Understanding varenicline function via key receptor and ligand interactions

Aiken, S., Fiorito, D., Harper, M., Pikus, G., Underhill, J., Murray, J., Rawlinson, J., O’Donoghue, A. C., Gotti, C., Lummis, S. C. R., et al. (2025) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2025.102992 · Cited by 3

Pest resistance mechanisms and comparative evaluation of conventional, biological, and nano-enabled pest control strategies

Bharadava, K., Makarani, N., & Kaushal, R. S. (2026) · Environmental Sciences Europe · doi:10.1186/s12302-026-01352-5 · Cited by 2

Harnessing computational modeling of ligand-receptor dynamics for site-specific drug delivery: A review

Raza, A., Firdous, A., Raza, M. A., & Ajazuddin, M. (2026) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2026.100468 · Cited by 2

Modes of Acetylcholine Signaling in the Prefrontal Cortex: Implications for Cholinergic Dysfunction and Disorders

Fecik, M. J., & Savage, L. M. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110462 · Cited by 2

Navigating the nanoscale: Principles of body navigation

Abbasi, S., Dirisala, A., Gonzalez‐Carter, D., Paraiso, W. K. D., Li, J., & Tockary, T. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-823994-0.00002-5 · Cited by 2

Development of a scintillation proximity assay for [3H]epibatidine binding sites of Tetronarce californica muscle-type nicotinic acetylcholine receptor

Springer, F., Freisleben, M., Muschik, S., Kohl, M., Worek, F., Meinel, L., Seeger, T., & Niessen, K. V. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.09.005 · Cited by 2

Cholinergic System Structure and Function Changes in Individuals with Down Syndrome During the Development of Alzheimer’s Disease

Russell, J. K., Conley, A. C., Wilson, J. E., & NEWHOUSE, P. A. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_523 · Cited by 3

Varenicline Attenuates Memory Impairment in Amyloid-Beta-Induced Rat Model of Alzheimer’s Disease

Athari, S. Z., Kazmi, S., Vatandoust, S. M., Mahmoudi, J., Farajdokht, F., Hajihosseinlou, F., Ghaderi, P., Majdi, A., & Sadigh‐Eteghad, S. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04338-6 · Cited by 3

Role of Glial Cells and Receptors in Schizophrenia Pathogenesis

Tizabi, Y., Antonelli, M. C., Tizabi, D., & Aschner, M. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04336-8 · Cited by 2

Investigation of anterior segment and pupillometry changes with Sirius corneal topography in chronic smokers

Birgül, R., & Sakallıoğlu, A. K. (2025) · BMC Ophthalmology · doi:10.1186/s12886-025-04131-7 · Cited by 2

Synaptically Located Nicotinic Acetylcholine Receptor Subunits in Neurons Involved in Dependency to Nicotine

Kohlmeier, K. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00007-1 · Cited by 2

Effect of Intrahippocampal Administration of α7 Subtype Nicotinic Receptor Agonist PNU-282987 and Its Solvent Dimethyl Sulfoxide on the Efficiency of Hypoxic Preconditioning in Rats

Zakharova, E. I., Proshin, A. T., Monakov, M. Y., & Dudchenko, A. M. (2021) · Molecules · doi:10.3390/molecules26237387 · Cited by 2

Bilateral Superior Cervical Sympathectomy Activates Signal Transducer and Activator of Transcription 3 Signal to Alleviate Myocardial Ischemia-Reperfusion Injury

Li, L., Gao, J., Gao, L., Li, L., Zhang, H., Zhao, W., & Xu, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.807298 · Cited by 3

Nicotine and Cardiovascular Function

Ialongo, C., Sabatini, D., & Grassi, M. (2020) · Springer eBooks · doi:10.1007/978-3-030-28008-6_52 · Cited by 2

Mechanism of hydrophobic gating in the acetylcholine receptor channel pore

Kumari, M., Khatoon, N., Sharma, R., Adusumilli, S., Auerbach, A. L., Kashyap, H. K., & Nayak, T. K. (2023) · The Journal of General Physiology · doi:10.1085/jgp.202213189 · Cited by 2

Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice

Caban, K. M., Seßenhausen, P., Stöckl, J. B., Popper, B., Mayerhofer, A., & Fröhlich, T. (2024) · PROTEOMICS · doi:10.1002/pmic.202300384 · Cited by 2

