Altered Placebo and Drug Labeling Changes the Outcome of Episodic Migraine Attacks
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In 459 migraine attacks, information provided to patients (from negative to neutral to positive) modified placebo and medication outcomes in a progressive fashion.
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In medical care, placebo and nocebo effects can affect how well a treatment works.
“In a clinical setting, it has been demonstrated that either or both placebo (positive expectancy of pain relief) and nocebo effects (negative expectancy of increased pain) influence the effectiveness of medical treatment (Kam-Hansen et al., 2014; Pollo et al., 2001).”
From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Kam-Hansen et al., 2014
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Harnessing the Placebo Effect in Pediatric Migraine Clinic
Faria, V., Linnman, C., Lebel, A., & Borsook, D. (2014) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2014.06.040 · Cited by 58 · see citing works
Κube, T., & Rief, W. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.11.022 · Cited by 57 · see citing works
Ballou, S., Kaptchuk, T. J., Hirsch, W., Nee, J. W., Iturrino, J., Hall, K. T., Kelley, J. M., Cheng, V., Kirsch, I., Jacobson, E., et al. (2017) · Trials · doi:10.1186/s13063-017-1964-x · Cited by 56 · see citing works
Self-citationZahrt, O. H., & Crum, A. J. (2017) · Health Psychology · doi:10.1037/hea0000531 · Cited by 57 · see citing works
Placebo effects in osteoarthritis: implications for treatment and drug development
Neogi, T., & Colloca, L. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01021-4 · Cited by 55 · see citing works
Nocebo vs. Placebo: The Challenges of Trial Design in Analgesia Research
Vase, L., Amanzio, M., & Price, D. D. (2015) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.31 · Cited by 54 · see citing works
“41 Thus, each patient was tested in seven conditions: one control condition, placebo with each of the three suggestions, and the active drug with each of the three suggestions.”
InfluentialDoes training general practitioners result in more shared decision making during consultations?
Sanders, A., Bensing, J. M., Essed, M. A. L. U., Magnée, T., de Wit, N. J., & Verhaak, P. F. M. (2016) · Patient Education and Counseling · doi:10.1016/j.pec.2016.10.002 · Cited by 54 · see citing works
Esch, T., & Stefano, G. B. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.913573 · Cited by 64 · see citing works
“The results from studies published by Kam-Hansen et al. (2014) and Kaptchuk et al. (2010) suggested that the placebo effect exists even in studies involving ‘‘open-label treatments’’ (i.e., when the patient is informed that he or she will be taking a drug with no active ingredients).”
ResultThe role of patient beliefs in open-label placebo effects.
Leibowitz, K. A., Hardebeck, E. J., Goyer, J. P., & Crum, A. J. (2019) · Health Psychology · doi:10.1037/hea0000751 · Cited by 56 · see citing works
“…of other conditions, including attention-deficit-hyperactivity disorder (ADHD), allergic rhinitis, migraines, and back pain (Carvalho et al., 2016; Kam-Hansen et al., 2014; Sandler & Bodfish, 2008; Sandler, Glesne, & Bodfish, 2010; Schaefer, Harke, & Denke, 2016; Schaefer, Sahin, & Berstecher,…”
Flowers, K. M., Patton, M. E., Hruschak, V., Fields, K. G., Schwartz, E., Zeballos, J., Kang, J. D., Edwards, R. R., Kaptchuk, T. J., & Schreiber, K. L. (2021) · Pain · doi:10.1097/j.pain.0000000000002185 · Cited by 52 · see citing works
Self-citationCurrow, D. C., Glare, P. A., Louw, S., Martin, P., Clark, K., Fazekas, B. S., & Agar, M. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-82120-8 · Cited by 50 · see citing works
Brihi, J. E., Horne, R., & Faasse, K. (2018) · Annals of Behavioral Medicine · doi:10.1093/abm/kay011 · Cited by 50 · see citing works
Unsolved, Forgotten, and Ignored Features of the Placebo Response in Medicine
Enck, P., Klosterhalfen, S., & Weimer, K. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.11.016 · Cited by 49 · see citing works
Placebo and nocebo responses in drug trials of epilepsy.
Zaccara, G., Giovannelli, F., & Schmidt, D. (2015) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.12.004 · Cited by 45 · see citing works
Placebo Analgesia in Rodents: Current and Future Research
Keller, A., Akintola, T., & Colloca, L. (2018) · International Review of Neurobiology · doi:10.1016/bs.irn.2018.02.001 · Cited by 45 · see citing works
“…Robinson, Verne, & Price, 2003, 2005), idiopathic and neuropathic pain (Petersen et al., 2012, 2014; Vase, Petersen, & Lund, 2014), low back pain (Carvalho et al., 2016; Hashmi et al., 2012), migraine (Kam-Hansen et al., 2014), and knee osteoarthritis (Gollub et al., 2018; Tetreault et al., 2016).”
