Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine

Mammalian nicotinic acetylcholine receptors: from structure to function

Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution

Unwin, P. N. T. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.12.031 · Cited by 1,677

Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium

Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471

Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System

Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197

Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors

McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070

Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons

McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022

Hippocampal synaptic transmission enhanced by low concentrations of nicotine

Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947

Emerging structure of the Nicotinic Acetylcholine receptors

Karlin, A. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn731 · Cited by 924

Nicotine and Carbamylcholine Binding to Nicotinic Acetylcholine Receptors as Studied in AChBP Crystal Structures

Celie, P. H. N., van Rossum-Fikkert, S. E., van Dijk, W. J., Brejc, K., Smit, A. B., & Sixma, T. K. (2004) · Neuron · doi:10.1016/s0896-6273(04)00115-1 · Cited by 781

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

Taly, A., Corringer, P., Guédin, D., Lestage, P. J., & Changeux, J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2927 · Cited by 743

The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells

Hilscher, M. M., Mikulovic, S., Perry, S. E., Lundberg, S., & Kullander, K. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106895 · Cited by 15

Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists

Hone, A. J., Rueda‐Ruzafa, L., Gordon, T. J., Gajewiak, J., Christensen, S. B., Dyhring, T., Albillos, A., & McIntosh, J. M. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14966 · Cited by 15

Treating brain diseases using systemic parenterally-administered protein therapeutics: Dysfunction of the brain barriers and potential strategies

Zaghmi, A., Drouin‐Ouellet, J., Brambilla, D., & Gauthier, M. A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120461 · Cited by 17

Effects of Nicotine Gum Administration on Vision (ENIGMA-Vis): Study Protocol of a Double-Blind, Randomized, and Controlled Clinical Trial

Fernandes, T. P., Hovis, J. K., de Almeida, N. L. P., Souto, J. J. S., Bonifácio, T. A. D. S., Rodrigues, S. J., Silva, G. M., Andrade, M. O., Silva, J. B., Gomes, G. H., et al. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00314 · Cited by 15

Cell signaling and epigenetic regulation of nicotine-induced carcinogenesis

Sun, Q., & Jin, C. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123426 · Cited by 15

Alterations in Neuronal Nicotinic Acetylcholine Receptors in the Pathogenesis of Various Cognitive Impairments

Guan, Z. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70069 · Cited by 14

New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence

Saravia, R., Ten-Blanco, M., Pereda-Pérez, I., & Berrendero, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413316 · Cited by 14

TRPC channels mediated calcium entry is required for proliferation of human airway smooth muscle cells induced by nicotine-nAChR

Jiang, Y., Zhou, Y., Peng, G., Tian, H., Pan, D., Liu, L., Yang, X., Li, C., Li, W., Chen, L., et al. (2018) · Biochimie · doi:10.1016/j.biochi.2018.12.004 · Cited by 14

Curare alkaloids from Matis Dart Poison: Comparison with d-tubocurarine in interactions with nicotinic, 5-HT3 serotonin and GABAA receptors

Spirova, E. N., Ivanov, I. A., Kasheverov, I. E., Kudryavtsev, D. S., Shelukhina, I. V., Garifulina, A. I., Son, L. V., Lummis, S. C. R., Garcia, G. R. M., Bussmann, R. W., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210182 · Cited by 17

Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions

Whiteaker, P., & George, A. A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106743 · Cited by 14

CHRNA5 gene variation affects the response of VTA dopaminergic neurons during chronic nicotine exposure and withdrawal

Yang, K., McLaughlin, I., Shaw, J. K., Cardé, N. A. Q., Dani, J. A., & Biasi, M. D. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109547 · Cited by 12

Cholinergic Modulation of Dendritic Signaling in Hippocampal GABAergic Inhibitory Interneurons

Pancotti, L., & Topolnik, L. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.06.011 · Cited by 13

Cell-Type Specific Neuromodulation of Excitatory and Inhibitory Neurons via Muscarinic Acetylcholine Receptors in Layer 4 of Rat Barrel Cortex