Ethanol's Action Mechanisms in the Brain

Marin, M. T., & Morais‐Silva, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805373-7.00016-5 · Cited by 2

Chapter 18. Neurobiology of Nicotine and Tobacco

Gubner, N. R., & Benowitz, N. L. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb18 · Cited by 2

Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse developmentPreprint

Rosenthal, J., Yin, J., Long, C., Spillman, E., Sheng, C., & Yuan, Q. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/790659 · Cited by 2

Data Exploration and Validation on dense knowledge graphs for biomedical researchPreprint

Dörpinghaus, J., Apke, A., Lage‐Rupprecht, V., & Stefan, A. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1912.06194 · Cited by 2

Renshaw cells, corelease and nicotinic receptors: The last journey in synaptic transmission

d’Incamps, B. L. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.041 · Cited by 1

Advantages of Neonicotinoids Over Other Classes of Pesticides

Kaur, J., & Kaur, J. (2024) · Sustainable landscape planning and natural resources management · doi:10.1007/978-3-031-45343-4_2 · Cited by 1

Pathology of oral nicotine pouches and their addiction mechanisms

Zou, H., Lyu, Q., & Hu, S. (2025) · Journal of Dentistry · doi:10.1016/j.jdent.2025.106272 · Cited by 4

α-Conotoxin LvID, an antagonist of α7 nicotinic acetylcholine receptor, mitigates Alzheimer-associated phenotypes by inhibiting Aβ deposition and reactive astrogliosis

Yue, S., Xing, H., Du, X., Wang, Y., Qin, R., He, J., Yu, J., zhangsun, D., Craik, D. J., McIntosh, J. M., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150933 · Cited by 1

Nonhuman Primate Anaesthesia in the Research Setting

Smuda, J., & Logothetis, N. K. (2026) · Springer eBooks · doi:10.1007/978-3-032-19476-3_5 · Cited by 1

Desformylflustrabromine (dFBr), a positive allosteric modulator of α4β2 nicotinic acetylcholine receptors decreases voluntary ethanol consumption and preference in male and female Sprague-Dawley rats

Decker, S., Davis, G., Vahora, I., Vukovic, A., Patel, P., & Suryanarayanan, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273715 · Cited by 1

Understanding the Impact of Flavors on Vaping and Nicotine Addiction-Related Behaviors

Olszewski, N. A., Tetteh-Quarshie, S., & Henderson, B. J. (2022) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-022-00253-0 · Cited by 1

Insights into Molecular Mechanism of Nicotine Addiction Based on Network Pharmacology and Molecular Docking Strategy

Zhang, S., Zhao, Y., Chang, Z., Chen, H., & Hou, H. (2023) · Journal of Computational Biophysics and Chemistry · doi:10.1142/s2737416523500497 · Cited by 1

Chromosome-Scale Genome Assembly of the Sheep-Biting Louse Bovicola ovis Using Nanopore Sequencing Data and Pore-C Analysis

Ong, C. T., Mody, K. T., Cavallaro, A. S., Yan, Y., Nguyen, L. T., Shao, R., Mitter, N., Mahony, T. J., & Ross, E. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147824 · Cited by 1

Molecular regulatory effect of the ergot alkaloid methylergometrine on the α3β4 nicotinic acetylcholine receptor

Kim, C., Pyeon, M., Yun, J., Yang, J., Lee, J., Yun, J., Yeom, H. D., Lee, G., & Lee, J. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151233 · Cited by 1

Molecular Diagnosis of Rare Autosomal Recessive Escobar Syndrome in a Consanguineous Pakistani Family

Sher, G., & Naeem, M. (2018) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2018.0122 · Cited by 1

Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction

Lee, A. M., & Picciotto, M. R. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.09.002 · Cited by 1

Residual Risk of Nicotine

Mathis, C., Smart, D. J., Xia, W., Phillips, B. W., Peitsch, M. C., Szostak, J., Poussin, C., & Luettich, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820490-0.00022-5 · Cited by 1

Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2

D’Souza, M. S., Seeley, S. L., Emerson, N., Rose-Malkamaki, M. J., Ho, S.-P., Tsai, Y., Kuo, H. R., Huan, C. Y., & Rorabaugh, B. R. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173338 · Cited by 1

