Placebo Analgesia in Rodents: Current and Future Research
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The investigation of placebo effects in animal pain models has received less attention than human research. This may be related to a number of difficulties, including the fact that animals lack the ability to use language and establish expectancies verbally, that animals cannot report and rate the extent to which they experience pain, and the inadequacy of current models of pain. Here, we describe the relatively small number of studies that have been published, communicating the opportunities and excitement of this research. We critically discuss pitfalls and limitations with the hope that this will advance future animal placebo-related research.
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The placebo response in chronic pain may substantially differ from that in acute pain.
“Interestingly, the placebo response in CP may substantially differ from that in AP.12”
From <p>Pain and Evil: From Local Nociception to Misery Following Social Harm</p> (2020) · cites this paper as [12]
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Additional file 2 of Re-evaluating the placebo response in recent canine dietary epilepsy trials
Schmidt, T., Meyerhoff, N., Meller, S., Twele, F., Charalambous, M., Berk, B. A., Law, T. H., Packer, R. M. A., Zanghi, B. M., Pan, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25893982
Additional file 1 of Re-evaluating the placebo response in recent canine dietary epilepsy trials
Schmidt, T., Meyerhoff, N., Meller, S., Twele, F., Charalambous, M., Berk, B. A., Law, T. H., Packer, R. M. A., Zanghi, B. M., Pan, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25893830
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Self-citation
- Authors
- Keller, A., Akintola, T., & Colloca, L.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Keller, Asaf
- Venue
- International Review of Neurobiology
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 138
- Pages
- 1-15
- ISSN
- 0074-7742 (ISSN-L)
- PMC
- PMC5918296
- OpenAlex
- W2791401629
- Cited by
- 45
- References
- 63
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 16 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 5
- FWCI
- 8.09
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS099245)
- National Institute of Dental and Craniofacial Research (R01DE025946)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Keywords
- placebo analgesia, placebo effect, animal models of pain, rodents, pain anticipation
- MeSH terms
- Analgesia, Animals, Conditioning, Classical, Placebo Effect, Mice, Rats, Chronic Pain, Acute Pain
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