Qi, G., & Feldmeyer, D. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.843025 · Cited by 10

Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds

Sarasamkan, J., Scheunemann, M., Apaijai, N., Palee, S., Parichatikanond, W., Arunrungvichian, K., Fischer, S., Chattipakorn, S. C., Deuther‐Conrad, W., Schüürmann, G., et al. (2016) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6b00146 · Cited by 13

Structural basis for ion selectivity and engineering in channelrhodopsins

Rappleye, M., & Berndt, A. (2019) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2019.04.008 · Cited by 13

Is There a Genetic Basis for Information Search Propensity? A Genotyping Experiment

Browne, G. J., & Walden, E. A. (2020) · MIS Quarterly · doi:10.25300/misq/2020/14718 · Cited by 13

Apoptosis in the neuroprotective effect of α7 nicotinic receptor in neurodegenerative models

Mugayar, A. A., Guimarães, G. D. S., de Oliveira, P. H. T., Miranda, R. L., & dos Santos, A. A. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25239 · Cited by 13

The molecular basis and evolution of toxin resistance in poison frogs

Coleman, J. L., & Cannatella, D. C. (2023) · Evolutionary Ecology · doi:10.1007/s10682-023-10258-0 · Cited by 16

Research progress and prospect on the safety of heated tobacco products

Liu, Y., Cao, J., Zhang, J., Chen, G., Luo, C., & Huang, L. (2024) · Toxicology · doi:10.1016/j.tox.2024.153823 · Cited by 12

The role of nicotinic acetylcholine receptors in the pathophysiology and pharmacotherapy of autism spectrum disorder: Focus on α7 nicotinic receptors

Öz, M., Kury, L. T. A., Sadek, B. S., & Mahgoub, M. (2024) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2024.106634 · Cited by 12

Extrinsic and intrinsic control of striatal cholinergic interneuron activity

Ratna, D., & Francis, T. C. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1528419 · Cited by 13

Anthelmintic resistance and homeostatic plasticity (Brugia malayi)

Kashyap, S. S., Verma, S., McHugh, M. A., Wolday, M., Williams, P., Robertson, A. P., & Martin, R. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-93911-4 · Cited by 12

Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors

McNeill, R. V., Palladino, V. S., Brunkhorst-Kanaan, N., Grimm, O., Reif, A., & Kittel‐Schneider, S. (2020) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2020.1809014 · Cited by 11

Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies

Pohanka, M. (2020) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557520666201117111715 · Cited by 12

Nicotine Activating α4β2 Nicotinic Acetylcholine Receptors to Suppress Neuroinflammation via JAK2-STAT3 Signaling Pathway in Ischemic Rats and Inflammatory Cells

Wang, Q., Gou, J., Guo, S., Feng, W., Han, T., Lai, R., Zhang, D., Diao, Y., & Yin, Y. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02797-4 · Cited by 11

New medications development for smoking cessation

Lengel, D., & Kenny, P. J. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100103 · Cited by 14

Human Nicotinic Acetylcholine Receptors: Part I—Structure, Function, and Role in Neuromuscular Transmission and CNS Functioning

Kulbatskii, D. S., Bychkov, M. L., & Lyukmanova, E. N. (2018) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162018060043 · Cited by 11

Impact of Nicotine on Cognition in Patients With Schizophrenia: A Narrative Review

Spasova, V., Mehmood, S., Minhas, A., Azhar, R., Anand, S., Abdelaal, S., Sham, S., Chauhan, T. M., & Dragas, D. (2022) · Cureus · doi:10.7759/cureus.24306 · Cited by 13

Overview

Akaike, A., & Izumi, Y. (2018) · Springer eBooks · doi:10.1007/978-981-10-8488-1_1 · Cited by 11

Novel agonist of α4β2* neuronal nicotinic receptor with antinociceptive efficacy in rodent models of acute and chronic pain

Sudo, R. T., Hayashida, K., Santos, A. N., Kawatani, M., Monteiro, C. E. D. S., Moreira, R. D., Trachez, M. M., Montes, G. C., & Zapata‐Sudo, G. (2018) · Journal of Pain Research · doi:10.2147/jpr.s169637 · Cited by 11