Novel Pharmacotherapies for L-DOPA-Induced Dyskinesia

Tizabi, Y., Getachew, B., Copeland, R., Moratalla, R., Patricio, F., Limón, I. D., Del-Bel, E., & Aschner, M. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_218 · Cited by 1

Ligand-gated ion channels: Putative target sites for anthelmintic therapy in muscle and intestine cells of parasitic nematodes

McHugh, M. A. (2021) · doi:10.31274/etd-20210609-117 · Cited by 1

The Cholinergic System

Abbas, S. F. (2019) · Chemical Biology of Neurodegeneration · doi:10.1002/9783527813421.ch4

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathwayPreprint

Isotani, R., Igarashi, M., Miura, M., Naruse, K., Kuranami, S., Katoh, M., Nomura, S., & Yamauchi, T. (2024) · eLife · doi:10.7554/elife.95267.3 · Cited by 1

How Varenicline Works: Identifying Critical Receptor and Ligand-based InteractionsPreprint

Aiken, S., Fiorito, D., Harper, M., Pikus, G., Underhill, J., Murray, J., Rawlinson, J., O’Donoghue, A. C., Gotti, C., Lummis, S. C. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.14.659675 · Cited by 1

Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat

Lekholm, J. M. (2016)

Nicotinic Cholinergic Mechanisms in Alcohol Abuse and Dependence

Rahman, S., & Bell, R. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813125-1.00044-1

Nicotine and Cardiovascular Function

Ialongo, C., Sabatini, D., & Grassi, M. (2019) · Springer eBooks · doi:10.1007/978-3-319-90305-7_52-1

Development of a Translational Model of Co-Use of Alcohol and Nicotine for Testing Potential Pharmacotherapies

Maggio, S. E. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.395

A study of the global effects of Apolipoprotein E using lipidomics

Hawksworth, J. I. (2019) · ORCA Online Research @Cardiff (Cardiff University)

Activation of the Sonic Hedgehog Effector Smoothened Counteracts L-Dopa Induced Dyskinesia by Restoring Cholinergic Interneuron Function

Malave, L. B. (2020) · CUNY Academic Works (City University of New York)

A-7 nAchR Macrophages and Nicotine Approach in Neuroprotection to COVID-19 4 Variables Equation?Preprint

Fucini, J., & Jean-Pierre, T. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3674367

JAK2/STAT3 Signaling Pathway Plays a Key Role in Nicotine Mediated Neuroinflammation Suppression in an Ischemic Rat ModelPreprint

Wang, Q., Han, T., Lai, R., Zhang, D., Diao, Y., Du, Y., & Yin, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-222193/v1

Basal Forebrain Cholinergic Signaling to Projection-Defined Cells within the Basolateral Amygdala Regulates Food IntakePreprint

Ortiz‐Guzman, J., Swanson, J., Kochukov, M. Y., Ung, K., Tantry, E. K., Addison, A. P., Dooling, S. W., Tong, Q., & Arenkiel, B. R. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3802025

Does Pre-cessation Physical Activity Impact Smoking Treatment Outcomes? A Longitudinal Study of Treatment-seeking Smokers in the General Population

Hoang, M. (2020) · TSpace (University of Toronto)

Regional Cerebral Blood Flow and Blood-oxygen-level-dependent Smoking-cue Reactivity Responses to Abstinence, Satiety, and Nicotine Replacement Therapy in Treatment-seeking Smokers: A Functional Magnetic Resonance Imaging Study

Wannas, P. A. (2020) · TSpace (University of Toronto)

Nicotine and its derivatives in healthy brain aging

Majdi, A., & Sadigh‐Eteghad, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00032-9

Regulatory effects of nicotine on neurite outgrowth in rat superior cervical ganglia cells

Kawasaki, H., Hino, H., Takayama, F., Kitamura, Y., Sendou, T., & Takatori, S. (2021) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2021.10.012

Comparing Pretreatment ModalitiesPreprint

Mammen, C. R. (2020) · doi:10.28971/532020mc44

Protein engineering and design in ion channels and receptors

Khatoon, N., Adusumilli, S., Dey, P., Sharma, R., Kampani, P., Shandilya, J., & Nayak, T. K. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2021.12.031