BackgroundContextually Aided Recovery (CARe): a scientific theory for innate healing
Newell, D., Lothe, L. R., & Raven, T. J. L. (2017) · Chiropractic & Manual Therapies · doi:10.1186/s12998-017-0137-z · Cited by 46 · see citing works
Placebo Improvement in Pharmacologic Treatment of Menopausal Hot Flashes
Freeman, E. W., Ensrud, K. E., Larson, J. C., Guthrie, K. A., Carpenter, J. S., Joffe, H., Newton, K. M., Sternfeld, B., & LaCroix, A. Z. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000143 · Cited by 45 · see citing works
“Other data show that placebos given after active drug treatment maintained the active drug outcome with reduced adverse effects (9).”
BackgroundMindfulness Meditation Modulates Pain Through Endogenous Opioids
Sharon, H., Maron-Katz, A., Ben Simon, E., Flusser, Y., Hendler, T., Tarrasch, R., & Brill, S. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.03.002 · Cited by 44 · see citing works
Deceptive and Nondeceptive Placebos to Reduce Pain
Κube, T., Rief, W., Vivell, M.-B., Schäfer, N. L., Vermillion, T., Körfer, K., & Glombiewski, J. A. (2019) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000781 · Cited by 44 · see citing works
The Ethics of Placebo Effects in Clinical Practice and Research
Annoni, M. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.031 · Cited by 44 · see citing works
Schaefer, M., Denke, C., Harke, R., Olk, N., Erkovan, M., & Enge, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-49466-6 · Cited by 44 · see citing works
What can be done to control the placebo response in clinical trials? A narrative review
Evans, K., Colloca, L., Peciña, M., & Katz, N. P. (2021) · Contemporary Clinical Trials · doi:10.1016/j.cct.2021.106503 · Cited by 44 · see citing works
How can placebo effects best be applied in clinical practice? A narrative review
Bystad, M. K., Wynn, R., & Bystad, C. (2015) · Psychology Research and Behavior Management · doi:10.2147/prbm.s75670 · Cited by 44 · see citing works
Placebo Effects and the Ethics of Therapeutic Communication: A Pragmatic Perspective
Annoni, M., & Miller, F. G. (2016) · Kennedy Institute of Ethics journal · doi:10.1353/ken.2016.0004 · Cited by 45 · see citing works
“In a recent study by Kam-Hansen et al. (2014), 66 patients with recurring migraine headaches were randomized using a 2 × 3 balanced-placebo design.”
MethodSchmitz, J., Müller, M., Stork, J., Eichler, I., Zöllner, C., Flor, H., & Klinger, R. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000501385 · Cited by 43 · see citing works
Healing in a Social Context: The Importance of Clinician and Patient Relationship
Wampold, B. E. (2021) · Frontiers in Pain Research · doi:10.3389/fpain.2021.684768 · Cited by 42 · see citing works
“As discussed earlier, placebo effects, most likely due to expectancies, can be created without face-to-face interactions (32, 33), say by written information.”
BackgroundOpen-label placebo for chronic low back pain: a 5-year follow-up
Carvalho, C., Pais, M., Cunha, L., Rebouta, P., Kaptchuk, T. J., & Kirsch, I. (2020) · Pain · doi:10.1097/j.pain.0000000000002162 · Cited by 40 · see citing works
Self-citationAn update on behavioral treatments in migraine - current knowledge and future options
Kropp, P., Meyer, B., Meyer, W., & Dresler, T. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1377611 · Cited by 37 · see citing works
Parental Attitudes About Placebo Use in Children
Faria, V., Kossowsky, J., Petkov, M. P., Kaptchuk, T. J., Kirsch, I., Lebel, A., & Borsook, D. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.10.018 · Cited by 37 · see citing works
Self-citationThe Placebo Effect in Cardiology: Understanding and Using It
Sheldon, R. S., & Opie, M. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.09.017 · Cited by 37 · see citing works
- Authors
- Kam-Hansen, S., Jakubowski, M., Kelley, J. M., Kirsch, I., Hoaglin, D. C., Kaptchuk, T. J., & Burstein, R.
- Affiliations
- Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
- Beth Israel Deaconess Medical Center (US)
- IC Independent Consulting (Australia) (AU)
- Corresponding author
- Kaptchuk, Ted J.
- Burstein, Rami
- Venue
- Science Translational Medicine
- Published
- 2014-01-08
- Volume
- 6
- Issue
- 218
- Pages
- 218ra5-218ra5
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4005597
- OpenAlex
- W2169836118
- Cited by
- 399
- References
- 22
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 21 · 2023: 26 · 2022: 28 · 2021: 38 · 2020: 47 · 2019: 38 · 2018: 42 · 2017: 36 · 2016: 27 · 2015: 29 · 2014: 29
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS069847, R37NS079678)
- National Center for Complementary and Integrative Health (K24AT004095)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Keywords
- episodic migraine, placebo effect, drug labeling, rizatriptan, patient information, analgesia
- MeSH terms
- Drug Labeling, Humans, Migraine Disorders, Pain Measurement, Placebos, Triazoles, Tryptamines, Treatment Outcome, Endpoint Determination
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