Del consumo ocasional del tabaco a la adicción a la nicotina

Matar-Khalil, S., Vallejo, C. P., & Portilla, C. U. (2022) · Nova · doi:10.22490/24629448.6592 · Cited by 10

The Role of the Acetylcholine System in Common Respiratory Diseases and COVID-19

Li, D., Wu, J., & Xiong, X. (2023) · Molecules · doi:10.3390/molecules28031139 · Cited by 10

Activation of nicotinic acetylcholine receptors induces potentiation and synchronization within in vitro hippocampal networks

Djemil, S., Chen, X., Zhang, Z., Lee, J., Rauf, M., Pak, D. T. S., & Dzakpasu, R. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14938 · Cited by 13

Dynamics and Interactions of GPI-Linked Lynx1 Protein with/without Nicotinic Acetylcholine Receptor in Membrane Bilayers

Dong, C., Kern, N. R., Anderson, K. R., Zhang, X.-H., Miwa, J., & Im, W. (2020) · Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c00159 · Cited by 10

Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease

Costantini, E., Carrarini, C., Borrelli, P., Rosa, M. D., Calisi, D., Consoli, S., D’Ardes, D., Cipollone, F., Nicola, M. D., ONOFRJ, M. C., et al. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00329-9 · Cited by 10

Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms

Ogawara, H. (2018) · Molecules · doi:10.3390/molecules23061476 · Cited by 11

Full rescue of an inactive olfactory receptor mutant by elimination of an allosteric ligand-gating site

Sharma, K., Balfanz, S., Baumann, A., & Korsching, S. I. (2018) · Scientific Reports · doi:10.1038/s41598-018-27790-7 · Cited by 10

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathwayPreprint

Isotani, R., Igarashi, M., Miura, M., Naruse, K., Kuranami, S., Katoh, M., Nomura, S., & Yamauchi, T. (2024) · eLife · doi:10.7554/elife.95267 · Cited by 10

Design, Synthesis, and Structure–Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors

Hone, A. J., Santiago, U., Harvey, P. J., Tekarli, B., Gajewiak, J., Craik, D. J., Camacho, C. J., & McIntosh, J. M. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00735 · Cited by 8

Structure, Dynamics, and Ligand Recognition of Human-Specific CHRFAM7A (Dupα7) Nicotinic Receptor Linked to Neuropsychiatric Disorders

Liu, D., de Souza, J. V. B., Ahmad, A., & Bronowska, A. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115466 · Cited by 9

Differential Effects of Nicotine, Alcohol, and Coexposure on Neuroimmune-Related Protein and Gene Expression in Corticolimbic Brain Regions of Rats

Randall, P. A., Sun, D., & Randall, P. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00413 · Cited by 9

Investigating the influence of perinatal nicotine exposure on genetic profiles of neurons in the sub-regions of the VTA

Kazemi, T., Avci, N. G., Keller, R. F., Akay, Y. M., & Akay, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-59248-0 · Cited by 9

Dose-dependent effects of GAT107, a novel allosteric agonist-positive allosteric modulator (ago-PAM) for the α7 nicotinic cholinergic receptor: a BOLD phMRI and connectivity study on awake rats

Brems, B. M., Sullivan, E. E., Connolly, J. G., Zhang, J., Chang, A., Ortiz, R. J., Cantwell, L., Kulkarni, P. P., Thakur, G. A., & Ferris, C. F. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1196786 · Cited by 8

The role of nicotinic receptors in alcohol consumption

Kamens, H. M., Flarend, G., & Horton, W. J. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106705 · Cited by 8

Effect of chronic vapor nicotine exposure on affective and cognitive behavior in male mice

Murdaugh, L., Miliano, C., Chen, I., Faunce, C. L., Natividad, L. A., Gregus, A. M., & Buczynski, M. W. (2024) · Scientific Reports · doi:10.1038/s41598-024-56766-z · Cited by 6

Compounding Methylene Blue with Selenium-decorated Graphene Quantum Dots to Improve Singlet Oxygen Production for Photodynamic Therapy Application

Khorshidi, A., Bahari, A., & Hamidabadi, V. F. (2024) · Journal of Fluorescence · doi:10.1007/s10895-024-03719-4 · Cited by 8

Neurobiological Considerations for Tobacco Use Disorder

Chawla, M., & Garrison, K. A. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0168-3 · Cited by 9

e‐Cigarettes for smoking cessation: Do they deliver?