Myofasziale Schmerzsyndrome

(2018) · Elsevier eBooks · doi:10.1016/b978-3-437-23097-4.00003-8

References

(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812922-7.09994-7

O Papel Bidirecional da Nicotina na Tarefa Go/No-Go: Um Ensaio Clínico Piloto

Rodrigues, S. J., Silva, G. M., Bonifácio, T. A. D. S., Limaverde, R. P., Gomes, M. E., Leite, L. H., de Almeida, N. L. P., Fernandes, T. P., & Santos, N. A. (2022) · Psico-USF · doi:10.1590/1413-82712022270112

The Effect of Low Dose Nicotine on Working Memory and Positive Emotion in Patients with Mild Cognitive ImpairmentPreprint

Samnia, Z., Yousefi, Z., Mahdavi, A., Suksatan, W., Nouri, S., & Khodadadi, E. (2022) · Research Square · doi:10.21203/rs.3.rs-1954093/v1

RC-4BC cells express nicotinic and muscarinic acetylcholine receptors

Zhubanova, G., & Filchakova, O. (2022) · PLoS ONE · doi:10.1371/journal.pone.0279284

Pharmacological actions of commonly used drugs

Yates, J. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90578-7.00008-6

nAChR structure

Boyd, R. T. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-819958-9.00003-7

Protective effects and mechanisms of auricular vagus nerve stimulation in the alleviation of acute ischemic cerebral injury in micePreprint

Chang, C.-C., Liou, K., Wang, Y., Hsu, C., Shen, Y., & Yen, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2662844/v1

Molecular Dynamics studies of Long Neurotoxins against nAChR provide key insights towards design of therapeutic peptides for DyskinesiaPreprint

Pandit, S., Saha, G., D., J., & Nagendra, H. G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.22.541753

Physico-Chemical Aspects of the Processes During the Combustion and Heating of Tobacco under Different Conditions

Idrizi, M., Achevski, B., Godzo, H., Mitić, K., Pejov, L., & Tonic-Ribarska, J. (2023) · Asian Journal of Chemistry · doi:10.14233/ajchem.2023.27728 · Cited by 1

THE EFFECT OF LOW DOSE NICOTINE ON ORKING MEMORY AND POSITIVE EMOTION IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT

Samnia, Z., Yousefi, Z., Jh, N., Khan, I. M., Rouzbahani, A., Nouri, S., & Khodadadi, E. (2023) · doi:10.53555/jptcp.v30i18.1838

Safety of E-Cigarettes and its Effectiveness in Smoking Cessation

Shete, A. V., Hajarnavis, A. M., Shete, M. V., Rajbhoj, A. N., Sande, A., & Channe, P. P. (2023) · Journal of international oral health · doi:10.4103/jioh.jioh_39_23

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathwayPreprint

Isotani, R., Igarashi, M., Miura, M., Naruse, K., Kuranami, S., & Yamauchi, T. (2024) · eLife · doi:10.7554/elife.95267.1

Modulatory Mechanism of NLRP3 Inflammasome in Heart Diseases: “An Enigma Wrapped in a Riddle”

Arora, A., Sharma, R., Kanwar, N., Gupta, V. K., Kaur, G., Bansal, P., & Kanwal, A. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815223941124010005

Impacts of Perinatal Nicotine Exposure on nAChR Expression and Glutamatergic Synaptic Transmission in the Mouse Auditory BrainstemPreprint

Wollet, M., Hernandez, A., Nip, K., Pugh, J. R., & Kim, J. H. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.08.592930

The ionotropic nicotinic acetylcholine receptors

Hammond, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-98811-7.00016-3

New insights into the effects of organometallic ruthenium complexes on nicotinic acetylcholine receptors

Trobec, T., Lamassiaude, N., Benoit, É., Žužek, M. C., Sepčić, K., Kladnik, J., Turel, I., Aráoz, R., & Frangež, R. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111213

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathwayPreprint

Isotani, R., Igarashi, M., Miura, M., Naruse, K., Kuranami, S., Katoh, M., Nomura, S., & Yamauchi, T. (2024) · eLife · doi:10.7554/elife.95267.2

Neonicotinoids Toxicity to Humans and Rodents

Costas‐Ferreira, C., & Faro, L. R. F. (2024) · Sustainable landscape planning and natural resources management · doi:10.1007/978-3-031-45343-4_11

Roles of metabotropic signaling of nicotine receptors in the development and maintenance of nicotine reward through regulation of dopamine D 3 receptor expression

Kundu, D., Acharya, S., Wang, S., Cao, Y., Kim, H. J., Cheong, J. H., & Kim, K. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16271

Novel nonsense mutation in gene CHRNA2 identified by whole-genome sequencing in infant with epilepsy disorder: A case report

Makhmetov, S., Temirkhanova, K., Rakhimova, S., Satvaldina, N., Kalendar, R. N., Kozhamkulov, U. A., Bolatov, A. K., Bayanova, M., Bazenova, A., Nazarova, L., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e41484

Nicotinic Acetylcholine Receptors, Cannabinoid Receptors, and Their Interplay in Drug Addiction

Vallés, A. S., & Barrantes, F. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-72219-6_24

Potentiation of Nicotine-Induced Currents by QO58, a Kv7 Channel Opener, in Intracardiac Ganglion Neurons of Rats

Arichi, S., Eto, K., Ogata, M., Sasaki‐Hamada, S., & Ishibashi, H. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b24-00498

Synthesis of high specific activity [N-methyl-3H] (S)-nicotine

Filer, C. N., & Pounds, S. (2025) · Journal of Radioanalytical and Nuclear Chemistry · doi:10.1007/s10967-025-10271-3

Deletion or enhancement of alpha-2 nAChRs (Chrna2) induces unique lifespan behavioral deficits

Wells, A. C., Mojica, C., Fowler, C. D., & Lotfipour, S. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110725

Mechanistic dissection of a dopamine-gated cation channel from Daphnia reveals key determinants of ligand selectivity and sensitivityPreprint

McRunnel, T. M., Reynoldson, T. E., Zhu, Y., Rahman, T., & Hardege, I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.31.685654

Nicotinic acetylcholine receptors function with adhesion molecule SAX-7 to reverse cell orientation during migration

Antonio, J., Strang, E., Arca, R. D. L., Sazinsky, M. H., Hasel-Kolossa, S. C., Wiesenthal, A., Celis, J. F. C., Gongalore, T., Bhandari, S., Yeasmin, S., et al. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.10.010

Ligand-gated ion channels

Tovar, K. R., & Westbrook, G. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-811114-7.00022-0

Medicinal and Nutritional Importance of Nicotiana spp. in Human Health

Shoaib, S., Jahan, R., Alomary, M. N., Barkat, M. A., Alghamdi, S. A., & Ansari, M. A. (2026) · Springer eBooks · doi:10.1007/978-981-95-3620-7_2

Multiple sources of β2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component Analysis of [18F]Flubatine PET images

Raval, N. R., Calakos, K. C., Zheng, M.-Q., Huttner, A. J., Esterlis, I., Huang, Y. H., Calhoun, V. D., Picciotto, M. R., Cosgrove, K., & Hillmer, A. T. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-025-02311-z

The central cholinergic system as a therapeutic target in Parkinson's disease

Miller, S. J., Yue, J., Bozal, S. B., Logan, R. A., & Hafler, B. P. (2026) · Journal of Parkinson s Disease · doi:10.1177/1877718x261427270 · Cited by 1

Imaging [18F]FDG PET/CT pilot study of nicotinic acetylcholinergic receptor α2 knock-out mice and α2 hypersensitive mice compared to control mice: Male-female differences and nicotine effects

Liang, C., Tucker, T., Coronel, A. D. L., Nguyen, E. H. N., Nguyen, J., Intskirveli, I., Lazar, R., Metherate, R., & Mukherjee, J. (2026) · PLoS ONE · doi:10.64898/2026.03.23.713331

Spinal cholinergic system and chronic pain

Dhanasobhon, D. (2017) · theses.fr (ABES) · doi:10.70675/c20bd6dbzc2eez4cffzb964zfb1f0222fee3

Polymorphisme rs16969968 de la sous-unité alpha-5 des récepteurs nicotiniques et Broncho-Pneumopathie Chronique Obstructive (BPCO)

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