Kitzen, J. M., McConaha, J. L., Bookser, M. L., Pergolizzi, J. V., Taylor, R., & Raffa, R. B. (2019) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12833 · Cited by 8

Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells

Qian, J., Mummalaneni, S., Larsen, J. D., Grider, J. R., Spielman, A. I., Özdener, M. H., & Lyall, V. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194089 · Cited by 8

The nicotinic α7 receptor agonist GTS-21 but not the nicotinic α4β2 receptor agonist ABT-418 attenuate the disrupting effects of anesthetic ketamine on recognition memory in rats

Pitsikas, N. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112778 · Cited by 8

α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer

Feng, X., Tian, Y., Guo, X., Lei, J. H., Yu, J., Zheng, C., Chen, M., Ding, R., Kwok, H. F., Luo, S., et al. (2025) · Biomolecules · doi:10.3390/biom15060835 · Cited by 7

Targeting Neuronal Alpha7 Nicotinic Acetylcholine Receptor Upregulation in Age-Related Neurological Disorders

Abraham, S. M., Suresh, S., & Komal, P. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01586-6 · Cited by 8

Pharmacology of Acetylcholine and Cholinergic Receptors

Kokaz, S. F., Deb, P. K., Abed, S. N., Al-Aboudi, A. F., Das, N., Younes, F. A., Salou, R. A., Bataineh, Y. A., Venugopala, K. N., & Mailavaram, R. P. (2020) · Springer eBooks · doi:10.1007/978-981-15-3556-7_3 · Cited by 7

Δ8-THC Induces Up-Regulation of Glutamatergic Pathway Genes in Differentiated SH-SY5Y: A Transcriptomic Study

Anchesi, I., Schepici, G., Chiricosta, L., Gugliandolo, A., Salamone, S., Caprioglio, D., Pollastro, F., & Mazzon, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119486 · Cited by 7

Multiple cholinergic receptor subtypes coordinate dual modulation of acetylcholine on anterior and posterior paraventricular thalamic neurons

Ye, Q., Nunez, J., & Zhang, X. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16115 · Cited by 8

Human α10 nicotinic acetylcholine receptor subunits assemble to form functional receptors

Tekarli, B., Azam, L., Hone, A. J., & McIntosh, J. M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108182 · Cited by 6

Molecular organization of central cholinergic synapses

Rosenthal, J., Zhang, D., Yin, J., Long, C., Yang, G., Li, Y., Lu, Z., Li, W., Yu, Z., Li, J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422173122 · Cited by 6

Tropisetron attenuates neuroinflammation and chronic neuropathic pain via α7nAChR activation in the spinal cord in rats

Zhang, Y., Yu, D., Gong, X., Meng, C., Lv, J., & Li, Q. (2022) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2022.2046923 · Cited by 6

Selective α3β4 Nicotinic Acetylcholine Receptor Ligand as a Potential Tracer for Drug Addiction

Kanasuwan, A., Deuther‐Conrad, W., Chongruchiroj, S., Sarasamkan, J., Chotipanich, C., Vajragupta, O., & Arunrungvichian, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043614 · Cited by 6

Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells

Hamilton, A., Zhang, Q., Gao, R., Hill, T. G., Salehi, A., Knudsen, J. G., Draper, M., Johnson, P. R. V., Rorsman, P., & Tarasov, A. (2024) · Diabetes · doi:10.2337/db23-0809 · Cited by 5

Novel Transgenic Zebrafish Lines to Study the CHRNA3‐B4‐A5 Gene Cluster

Hua, Y., Habicher, J., Carl, M., Manuel, R., & Boije, H. (2024) · Developmental Neurobiology · doi:10.1002/dneu.22956 · Cited by 6

Unraveling the Role of CHRNA6, the Neuronal α6 Nicotinic Acetylcholine Receptor Subunit

Heydary, Y. H., Castro, E. M., Lotfipour, S., & Leslie, F. M. (2025) · Receptors · doi:10.3390/receptors4010001 · Cited by 8

Nicotinic acetylcholine gene cluster CHRNA5-A3-B4 variants influence smoking status in a Bangladeshi population

Chaity, N. I., Sultana, T. N., Hasan, M. M., Shrabonee, I. I., Nahid, N. A., Islam, M. S., & Apu, M. N. H. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00243-1 · Cited by 8

Exploring Neurobehaviour in Zebrafish Embryos as a Screening Model for Addictiveness of Substances

Havermans, A., Zwart, E., Cremers, H., van Schijndel, M. D. M., Constant, R. S., Mešković, M., Worutowicz, L. X., Pennings, J. L. A., Talhout, R., van der Ven, L. T. M., et al. (2021) · Toxics · doi:10.3390/toxics9100250 · Cited by 6

Clearing the Haze: How Does Nicotine Affect Hematopoiesis before and after Birth?

Cool, T., y Baena, A. R., & Forsberg, E. C. (2021) · Cancers · doi:10.3390/cancers14010184 · Cited by 6

Nicotine

Veljkovic, E., Xia, W., Phillips, B. W., Wong, E. T., Ho, J., Oviedo, A., Hoeng, J., & Peitsch, M. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812922-7.00009-3 · Cited by 6

Expression, correlation, and prognostic significance of different nicotinic acetylcholine receptors, programed death ligand 1, and dopamine receptor D2 in lung adenocarcinoma

Pal, K., Hussain, T., Xie, H., Li, S., Yang, P., Mansfield, A. S., Lou, Y., Chowdhury, S., & Mukhopadhyay, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.959500 · Cited by 6

Central Cholinergic Synapse Formation in Optimized Primary Septal-Hippocampal Co-cultures

Djemil, S., Ressel, C. R., Abdel‐Ghani, M., Schneeweis, A. K., & Pak, D. T. S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00948-6 · Cited by 7

Nicotinic receptor modulation of primary afferent excitability with selective regulation of Aδ-mediated spinal actions

Shreckengost, J., Halder, M., Mena-Avila, E., Garcia-Ramirez, D. L., Quevedo, J. N., & Hochman, S. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00228.2020 · Cited by 6

Protective Mechanism of Luteinizing Hormone and Follicle-Stimulating Hormone Against Nicotine-Induced Damage of Mouse Early Folliculogenesis

Liu, W., Zhang, Y., Wang, Y., Klinger, F. G., Tan, S., Farini, D., Felici, M. D., Shen, W., & Cheng, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.723388 · Cited by 6

Nicotine-Induced Endoplasmic Reticulum Stress and Airway Smooth Muscle Cell Proliferation Is Mediated by α7nAChR and Chaperones-RIC-3 and TMEM35

Borkar, N. A., Thompson, M. A., Kelley, B., Shiferaw, B. T., Hamrick, S. K., Sathish, V., Prakash, Y. S., & Pabelick, C. M. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2024-0194oc · Cited by 5

Nicotine from a Different Angle: Biological Effects from a Psychoneuroimmunological Perspective

Sinkevicius, L. V., Sakalauskaitė, S., Bukovskis, M., Lõokene, M., Valvere, V., Gradauskienė, B., & Viigimaa, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136437 · Cited by 6

Nicotine neurotoxicity exacerbation following engineered Ag and Cu (50–60 nm) nanoparticles intoxication. Neuroprotection with nanowired delivery of antioxidant compound H-290/51 together with serotonin 5-HT3 receptor antagonist ondansetron

Tian, Z. R., Sharma, A., Muresanu, D. F., Sharma, S., Feng, L., Zhang, Z., Li, C., Buzoianu, A. D., Lafuente, J. V., Nozari, A., et al. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.07.002 · Cited by 5

An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites

da Silva, P. R., Pazos, N. D. N., Andrade, J., de Sousa, N. F., Pires, H. F. O., Lima, J. L. D. F., Dias, A. L., Salvadori, M. G. D. S. S., Golzio, A. M. F. D. O., de Castro, R. D., et al. (2024) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575261945231122062659 · Cited by 5

Sub-chronic nicotine exposure influences methamphetamine self-administration and dopamine overflow in a sex-and genotype-dependent manner in humanized CHRNA6 3′-UTR SNP (rs2304297) adolescent rats

Carreño, D., Facundo, A., Cardenas, A. M., & Lotfipour, S. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1445303 · Cited by 6

Novel Pharmacotherapies for L-DOPA-Induced Dyskinesia

Tizabi, Y., Getachew, B., Copeland, R., Moratalla, R., Patricio, F., Limón, I. D., Bel, E. D., & Aschner, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-71519-9_218-1 · Cited by 5

Pharmacokinetics and Pharmacodynamics: Fundamentals and Role(s) in Drug Discovery and Development

Mittal, A., Ghai, R., Srivastava, A., Ghosh, D., & Nagarajan, K. (2023) · Springer eBooks · doi:10.1007/978-981-99-2302-1_15 · Cited by 5

Ionotropic Receptors

Meriney, S. D., & Fanselow, E. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815320-8.00011-9 · Cited by 5

Bibliometric analysis of nicotinic acetylcholine receptors channel research (2000-2020)

Zhu, X., Zhou, Y., Yuan, G., Shi, J., Shi, S., Zhang, L., Chai, R., Du, Y., Duan, C., & Hu, Y. (2021) · Channels · doi:10.1080/19336950.2021.1882113 · Cited by 5

Correlates of Tobacco Use Among People with Mental Illness Within Asia: A Scoping Review

Parul, P., Joseph, B., Datta, S., & Rahman, M. A. (2024) · Community Mental Health Journal · doi:10.1007/s10597-024-01336-w · Cited by 4

Organofosforados e organoclorados: toxicologia médica e reflexos ambientais

Miler-da-Silva, L. L., & Garrido, R. G. (2021) · Research Society and Development · doi:10.33448/rsd-v10i10.18853 · Cited by 4

Nicotinic acetylcholine receptors: Diversity and physiological importance for neurodegenerative disorders and development of organophosphate antidotes

Zandona, A. (2020) · Periodicum Biologorum · doi:10.18054/pb.v121-122i3-4.10547 · Cited by 5

Neurotransmitter Systems

Weis, S., Sonnberger, M., Dunzinger, A., Voglmayr, E., Aichholzer, M., Kleiser, R., & Strasser, P. (2019) · Springer eBooks · doi:10.1007/978-3-7091-1544-2_13 · Cited by 4

Pre-validation of an alternative test method for prediction of developmental neurotoxicity

Jeong, S., Park, S.-M., Jo, N. R., Kwon, J., Lee, J., Kim, K., Go, S. M., Cai, L., Ahn, D., Lee, S. D., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113070 · Cited by 4

Synthesis and Biological Activity of Novel α-Conotoxins Derived from Endemic Polynesian Cone Snails

Souf, Y., Lokaj, G., Veeresh, K., Saed, Y., Raviglione, D., Brik, A., Nicke, A., Inguimbert, N., & Dutertre, S. (2023) · Marine Drugs · doi:10.3390/md21060356 · Cited by 4

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

Isotani, R., Igarashi, M., Miura, M., Naruse, K., Kuranami, S., Katoh, M., Nomura, S., & Yamauchi, T. (2025) · eLife · doi:10.7554/elife.95267.4 · Cited by 3

Chimeric Approach to Identify Molecular Determinants of Nicotinic Acetylcholine Receptors

Sapkota, P., Akaberi, S. M., Ghimire, B., & Sharma, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27021091 · Cited by 3

Acetylcholine - Recent Advances and New Perspectives

Heinbockel, T. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.106304 · Cited by 3

Cotinine as a Possible Allosteric Modulator of Nicotine Effects in Various Models

Pagán, O. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00008-3 · Cited by 3

Simulations of Promising Indolizidine—α6-β2 Nicotinic Acetylcholine Receptor Complexes

Acquah, F. A., Paramel, M., Kuta, A., Hussaini, S. R., Wallace, D. R., & Mooers, B. H. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157934 · Cited by 3

TOBACCO USE DISORDER AND DUAL DISORDERS Joint statement by the Spanish Psychiatry Society and the Spanish Dual Disorders Society.

Szerman, N., Carlos, P., Pinet, C., Martínez-Raga, J., Basurte, I., & Sáiz, P. A. (2022) · Actas Españolas de Psiquiatría · Cited by 4

SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats

Braunscheidel, K. M., Voren, G., Fowler, C. D., Lu, Q., Kuryatov, A., Cameron, M. D., Ibáñez-Tallon, I., Lindstrom, J. M., Kamenecka, T. M., & Kenny, P. J. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1459098 · Cited by 3

Alteration in behavior of rat after chronic exposure to acetamiprid

Mondal, S., Pradhan, S., & Mukhopadhayay, S. K. (2019) · Veterinary World · doi:10.14202/vetworld.2019.254-257 · Cited by 3

The Association between the Binding Processes of Working Memory and Vascular Risk Profile in Adults

Bika, E., Μoraitou, D., Masoura, E. V., Kolios, G. C., Παπαντωνίου, Γ., Sofologi, M., Papaliagkas, V. T., & Ntritsos, G. (2021) · Brain Sciences · doi:10.3390/brainsci11091140 · Cited by 3

Desformylflustrabromine (dFBr), a positive allosteric modulator of the α4β2 nicotinic receptor modulates the hypnotic response to ethanol

DeCristofano, L., Decker, S., Schulte, M. K., & Suryanarayanan, A. (2021) · Alcohol · doi:10.1016/j.alcohol.2021.02.005 · Cited by 3

Efficacy and safety of repetitive transcranial magnetic stimulation in the treatment of male smokers with tobacco use disorder: a randomized controlled trial

Mousa, S. W., Badawy, A. A., Attia, G. F., & Ghareeb, W. A. E. S. (2025) · Middle East Current Psychiatry · doi:10.1186/s43045-025-00503-3 · Cited by 2

Subtype-selective effect and molecular regulation of celastrol and triptolide at human nicotinic acetylcholine receptors

Moon, M., Pyeon, M., Yang, J., Yun, J., Yeom, H. D., Lee, M., Lee, G., & Lee, J. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111412 · Cited by 2

Molecular regulation and subtype-specific effects of naringenin and naringin on nicotinic acetylcholine receptors expressed in Xenopus oocytes

Yun, J., Moon, M., Yang, J., Yeom, H. D., Lee, M., Lee, G., & Lee, J. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118494 · Cited by 2

Early nicotine initiation and white matter integrity: Associations from late childhood to mid-adolescence

Sullivan, R. M., Wallace, A. L., May, A. C., Lyman, J., Lisdahl, K., Wade, N., Courtney, K., Doran, N., & Jacobus, J. (2025) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2025.112954 · Cited by 3

Recent advances in understanding the structure of nicotinic acetylcholine receptors

Zouridakis, M., Zisimopoulou, P., Poulas, K., & Tzartos, S. (2009) · IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology · doi:10.1002/iub.170 · Cited by 65

Neuronal nicotinic acetylcholine receptors: from structure to therapeutics

Clementi, F., Fornasari, D., & Gotti, C. (2000) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01423-6 · Cited by 37

Molecular Diversity of Neuronal Nicotinic Acetylcholine Receptors

McGehee, D. S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11330.x · Cited by 101

Critical Review Recent Advances in Understanding the Structure of Nicotinic

Receptors, A., Zouridakis, M., Zisimopoulou, P., Poulas, K., & Tzartos, S. J. (2015)

Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling

Papke, R. L., & Lindstrom, J. M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108021 · Cited by 128